| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alberto Jaramillo-Jimenez, Yinbing Ying, Ping Ren, Zhan Xiao, Qian Zhang, Jian Wang, Han Rong, Miguel Germán Borda, Laura Bonanni, Dag Aarsland, Donghui W. Prodromal Dementia With Lewy Bodies and Recurrent Panic Attacks as the First Symptom: A Case Report. Frontiers in neurology. vol 13. 2022-05-02. PMID:35493812. |
we provide an extended description of the clinical presentation and course from psychiatric-onset dlb to dementia in an 83-year-old woman. |
2022-05-02 |
2023-08-13 |
Not clear |
| Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Gies. Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial. EBioMedicine. vol 80. 2022-05-02. PMID:35500536. |
synucleinopathies such as parkinson ́s disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa) are characterized by deposition of misfolded and aggregated α-synuclein. |
2022-05-02 |
2023-08-13 |
Not clear |
| F Blanc, O Bousige. Biomarkers and diagnosis of dementia with Lewy bodies including prodromal: Practical aspects. Revue neurologique. 2022-05-01. PMID:35491246. |
dementia with lewy bodies (dlb) is a common form of cognitive neurodegenerative disease. |
2022-05-01 |
2023-08-13 |
Not clear |
| Federico Rodriguez-Porcel, Kathryn A Wyman-Chick, Carla Abdelnour Ruiz, Jon B Toledo, Daniel Ferreira, Prabitha Urwyler, Rimona S Weil, Joseph Kane, Andrea Pilotto, Arvid Rongve, Bradley Boeve, John-Paul Taylor, Ian McKeith, Dag Aarsland, Simon J G Lewi. Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations. Translational neurodegeneration. vol 11. issue 1. 2022-05-01. PMID:35491418. |
although dementia with lewy bodies (dlb) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as alzheimer's or parkinson's disease. |
2022-05-01 |
2023-08-13 |
Not clear |
| Grace M Lloyd, Zachary A Sorrentino, Stephan Quintin, Kimberly-Marie M Gorion, Brach M Bell, Giavanna Paterno, Brooke Long, Stefan Prokop, Benoit I Giasso. Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice. Acta neuropathologica. 2022-04-30. PMID:35488930. |
accumulation of αsyn inclusions is a key feature of dementia with lewy bodies (dlb) and multiple system atrophy (msa), and are found as additional pathology in alzheimer's disease (ad) such as ad with amygdala predominant lewy bodies (ad/alb). |
2022-04-30 |
2023-08-13 |
mouse |
| Yu Ren, Qing Wang, Zexian Yang, Linyin Feng, Yu Zhan. MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation. Biochemical and biophysical research communications. vol 611. 2022-04-26. PMID:35472607. |
dementia with lewy bodies (dlb) is the second most common type of neurodegenerative dementia after alzheimer's disease (ad). |
2022-04-26 |
2023-08-13 |
mouse |
| Li Yang Tan, Kwan Hou Tang, Lynette Yu You Lim, Jia Xin Ong, Hyokeun Park, Sangyong Jun. α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword. Biomolecules. vol 12. issue 4. 2022-04-23. PMID:35454096. |
α-synuclein (α-syn) is a presynaptic, lipid-binding protein strongly associated with the neuropathology observed in parkinson's disease (pd), dementia with lewy bodies (dlb), and alzheimer's disease (ad). |
2022-04-23 |
2023-08-13 |
Not clear |
| Urmi Sengupta, Rakez Kaye. Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. Progress in neurobiology. 2022-04-21. PMID:35447272. |
aggregation of specific proteins are histopathological hallmarks of several neurodegenerative diseases, such as, amyloid β (aβ) plaques and tau neurofibrillary tangles in alzheimer's disease (ad); morphologically different inclusions of ratiometric 3 repeat (3r) and 4 repeat (4r) tau isoforms in progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and pick's disease (pid); α-synuclein (α-syn) containing lewy bodies (lbs) and dystrophic lewy neurites (lns) in parkinson's disease (pd) and dementia with lewy bodies (dlb). |
2022-04-21 |
2023-08-13 |
Not clear |
| Urvi Desai, Julie Chandler, Noam Kirson, Mihaela Georgieva, Hoi Ching Cheung, Ben Westermeyer, Henry Lane, Kevin Bigla. Epidemiology and economic burden of Lewy body dementia in the United States. Current medical research and opinion. 2022-04-20. PMID:35442134. |
to describe the trends in epidemiology, healthcare resource use (hcru), and costs associated with lewy body dementia (lbd), dementia with lewy bodies (dlb), and parkinson's disease dementia (pdd) in the united states. |
2022-04-20 |
2023-08-13 |
Not clear |
| Simona S Ghanem, Nour K Majbour, Nishant N Vaikath, Mustafa T Ardah, Daniel Erskine, Nanna Møller Jensen, Muneera Fayyad, Indulekha P Sudhakaran, Eftychia Vasili, Katerina Melachroinou, Ilham Y Abdi, Ilaria Poggiolini, Patricia Santos, Anton Dorn, Paolo Carloni, Kostas Vekrellis, Johannes Attems, Ian McKeith, Tiago F Outeiro, Poul Henning Jensen, Omar M A El-Agna. α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 15. 2022-04-18. PMID:35353605. |
α-synuclein (α-syn) phosphorylation at serine 129 (ps129–α-syn) is substantially increased in lewy body disease, such as parkinson’s disease (pd) and dementia with lewy bodies (dlb). |
