| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca R Valentino, Chloe Ramnarine, Michael G Heckman, Patrick W Johnson, Alexandra I Soto-Beasley, Ronald L Walton, Shunsuke Koga, Koji Kasanuki, Melissa E Murray, Ryan J Uitti, Julie A Fields, Hugo Botha, Vijay K Ramanan, Kejal Kantarci, Val J Lowe, Clifford R Jack, Nilufer Ertekin-Taner, Rodolfo Savica, Jonathan Graff-Radford, Ronald C Petersen, Joseph E Parisi, R Ross Reichard, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Zbigniew K Wszolek, Dennis W Dickson, Owen A Ros. Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures. Acta neuropathologica communications. vol 10. issue 1. 2022-07-14. PMID:35836284. |
dementia with lewy bodies (dlb) is clinically diagnosed when patients develop dementia less than a year after parkinsonism onset. |
2022-07-14 |
2023-08-14 |
Not clear |
| David J Koss, Daniel Erskine, Andrew Porter, Pawel Palmoski, Hariharan Menon, Olivia G J Todd, Marta Leite, Johannes Attems, Tiago F Outeir. Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-07-06. PMID:35794636. |
dementia with lewy bodies (dlb) is pathologically defined by the cytoplasmic accumulation of alpha-synuclein (asyn) within neurons in the brain. |
2022-07-06 |
2023-08-14 |
human |
| Teresa R Kee, Jessica L Wehinger, Pamela Espinoza Gonzalez, Eric Nguyen, Kyle C McGill Percy, Sophia A Khan, Dale Chaput, Xinming Wang, Tian Liu, David E Kang, Jung-A A Wo. Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation. Human molecular genetics. 2022-07-05. PMID:35786718. |
multiple mutations in chchd2 have been associated with lewy body disorders (lbds), such as parkinson's disease (pd) and dementia with lewy bodies (dlb), with the chchd2-t61i mutation being the most widely studied. |
2022-07-05 |
2023-08-14 |
mouse |
| Daichi Shigemizu, Yuya Asanomi, Shintaro Akiyama, Sayuri Higaki, Takashi Sakurai, Kengo Ito, Shumpei Niida, Kouichi Ozak. Network-based meta-analysis and the candidate gene association studies reveal novel ethnicity-specific variants in MFSD3 and MRPL43 associated with dementia with Lewy bodies. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2022-06-29. PMID:35765761. |
dementia with lewy bodies (dlb) is the second most common form of neurodegenerative dementia in elderly people, following alzheimer's disease. |
2022-06-29 |
2023-08-14 |
Not clear |
| Tomoyuki Miyamoto, Masayuki Miyamot. Odor identification predicts the transition of patients with isolated RBD: A retrospective study. Annals of clinical and translational neurology. 2022-06-29. PMID:35767550. |
to determine if the severity of olfactory dysfunction in isolated rem sleep behavior disorder (irbd) predicts conversion to parkinson's disease (pd) or dementia with lewy bodies (dlb). |
2022-06-29 |
2023-08-14 |
Not clear |
| Yukio Imamura, Ayami Okuzumi, Saki Yoshinaga, Akiko Hiyama, Yoshiaki Furukawa, Tomohiro Miyasaka, Nobutaka Hattori, Nobuyuki Nukin. Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission. Communications biology. vol 5. issue 1. 2022-06-29. PMID:35768587. |
synucleinopathies are neurodegenerative disorders including parkinson disease (pd), dementia with lewy body (dlb), and multiple system atrophy (msa) that involve deposits of the protein alpha-synuclein (α-syn) in the brain. |
2022-06-29 |
2023-08-14 |
Not clear |
| Annette Janzen, David Vadasz, Jan Booij, Markus Luster, Damiano Librizzi, Martin T Henrich, Lars Timmermann, Mahboubeh Habibi, Elisabeth Sittig, Geert Mayer, Fanni Geibl, Wolfgang Oerte. Progressive Olfactory Impairment and Cardiac Sympathetic Denervation in REM Sleep Behavior Disorder. Journal of Parkinson's disease. 2022-06-27. PMID:35754288. |
