| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tim E Moors, Silvia Paciotti, Angela Ingrassia, Marialuisa Quadri, Guido Breedveld, Anna Tasegian, Davide Chiasserini, Paolo Eusebi, Gonzalo Duran-Pacheco, Thomas Kremer, Paolo Calabresi, Vincenzo Bonifati, Lucilla Parnetti, Tommaso Beccari, Wilma D J van de Ber. Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson's Disease and Dementia with Lewy Bodies. Molecular neurobiology. vol 56. issue 2. 2019-07-11. PMID:29948939. |
mutations in the gba gene, encoding the lysosomal hydrolase glucocerebrosidase (gcase), are the most common known genetic risk factor for parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2019-07-11 |
2023-08-13 |
Not clear |
| Celia Kun-Rodrigues, Tatiana Orme, Susana Carmona, Dena G Hernandez, Owen A Ross, John D Eicher, Claire Shepherd, Laura Parkkinen, Lee Darwent, Michael G Heckman, Sonja W Scholz, Juan C Troncoso, Olga Pletnikova, Ted Dawson, Liana Rosenthal, Olaf Ansorge, Jordi Clarimon, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda M Halliday, John Hardy, John Q Trojanowski, Dennis W Dickson, Andrew Singleton, David J Stone, Rita Guerreiro, Jose Bra. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of aging. vol 75. 2019-07-11. PMID:30448004. |
the role of genetic variability in dementia with lewy bodies (dlb) is now indisputable; however, data regarding copy number variation (cnv) in this disease has been lacking. |
2019-07-11 |
2023-08-13 |
Not clear |
| Giovanni Rizzo, Simona Arcuti, Massimiliano Copetti, Maria Alessandria, Rodolfo Savica, Andrea Fontana, Rocco Liguori, Giancarlo Logroscin. Accuracy of clinical diagnosis of dementia with Lewy bodies: a systematic review and meta-analysis. Journal of neurology, neurosurgery, and psychiatry. vol 89. issue 4. 2019-07-08. PMID:29030419. |
the diagnosis of dementia with lewy bodies (dlb) is based on diagnostic clinical criteria, which were updated over the years. |
2019-07-08 |
2023-08-13 |
Not clear |
| Eleanor King, John Tiernan O'Brien, Paul Donaghy, Christopher Morris, Nicola Barnett, Kirsty Olsen, Carmen Martin-Ruiz, John-Paul Taylor, Alan J Thoma. Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias. Journal of neurology, neurosurgery, and psychiatry. vol 89. issue 4. 2019-07-08. PMID:29248892. |
there is growing evidence for the role of systemic inflammation in alzheimer's disease (ad) and other neurodegenerative diseases; however the systemic inflammatory profile in dementia with lewy bodies (dlb) has never before been investigated. |
2019-07-08 |
2023-08-13 |
Not clear |
| Tiago Fleming Outeiro, David J Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi, David Burn, Paul Donaghy, Christopher Morris, John-Paul Taylor, Alan Thomas, Johannes Attems, Ian McKeit. Dementia with Lewy bodies: an update and outlook. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30665447. |
dementia with lewy bodies (dlb) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. |
2019-07-05 |
2023-08-13 |
Not clear |
| Tiago Fleming Outeiro, David J Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi, David Burn, Paul Donaghy, Christopher Morris, John-Paul Taylor, Alan Thomas, Johannes Attems, Ian McKeit. Dementia with Lewy bodies: an update and outlook. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30665447. |
since many pd patients develop dementia as disease progresses, there has been controversy about the separation of dlb from pd dementia (pdd) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. |
2019-07-05 |
2023-08-13 |
Not clear |
| Esteban Luna, Samantha C Decker, Dawn M Riddle, Anna Caputo, Bin Zhang, Tracy Cole, Carrie Caswell, Sharon X Xie, Virginia M Y Lee, Kelvin C Lu. Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity. Acta neuropathologica. vol 135. issue 6. 2019-07-01. PMID:29502200. |
the accumulation of misfolded α-synuclein (asyn) and neuron loss define several neurodegenerative disorders including parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2019-07-01 |
2023-08-13 |
Not clear |
| Masato Ishibashi, Noriyuki Kimura, Kaori Sumi, Yasuhiro Aso, Etsuro Matsubar. Comparison of brain perfusion patterns in dementia with Lewy bodies patients with or without cingulate island sign. Geriatrics & gerontology international. vol 19. issue 3. 2019-06-28. PMID:30548751. |
the aim of the present study was to examine the differences in the brain perfusion single-photon emission computed tomography patterns compared in dementia with lewy bodies (dlb) with or without cingulate island sign (cis). |
2019-06-28 |
2023-08-13 |
Not clear |
| Natalie R S Goldberg, Samuel E Marsh, Joseph Ochaba, Brandon C Shelley, Hayk Davtyan, Leslie M Thompson, Joan S Steffan, Clive N Svendsen, Mathew Blurton-Jone. Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies. Stem cells translational medicine. vol 6. issue 6. 2019-06-27. PMID:28225193. |
within this diverse group, dementia with lewy bodies (dlb) is characterized by the aberrant accumulation of α-syn in cortical, hippocampal, and brainstem neurons, resulting in multiple cellular stressors that particularly impair dopamine and glutamate neurotransmission and related motor and cognitive function. |
2019-06-27 |
2023-08-13 |
human |
| Michael G Erkkinen, Mee-Ohk Kim, Michael D Geschwin. Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. Cold Spring Harbor perspectives in biology. vol 10. issue 4. 2019-06-26. PMID:28716886. |
