| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobuhiko Takai, Xue-Zhi Sun, Koichi Ando, Kenichi Mishima, Sentaro Takahash. Ectopic neurons in the hippocampus may be a cause of learning disability after prenatal exposure to X-rays in rats. Journal of radiation research. vol 45. issue 4. 2005-05-12. PMID:15635267. |
this may suggest that the cognitive dysfunction induced by prenatal exposure to x-ray irradiation may be, at least in part, attributable to ectopic neurons of the hippocampus. |
2005-05-12 |
2023-08-12 |
rat |
| Recep Sutcu, Irfan Altuntas, Erol Eroglu, Namik Deliba. Effects of ischemia-reperfusion on NMDA receptor subunits 2a and 2b level in rat hippocampus. The International journal of neuroscience. vol 115. issue 3. 2005-05-04. PMID:15804717. |
these results suggested that the alteration in hippocampal nmdar2 subunit concentrations after ischemia-reperfusion might be invovlved in cognitive dysfunction and excitotoxicity. |
2005-05-04 |
2023-08-12 |
rat |
| Brian H Harvey, Carla Naciti, Linda Brand, Dan J Stei. Serotonin and stress: protective or malevolent actions in the biobehavioral response to repeated trauma? Annals of the New York Academy of Sciences. vol 1032. 2005-04-19. PMID:15677425. |
structural hippocampus and prefrontal cortex changes occur in patients with posttraumatic stress disorder (ptsd) that appears correlated with cognitive dysfunction. |
2005-04-19 |
2023-08-12 |
rat |
| Ken Sawada, Alasdair M Barr, Masato Nakamura, Kunimasa Arima, Clint E Young, Andrew J Dwork, Peter Falkai, Anthony G Phillips, William G Hone. Hippocampal complexin proteins and cognitive dysfunction in schizophrenia. Archives of general psychiatry. vol 62. issue 3. 2005-03-21. PMID:15753239. |
hippocampal complexin proteins and cognitive dysfunction in schizophrenia. |
2005-03-21 |
2023-08-12 |
Not clear |
| Katherine F Y Chan, Zhengping Jia, Patricia A Murphy, W McIntyre Burnham, Miguel A Cortez, O Carter Snea. Learning and memory impairment in rats with chronic atypical absence seizures. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530872. |
aas involves both the hippocampal and thalamocortical circuitry in slow spike-and-wave discharges (sswd) and is associated with cognitive dysfunction. |
2004-12-29 |
2023-08-12 |
rat |
| Charles L Limoli, Radoslaw Rola, Erich Giedzinski, Sailaja Mantha, Ting-Ting Huang, John R Fik. Cell-density-dependent regulation of neural precursor cell function. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 45. 2004-12-28. PMID:15522966. |
stress-induced reductions of neural precursor cells from the subgranular zone of the hippocampal dentate gyrus have been linked to impaired neurogenesis and cognitive dysfunction. |
2004-12-28 |
2023-08-12 |
mouse |
| Czeslawa Kowal, Lorraine A DeGiorgio, Tsukasa Nakaoka, Hoby Hetherington, Patricio T Huerta, Betty Diamond, Bruce T Volp. Cognition and immunity; antibody impairs memory. Immunity. vol 21. issue 2. 2004-09-21. PMID:15308099. |
they bind preferentially to hippocampal neurons and cause neuronal death with resulting cognitive dysfunction and altered hippocampal metabolism on magnetic resonance spectroscopy. |
2004-09-21 |
2023-08-12 |
mouse |
| Zhiming Wen, Hee-Yong Ki. Alterations in hippocampal phospholipid profile by prenatal exposure to ethanol. Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189339. |
alteration of the phospholipid profile in the hippocampus resulting from exposure to ethanol during prenatal and developmental stages may have significant implications with respect to the cognitive dysfunction observed in fetal alcohol syndrome. |
2004-07-22 |
2023-08-12 |
rat |
| Osamu Yokota, Seishi Terada, Hideki Ishizu, Takeshi Ishihara, Hanae Nakashima, Aki Kugo, Kuniaki Tsuchiya, Kenji Ikeda, Toshiyuki Hayabara, Yuko Saito, Shigeo Murayama, Kenji Uéda, Frédéric Checler, Shigetoshi Kurod. Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. Acta neuropathologica. vol 107. issue 5. 2004-06-28. PMID:14991384. |
these findings suggest that (1) the frontal cortex and hippocampus of mnd are involved in the same pathogenic process associated with cox-2 induction that has been observed in spinal anterior horn cells, (2) cox-2 induction in the cerebrum is a pathogenic process that can occur even in the absence of upi formation in mnd, and (3) cox-2 expression in the cerebrum may be associated with cognitive dysfunction in mnd. |
2004-06-28 |
2023-08-12 |
Not clear |
| Roy G Cutler, Jeremiah Kelly, Kristin Storie, Ward A Pedersen, Anita Tammara, Kimmo Hatanpaa, Juan C Troncoso, Mark P Mattso. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 7. 2004-03-16. PMID:14970312. |
