| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caiping Yang, Hai Wang, Chaojiu Li, Huiyan Niu, Shunkui Luo, Xingzhi Gu. Association between clusterin concentration and dementia: a systematic review and meta-analysis. Metabolic brain disease. vol 34. issue 1. 2019-06-06. PMID:30291488. |
the aim of our study was to determine the relationship between clu concentration and the late-life cognitive outcomes including mild cognitive impairment (mci), alzheimer's disease (ad), vascular dementia (vad), parkinson's disease related dementia (pdd), lewy body dementia (dlb) and frontotemporal dementia (ftd). |
2019-06-06 |
2023-08-13 |
Not clear |
| Mine Sezgin, Basar Bilgic, Sule Tinaz, Murat Emr. Parkinson's Disease Dementia and Lewy Body Disease. Seminars in neurology. vol 39. issue 2. 2019-06-06. PMID:30925619. |
dementia with lewy bodies (dlb) and parkinson's disease dementia (pd-d) are lewy body-related neurodegenerative disorders sharing common clinical and neuropathological findings. |
2019-06-06 |
2023-08-13 |
Not clear |
| Mine Sezgin, Basar Bilgic, Sule Tinaz, Murat Emr. Parkinson's Disease Dementia and Lewy Body Disease. Seminars in neurology. vol 39. issue 2. 2019-06-06. PMID:30925619. |
clinical differentiation between dlb and pd-d is based on an arbitrary distinction between the time of onset of parkinsonism and cognitive symptoms; extrapyramidal symptoms precede dementia in pd-d, whereas it coincides with or follows dementia within 1 year in dlb. |
2019-06-06 |
2023-08-13 |
Not clear |
| Alex Iranzo, Sergi Borrego, Isabel Vilaseca, Carles Martí, Mónica Serradell, Raquel Sánchez-Valle, Gabor G Kovacs, Francesc Valldeoriola, Carles Gaig, Joan Santamaria, Eduard Tolosa, Ellen Gelp. α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder. Sleep. vol 41. issue 8. 2019-06-05. PMID:29790977. |
to assess whether biopsy of the labial minor salivary glands safely detects phosphorylated α-synuclein (pas) deposits in idiopathic rapid eye movement sleep behavior disorder (irbd), a condition that precedes the cardinal manifestations of synuclein disorders associated with lewy-type pathology, namely, parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2019-06-05 |
2023-08-13 |
Not clear |
| Jurre den Haan, Tjado H J Morrema, Annemieke J Rozemuller, Femke H Bouwman, Jeroen J M Hoozeman. Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer's disease brains: Implications for in-vivo diagnostics. Acta neuropathologica communications. vol 6. issue 1. 2019-06-05. PMID:30092839. |
for this study we included brains of early onset ad, late onset ad, primary age-related tauopathy (part), cerebral amyloid angiopathy (caa), frontotemporal lobar degeneration (ftld) with tau or tar dna-binding protein 43 (tdp-43) inclusions, dementia with lewy bodies (dlb), parkinson's disease (pd) and control cases without brain pathology. |
2019-06-05 |
2023-08-13 |
Not clear |
| Linda A Hershey, Rhonda Coleman-Jackso. Pharmacological Management of Dementia with Lewy Bodies. Drugs & aging. vol 36. issue 4. 2019-06-04. PMID:30680679. |
dementia with lewy bodies (dlb) is a complex disease that involves a variety of cognitive, behavioral and neurological symptoms, including progressive memory loss, visual hallucinations, parkinsonism, cognitive fluctuations and rapid eye movement sleep behavior disorder (rbd). |
2019-06-04 |
2023-08-13 |
Not clear |
| Linda A Hershey, Rhonda Coleman-Jackso. Pharmacological Management of Dementia with Lewy Bodies. Drugs & aging. vol 36. issue 4. 2019-06-04. PMID:30680679. |
the median age of onset for dlb (76.3 years) is younger than that seen in pd dementia (81.4 years). |
2019-06-04 |
2023-08-13 |
Not clear |
| Linda A Hershey, Rhonda Coleman-Jackso. Pharmacological Management of Dementia with Lewy Bodies. Drugs & aging. vol 36. issue 4. 2019-06-04. PMID:30680679. |
pimavanserin may prove to be a useful treatment for psychosis in dlb patients, but like other antipsychotic drugs that are used in dementia patients, there is a small increased risk of mortality. |
2019-06-04 |
2023-08-13 |
Not clear |
| E E Vasenina, O A Gankina, O S Levi. [The addition of memantine to galantamine increases treatment efficacy in patients with moderate dementia with Lewy bodies]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 6. Vyp. 2. 2019-05-31. PMID:30346431. |
dementia with lewy bodies (dlb) is the most frequent cause of dementia in the elderly. |
2019-05-31 |
2023-08-13 |
Not clear |
| Airi Tarutani, Tetsuaki Arai, Shigeo Murayama, Shin-Ichi Hisanaga, Masato Hasegaw. Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods. Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29669601. |
α-syn aggregates extracted from brains of multiple system atrophy (msa) patients showed higher seeding activity than those extracted from patients with dementia with lewy bodies (dlb), and their potency was similar to that of synthetic α-syn fibrils. |
2019-05-30 |
2023-08-13 |
mouse |
| Jessica M Froula, Benjamin W Henderson, Jose Carlos Gonzalez, Jada H Vaden, John W Mclean, Yumei Wu, Gokulakrishna Banumurthy, Linda Overstreet-Wadiche, Jeremy H Herskowitz, Laura A Volpicelli-Dale. α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons. Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29716652. |