isolated rapid eye movement sleep behavior disorder (irbd) is prodromal for parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-06-27 |
2023-08-14 |
Not clear |
| Olivier Bousiges, Frédéric Blan. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742814. |
dementia with lewy bodies (dlb) is a common form of cognitive neurodegenerative disease. |
2022-06-24 |
2023-08-14 |
Not clear |
| Bernhard Iglseder, Rüdiger Lang. [Atypical Parkinson's syndrome in old age]. Zeitschrift fur Gerontologie und Geriatrie. 2022-06-24. PMID:35748931. |
atypical parkinson syndromes represent a neuropathologically heterogeneous group and include the clinical entities dementia with lewy bodies (dlb), multiple system atrophy (msa), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd). |
2022-06-24 |
2023-08-14 |
Not clear |
| Jinghuan Gan, Shuai Liu, Zhichao Chen, Yaqi Yang, Lingyun Ma, Qingbo Meng, Xiao-Dan Wang, Chunyan Liu, Xudong Li, Wei Zhang, Yong J. Elevated Plasma Orexin-A Levels in Prodromal Dementia with Lewy Bodies. Journal of Alzheimer's disease : JAD. vol 1. issue -1. 2022-06-20. PMID:35723094. |
studies on plasma orexin-a levels in prodromal dementia with lewy bodies (dlb) and the relationship with clinical manifestations are rare. |
2022-06-20 |
2023-08-14 |
Not clear |
| Ammar Natalwala, Ranya Behbehani, Ratsuda Yapom, Tilo Kunat. An Isogenic Collection of Pluripotent Stem Cell Lines With Elevated α-Synuclein Expression Validated for Neural Induction and Cortical Neuron Differentiation. Frontiers in cell and developmental biology. vol 10. 2022-06-17. PMID:35712660. |
α-synuclein (αsyn) is a small, disordered protein that becomes aggregated in lewy body diseases, such as parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-06-17 |
2023-08-14 |
human |
| b' Joan Prats-Climent, Maria Teresa Gandia-Ferrero, Irene Torres-Espallardo, Lourdes \\xc3\\x81lvarez-Sanchez, Bego\\xc3\\xb1a Mart\\xc3\\xadnez-Sanchis, Consuelo Ch\\xc3\\xa1fer-Peric\\xc3\\xa1s, Ignacio G\\xc3\\xb3mez-Rico, Leonor Cerd\\xc3\\xa1-Alberich, Fernando Aparici-Robles, Miquel Baquero-Toledo, Mar\\xc3\\xada Jos\\xc3\\xa9 Rodr\\xc3\\xadguez-\\xc3\\x81lvarez, Luis Mart\\xc3\\xad-Bonmat\\xc3\\xa. Artificial Intelligence on FDG PET Images Identifies Mild Cognitive Impairment Patients with Neurodegenerative Disease. Journal of medical systems. vol 46. issue 8. 2022-06-17. PMID:35713815.' |
the purpose of this project is to develop and validate a deep learning (dl) fdg pet imaging algorithm able to identify patients with any neurodegenerative diseases (alzheimer's disease (ad), frontotemporal degeneration (ftd) or dementia with lewy bodies (dlb)) among patients with mild cognitive impairment (mci). |
2022-06-17 |
2023-08-14 |
human |
| Matej Perovnik, Petra Tomše, Jan Jamšek, Chris Tang, David Eidelberg, Maja Troš. Metabolic brain pattern in dementia with Lewy bodies: Relationship to Alzheimer's disease topography. NeuroImage. Clinical. vol 35. 2022-06-16. PMID:35709556. |
dementia with lewy bodies (dlb) is the second most common neurodegenerative dementia, that shares clinical and metabolic similarities with both alzheimer's and parkinson's disease. |
2022-06-16 |
2023-08-14 |
Not clear |
| Karima Schwab, Zoi Chasapopoulou, Silke Frahm, Mandy Magbagbeolu, Anna Cranston, Charles R Harrington, Claude M Wischik, Franz Theuring, Gernot Riede. Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine. Cellular signalling. 2022-06-16. PMID:35709886. |