alzheimer's disease (ad) is an age-related disorder characterized by deposition of amyloid beta-peptide (abeta) and degeneration of neurons in brain regions such as the hippocampus, resulting in progressive cognitive dysfunction. |
2004-03-16 |
2023-08-12 |
Not clear |
| Christine T Ekdahl, Jan-Hendrik Claasen, Sara Bonde, Zaal Kokaia, Olle Lindval. Inflammation is detrimental for neurogenesis in adult brain. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14581618. |
our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation. |
2004-01-05 |
2023-08-12 |
rat |
| Anelise Lazaris, Fabrice Bertrand, Christine Lazarus, Rodrigue Galani, Jeanne Stemmelin, Raphaël Poirier, Christian Kelche, Jean-Christophe Casse. Baseline and 8-OH-DPAT-induced release of acetylcholine in the hippocampus of aged rats with different levels of cognitive dysfunction. Brain research. vol 967. issue 1-2. 2003-06-05. PMID:12650979. |
baseline and 8-oh-dpat-induced release of acetylcholine in the hippocampus of aged rats with different levels of cognitive dysfunction. |
2003-06-05 |
2023-08-12 |
rat |
| Jonathan H Williams, Erlick A C Pereira, Marc M Budge, Kevin M Bradle. Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people. Age and ageing. vol 31. issue 6. 2003-05-30. PMID:12446289. |
hippocampal atrophy and higher levels of homocysteine may both predict cognitive dysfunction in community-dwelling older people. |
2003-05-30 |
2023-08-12 |
Not clear |
| Bruce F Pennington, Jennifer Moon, Jamie Edgin, Jennifer Stedron, Lynn Nade. The neuropsychology of Down syndrome: evidence for hippocampal dysfunction. Child development. vol 74. issue 1. 2003-05-28. PMID:12625437. |
in sum, these results indicate a particular weakness in hippocampal functions in ds in the context of overall cognitive dysfunction. |
2003-05-28 |
2023-08-12 |
mouse |
| Huangui Xiong, Jeffery Boyle, Matthew Winkelbauer, Santhi Gorantla, Jialin Zheng, Anuja Ghorpade, Yuri Persidsky, Kimberly A Carlson, Howard E Gendelma. Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia. Journal of neuroscience research. vol 71. issue 4. 2003-04-01. PMID:12548717. |
the induction of il-8 in had, its inhibition of ltp, and the expression of its receptor, cxcr2, in the hippocampus all suggest that it plays a role in the cognitive dysfunction associated with had. |
2003-04-01 |
2023-08-12 |
human |
| Patrick R Hof, Thierry Bussière, Gabriel Gold, Enikö Kövari, Panteleimon Giannakopoulos, Constantin Bouras, Daniel P Perl, John H Morriso. Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 62. issue 1. 2003-02-11. PMID:12528818. |
here, we performed a stereologic assessment of the proportions of intracellular and extracellular (ghost) nfts (infts and enfts, respectively) and unaffected neurons in layer ii of the entorhinal cortex and in the pyramidal cell layer of the ca1 field of the hippocampus in elderly control cases compared to cases with varying degrees of cognitive dysfunction. |
2003-02-11 |
2023-08-12 |
Not clear |
| E Vaucher, P Fluit, M A Chishti, D Westaway, H T J Mount, S Ka. Object recognition memory and cholinergic parameters in mice expressing human presenilin 1 transgenes. Experimental neurology. vol 175. issue 2. 2002-07-15. PMID:12061869. |
as cognitive dysfunction in ad is associated with a dramatic loss of cholinergic innervation particularly in the hippocampus and neocortex, we investigated learning and cholinergic neurochemistry in transgenic mice expressing pathogenic mutant l286v or wild-type(wt) human ps1 transgenes. |
2002-07-15 |
2023-08-12 |
mouse |
| V I Reus, O M Wolkowit. Antiglucocorticoid drugs in the treatment of depression. Expert opinion on investigational drugs. vol 10. issue 10. 2002-02-28. PMID:11772285. |
in patients with endogenous depression, hypercortisolaemia is associated with cognitive dysfunction and possibly a decrease in hippocampal volume. |
2002-02-28 |
2023-08-12 |
Not clear |
| H Wolf, M Grunwald, F Kruggel, S G Riedel-Heller, S Angerhöfer, A Hojjatoleslami, A Hensel, T Arendt, H Gert. Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of aging. vol 22. issue 2. 2001-05-03. PMID:11182467. |
we conclude that hippocampal atrophy is sensitive to detect cognitive dysfunction and subjects at risk for alzheimer's disease in the elderly population. |
2001-05-03 |
2023-08-12 |
human |
| M J Leoni, X H Chen, A L Mueller, J Cheney, T K McIntosh, D H Smit. NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat. Experimental neurology. vol 166. issue 2. 2001-01-04. PMID:11085909. |
nps 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat. |
2001-01-04 |
2023-08-12 |
rat |