| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ajay K Pandey, Farzana Zerin, Sreelakshmi N Menon, Tanzia I Tithi, Khue P Nguyen, Tran Vo, Morgan L Daniel, Sherif Hafez, Md Ashraful Alam, Raquibul Hasa. Neflamapimod induces vasodilation in resistance mesenteric arteries by inhibiting p38 MAPKα and downstream Hsp27 phosphorylation. Scientific reports. vol 12. issue 1. 2022-03-23. PMID:35318382. |
neflamapimod, a selective inhibitor of p38 mitogen activated protein kinase alpha (mapkα), is under clinical investigation for its efficacy in alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2022-03-23 |
2023-08-13 |
rat |
| Jay Amin, Daniel Erskine, Paul C Donaghy, Ajenthan Surendranathan, Peter Swann, Amy P Kunicki, Delphine Boche, Clive Holmes, Ian G McKeith, John T O'Brien, Jessica L Teeling, Alan J Thoma. Inflammation in dementia with Lewy bodies. Neurobiology of disease. 2022-03-22. PMID:35314318. |
dementia with lewy bodies (dlb) is the second most common neurodegenerative cause of dementia, behind alzheimer's disease (ad). |
2022-03-22 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
the cellular alterations of the hippocampus lead to memory decline, a shared symptom between alzheimer's disease (ad) and dementia with lewy bodies (dlb) patients. |
2022-03-17 |
2023-08-13 |
Not clear |
| Carlo Alberto Artusi, Domiziana Rinaldi, Roberta Balestrino, Leonardo Lopian. Deep brain stimulation for atypical parkinsonism: A systematic review on efficacy and safety. Parkinsonism & related disorders. 2022-03-15. PMID:35288028. |
atypical parkinsonisms (aps) -including progressive supranuclear palsy (psp), multiple system atrophy (msa), and dementia with lewy bodies (dlb)- are neurodegenerative diseases lacking satisfying symptomatic therapies. |
2022-03-15 |
2023-08-13 |
Not clear |
| Paul C Donaghy, Simon J Cockell, Carmen Martin-Ruiz, Jonathan Coxhead, Joseph Kane, Daniel Erskine, David Koss, John-Paul Taylor, Christopher M Morris, John T O'Brien, Alan J Thoma. Blood mRNA Expression in Alzheimer's Disease and Dementia With Lewy Bodies. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2022-03-14. PMID:35283023. |
the objective of this study was to investigate the expression of genes in alzheimer's disease (ad) and dementia with lewy bodies (dlb), both at the mild cognitive impairment (mci) and dementia stages, to improve our understanding of disease pathophysiology and investigate the potential for diagnostic and prognostic biomarkers based on mrna expression. |
2022-03-14 |
2023-08-13 |
Not clear |
| Qin Chen, Scott A Przybelski, Matthew L Senjem, Christopher G Schwarz, Timothy G Lesnick, Hugo Botha, David S Knopman, Jonathan Graff-Radford, Rodolfo Savica, David T Jones, Julie A Fields, Manoj K Jain, Neill R Graff-Radford, Tanis J Ferman, Walter K Kremers, Clifford R Jack, Ronald C Petersen, Bradley F Boeve, Val J Lowe, Kejal Kantarc. Longitudinal Tau Positron Emission Tomography in Dementia with Lewy Bodies. Movement disorders : official journal of the Movement Disorder Society. 2022-03-09. PMID:35261094. |
patients with dementia with lewy bodies (dlb) may have overlapping alzheimer's disease pathology. |
2022-03-09 |
2023-08-13 |
Not clear |
| Andrew Chang, Xinyu Xiang, Jing Wang, Carolyn Lee, Tamta Arakhamia, Marija Simjanoska, Chi Wang, Yari Carlomagno, Guoan Zhang, Shikhar Dhingra, Manon Thierry, Jolien Perneel, Bavo Heeman, Lauren M Forgrave, Michael DeTure, Mari L DeMarco, Casey N Cook, Rosa Rademakers, Dennis W Dickson, Leonard Petrucelli, Michael H B Stowell, Ian R A Mackenzie, Anthony W P Fitzpatric. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell. 2022-03-05. PMID:35247328. |
a combination of cryoelectron microscopy and mass spectrometry was used to solve the structures of tmem106b fibrils at a resolution of 2.7 Å from postmortem human brain tissue afflicted with frontotemporal lobar degeneration with tdp-43 pathology (ftld-tdp, n = 8), progressive supranuclear palsy (psp, n = 2), or dementia with lewy bodies (dlb, n = 1). |
