| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideki Kanemoto, Yuto Satake, Takashi Suehiro, Daiki Taomoto, Fuyuki Koizumi, Shunsuke Sato, Tamiki Wada, Keiko Matsunaga, Eku Shimosegawa, Mamoru Hashimoto, Kenji Yoshiyama, Manabu Iked. Characteristics of very late-onset schizophrenia-like psychosis as prodromal dementia with Lewy bodies: a cross-sectional study. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-22. PMID:36138485. |
this study aimed to identify cases of potential prodromal dlb in very late-onset schizophrenia-like psychosis (vloslp), using indicative biomarkers of dementia with lewy bodies (dlb), and to evaluate the characteristics of psychosis as prodromal dlb. |
2022-09-22 |
2023-08-14 |
Not clear |
| Carol X-Q Chen, Eric Deneault, Narges Abdian, Zhipeng You, Julien Sirois, Michael Nicouleau, Irina Shlaifer, Lorenza Villegas, Marie-Noëlle Boivin, Lydiane Gaborieau, Jason Karamchandani, Lenore K Beitel, Edward A Fon, Thomas M Durca. Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson's associated GBA gene. Stem cell research. vol 64. 2022-09-21. PMID:36130446. |
heterozygous gba mutations have been associated with the development of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-09-21 |
2023-08-14 |
Not clear |
| Ying Jiang, John J Alam, Stephen N Gomperts, Paul Maruff, Afina W Lemstra, Ursula A Germann, Philip H Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S Basavarajappa, John F Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D Prins, Charlotte E Teunissen, John E Harrison, Philip Scheltens, Ralph A Nixo. Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration. Nature communications. vol 13. issue 1. 2022-09-21. PMID:36130946. |
we also report on the results of an exploratory (hypothesis-generating) phase 2a randomized double-blind 16-week placebo-controlled clinical trial (clinical trial registration: nct04001517/eudract #2019-001566-15) of neflamapimod in mild-to-moderate dementia with lewy bodies (dlb), a disease in which bfcn degeneration is an important driver of disease expression. |
2022-09-21 |
2023-08-14 |
mouse |
| Norio Murayama, Kazumi Ota, Eizo Isek. The Bender Gestalt Test is useful for clinically diagnosing dementia with Lewy bodies: Analysis of its sensitivity, specificity, and clinical characteristics of the figure copy. Applied neuropsychology. Adult. 2022-09-19. PMID:36121098. |
a previous study that evaluated the ability of the bender gestalt test (bgt) to discriminate between dementia with lewy bodies (dlb) and alzheimer's disease (ad) suggested that a total score of 98 is the optimal cutoff value for discriminating between these two diseases and that dlb tends to exhibit unique errors; i.e., "element deformation" and "gestalt destruction." |
2022-09-19 |
2023-08-14 |
human |
| Rachel E Lackie, Aline S de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madrer, Nadun C Karunatilleke, Benjamin S Rutledge, Stephanie Tullo, Anne Brickenden, Matthew E R Maitland, David Greenberg, Daniel Gallino, Wen Luo, Anoosha Attaran, Irina Shlaifer, Esther Del Cid Pellitero, Caroline Schild-Poulter, Thomas M Durcan, Edward A Fon, Martin Duennwald, Flavio H Beraldo, M Mallar Chakravarty, Timothy J Bussey, Lisa M Saksida, Hermona Soreq, Wing-Yiu Choy, Vania F Prado, Marco A M Prad. Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo. Acta neuropathologica. 2022-09-19. PMID:36121476. |
the predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to misfolding and aggregation in synucleinopathies, such as parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-09-19 |
2023-08-14 |
mouse |
| Allison Beers Constant, Rakshathi Basavaraju, Jeanelle France, Lawrence S Honig, Karen S Marder, Frank Anthony Provenzan. Longitudinal Patterns of Cortical Atrophy on MRI in Patients With Alzheimer Disease With and Without Lewy Body Pathology. Neurology. 2022-09-19. PMID:36123123. |
