| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tracey Evans, Wai Ling Kok, Katrina Cowan, Megan Hefford, Oleg Anichtchi. Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients. Brain research. vol 1681. 2018-08-15. PMID:29278715. |
dementia with lewy bodies (dlb) is the second most prevalent neurodegenerative dementia, where an accumulation of aggregated fibrillar alpha-synuclein in neurons of limbic and forebrain regions of the brain leads to visual hallucination, cognitive impairment of a fluctuating nature and extrapyramidal motor disturbances. |
2018-08-15 |
2023-08-13 |
human |
| Yasuyuki Honjo, Takashi Ayaki, Tomohisa Horibe, Hidefumi Ito, Ryosuke Takahashi, Koji Kawakam. FKBP12-immunopositive inclusions in patients with α-synucleinopathies. Brain research. vol 1680. 2018-08-14. PMID:29246765. |
α-synuclein (α-syn), a presynaptic protein with the tendency to aggregate, is linked to α-synucleinopathies such as parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2018-08-14 |
2023-08-13 |
Not clear |
| Magdalena I Tolea, James E Galvi. The genetics of dementia with Lewy bodies. Handbook of clinical neurology. vol 148. 2018-08-10. PMID:29478592. |
dementia with lewy bodies (dlb), the most common non-ad neurodegenerative disease has in the past several decades attracted the attention of the neurological scientific community due to its highly negative impact on the quality of life of both the affected individuals and those caring for them. |
2018-08-10 |
2023-08-13 |
Not clear |
| Masahiro Hata, Ryu Kurimoto, Hiroaki Kazui, Ryouhei Ishii, Leonides Canuet, Yasunori Aoki, Shunichiro Ikeda, Shingo Azuma, Takashi Suehiro, Shunsuke Sato, Yukiko Suzuki, Hideki Kanemoto, Kenji Yoshiyama, Masao Iwase, Manabu Iked. Alpha event-related synchronization after eye closing differs in Alzheimer's disease and dementia with Lewy bodies: a magnetoencephalography study. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 18. issue 3. 2018-08-01. PMID:29424040. |
the electroencephalography (eeg) abnormalities found in patients with dementia with lewy bodies (dlb) are conflicting. |
2018-08-01 |
2023-08-13 |
Not clear |
| Iris Zahirovic, Gustav Torisson, Carina Wattmo, Elisabet Londo. Psychotropic and anti-dementia treatment in elderly persons with clinical signs of dementia with Lewy bodies: a cross-sectional study in 40 nursing homes in Sweden. BMC geriatrics. vol 18. issue 1. 2018-07-31. PMID:29454305. |
furthermore, elderly persons with dementia with lewy bodies (dlb) are often hypersensitive to antipsychotics with numerous serious adverse events such as somnolence, sedation, extra-pyramidal symptoms, delirium and increased mortality. |
2018-07-31 |
2023-08-13 |
Not clear |
| Iris Zahirovic, Gustav Torisson, Carina Wattmo, Elisabet Londo. Psychotropic and anti-dementia treatment in elderly persons with clinical signs of dementia with Lewy bodies: a cross-sectional study in 40 nursing homes in Sweden. BMC geriatrics. vol 18. issue 1. 2018-07-31. PMID:29454305. |
the aim of this study was to investigate the usage of psychotropics with a focus on antipsychotics and anti-dementia medication (according to the anatomical therapeutic chemical classification system) in elderly persons with clinical signs of dlb living in dementia nursing homes (nhs) in sweden. |
2018-07-31 |
2023-08-13 |
Not clear |
| Ki Hoon Kim, Suk Yun Kang, Dong Ah Shin, Seong Yi, Yoon Ha, Keung Nyun Kim, Young Ho Sohn, Phil Hyu Le. Parkinson's disease-related non-motor features as risk factors for post-operative delirium in spinal surgery. PloS one. vol 13. issue 4. 2018-07-30. PMID:29630637. |
the clinical features of postoperative delirium are similar to the core features of alpha synuclein-related cognitive disorders, such as parkinson's disease dementia (pdd) or dementia with lewy bodies (dlb). |
2018-07-30 |
2023-08-13 |
Not clear |
| Mal-Gi Choi, Mi Jin Kim, Do-Geun Kim, Ri Yu, You-Na Jang, Won-Jong O. Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide. PloS one. vol 13. issue 4. 2018-07-27. PMID:29608598. |
α-synuclein (α-syn) is a major component of lewy bodies found in synucleinopathies including parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2018-07-27 |
2023-08-13 |
mouse |
| Masaaki Waragai, Masaru Moriya, Takeshi Noj. Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:28968236. |
the 289 participants were retrospectively divided into five groups 7 years after baseline: 200 (69%) remained cognitively normal; 53 (18%) developed mild cognitive impairment (mci); 21 (7%) developed ad; eight (2%) developed parkinson's disease with normal cognition, and seven (2%) developed dementia with lewy bodies (dlb). |
2018-07-23 |
2023-08-13 |
human |
| Ching-Chi Chang, Hsin-Hua Li, Yen-Ting Chang, Ying-Jui Ho, Ling-Jia Hsieh, Pai-Yi Chiu, Yu-Shih Cheng, Chih-Li Lin, Te-Jen La. Aβ exacerbates α-synuclein-induced neurotoxicity through impaired insulin signaling in α-synuclein-overexpressed human SK-N-MC neuronal cells. CNS neuroscience & therapeutics. vol 24. issue 1. 2018-07-20. PMID:29092095. |