this review summarizes and highlights clinical aspects of several of the most commonly encountered neurodegenerative diseases, including ad, frontotemporal dementia (ftd) and its variants, progressive supranuclear palsy (psp), corticobasal degeneration (cbd), parkinson's disease (pd), dementia with lewy bodies (dlb), multiple system atrophy (msa), and huntington's disease (hd). |
2019-06-26 |
2023-08-13 |
Not clear |
| Daniel A Barone, Claire Henchcliff. Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 129. issue 8. 2019-06-26. PMID:29883833. |
however, rbd alone is now considered to be a potential harbinger of later development of neurodegenerative disorders, in particular pd, msa, dementia with lewy bodies (dlb), and pure autonomic failure. |
2019-06-26 |
2023-08-13 |
Not clear |
| Min Seung Kim, Jung Han Yoon, Ji Man Hon. Early differentiation of dementia with Lewy bodies and Alzheimer's disease: Heart rate variability at mild cognitive impairment stage. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 129. issue 8. 2019-06-26. PMID:29883835. |
our study aimed to investigate whether heart rate variability (hrv) could be a useful diagnostic screening tool at mci (mild cognitive impairment) stage of dementia with lewy bodies (dlb) from alzheimer's disease (ad). |
2019-06-26 |
2023-08-13 |
Not clear |
| Tomoyuki Kawad. Risk of caregiver burden in patients with three types of dementia. International psychogeriatrics. vol 31. issue 1. 2019-06-24. PMID:30729907. |
(2017) investigated caregiver burden of patients with frontotemporal lobar degeneration (ftd) and dementia with lewy bodies (dlb), which was compared with caregivers of patients with alzheimer's disease. |
2019-06-24 |
2023-08-13 |
Not clear |
| Elisabet Londos, Oskar Hansson, Ingmar Rosén, Elisabet Englun. Extreme sleep pattern in Lewy body dementia: a hypothalamic matter? BMJ case reports. vol 12. issue 3. 2019-06-24. PMID:30852516. |
excessive sleep during the night and for >2 hours during the day is part of the fluctuating wakefulness criterion of dementia with lewy bodies (dlb). |
2019-06-24 |
2023-08-13 |
Not clear |
| Koji Kasanuki, Tanis J Ferman, Melissa E Murray, Michael G Heckman, Otto Pedraza, Fadi S Hanna Al-Shaikh, Takayasu Mishima, Nancy N Diehl, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Neill R Graff-Radford, Dennis W Dickso. Daytime sleepiness in dementia with Lewy bodies is associated with neuronal depletion of the nucleus basalis of Meynert. Parkinsonism & related disorders. vol 50. 2019-06-21. PMID:29429645. |
excessive daytime sleepiness is a commonly reported clinical feature of dementia with lewy bodies (dlb) that can occur early in the disease. |
2019-06-21 |
2023-08-13 |
Not clear |
| Koji Kasanuki, Tanis J Ferman, Melissa E Murray, Michael G Heckman, Otto Pedraza, Fadi S Hanna Al-Shaikh, Takayasu Mishima, Nancy N Diehl, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Neill R Graff-Radford, Dennis W Dickso. Daytime sleepiness in dementia with Lewy bodies is associated with neuronal depletion of the nucleus basalis of Meynert. Parkinsonism & related disorders. vol 50. 2019-06-21. PMID:29429645. |
cholinergic depletion is known to be severe in dlb, even when dementia severity is mild. |
2019-06-21 |
2023-08-13 |
Not clear |
| Ana Gámez-Valero, Alex Iranzo, Monica Serradell, Dolores Vilas, Joan Santamaria, Carles Gaig, Ramiro Álvarez, Aurelio Ariza, Eduardo Tolosa, Katrin Beye. Glucocerebrosidase gene variants are accumulated in idiopathic REM sleep behavior disorder. Parkinsonism & related disorders. vol 50. 2019-06-21. PMID:29487000. |
glucocerebrosidase (gba) gene variants are associated with the development of the lewy body disorders (lbd) parkinson disease (pd) and dementia with lewy bodies (dlb). |
2019-06-21 |
2023-08-13 |
Not clear |
| Cindy Chi-Ching Pang, Clemens Kiecker, John T O'Brien, Wendy Noble, Raymond Chuen-Chung Chan. Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 25. issue 2. 2019-06-19. PMID:29865938. |
in models of epilepsy and hypoxia, the ca2 exhibits higher resilience to cell death and hypoxia in comparison with neighboring regions, and while hippocampal atrophy remains poorly understood in parkinson's disease (pd) and dementia with lewy bodies (dlb), findings from postmortem pd brain demonstrates clear accumulation of α-synuclein pathology in ca2, and the ca2-ca3 region shows relatively more atrophy compared with other hippocampal subfields. |
2019-06-19 |
2023-08-13 |
Not clear |
| Jiayin Zhou, Yuanyuan Deng, Fei Li, Caixia Yin, Jingshan Shi, Qihai Gon. Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30590319. |
inflammation in central nervous system (cns) plays a vital role in neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease (pd), lewy body dementia (dlb), hiv-related dementia and traumatic brain injury. |
2019-06-13 |
2023-08-13 |
rat |
| Tanis J Ferman, Naoya Aoki, Julia E Crook, Melissa E Murray, Neill R Graff-Radford, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Jonathan Graff-Radford, Otto Pedraza, Kejal Kantarci, Bradley F Boeve, Dennis W Dickso. The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 3. 2019-06-06. PMID:29100980. |
we sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid β (aβ) to duration of illness in dementia with lewy bodies (dlb). |
2019-06-06 |
2023-08-13 |
Not clear |