neuronal inclusions composed of α-synuclein (α-syn) characterize parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2019-05-30 |
2023-08-13 |
mouse |
| Jessica M Froula, Benjamin W Henderson, Jose Carlos Gonzalez, Jada H Vaden, John W Mclean, Yumei Wu, Gokulakrishna Banumurthy, Linda Overstreet-Wadiche, Jeremy H Herskowitz, Laura A Volpicelli-Dale. α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons. Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29716652. |
cognitive dysfunction defines dlb, and up to 80% of pd patients develop dementia. |
2019-05-30 |
2023-08-13 |
mouse |
| Richard A Armstron. A comparison of the spatial patterns of β-amyloid (Aβ) deposits in five neurodegenerative disorders. Folia neuropathologica. vol 56. issue 4. 2019-05-30. PMID:30786665. |
alzheimer's disease neuropathologic change (adnc) in the form of -amyloid (a) deposits is important not only in the pathogenesis of alzheimer's disease (ad) and down's syndrome (ds) but also as a 'co-pathology' in disorders such as dementia with lewy bodies (dlb), corticobasal degeneration (cbd), and chronic traumatic encephalopathy (cte). |
2019-05-30 |
2023-08-13 |
Not clear |
| Byron Creese, Emily Bell, Iskandar Johar, Paul Francis, Clive Ballard, Dag Aarslan. Glucocerebrosidase mutations and neuropsychiatric phenotypes in Parkinson's disease and Lewy body dementias: Review and meta-analyses. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 177. issue 2. 2019-05-28. PMID:28548708. |
heterozygous mutations in glucocerebrosidase gene (gba) are a major genetic risk factor for parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2019-05-28 |
2023-08-13 |
Not clear |
| Francesca Longhena, Gaia Faustini, Tatiana Varanita, Michela Zaltieri, Vanessa Porrini, Isabella Tessari, Pietro Luigi Poliani, Cristina Missale, Barbara Borroni, Alessandro Padovani, Luigi Bubacco, Marina Pizzi, PierFranco Spano, Arianna Bellucc. Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains. Brain pathology (Zurich, Switzerland). vol 28. issue 6. 2019-05-28. PMID:29330884. |
lewy bodies (lb) and lewy neurites (ln), which are primarily composed of α-synuclein (α-syn), are neuropathological hallmarks of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2019-05-28 |
2023-08-13 |
human |
| Fernando L Pagan, Michaeline L Hebron, Barbara Wilmarth, Yasar Torres-Yaghi, Abigail Lawler, Elizabeth E Mundel, Nadia Yusuf, Nathan J Starr, Joy Arellano, Helen H Howard, Margo Peyton, Sara Matar, Xiaoguang Liu, Alan J Fowler, Sorell L Schwartz, Jaeil Ahn, Charbel Mouss. Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease. Pharmacology research & perspectives. vol 7. issue 2. 2019-05-28. PMID:30906562. |
we previously showed that nilotinib penetrates the blood-brain barrier (bbb) and potentially improves clinical outcomes in individuals with pd and dementia with lewy bodies (dlb). |
2019-05-28 |
2023-08-13 |
human |
| Hideto Joki, Yuichi Higashiyama, Yoshiharu Nakae, Chiharu Kugimoto, Hiroshi Doi, Katsuo Kimura, Hitaru Kishida, Naohisa Ueda, Tatsu Nakano, Tatsuya Takahashi, Shigeru Koyano, Hideyuki Takeuchi, Fumiaki Tanak. White matter hyperintensities on MRI in dementia with Lewy bodies, Parkinson's disease with dementia, and Alzheimer's disease. Journal of the neurological sciences. vol 385. 2019-05-24. PMID:29406924. |
in dementia with lewy bodies (dlb) and parkinson's disease with dementia (pdd), it is still debated whether white matter hyperintensities (wmh) on mri reflect atherosclerotic cerebrovascular changes or alzheimer's disease (ad)-related pathology such as cerebral amyloid angiopathy. |
2019-05-24 |
2023-08-13 |
Not clear |
| Amellia McCormack, Damien J Keating, Nusha Chegeni, Alex Colella, Jing Jing Wang, Tim Chatawa. Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism. Neurotoxicity research. vol 35. issue 4. 2019-05-23. PMID:30796693. |
proteinaceous α-synuclein-containing inclusions are found in affected brain regions in patients with parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2019-05-23 |
2023-08-13 |
Not clear |
| Myrto Stylianou, Nicholas Murphy, Luis R Peraza, Sara Graziadio, Ruth Cromarty, Alison Killen, John T O' Brien, Alan J Thomas, Fiona E N LeBeau, John-Paul Taylo. Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and an aid to differential diagnosis. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 129. issue 6. 2019-05-20. PMID:29656189. |
we investigated for quantitative eeg (qeeg) differences between alzheimer's disease (ad), dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd) patients and healthy controls, and for qeeg signatures of cognitive fluctuations (cfs) in dlb. |
2019-05-20 |
2023-08-13 |
Not clear |
| Tayyabah Yousaf, George Dervenoulas, Polytimi-Eleni Valkimadi, Marios Politi. Neuroimaging in Lewy body dementia. Journal of neurology. vol 266. issue 1. 2019-05-20. PMID:29761296. |
lewy body dementia (dlb) is a common form of cognitive impairment, accounting for 30% of dementia cases in ages over 65 years. |
2019-05-20 |
2023-08-13 |
Not clear |