| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Takuma, A Matsuo, Y Himeno, Y Hoshina, Y Ohno, Y Funatsu, S Arai, H Kamei, H Mizoguchi, T Nagai, K Koike, M Inoue, K Yamad. 17beta-estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Neuroscience. vol 146. issue 1. 2007-07-18. PMID:17320294. |
17beta-estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. |
2007-07-18 |
2023-08-12 |
human |
| K Takuma, A Matsuo, Y Himeno, Y Hoshina, Y Ohno, Y Funatsu, S Arai, H Kamei, H Mizoguchi, T Nagai, K Koike, M Inoue, K Yamad. 17beta-estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Neuroscience. vol 146. issue 1. 2007-07-18. PMID:17320294. |
we further examined the effect of estrogen against cognitive dysfunction and hippocampal changes of ovx/stress rats. |
2007-07-18 |
2023-08-12 |
human |
| Yang Fan, Zhengyan Liu, Philip R Weinstein, John R Fike, Jialing Li. Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241265. |
our data suggest that there is still a considerable amount of plasticity remaining in the hippocampal progenitor cells in adult animals after radiation injury, which can become a target of therapeutic intervention for radiation-induced cognitive dysfunction. |
2007-04-05 |
2023-08-12 |
Not clear |
| Helen L Hellmich, Kristine A Eidson, Bridget A Capra, Jeanna M Garcia, Deborah R Boone, Bridget E Hawkins, Tatsuo Uchida, Douglas S Dewitt, Donald S Proug. Injured Fluoro-Jade-positive hippocampal neurons contain high levels of zinc after traumatic brain injury. Brain research. vol 1127. issue 1. 2007-03-09. PMID:17109824. |
hippocampal damage contributes to cognitive dysfunction after traumatic brain injury (tbi). |
2007-03-09 |
2023-08-12 |
rat |
| Shizuo Nakamura, Norihito Murayama, Takafumi Noshita, Ryoko Katsuragi, Tomochika Ohn. Cognitive dysfunction induced by sequential injection of amyloid-beta and ibotenate into the bilateral hippocampus; protection by memantine and MK-801. European journal of pharmacology. vol 548. issue 1-3. 2006-12-12. PMID:16952349. |
cognitive dysfunction induced by sequential injection of amyloid-beta and ibotenate into the bilateral hippocampus; protection by memantine and mk-801. |
2006-12-12 |
2023-08-12 |
rat |
| Susumu Kotani, Eiko Sakaguchi, Shogo Warashina, Noriyuki Matsukawa, Yoshiyuki Ishikura, Yoshinobu Kiso, Manabu Sakakibara, Tanihiro Yoshimoto, Jianzhong Guo, Tetsumori Yamashim. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neuroscience research. vol 56. issue 2. 2006-11-28. PMID:16905216. |
age-dependent increase of peroxidation of membrane fatty acids such as arachidonic acid (ara) and docosahexaenoic acid (dha) in neurons was reported to cause a decline of the hippocampal long-term potentiation (ltp) and cognitive dysfunction in rodents. |
2006-11-28 |
2023-08-12 |
human |
| Xu Cui, Pingping Zuo, Qing Zhang, Xuekun Li, Yazhuo Hu, Jiangang Long, Lester Packer, Jiankang Li. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. Journal of neuroscience research. vol 84. issue 3. 2006-11-01. PMID:16710848. |
a concomitant treatment with lipoic acid ameliorated cognitive dysfunction and neurodegeneration in the hippocampus, and also reduced peripheral oxidative damage by decreasing malondialdehyde and increasing t-aoc and t-sod, without an effect on gsh-px. |
2006-11-01 |
2023-08-12 |
mouse |
| Ashley R Kochanek, Anthony E Kline, Wei-Min Gao, Mandeep Chadha, Yichen Lai, Robert S B Clark, C Edward Dixon, Larry W Jenkin. Gel-based hippocampal proteomic analysis 2 weeks following traumatic brain injury to immature rats using controlled cortical impact. Developmental neuroscience. vol 28. issue 4-5. 2006-11-01. PMID:16943664. |
significant changes in key proteins involved in glial and neuronal stress, oxidative metabolism, calcium uptake and neurotransmitter function were found 2 weeks after injury, and their potential roles in hippocampal plasticity and cognitive dysfunction were discussed. |
2006-11-01 |
2023-08-12 |
rat |
| Young Hae Chong, Yoo Jeong Shin, Eun Ok Lee, Rakez Kayed, Charles G Glabe, Andrea J Tenne. ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. The Journal of biological chemistry. vol 281. issue 29. 2006-09-19. PMID:16714296. |
in this study, we investigated the molecular basis for the altered signal transduction associated with soluble amyloid beta-protein (abeta) oligomer-mediated neurotoxicity in the hippocampus, which is primarily linked to cognitive dysfunction in alzheimer disease (ad). |
2006-09-19 |
2023-08-12 |
rat |
| Kenneth T Kishida, Charles A Hoeffer, Daoying Hu, Maryland Pao, Steven M Holland, Eric Klan. Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease. Molecular and cellular biology. vol 26. issue 15. 2006-09-19. PMID:16847341. |
taken together, our results are consistent with nadph oxidase being required for hippocampal synaptic plasticity and memory and are consistent with reports of cognitive dysfunction in patients with cgd. |