the accumulation of alpha-synuclein (α-syn) into lewy bodies in cortical and subcortical regions has been linked to the pathogenesis of synucleinopathies such as parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-06-16 |
2023-08-14 |
mouse |
| Eun Joo Chung, Hwa Jin Cho, Dae Young Hur, Yeong Seok Kim, Kyung-Hwa Lee, Sang Jin Ki. One Autopsy Proved Neocortical Lewy Body Disease Without the Involvement of the Olfactory Bulb and Brainstem. Journal of Korean medical science. vol 37. issue 23. 2022-06-14. PMID:35698841. |
lewy bodies (lbs) and lewy neurites (lns) are pathological hallmarks of parkinson's disease (pd) or dementia with lbs (dlb). |
2022-06-14 |
2023-08-14 |
Not clear |
| Hengxu Mao, Yongyi Ye, Xiang Sun, Chen Qian, Baoyan Wang, Linghai Xie, Shizhong Zhan. Quiescent Elongation of α-Synuclein Pre-form Fibrils Under Different Solution Conditions. Frontiers in neuroscience. vol 16. 2022-06-13. PMID:35692426. |
the intracellular aggregation of α-synuclein in neurons/glia is considered to be a key step in the pathogenesis of synucleinopathy [including parkinson's disease (pd), dementia with lewy body (dlb), multiple system atrophy (msa), etc.]. |
2022-06-13 |
2023-08-14 |
Not clear |
| Kurt A Jellinge. Are there morphological differences between Parkinson's disease-dementia and dementia with Lewy bodies? Parkinsonism & related disorders. vol 100. 2022-06-12. PMID:35691178. |
parkinson's disease dementia (pdd) and dementia with lewy bodies (dlb) are two major neurocognitive disorders in the spectrum of lewy body diseases that overlap in many clinical and neuropathological features, although they show several differences. |
2022-06-12 |
2023-08-14 |
Not clear |
| Sakshi Prasad, Maanya Rajasree Katta, Shuchi Abhishek, Rishala Sridhar, Sai Sudha Valisekka, Maha Hameed, Jasneet Kaur, Namrata Wali. Recent advances in Lewy body dementia: A comprehensive review. Disease-a-month : DM. 2022-06-11. PMID:35690493. |
strikingly, many of the pharmacologic treatments used to treat behavioral and cognitive symptoms in other forms of dementia exacerbate the symptoms of dlb. |
2022-06-11 |
2023-08-14 |
human |
| Karen Zagorski, Gor Chailyan, Armine Hovakimyan, Tatevik Antonyan, Sepideh Kiani Shabestari, Irina Petrushina, Hayk Davtyan, David H Cribbs, Mathew Blurton-Jones, Eliezer Masliah, Michael G Agadjanyan, Anahit Ghochikya. Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682759. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are characterized by the aberrant accumulation of intracytoplasmic misfolded and aggregated α-synuclein (α-syn), resulting in neurodegeneration associated with inflammation. |
2022-06-10 |
2023-08-14 |
mouse |
| Tim E Moors, Daniel Mona, Stefan Luehe, Gonzalo Duran-Pacheco, Liz Spycher, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N Hug, Thomas Kremer, Mirko Ritter, Sebastian Dziadek, Gregor Dernick, Wilma D J van de Berg, Markus Britschg. Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies. Acta neuropathologica communications. vol 10. issue 1. 2022-06-06. PMID:35659116. |
based on immunostainings and biochemical analyses, certain post-translationally modified alpha-synuclein (asyn) variants, including c-terminally truncated (ctt) and serine-129 phosphorylated (pser129) asyn, are proposed to be involved in the pathogenesis of synucleinopathies such as parkinson's disease with (pdd) and without dementia (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2022-06-06 |
2023-08-14 |
human |