2022-03-05 |
2023-08-13 |
human |
| Matthew Ingram, Sean J Colloby, Michael J Firbank, Jim J Lloyd, John T O'Brien, John-Paul Taylo. Spatial covariance analysis of FDG-PET and HMPAO-SPECT for the differential diagnosis of dementia with Lewy bodies and Alzheimer's disease. Psychiatry research. Neuroimaging. vol 322. 2022-03-05. PMID:35247828. |
we investigated diagnostic characteristics of spatial covariance analysis (sca) of fdg-pet and hmpao-spect scans in the differential diagnosis of dementia with lewy bodies (dlb) and alzheimer's disease (ad), in comparison with visual ratings and region of interest (roi) analysis. |
2022-03-05 |
2023-08-13 |
Not clear |
| Mirella Russo, Claudia Carrarini, Angelo Di Iorio, Raffaello Pellegrino, Amalia Cecilia Bruni, Salvatore Caratozzolo, Annalisa Chiari, Stefano Pretta, Camillo Marra, Maria Sofia Cotelli, Andrea Arighi, Giorgio G Fumagalli, Tatiana Cataruzza, Francesca Caso, Cristina Paci, Mara Rosso, Serena Amici, David Giannandrea, Andrea Pilotto, Simona Luzzi, Annalisa Castellano, Fabrizia D'antonio, Antonina Luca, Giorgio Gelosa, Tommaso Piccoli, Marco Mauri, Federica Agosta, Claudio Babiloni, Barbara Borroni, Marco Bozzali, Massimo Filippi, Daniela Galimberti, Roberto Monastero, Cristina Muscio, Lucilla Parnetti, Daniela Perani, Laura Serra, Vincenzo Silani, Pietro Tiraboschi, Annachiara Cagnin, Alessandro Padovani, Laura Bonann. Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem). Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2022-03-04. PMID:35244829. |
accuracy of the clinical diagnosis of dementia with lewy bodies (dlb) among the italian dementia centers: a study by the italian dlb study group (dlb-sindem). |
2022-03-04 |
2023-08-13 |
Not clear |
| Mirella Russo, Claudia Carrarini, Angelo Di Iorio, Raffaello Pellegrino, Amalia Cecilia Bruni, Salvatore Caratozzolo, Annalisa Chiari, Stefano Pretta, Camillo Marra, Maria Sofia Cotelli, Andrea Arighi, Giorgio G Fumagalli, Tatiana Cataruzza, Francesca Caso, Cristina Paci, Mara Rosso, Serena Amici, David Giannandrea, Andrea Pilotto, Simona Luzzi, Annalisa Castellano, Fabrizia D'antonio, Antonina Luca, Giorgio Gelosa, Tommaso Piccoli, Marco Mauri, Federica Agosta, Claudio Babiloni, Barbara Borroni, Marco Bozzali, Massimo Filippi, Daniela Galimberti, Roberto Monastero, Cristina Muscio, Lucilla Parnetti, Daniela Perani, Laura Serra, Vincenzo Silani, Pietro Tiraboschi, Annachiara Cagnin, Alessandro Padovani, Laura Bonann. Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem). Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2022-03-04. PMID:35244829. |
dementia with lewy bodies (dlb) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. |
2022-03-04 |
2023-08-13 |
Not clear |
| Sarah Payne, Jane B Shofer, Andrew Shutes-David, Ge Li, Adrienne Jankowski, Pamela Dean, Debby Tsuan. Correlates of Conversion from Mild Cognitive Impairment to Dementia with Lewy Bodies: Data from the National Alzheimer Coordinating Center. Journal of Alzheimer's disease : JAD. 2022-02-25. PMID:35213374. |
many patients with dementia with lewy bodies (dlb) miss out on the best standards of care and psychosocial support due to diagnostic delays or inaccuracies following symptom onset. |
2022-02-25 |
2023-08-13 |
Not clear |
| Yu Zhang, Qi Wu, Yu Ren, Ye Zhang, Linyin Fen. A53T α-synuclein induces neurogenesis impairment and cognitive dysfunction in line M83 transgenic mice and reduces the proliferation of embryonic neural stem cells. Brain research bulletin. 2022-02-19. PMID:35182691. |
dementia with lewy body (dlb) is the second most common degenerative dementia after alzheimer's disease. |
2022-02-19 |
2023-08-13 |
mouse |
| Tomonori Murayama, Seiju Kobayashi, Tomotaka Ishida, Kumiko Utsumi, Chiaki Kawanish. Associations Between Regional Cerebral Blood Flow and Psychiatric Symptoms in Dementia With Lewy Bodies Without Parkinsonism. American journal of Alzheimer's disease and other dementias. vol 37. 2022-02-16. PMID:35171729. |
