| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhou, Tao Liu, Hanjin Cui, Rong Fan, Chunhu Zhang, Weijun Peng, Ali Yang, Lin Zhu, Yang Wang, Tao Tan. Xuefu zhuyu decoction improves cognitive impairment in experimental traumatic brain injury via synaptic regulation. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069769. |
the damage to synaptic plasticity, one of the key mechanisms of cognitive dysfunction, becomes the potential therapeutic strategy of tbi. |
2019-11-20 |
2023-08-13 |
rat |
| Jiahuan Hao, Yuxue Chen, Ensheng Yao, Xinghua Li. Soluble epoxide hydrolase inhibition alleviated cognitive impairments via NRG1/ErbB4 signaling after chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis in mice. Brain research. vol 1699. 2019-09-30. PMID:30343686. |
bcas-induced cerebral hypoperfused mice treated with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (tppu), a potent soluble epoxide hydrolase (seh) inhibitor, exhibited amelioration of cognitive dysfunction and improved synaptic plasticity. |
2019-09-30 |
2023-08-13 |
mouse |
| Jian-Xin Jia, Xu-Sheng Yan, Wei Song, Xin Fang, Zhi-Ping Cai, Dong-Sheng Huo, He Wang, Zhan-Jun Yan. The protective mechanism underlying phenylethanoid glycosides (PHG) actions on synaptic plasticity in rat Alzheimer's disease model induced by beta amyloid 1-42. Journal of toxicology and environmental health. Part A. vol 81. issue 21. 2019-08-26. PMID:30430925. |
phenylethanoid glycosides (phg), derived from herba cistanche, were found to exert protective effects on cognitive dysfunctions by improving synaptic plasticity in alzheimer's disease (ad) rat model. |
2019-08-26 |
2023-08-13 |
rat |
| Fei Wang, Pan Kang, Zhaoyang Li, Qiao Ni. Role of MLL in the modification of H3K4me3 in aluminium-induced cognitive dysfunction. Chemosphere. vol 232. 2019-08-15. PMID:31152896. |
the h3k4-specific methyltransferase mll is essential for hippocampal synaptic plasticity and might be involved in cognitive dysfunction. |
2019-08-15 |
2023-08-13 |
human |
| Zhao-Hui Yao, Xiao-Li Yao, Shao-Feng Zhang, Ji-Chang Hu, Yong Zhan. Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion. Neural plasticity. vol 2019. 2019-05-13. PMID:30923551. |
these events contribute to synaptic plasticity and cognitive dysfunction after cch. |
2019-05-13 |
2023-08-13 |
rat |
| Shitong Xiang, Yu Zhou, Jingxuan Fu, Tao Zhan. rTMS pre-treatment effectively protects against cognitive and synaptic plasticity impairments induced by simulated microgravity in mice. Behavioural brain research. vol 359. 2019-04-23. PMID:30292903. |
previous studies showed that repetitive transcranial magnetic stimulation (rtms), as a novel non-invasive technique, alleviated cognitive dysfunctions and facilitated synaptic plasticity. |
2019-04-23 |
2023-08-13 |
mouse |
| Ana Saavedra, Gerardo García-Díaz Barriga, Esther Pérez-Navarro, Jordi Alberc. Huntington's disease: novel therapeutic perspectives hanging in the balance. Expert opinion on therapeutic targets. vol 22. issue 5. 2019-01-03. PMID:29671352. |
cognitive dysfunction and neuropsychiatric symptoms are also present and they occur in the absence of cell death in most mouse models, pointing to neuronal dysfunction and abnormal synaptic plasticity as causative mechanisms. |
2019-01-03 |
2023-08-13 |
mouse |
| Yi-Jen Wu, Chou-Ching Lin, Che-Ming Yeh, Miao-Er Chien, Ming-Chung Tsao, Philip Tseng, Chin-Wei Huang, Kuei-Sen Hs. Repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats. Brain stimulation. vol 10. issue 6. 2018-10-10. PMID:28870510. |
repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats. |
2018-10-10 |
2023-08-13 |
rat |
| Fei Mao, Huan Wang, Wei Ni, Xinyu Zheng, Manjiong Wang, Keting Bao, Dazheng Ling, Xiaokang Li, Yixiang Xu, Haiyan Zhang, Jian L. Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. vol 9. issue 2. 2018-08-17. PMID:29068218. |
importantly, 1w·cit (citrate of 1w) could reverse the cognitive dysfunction of scopolamine-induced ad mice and exhibited an excellent effect on enhancing camp response element-binding protein (creb) phosphorylation in vivo, a crucial factor in memory formation and synaptic plasticity. |
2018-08-17 |
2023-08-13 |
mouse |
| Xin Wu, Jian-Feng Ga. [Involvement of aquaporin-4 in synaptic plasticity, learning and memory]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 3. 2017-10-03. PMID:28638927. |
this article is to review some research progresses of the function of aqp-4 in synaptic plasticity, learning and memory, and propose the possible role of aqp-4 as a new target in the treatment of cognitive dysfunction. |
2017-10-03 |
2023-08-13 |
Not clear |
| Xia Tian, Yanlin Liu, Guangwei Ren, Ling Yin, Xiaoyan Liang, Tao Geng, Heqin Dang, Rufeng A. Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity. Brain research. vol 1650. 2017-08-21. PMID:27566063. |
