| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beatrice Arosio, Franca Rosa Guerini, Richard C Oude Voshaar, Ivan Aprahamia. Blood Brain-Derived Neurotrophic Factor (BDNF) and Major Depression: Do We Have a Translational Perspective? Frontiers in behavioral neuroscience. vol 15. 2021-03-03. PMID:33643008. |
blood brain-derived neurotrophic factor (bdnf) and major depression: do we have a translational perspective? |
2021-03-03 |
2023-08-13 |
Not clear |
| Galen Chan, Tea Rosic, Stanislav Pasyk, Mahshid Dehghan, Zainab Samaa. Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls. Neuropsychiatric disease and treatment. vol 17. 2021-02-26. PMID:33628025. |
studies have investigated serum bdnf as a biomarker for psychiatric disorders such as depression and schizophrenia. |
2021-02-26 |
2023-08-13 |
Not clear |
| Wei Zheng, Qiaomei Cen, Sha Nie, Minyi Li, Rong Zeng, Sumiao Zhou, Dongbin Cai, Miaoling Jiang, Xiong Huan. Serum BDNF levels and the antidepressant effects of electroconvulsive therapy with ketamine anaesthesia: a preliminary study. PeerJ. vol 9. 2021-02-20. PMID:33604173. |
to firstly examine the relationship between serum brain-derived neurotrophic factor (bdnf) levels and antidepressant response to ketamine as an anaesthesia in electroconvulsive therapy (ect) in chinese patients with treatment-refractory depression (trd). |
2021-02-20 |
2023-08-13 |
Not clear |
| Naeem Ur Rehman, Khadijeh Esmaeilpour, Sara Joushi, Muzaffar Abbas, Mariya Al-Rashida, Khalid Rauf, Yaser Masoumi-Ardakan. Effect of 4-Fluoro-N-(4-sulfamoylbenzyl) Benzene Sulfonamide on cognitive deficits and hippocampal plasticity during nicotine withdrawal in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-19. PMID:33152941. |
plasma bdnf level was reduced during nicotine withdrawal as compared to the saline group reflecting mild cognitive impairment, stress, and depression. |
2021-02-19 |
2023-08-13 |
rat |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
potential mechanisms of depression involving herbal medicines and their specific compounds include elevated 5-ht level and downstream bdnf pathway. |
2021-02-19 |
2023-08-13 |
Not clear |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
thus, the antidepressant properties of both these compounds can be attributed to their ability to influence 5-ht and bdnf pathway, and thereby suggesting that this combination strategy can definitely act as alternative therapy for depression disorder with very limited side effects. |
2021-02-19 |
2023-08-13 |
Not clear |
| Chi Him Poon, Boon Chin Heng, Lee Wei Li. New insights on brain-derived neurotrophic factor epigenetics: from depression to memory extinction. Annals of the New York Academy of Sciences. vol 1484. issue 1. 2021-02-16. PMID:32808327. |
although abnormal brain-derived neurotrophic factor (bdnf) expression in depression has gained much support from preclinical and clinical research, how it mediates behavioral alterations in the depressed state remains largely obscure. |
2021-02-16 |
2023-08-13 |
Not clear |
| Chi Him Poon, Boon Chin Heng, Lee Wei Li. New insights on brain-derived neurotrophic factor epigenetics: from depression to memory extinction. Annals of the New York Academy of Sciences. vol 1484. issue 1. 2021-02-16. PMID:32808327. |
in this review, we discuss key research on stress-induced depression from both preclinical and clinical studies, which revealed that differential epigenetic regulation of specific bdnf exons is associated with depression pathophysiology. |
2021-02-16 |
2023-08-13 |
Not clear |
| Chi Him Poon, Boon Chin Heng, Lee Wei Li. New insights on brain-derived neurotrophic factor epigenetics: from depression to memory extinction. Annals of the New York Academy of Sciences. vol 1484. issue 1. 2021-02-16. PMID:32808327. |
considering that bdnf has a central role in depression, we argue that memory extinction, an adaptive response to fear exposure, is dependent on bdnf modulation and holds promise as a prospective target for alleviating or treating depression and anxiety disorders. |
2021-02-16 |
2023-08-13 |
Not clear |
| Jung Lee, Kyung Hwa Lee, Seong Hae Kim, Ji Youn Han, Soon-Beom Hong, Soo-Churl Cho, Jae-Won Kim, David Bren. Early changes of serum BDNF and SSRI response in adolescents with major depressive disorder. Journal of affective disorders. vol 265. 2021-02-15. PMID:32090756. |
however, in adolescents, bdnf levels in depression and their changes during antidepressant treatment are relatively unknown. |
2021-02-15 |
2023-08-13 |
Not clear |
| Xin Zhang, Katie Kanter, Jiegen Chen, Seungtae Kim, Yaomin Wang, Clementine Adeyemi, Sandra C O'Buckley, Andrea G Nackle. Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice. Pain. vol 161. issue 2. 2021-02-02. PMID:31972854. |
pain and depressive-like behavior were measured over 14 days, and brain-derived neurotrophic factor (bdnf; a factor involved in nociception and depression) and glucocorticoid receptor (gr; a stress-related receptor) expression were measured on day 14. |
2021-02-02 |
2023-08-13 |
mouse |
| Robbie Woods, Opal McInnis, Marc Bedard, Ajani Asokumar, Samantha Santoni, Hymie Anisman, Kimberly Matheson, Robyn J McQuai. Social support and unsupportive interactions in relation to depressive symptoms: Implication of gender and the BDNF polymorphism. Social neuroscience. vol 15. issue 1. 2021-01-29. PMID:31364951. |