because dementia with lewy bodies (dlb) has various psychiatric symptoms, early diagnosis in patients without parkinsonism is difficult. |
2022-02-16 |
2023-08-13 |
Not clear |
| Antonio Longobardi, Roland Nicsanu, Sonia Bellini, Rosanna Squitti, Marcella Catania, Pietro Tiraboschi, Claudia Saraceno, Clarissa Ferrari, Roberta Zanardini, Giuliano Binetti, Giuseppe Di Fede, Luisa Benussi, Roberta Ghidon. Cerebrospinal Fluid EV Concentration and Size Are Altered in Alzheimer's Disease and Dementia with Lewy Bodies. Cells. vol 11. issue 3. 2022-02-15. PMID:35159272. |
alzheimer's disease (ad), dementia with lewy bodies (dlb) and frontotemporal dementia (ftd) represent the three major neurodegenerative dementias characterized by abnormal brain protein accumulation. |
2022-02-15 |
2023-08-13 |
human |
| Qi Zeng, Mengchao Cu. Current Progress in the Development of Probes for Targeting α-Synuclein Aggregates. ACS chemical neuroscience. 2022-02-15. PMID:35167269. |
α-synuclein aggregates abnormally into intracellular inclusions in parkinson's disease (pd), dementia with lewy bodies (dlb), multiple system atrophy (msa), and many other neurological disorders, closely connecting with their pathogenesis. |
2022-02-15 |
2023-08-13 |
Not clear |
| Alba Cervantes González, Olivia Belbi. Fluid markers of synapse degeneration in synucleinopathies. Journal of neural transmission (Vienna, Austria : 1996). 2022-02-11. PMID:35147800. |
the abnormal accumulation of α-synuclein in the brain is a common feature of parkinson's disease (pd), pd dementia (pdd), dementia with lewy bodies (dlb) and multiple system atrophy (msa), and synucleinopathies that present with overlapping but distinct clinical symptoms that include motor and cognitive deficits. |
2022-02-11 |
2023-08-13 |
Not clear |
| Fei Wang, Min Fei, Wen-Zheng Hu, Xiao-Dan Wang, Shuai Liu, Yan Zeng, Jin-Hong Zhang, Yang Lv, Jian-Ping Niu, Xin-Ling Meng, Pan Cai, Yang Li, Bao-Zhi Gang, Yong You, Yan Lv, Yong J. Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study. Frontiers in neuroscience. vol 15. 2022-02-10. PMID:35140587. |
most of the studies on constipation in dementia patients have focused on the population with α-synucleinopathies [parkinson's disease dementia (pdd), dementia with lewy bodies (dlb)]. |
2022-02-10 |
2023-08-13 |
Not clear |
| Yukinori Okada, Makoto Shiraishi, Koji Hori, Keiichro Yamaguchi, Yasuhiro Hasegaw. Relationship between cerebral blood flow reduction patterns on scintigraphy and nonmotor symptoms in new-onset Lewy body disease. Nuclear medicine review. Central & Eastern Europe. vol 25. issue 1. 2022-02-09. PMID:35137933. |
this study aimed to investigate the relationship between patterns of reduced cerebral blood flow (cbf) evaluated by means of 123i-n-isopropyl-p-iodoamphetamine ([123i]imp) scintigraphy and nonmotor symptoms in new-onset lewy body disease (parkinson's disease and dementia with lewy bodies [dlb]). |
2022-02-09 |
2023-08-13 |
Not clear |
| Miguel Germán Borda, Nicolás Castellanos-Perilla, Diego Alejandro Tovar-Rios, Daniel Ferreira, Gustavo Duque, Dag Aarslan. Tongue muscle mass is associated with total grey matter and hippocampal volumes in Dementia with Lewy Bodies. Archives of gerontology and geriatrics. vol 100. 2022-02-08. PMID:35134612. |
we have measured muscle volume and fat accumulation in masseter and tongue muscle, and aim to explore their association with the total grey matter volume using mri in older adults recently diagnosed with alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2022-02-08 |
2023-08-13 |
Not clear |
| Jacob I Ayers, Joanne Lee, Octovia Monteiro, Amanda L Woerman, Ann A Lazar, Carlo Condello, Nick A Paras, Stanley B Prusine. Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 6. 2022-02-04. PMID:35115402. |
different α-synuclein conformers cause at least three distinct α-synucleinopathies: multiple system atrophy (msa), dementia with lewy bodies (dlb), and parkinson's disease (pd). |
2022-02-04 |
2023-08-13 |
mouse |