| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gültekin Tamgüney, Amos D Korczy. A critical review of the prion hypothesis of human synucleinopathies. Cell and tissue research. vol 373. issue 1. 2019-04-01. PMID:29116402. |
parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa) are neurodegenerative disorders which have been pathologically classified as synucleinopathies, since they are associated with pathognomonic deposits of misfolded alpha-synuclein in cells of the nervous system. |
2019-04-01 |
2023-08-13 |
human |
| W Peelaerts, L Bousset, V Baekelandt, R Melk. ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences. Cell and tissue research. vol 373. issue 1. 2019-04-01. PMID:29704213. |
because of the features they share with the prion protein, prp, the characteristics of pathogenic protein aggregates in several progressive brain disorders, including different types of lewy body diseases (lbds), such as parkinson's disease (pd), multiple system atrophy (msa) and dementia with lewy bodies (dlb), have been actively investigated. |
2019-04-01 |
2023-08-13 |
Not clear |
| Wei Lin, Yuan-Chang Xie, Po-Ya Cheng, Ling-Ying Dong, Guang-Uei Hung, Pai-Yi Chi. Association of visual hallucinations with very mild degenerative dementia due to dementia with Lewy bodies. PloS one. vol 13. issue 10. 2019-04-01. PMID:30321234. |
complex, well-formed, and detailed visual hallucinations (vhs) are among the core clinical features of dementia with lewy bodies (dlb). |
2019-04-01 |
2023-08-13 |
Not clear |
| Mamoru Hashimot. [The Adaptation of Anti-dementia Drugs for BPSD]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 118. issue 6. 2019-03-25. PMID:30620504. |
during the last few years, a large body of evidence has been accumulated to support the use of antidementia medication for bpsd in both alzheimer's disease (ad) and dementia with lewy bodies (dlb) patients. |
2019-03-25 |
2023-08-13 |
Not clear |
| Mamoru Hashimot. [The Adaptation of Anti-dementia Drugs for BPSD]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 118. issue 6. 2019-03-25. PMID:30620504. |
on the selection of antidemen- tia drugs for bpsd, the following 3 factors should be considered : 1) the type of dementia the patients have (ad or dlb), 2) the type of drugs to be selected (cholinesterase inhibitors or memantine), and 3) the type of bpsd to be treated (such as delusions, hallucinations, agitation, and apathy). |
2019-03-25 |
2023-08-13 |
Not clear |
| Olivier Bousiges, Frédéric Blan. Diagnostic value of cerebro-spinal fluid biomarkers in dementia with lewy bodies. Clinica chimica acta; international journal of clinical chemistry. vol 490. 2019-03-22. PMID:30471248. |
dementia with lewy bodies (dlb) is the second most common form of dementia after alzheimer's disease (ad), accounting for 15% to 20% of neuropathologically defined cases. |
2019-03-22 |
2023-08-13 |
Not clear |
| Emma Robson, Clare Tweedy, Nelson Manzanza, John-Paul Taylor, Peter Atkinson, Fiona Randall, Amy Reeve, Gavin J Clowry, Fiona E N LeBea. Impaired Fast Network Oscillations and Mitochondrial Dysfunction in a Mouse Model of Alpha-synucleinopathy (A30P). Neuroscience. vol 377. 2019-03-11. PMID:29524634. |
intracellular accumulation of alpha-synuclein (α-syn) is a key pathological process evident in lewy body dementias (lbds), including parkinson's disease dementia (pdd) and dementia with lewy bodies (dlb). |
2019-03-11 |
2023-08-13 |
mouse |
| Kyota Fujita, Hidenori Homma, Kanoh Kondo, Masashi Ikuno, Hodaka Yamakado, Kazuhiko Tagawa, Shigeo Murayama, Ryosuke Takahashi, Hitoshi Okazaw. Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. eNeuro. vol 5. issue 4. 2019-03-08. PMID:30225354. |
here, we demonstrate that similar changes in marcks occur in parkinson's disease (pd) and dementia with lewy bodies (dlb) pathologies in both mouse models and human patients. |
2019-03-08 |
2023-08-13 |
mouse |
| Fumiaki Ikawa, Naoko Sumi, Tomokazu Nishikawa, Hirofumi Maruyama, Takafumi Miyach. [A case of dementia with Lewy bodies and Hashimoto encephalopathy successfully treated with immunotherapy]. Rinsho shinkeigaku = Clinical neurology. vol 59. issue 2. 2019-03-06. PMID:30700687. |
we report a 77-year-old woman suffering from dementia with lewy bodies (dlb) who presented with hashimoto encephalopathy. |
2019-03-06 |
2023-08-13 |
Not clear |
| Kazunori Sano, Ryuichiro Atarashi, Katsuya Satoh, Daisuke Ishibashi, Takehiro Nakagaki, Yasushi Iwasaki, Mari Yoshida, Shigeo Murayama, Kenichi Mishima, Noriyuki Nishid. Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC. Molecular neurobiology. vol 55. issue 5. 2019-02-26. PMID:28550528. |
using the real-time quaking-induced conversion (rt-quic) seeding assay, we investigated whether brain tissues from cases of dementia with lewy bodies (dlb), which contain serine 129 (ser129)-phosphorylated insoluble aggregates of αsyn, can convert escherichia coli-derived recombinant αsyn (r-αsyn) to fibrils. |