2006-09-19 |
2023-08-12 |
mouse |
| Xu Cui, Pingping Zuo, Qing Zhang, Xuekun Li, Yazhuo Hu, Jiangang Long, Lester Packer, Jiankang Li. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. Journal of neuroscience research. vol 83. issue 8. 2006-09-08. PMID:16555301. |
a concomitant treatment with lipoic acid ameliorated cognitive dysfunction and neurodegeneration in the hippocampus and also reduced peripheral oxidative damage by decreasing malondialdehyde and increasing t-aoc and t-sod, without an effect on gsh-px. |
2006-09-08 |
2023-08-12 |
mouse |
| Juan Liu, Toshihito Suzuki, Tatsunori Seki, Takashi Namba, Atsushi Tanimura, Heii Ara. Effects of repeated phencyclidine administration on adult hippocampal neurogenesis in the rat. Synapse (New York, N.Y.). vol 60. issue 1. 2006-08-04. PMID:16596623. |
further studies are required to elucidate the biological significance of hippocampal neurogenesis in the mechanisms underlying the development of cognitive dysfunctions and the psychosis of schizophrenia. |
2006-08-04 |
2023-08-12 |
rat |
| Hai-Fa Qiao, Sheng Yang, Wen-Xia Zhou, Yong-Xiang Zhan. NT-1, an active constituent extracted from Tiaoxin Recipe, enhances long-term potentiation of CA1 subfield in rat hippocampal slices. Life sciences. vol 79. issue 1. 2006-06-26. PMID:16458933. |
in the present study, using hippocampal slice preparations, we investigated the mechanisms by which nt-1 improves cognitive dysfunction contributed to corticosterone (cort). |
2006-06-26 |
2023-08-12 |
rat |
| M F Montaron, E Drapeau, D Dupret, P Kitchener, C Aurousseau, M Le Moal, P V Piazza, D N Abrou. Lifelong corticosterone level determines age-related decline in neurogenesis and memory. Neurobiology of aging. vol 27. issue 4. 2006-05-25. PMID:15953661. |
altogether, these results indicate that the extent of lifetime exposure to glucocorticoids determines the extent of age-related decline in hippocampal neurogenesis and consequently age-related cognitive dysfunctions. |
2006-05-25 |
2023-08-12 |
rat |
| Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata, Takaomi C Saido, Dayong Wang, Min-Wei Wang, Hiroyuki Mizoguchi, Yukihiro Noda, Toshitaka Nabeshim. Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16382024. |
these results indicate that continuous infusion of thiorphan into the hippocampus causes cognitive dysfunction and reduces cholinergic activity by raising the level of abeta in the hippocampus and suggest that a reduction of neprilysin activity contributes to the deposition of abeta and development of alzheimer's disease. |
2006-05-25 |
2023-08-12 |
rat |
| Eva Elgh, Ann Lindqvist Astot, Markku Fagerlund, Sture Eriksson, Tommy Olsson, Birgitta Näsma. Cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in Alzheimer's disease. Biological psychiatry. vol 59. issue 2. 2006-03-09. PMID:16125145. |
cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in alzheimer's disease. |
2006-03-09 |
2023-08-12 |
Not clear |
| Kenichi Tokita, Tatsuo Inoue, Shunji Yamazaki, Feng Wang, Takayuki Yamaji, Nobuya Matsuoka, Seitaro Muto. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16325809. |
here, we wanted to determine whether fk962 retained the ability of the parent compound to both facilitate somatostatinergic nerve activity in hippocampal neurons and to ameliorate cognitive dysfunction in rat models. |
2006-02-08 |
2023-08-12 |
rat |
| Takeshi Enomoto, Takeshi Osugi, Hisashi Satoh, Tracy K McIntosh, Toshitaka Nabeshim. Pre-Injury magnesium treatment prevents traumatic brain injury-induced hippocampal ERK activation, neuronal loss, and cognitive dysfunction in the radial-arm maze test. Journal of neurotrauma. vol 22. issue 7. 2005-09-27. PMID:16004581. |
pre-injury magnesium treatment prevents traumatic brain injury-induced hippocampal erk activation, neuronal loss, and cognitive dysfunction in the radial-arm maze test. |
2005-09-27 |
2023-08-12 |
rat |
| Takeshi Enomoto, Takeshi Osugi, Hisashi Satoh, Tracy K McIntosh, Toshitaka Nabeshim. Pre-Injury magnesium treatment prevents traumatic brain injury-induced hippocampal ERK activation, neuronal loss, and cognitive dysfunction in the radial-arm maze test. Journal of neurotrauma. vol 22. issue 7. 2005-09-27. PMID:16004581. |
the present study demonstrates that pretreatment with mg(2+) prevents post-traumatic hippocampal erk activation and neuronal loss, and cognitive dysfunction in the radial-arm maze test. |
2005-09-27 |
2023-08-12 |
rat |
| Durgul Ozdemir, Kazim Tugyan, Nazan Uysal, Ulker Sonmez, Atac Sonmez, Osman Acikgoz, Nail Ozdemir, Murat Duman, Hasan Ozka. Protective effect of melatonin against head trauma-induced hippocampal damage and spatial memory deficits in immature rats. Neuroscience letters. vol 385. issue 3. 2005-09-06. PMID:15970378. |
it is well known that head trauma induces the cognitive dysfunction resulted from hippocampal damage. |
2005-09-06 |
2023-08-12 |
rat |