although its physiological role is still unclear, the aggregation of αsyn has been recognized as responsible for some neurodegenerative disorders such as dementia with lewy bodies (dlb). |
2018-07-20 |
2023-08-13 |
human |
| Peter T Nelson, Wang-Xia Wang, Sarah A Janse, Katherine L Thompso. MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls. Brain research. vol 1678. 2018-07-16. PMID:29146111. |
here, we evaluated the expression of mirnas in anterior cingulate (ac; brodmann area [ba] 24) and primary motor (mo; ba 4) cortical tissue from aged human brains in the university of kentucky ad center autopsy cohort, with a focus on dementia with lewy bodies (dlb). |
2018-07-16 |
2023-08-13 |
human |
| Diana L Price, Edward Rockenstein, Michael Mante, Anthony Adame, Cassia Overk, Brian Spencer, Karen X Duong-Polk, Douglas Bonhaus, James Lindsey, Eliezer Maslia. Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies. Scientific reports. vol 6. 2018-07-13. PMID:27389831. |
abnormal α-synuclein (α-syn) accumulation in the cns may underlie neuronal cell and synaptic dysfunction leading to motor and cognitive deficits in synucleinopathies including parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2018-07-13 |
2023-08-13 |
mouse |
| Silvia Favaretto, Uwe Walter, Claudio Baracchini, Annachiara Cagni. Transcranial Sonography in Neurodegenerative Diseases with Cognitive Decline. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29103031. |
here, we aimed to review the main applications of tcs in neurodegenerative diseases presenting with dementia syndrome, focusing on alzheimer's disease (ad), dementia with lewy bodies (dlb), frontotemporal lobar degeneration, idiopathic normal pressure hydrocephalus, and atypical and secondary parkinsonisms. |
2018-07-13 |
2023-08-13 |
Not clear |
| Annabel Price, Redwan Farooq, Jin-Min Yuan, Vandana B Menon, Rudolf N Cardinal, John T O'Brie. Mortality in dementia with Lewy bodies compared with Alzheimer's dementia: a retrospective naturalistic cohort study. BMJ open. vol 7. issue 11. 2018-07-12. PMID:29101136. |
to use routine clinical data to investigate survival in dementia with lewy bodies (dlb) compared with alzheimer's dementia (ad). |
2018-07-12 |
2023-08-13 |
Not clear |
| Annabel Price, Redwan Farooq, Jin-Min Yuan, Vandana B Menon, Rudolf N Cardinal, John T O'Brie. Mortality in dementia with Lewy bodies compared with Alzheimer's dementia: a retrospective naturalistic cohort study. BMJ open. vol 7. issue 11. 2018-07-12. PMID:29101136. |
dlb is the second most common dementia subtype after ad, accounting for around 7% of dementia diagnoses in secondary care, though studies suggest that it is underdiagnosed by up to 50%. |
2018-07-12 |
2023-08-13 |
Not clear |
| Pai-Yi Chiu, Po-Ren Teng, Cheng-Yu Wei, Chein-Wei Wang, Chun-Tang Tsa. Gender difference in the association and presentation of visual hallucinations in dementia with Lewy bodies: a cross-sectional study. International journal of geriatric psychiatry. vol 33. issue 1. 2018-07-09. PMID:28295599. |
visual hallucinations (vhs) are among the most striking features of dementia with lewy bodies (dlb). |
2018-07-09 |
2023-08-13 |
Not clear |
| Greg J Elder, Karen Mactier, Sean J Colloby, Rosie Watson, Andrew M Blamire, John T O'Brien, John-Paul Taylo. The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies. International journal of geriatric psychiatry. vol 32. issue 11. 2018-07-06. PMID:28425185. |
the level of hippocampal atrophy in dementia with lewy bodies (dlb) is typically less than that observed in alzheimer's disease (ad). |
2018-07-06 |
2023-08-13 |
Not clear |
| Paul C Donaghy, Nicola Barnett, Kirsty Olsen, John-Paul Taylor, Ian G McKeith, John T O'Brien, Alan J Thoma. Symptoms associated with Lewy body disease in mild cognitive impairment. International journal of geriatric psychiatry. vol 32. issue 11. 2018-07-06. PMID:28556415. |
dementia with lewy bodies (dlb) is associated with a range of cognitive and non-cognitive symptoms. |
2018-07-06 |
2023-08-13 |
Not clear |
| Atsutaka Okizaki, Michihiro Nakayama, Kaori Nakajima, Takayuki Katayama, Takahiro Uno, Fumiyoshi Morikawa, Juichiro Naoe, Koji Takahash. Inter- and intra-observer reproducibility of quantitative analysis for FP-CIT SPECT in patients with DLB. Annals of nuclear medicine. vol 31. issue 10. 2018-06-25. PMID:28913731. |
dopamine transporter single photon emission ct (dat-spect) is useful in the evaluation of dementia with lewy bodies (dlb). |
2018-06-25 |
2023-08-13 |
Not clear |
| Lidia Tagliafierro, Omolara-Chinue Glenn, Madison E Zamora, Thomas G Beach, Randy L Woltjer, Michael W Lutz, Ornit Chiba-Fale. Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 11. 2018-06-18. PMID:28431219. |
the α-synuclein (snca) gene has been implicated in the etiology of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2018-06-18 |
2023-08-13 |
Not clear |