2019-02-26 |
2023-08-13 |
Not clear |
| Georgia Minakaki, Stefanie Menges, Agnes Kittel, Evangelia Emmanouilidou, Iris Schaeffner, Katalin Barkovits, Anna Bergmann, Edward Rockenstein, Anthony Adame, Franz Marxreiter, Brit Mollenhauer, Douglas Galasko, Edit Irén Buzás, Ursula Schlötzer-Schrehardt, Katrin Marcus, Wei Xiang, Dieter Chichung Lie, Kostas Vekrellis, Eliezer Masliah, Jürgen Winkler, Jochen Klucke. Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype. Autophagy. vol 14. issue 1. 2019-02-26. PMID:29198173. |
the autophagy-lysosome pathway (alp) regulates intracellular homeostasis of the cytosolic protein snca/alpha-synuclein and is impaired in synucleinopathies, including parkinson disease and dementia with lewy bodies (dlb). |
2019-02-26 |
2023-08-13 |
mouse |
| Massimo Filippi, Federica Agost. MRI of non-Alzheimer's dementia: current and emerging knowledge. Current opinion in neurology. vol 31. issue 4. 2019-02-21. PMID:29746400. |
this review emphasizes the potential applications of mri in the main non-alzheimer's dementia such as dementia with lewy bodies (dlb) and frontotemporal dementia (ftd). |
2019-02-21 |
2023-08-13 |
Not clear |
| Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Jun Utsumi, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayash. Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. Neuroscience letters. vol 684. 2019-02-20. PMID:29966750. |
neurodegenerative disorders such as parkinson's disease (pd) and dementia with lewy bodies (dlb) are characterized by impairment of autophagy. |
2019-02-20 |
2023-08-13 |
mouse |
| Run Yan, Jie Zhang, Hye-Jin Park, Eun S Park, Stephanie Oh, Haiyan Zheng, Eunsung Junn, Michael Voronkov, Jeffry B Stock, M Maral Mouradia. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 51. 2019-02-15. PMID:30509990. |
hyperphosphorylated α-synuclein in lewy bodies and lewy neurites is a characteristic neuropathological feature of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2019-02-15 |
2023-08-13 |
Not clear |
| Myung Jong Kim, Sohee Jeon, Lena F Burbulla, Dimitri Krain. Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function. Human molecular genetics. vol 27. issue 11. 2019-02-14. PMID:29579237. |
mutations in gba1 lead to gaucher's disease and are a major risk factor for parkinson's disease (pd) and dementia with lewy bodies (dlb), synucleinopathies characterized by accumulation of intracellular α-synuclein. |
2019-02-14 |
2023-08-13 |
Not clear |
| Andrew M Blamir. MR approaches in neurodegenerative disorders. Progress in nuclear magnetic resonance spectroscopy. vol 108. 2019-02-12. PMID:30538047. |
in this review, we consider the range of mr-based measurements and describe the findings in ad, but also contrast these with the second most common dementia, dementia with lewy bodies (dlb). |
2019-02-12 |
2023-08-13 |
Not clear |
| Victoria Larsson, Gustav Torisson, Elisabet Londo. Relative survival in patients with dementia with Lewy bodies and Parkinson's disease dementia. PloS one. vol 13. issue 8. 2019-02-08. PMID:30096198. |
the understanding of survival in dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd) is limited, as well as the impact of these diagnoses in an ageing co-morbid population. |
2019-02-08 |
2023-08-13 |
Not clear |
| Leonie J M Vergouw, Mariet Salomé, Anke G Kerklaan, Christiaan Kies, Gerwin Roks, Esther van den Berg, Frank Jan de Jon. The Pentagon Copying Test and the Clock Drawing Test as Prognostic Markers in Dementia with Lewy Bodies. Dementia and geriatric cognitive disorders. vol 45. issue 5-6. 2019-02-04. PMID:29996144. |
to determine whether the pentagon copying test (pct) and the clock drawing test (cdt) are associated with nursing home admission or survival in dementia with lewy bodies (dlb). |
2019-02-04 |
2023-08-13 |
Not clear |
| Fleur A McLeary, Alexandre N Rcom-H'cheo-Gauthier, Jessica Kinder, Michael Goulding, Tien K Khoo, George D Mellick, Roger S Chung, Dean L Pountne. Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism. Neurotoxicity research. vol 33. issue 2. 2019-01-31. PMID:29064068. |
intracellular aggregates of α-synuclein are the pathological hallmark of parkinson's disease (pd) and dementia with lewy bodies (dlb), being linked to neurotoxicity. |
2019-01-31 |
2023-08-13 |
Not clear |
| Alberto Benussi, Valentina Dell'Era, Valentina Cantoni, Clarissa Ferrari, Salvatore Caratozzolo, Luca Rozzini, Antonella Alberici, Alessandro Padovani, Barbara Borron. Discrimination of atypical parkinsonisms with transcranial magnetic stimulation. Brain stimulation. vol 11. issue 2. 2019-01-28. PMID:29195744. |
dementia with lewy bodies (dlb), progressive supranuclear palsy (psp) or corticobasal syndrome (cbs) still remains problematic. |
2019-01-28 |
2023-08-13 |
Not clear |