although alzheimer's disease (ad) and dementia with lewy bodies (dlb) represent two different pathologies, they have clinical overlap, and there is a significant degree of co-occurrence of their neuropathological findings. |
2022-09-19 |
2023-08-14 |
Not clear |
| Jinghuan Gan, Zhichao Chen, Shuai Liu, Zhihong Shi, Yiming Liu, Xiao-Dan Wang, Chunyan Liu, Yong J. The presence and co-incidence of geriatric syndromes in older patients with mild-moderate Lewy body dementia. BMC neurology. vol 22. issue 1. 2022-09-19. PMID:36123648. |
the purpose of this study is to investigate the distributions of apolipoprotein e (apoe) ε4 and geriatric symptoms, and explore their associaitons in dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd). |
2022-09-19 |
2023-08-14 |
Not clear |
| Troy A Webber, Andrew M Kiselica, Cynthia Mikula, Steven P Wood. Dispersion-based cognitive intra-individual variability in dementia with Lewy bodies. Neuropsychology. 2022-09-15. PMID:36107707. |
cognitive fluctuations are characteristic of dementia with lewy bodies (dlb) but challenging to measure. |
2022-09-15 |
2023-08-14 |
Not clear |
| Yang Yang, Yang Shi, Manuel Schweighauser, Xianjun Zhang, Abhay Kotecha, Alexey G Murzin, Holly J Garringer, Patrick W Cullinane, Yuko Saito, Tatiana Foroud, Thomas T Warner, Kazuko Hasegawa, Ruben Vidal, Shigeo Murayama, Tamas Revesz, Bernardino Ghetti, Masato Hasegawa, Tammaryn Lashley, Sjors H W Scheres, Michel Goeder. Structures of α-synuclein filaments from human brains with Lewy pathology. Nature. 2022-09-15. PMID:36108674. |
pd dementia (pdd) is clinically and neuropathologically similar to dementia with lewy bodies (dlb), which is diagnosed when cognitive impairment precedes parkinsonian motor signs or begins within one year from their onset (4). |
2022-09-15 |
2023-08-14 |
human |
| Tai-Yi Chen, Po-Chi Chan, Ching-Fang Tsai, Cheng-Yu Wei, Pai-Yi Chi. White matter hyperintensities in dementia with Lewy bodies are associated with poorer cognitive function and higher dementia stages. Frontiers in aging neuroscience. vol 14. 2022-09-12. PMID:36092817. |
however, the association between wmhs and clinical presentations of dementia with lewy bodies (dlb) has rarely been studied. |
2022-09-12 |
2023-08-14 |
Not clear |
| Niamh McCombe, Alok Joshi, David P Finn, Paula L McClean, Gemma Roberts, John T O'Brien, Alan J Thomas, Joseph P M Kane, KongFatt Wong-Li. Distinguishing Lewy Body Dementia from Alzheimer's Disease using Machine Learning on Heterogeneous Data: A Feasibility Study. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2022. 2022-09-10. PMID:36085984. |
dementia with lewy bodies (dlb) is the second most common form of dementia, but diagnostic markers for dlb can be expensive and inaccessible, and many cases of dlb are undiagnosed. |
2022-09-10 |
2023-08-14 |
Not clear |
| Niamh McCombe, Alok Joshi, David P Finn, Paula L McClean, Gemma Roberts, John T O'Brien, Alan J Thomas, Joseph P M Kane, KongFatt Wong-Li. Distinguishing Lewy Body Dementia from Alzheimer's Disease using Machine Learning on Heterogeneous Data: A Feasibility Study. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2022. 2022-09-10. PMID:36085984. |
clinical relevance- simple and interpretable high-performing machine learning algorithms identified a variety of readily available clinical assessments for differential diagnosis of dementia offering the opportunities to incorporate various simple and inexpensive screening tests for dlb and addressing the problem of dlb underdiagnosis. |
2022-09-10 |
2023-08-14 |
Not clear |
| Yevgenia Rosenblum, Inbal Maidan, Orly Goldstein, Mali Gana-Weisz, Avi Orr-Urtreger, Noa Bregman, Nir Giladi, Anat Mirelman, Tamara Shine. Decreased delta-band event-related power in dementia with Lewy bodies with a mutation in the glucocerebrosidase gene. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 143. 2022-09-10. PMID:36087397. |