reduced levels of brain derived neurotrophic factor (bdnf), through its role in neurogenesis and neuroplasticity, may be involved in the evolution and maintenance of depression. |
2021-01-29 |
2023-08-13 |
Not clear |
| Jie Kang, Di Wang, Yongchang Duan, Lin Zhai, Lin Shi, Fei Gu. Aerobic Exercise Prevents Depression via Alleviating Hippocampus Injury in Chronic Stressed Depression Rats. Brain sciences. vol 11. issue 1. 2021-01-26. PMID:33374661. |
in contrast, ae upregulated phosphorylation of ampar receptor and brain-derived neurotrophic factor (bdnf) hippocampus in cums depression rats. |
2021-01-26 |
2023-08-13 |
rat |
| G M Mandolini, M Lazzaretti, G Delvecchio, C Bressi, J C Soares, P Brambill. Association between serum BDNF levels and maternal perinatal depression: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. Journal of affective disorders. vol 261. 2021-01-25. PMID:31416610. |
association between serum bdnf levels and maternal perinatal depression: a review: special section on "translational and neuroscience studies in affective disorders" section editor, maria nobile md, phd. |
2021-01-25 |
2023-08-13 |
Not clear |
| G M Mandolini, M Lazzaretti, G Delvecchio, C Bressi, J C Soares, P Brambill. Association between serum BDNF levels and maternal perinatal depression: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. Journal of affective disorders. vol 261. 2021-01-25. PMID:31416610. |
however, it is still unclear if a similar deficit in bdnf concentrations might also characterize maternal perinatal depression. |
2021-01-25 |
2023-08-13 |
Not clear |
| Somaye Yosaee, Sepideh Soltani, Alireza Esteghamati, Seyed Abbas Motevalian, Mehdi Tehrani-Doost, Cain C T Clark, Shima Jazayer. Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial. Nutrition (Burbank, Los Angeles County, Calif.). vol 71. 2021-01-21. PMID:31837640. |
the aim of this study was to investigate the effects of zinc, vitamin d, and their co-supplementation versus placebo on changes in the beck depression inventory ii (bdi-ii) score, serum cortisol level, and brain-derived neurotrophic factor (bdnf) in obese/overweight patients with depressive symptoms. |
2021-01-21 |
2023-08-13 |
Not clear |
| Simon Sanwald, Christian Montag, Markus Kiefe. Depressive Emotionality Moderates the Influence of the BDNF Val66Met Polymorphism on Executive Functions and on Unconscious Semantic Priming. Journal of molecular neuroscience : MN. vol 70. issue 5. 2021-01-04. PMID:32002751. |
the brain-derived neurotrophic factor (bdnf) val66met (substitution of valine (val) to methionine (met) at codon 66) polymorphism has been shown to be associated with executive functions as well as depression. |
2021-01-04 |
2023-08-13 |
human |
| Qingfei Chen, Feifei Wang, Yunchao Zhang, Yan Liu, Li An, Zhongliang Ma, Jingzhong Zhang, Shuang Y. Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction of BDNF expression in developmental stages. Biochemical and biophysical research communications. vol 527. issue 1. 2020-12-21. PMID:32446386. |
brain-derived neurotrophic factor (bdnf), which regulates the neuronal survival, differentiation and synaptic plasticity, has been proved to play a critical role in the pathology and treatment of several psychiatric disorders including depression. |
2020-12-21 |
2023-08-13 |
Not clear |
| Sumita Chakrapani, Noha Eskander, Lorenzo A De Los Santos, Basiru A Omisore, Jihan A Mostaf. Neuroplasticity and the Biological Role of Brain Derived Neurotrophic Factor in the Pathophysiology and Management of Depression. Cureus. vol 12. issue 11. 2020-12-16. PMID:33312794. |
studies involving a neurotrophic factor called brain derived neurotrophic factor (bdnf) and its associated signaling pathways have solidified our understanding of the pathophysiology of depression. the objective of this literature review is to gain a better understanding of the mechanism by which reduced levels of bdnf are implicated in depression and how antidepressants facilitate the treatment of depression by increasing bdnf levels. the specific approach is to learn about the key involvements of bdnf and its receptor trkb (tropomyosin receptor kinase b) and how their interactions and subsequent intracellular signaling cascades bring about enhanced neuroplastic changes. in this literature review, we searched for past review articles focusing on bdnf. we collected data using pubmed and created a summary of our findings. the results showed that stress and depression through the reduction of bdnf levels contribute to neuroplastic changes while antidepressants through enhanced bdnf levels are able to generate positive neuroplastic outcomes and thereby help resolve depressive symptoms. in this paper, we will delve into how a better understanding of the neural circuitry involving bdnf will enable us to both understand how current antidepressants work in the limbic regions of the brain as well as search for novel rapid-acting antidepressants to use in clinical practice. |
2020-12-16 |
2023-08-13 |
Not clear |
| Wei Zheng, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhang, Su-Miao Zhou, Su Yan, Ming-Zhe Yang, Sha Nie, Yu-Ping Nin. Association between plasma levels of BDNF and the antisuicidal effects of repeated ketamine infusions in depression with suicidal ideation. Therapeutic advances in psychopharmacology. vol 10. 2020-12-08. PMID:33282177. |
association between plasma levels of bdnf and the antisuicidal effects of repeated ketamine infusions in depression with suicidal ideation. |
2020-12-08 |
2023-08-13 |
Not clear |