2022-04-18 |
2023-08-16 |
mouse |
| Song Xie, Jiajun Yang, Shenghui Huang, Yuanlan Fan, Tao Xu, Jiangshuang He, Jiahao Guo, Xiang Ji, Zhibo Wang, Peijun Li, Jiangfan Chen, Yi Zhan. Disrupted myelination network in the cingulate cortex of Parkinson's disease. IET systems biology. 2022-04-08. PMID:35394697. |
furthermore, downregulation of myelination pathways in the cingulate cortex were shared and validated in another independent rnaseq cohort of dementia with lewy bodies (dlb). |
2022-04-08 |
2023-08-13 |
mouse |
| Yian Gu, Anton Kociolek, Kayri K Fernandez, Stephanie A Cosentino, Carolyn Wei Zhu, Zhezhen Jin, James B Leverenz, Yaakov B Ster. Clinical Trajectories at the End of Life in Dementia Patients With Alzheimer Disease and Lewy Body Neuropathologic Changes. Neurology. 2022-04-05. PMID:35379761. |
however, inconsistent findings have been reported with regard to the disease courses of the two most common dementias, alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2022-04-05 |
2023-08-13 |
Not clear |
| Yian Gu, Anton Kociolek, Kayri K Fernandez, Stephanie A Cosentino, Carolyn Wei Zhu, Zhezhen Jin, James B Leverenz, Yaakov B Ster. Clinical Trajectories at the End of Life in Dementia Patients With Alzheimer Disease and Lewy Body Neuropathologic Changes. Neurology. 2022-04-05. PMID:35379761. |
using autopsy-confirmed diagnoses, we aimed to examine the disease trajectories in the years before death among dementia patients with pure ad, pure dlb, or mixed (ad and dlb) pathologies. |
2022-04-05 |
2023-08-13 |
Not clear |
| Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudse. An Frontiers in neuroscience. vol 16. 2022-04-04. PMID:35368260. |
we here establish a pig model with cerebral injections of α-synuclein preformed fibrils or brain homogenate from postmortem human brain tissue from individuals with alzheimer's disease (ad) or dementia with lewy body (dlb) into the pig's brain, using minimally invasive surgery and validated against saline injections. |
2022-04-04 |
2023-08-13 |
human |
| Fatma Sena Dost, Esra Ates Bulut, Ozge Dokuzlar, Derya Kaya, Feyza Mutlay, Besra Hazal Yesil Gurel, Ahmet Turan Isi. Sarcopenia is as common in older patients with dementia with Lewy bodies as it is in those with Alzheimer's disease. Geriatrics & gerontology international. 2022-04-04. PMID:35373438. |
alzheimer's disease (ad) and dementia with lewy body (dlb) constitute the most common types of dementia, and are two common geriatric syndromes; however, sarcopenia has not been elaborately evaluated in dlb so far. |
2022-04-04 |
2023-08-13 |
Not clear |
| Yukiko Suzuki, Maki Suzuki, Kazue Shigenobu, Kazuhiro Shinosaki, Yasunori Aoki, Hirokazu Kikuchi, Toru Baba, Mamoru Hashimoto, Toshihiko Araki, Kristinn Johnsen, Manabu Ikeda, Etsuro Mor. A prospective multicenter validation study of a machine learning algorithm classifier on quantitative electroencephalogram for differentiating between dementia with Lewy bodies and Alzheimer's dementia. PloS one. vol 17. issue 3. 2022-03-31. PMID:35358240. |
an early and accurate diagnosis of dementia with lewy bodies (dlb) is critical because treatments and prognosis of dlb are different from alzheimer's disease (ad). |
2022-03-31 |
2023-08-13 |
Not clear |
| Laura Ferré-González, Carmen Peña-Bautista, Miguel Baquero, Consuelo Cháfer-Pericá. Assessment of Lipid Peroxidation in Alzheimer's Disease Differential Diagnosis and Prognosis. Antioxidants (Basel, Switzerland). vol 11. issue 3. 2022-03-25. PMID:35326200. |
previous studies have shown specificity between lipid peroxidation compounds and other dementias (e.g., lewy bodies (dlb), frontotemporal dementia (ftd)), but more research is required. |
2022-03-25 |
2023-08-13 |
human |
| Katharina Strempfl, Michael S Unger, Stefanie Flunkert, Andrea Trost, Herbert A Reitsamer, Birgit Hutter-Paier, Ludwig Aigne. Leukotriene Signaling as a Target in α-Synucleinopathies. Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327537. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are two common types of α-synucleinopathies and represent a high unmet medical need. |
2022-03-25 |
2023-08-13 |
Not clear |
| Eya Khadhraoui, Sebastian Johannes Müller, Niels Hansen, Christian Heiner Riedel, Philip Langer, Charles Timäeus, Jens Wiltfang, Caroline Bouter, Claudia Lange, Marielle Erns. Manual and automated analysis of atrophy patterns in dementia with Lewy bodies on MRI. BMC neurology. vol 22. issue 1. 2022-03-25. PMID:35331168. |
dementia with lewy bodies (dlb) is the second most common dementia type in patients older than 65 years. |
2022-03-25 |
2023-08-13 |
human |
| Li Liu, Jia Li, Wei Quan, Yidan Qin, Qinghui Zhang, Xiaochen Pei, Hang Su, Jing Xu, Jiajun Che. Effect of GBA gene variants on clinical characteristics of dementia with Lewy bodies: a review and meta-analyses. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2022-03-25. PMID:35332438. |
glucocerebrosidase (gba) gene may be a risk factor for dementia with lewy bodies (dlb). |
2022-03-25 |
2023-08-13 |
Not clear |