to compare event-related oscillations in patients with dementia with lewy bodies (dlb) who are carriers and non-carriers of glucocerebrosidase (gba) mutations. |
2022-09-10 |
2023-08-14 |
Not clear |
| Sinead Gaubert, Claire Hourregue, François Mouton-Liger, Périne Millot, Mélanie Franco, Elodie Amar-Bouaziz, Dag Aarsland, Jacques Hugon, Claire Paque. Exploring the link between GBA1 mutations and Dementia with Lewy bodies, A Mini-Review. Neuroscience and biobehavioral reviews. 2022-09-09. PMID:36084847. |
dementia with lewy bodies (dlb) is a neurodegenerative disease linked to abnormal accumulation of phosphorylated α-synuclein. |
2022-09-09 |
2023-08-14 |
Not clear |
| Dimitriou Tatiana-Danai, Papatriantafyllou John, Konsta Anastasia, Kazis Dimitrios, Athanasiadis Loukas, Ioannidis Panagiotis, Koutsouraki Efrosini, Tegos Thomas, Tsolaki Magd. Non-Pharmacological Interventions for the Hallucinations in Patients with Dementia. A Cross-Over Randomized Controlled Trial. Journal of clinical cases & reports. vol 5. issue 4. 2022-09-05. PMID:36061372. |
hallucinations is a core characteristic symptom in lewy body dementia (dlb) and parkinson's dementia (pdd). |
2022-09-05 |
2023-08-14 |
Not clear |
| Michiyo Iba, Ross A McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Maslia. Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD. Molecular neurodegeneration. vol 17. issue 1. 2022-09-05. PMID:36064424. |
although ɑ-synuclein (ɑ-syn) spreading in age-related neurodegenerative diseases such as parkinson's disease (pd) and dementia with lewy bodies (dlb) has been extensively investigated, the role of aging in the manifestation of disease remains unclear. |
2022-09-05 |
2023-08-14 |
mouse |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
here, we have investigated the immunological and biochemical properties of aggregated tau species in different brain cell types in tau-induced neurodegenerative diseases such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). |
2022-09-02 |
2023-08-14 |
mouse |
| Zhou Su, Shuai Liu, Gang Chen, Jinghuan Gan, Xinran Bao, Hongcan Zhu, Xiaodan Wang, Hao Wu, Yong J. Pisa syndrome in dementia with Lewy bodies: A Chinese multicenter study. Parkinsonism & related disorders. vol 103. 2022-08-30. PMID:36041278. |
pisa syndrome (ps) is rarely reported in dementia with lewy bodies (dlb). |
2022-08-30 |
2023-08-14 |
Not clear |
| David P Salmon, Denis S Smirnov, David G Coughlin, Joanne M Hamilton, Kelly M Landy, J Vincent Filoteo, Annie Hiniker, Lawrence A Hansen, Douglas Galask. Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease. Neurology. 2022-08-26. PMID:36028327. |
patients with dementia with lewy bodies (dlb) perform worse than those with alzheimer's disease (ad) on tests of visual perception but the clinical utility of these tests remains unknown because studies often had clinically-diagnosed groups that may inadvertently cross-contaminate lewy body disease (lbd) with pure ad pathology, employed experimental tests not easily adaptable for clinical use, and had no way to examine relationships between severity of lbd pathology and degree of cognitive impairment. |
2022-08-26 |
2023-08-14 |
Not clear |
| Euna Choi, Ji Won Han, Seung Wan Suh, Jong Bin Bae, Ji Hyun Han, Subin Lee, Sang Eun Kim, Ki Woong Ki. Altered resting state brain metabolic connectivity in dementia with Lewy bodies. Frontiers in neurology. vol 13. 2022-08-25. PMID:36003295. |
although dementia with lewy bodies (dlb) have parkinsonism in common with parkinson's disease (pd) or pd dementia (pdd), they have different neuropathologies that underlie parkinsonism. |
2022-08-25 |
2023-08-14 |
Not clear |