therefore, we tested its influence against cognitive dysfunction as well as on hippocampal structural synaptic plasticity in streptozotocin-induced diabetic rats. |
2017-08-21 |
2023-08-13 |
rat |
| Miklós Sárvári, Imre Kalló, Erik Hrabovszky, Norbert Solymosi, Zsolt Liposit. Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats. Endocrinology. vol 158. issue 1. 2017-06-23. PMID:27805868. |
the findings indicate that surgical gonadectomy carried out at middle-age robustly changes the hippocampal transcriptome that alters neurogenesis, synaptic plasticity, immune modulation, causing cognitive dysfunctions. |
2017-06-23 |
2023-08-13 |
rat |
| Mehdi Khodamoradi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Khadije Esmaeilpour, Vahid Sheiban. Effects of genistein on cognitive dysfunction and hippocampal synaptic plasticity impairment in an ovariectomized rat kainic acid model of seizure. European journal of pharmacology. vol 786. 2017-03-10. PMID:27235295. |
effects of genistein on cognitive dysfunction and hippocampal synaptic plasticity impairment in an ovariectomized rat kainic acid model of seizure. |
2017-03-10 |
2023-08-13 |
rat |
| Sung-Soo Jang, Sara E Royston, Gunhee Lee, Shuwei Wang, Hee Jung Chun. Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity. Neural plasticity. vol 2016. 2016-12-30. PMID:27127657. |
pathologic accumulation of soluble amyloid-β (aβ) oligomers impairs synaptic plasticity and causes epileptic seizures, both of which contribute to cognitive dysfunction in ad. |
2016-12-30 |
2023-08-13 |
rat |
| Somayeh Zargooshnia, Siamak Shahidi, Fatemeh Ghahremanitamadon, Ali Nikkhah, Mehdi Mehdizadeh, Sara Soleimani As. The protective effect of Borago Officinalis extract on amyloid β (25-35)-induced long term potentiation disruption in the dentate gyrus of male rats. Metabolic brain disease. vol 30. issue 1. 2016-03-17. PMID:25060965. |
this data suggest that aβ (25-35) can effectively inhibit ltp in the granular cells of the dg in hippocampus, and borage supplementation reverse the synaptic plasticity in dg following aβ treatment and that borage consumption may lead to an improvement of ad-induced cognitive dysfunction. |
2016-03-17 |
2023-08-13 |
rat |
| Albert Giralt, Ana Saavedra, Jordi Alberch, Esther Pérez-Navarr. Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms. Journal of Huntington's disease. vol 1. issue 2. 2016-02-23. PMID:25063329. |
alterations in hippocampal synaptic plasticity and function found in hd mouse models highlight that changes in the functioning of the hippocampal formation contribute to cognitive dysfunction in humans. |
2016-02-23 |
2023-08-13 |
mouse |
| Natália D Linhares, Marta Svartman, Tatiane C Rodrigues, Carla Rosenberg, Eugênia R Valadare. Subtelomeric 6p25 deletion/duplication: Report of a patient with new clinical findings and genotype-phenotype correlations. European journal of medical genetics. vol 58. issue 5. 2016-02-16. PMID:25817395. |
in addition, as our patient had a duplication including nrn1, a gene related with neurodevelopment, synaptic plasticity and cognitive dysfunction in schizophrenia, we suggest that this gene could be associated with her white matter abnormalities and neurocognitive phenotype. |
2016-02-16 |
2023-08-13 |
Not clear |
| Bianca De Filippis, Daniela Valenti, Valentina Chiodi, Antonella Ferrante, Lidia de Bari, Carla Fiorentini, Maria Rosaria Domenici, Laura Ricceri, Rosa Anna Vacca, Alessia Fabbri, Giovanni Laviol. Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 6. 2016-02-16. PMID:25890884. |
modulation of rho gtpases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling rett syndrome. |
2016-02-16 |
2023-08-13 |
mouse |
| Chen Zhang, Yiru Fang, Lin X. Glutamate receptor 1 phosphorylation at serine 845 contributes to the therapeutic effect of olanzapine on schizophrenia-like cognitive impairments. Schizophrenia research. vol 159. issue 2-3. 2015-08-19. PMID:25219486. |
these data suggest that the therapeutic effect of olz on cognitive dysfunctions may be due to its contribution to synaptic plasticity via the ability to upregulate the state of glur1 ser845 phosphorylation. |
2015-08-19 |
2023-08-13 |
rat |
| Sanjeev K Bhardwaj, Yiu Chung Tse, Richard Ryan, Tak Pan Wong, Lalit K Srivastav. Impaired adrenergic-mediated plasticity of prefrontal cortical glutamate synapses in rats with developmental disruption of the ventral hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:24917197. |
the data suggest that impaired α-1 adrenergic regulation of cortical glutamatergic synaptic plasticity may be an important mechanism in cognitive dysfunctions reported in neurodevelopmental psychiatric disorders. |
2015-07-07 |
2023-08-13 |
rat |