| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuo Zhang, Hongli Zhou, Jiyin Zho. Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction. Journal of molecular endocrinology. vol 66. issue 4. 2021-06-16. PMID:33729996. |
neuritin overexpression in the hippocampus of db/db mice significantly ameliorated cognitive dysfunction, hippocampal neuronal impairment, and synaptic plasticity deterioration, and inhibited astrogliosis and the jak2/stat3 signaling pathway in the hippocampus. |
2021-06-16 |
2023-08-13 |
mouse |
| Xinxin Xu, Xi Xiao, Yuxing Yan, Tao Zhan. Activation of liver X receptors prevents emotional and cognitive dysfunction by suppressing microglial M1-polarization and restoring synaptic plasticity in the hippocampus of mice. Brain, behavior, and immunity. vol 94. 2021-05-27. PMID:33662504. |
activation of liver x receptors prevents emotional and cognitive dysfunction by suppressing microglial m1-polarization and restoring synaptic plasticity in the hippocampus of mice. |
2021-05-27 |
2023-08-13 |
mouse |
| Bingrui Xiong, Wen Zhang, Longqing Zhang, Xian Huang, Wenchang Zhou, Qian Zou, Anne Manyande, Jie Wang, Yuke Tian, Xuebi Tia. Hippocampal glutamatergic synapses impairment mediated novel-object recognition dysfunction in rats with neuropathic pain. Pain. vol 161. issue 8. 2021-04-21. PMID:32701842. |
ultra-high-performance liquid chromatography revealed lower levels of d-serine in the hippocampus of the spared nerve injury rats and that d-serine treatment could restore synaptic plasticity and cognitive dysfunction. |
2021-04-21 |
2023-08-13 |
rat |
| Thomas M Barber, Ioannis Kyrou, Harpal S Randeva, Martin O Weicker. Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction. International journal of molecular sciences. vol 22. issue 2. 2021-03-30. PMID:33430419. |
furthermore, the emergent data over recent decades support an important role of obesity- and t2d-related central ir in the development of cognitive dysfunction, including effects on hippocampal synaptic plasticity. |
2021-03-30 |
2023-08-13 |
Not clear |
| Zeba Mueed, Devanshu Mehta, Pankaj K Rai, Mohammad A Kamal, Nitesh K Podda. Cross-Interplay between Osmolytes and mTOR in Alzheimer's Disease Pathogenesis. Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32418522. |
however, tmao affects the aging process adversely by deregulating the mtor signalling pathway and then kindling cognitive dysfunction via degradation of chemical synapses and synaptic plasticity. |
2021-03-19 |
2023-08-13 |
Not clear |
| Koji Hoshino, Yuka Uchinami, Yosuke Uchida, Hitoshi Saito, Yuji Morimot. Interleukin-1β Modulates Synaptic Transmission and Synaptic Plasticity During the Acute Phase of Sepsis in the Senescence-Accelerated Mouse Hippocampus. Frontiers in aging neuroscience. vol 13. 2021-03-03. PMID:33643027. |
this study aimed to investigate the manner in which aging and pre-existing cognitive dysfunction modified neuroinflammation, synaptic plasticity, and basal synaptic transmission during the acute phase of sepsis using senescence-accelerated mice prone 8 (samp8) and senescence-accelerated resistant mice 1 (samr1). |
2021-03-03 |
2023-08-13 |
mouse |
| Zhao-Hui Yao, Jing Wang, Bing-Zhen Shen, Yu-Tong Li, Xiao-Li Yao, Shao-Feng Zhang, Yong Zhang, Ji-Chang Hu, Yan-Chun Xi. Identification of a hippocampal lncRNA-regulating network in cognitive dysfunction caused by chronic cerebral hypoperfusion. Aging. vol 12. issue 19. 2020-12-19. PMID:33040050. |
long non-coding rna is involved in synaptic plasticity and cognitive function, but whether lncrna is involved in cognitive dysfunction caused by cch has not yet been reported. |
2020-12-19 |
2023-08-13 |
Not clear |
| Xiaole Tang, Yilin Zhao, Zhiqiang Zhou, Jing Yan, Biyun Zhou, Xiaohui Chi, Ailin Luo, Shiyong L. Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice. Oxidative medicine and cellular longevity. vol 2020. 2020-10-19. PMID:32148659. |
sirtuin 1 (sirt1) plays an important role in synaptic plasticity and cognitive performance, and its abnormal reduction is associated with cognitive dysfunction in neurodegenerative diseases. |
2020-10-19 |
2023-08-13 |
mouse |
| Mario Stampanoni Bassi, Sara Garofalo, Girolama A Marfia, Luana Gilio, Ilaria Simonelli, Annamaria Finardi, Roberto Furlan, Giulia M Sancesario, Jonny Di Giandomenico, Marianna Storto, Francesco Mori, Diego Centonze, Ennio Iezz. Amyloid-β Homeostasis Bridges Inflammation, Synaptic Plasticity Deficits and Cognitive Dysfunction in Multiple Sclerosis. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:29209169. |
amyloid-β homeostasis bridges inflammation, synaptic plasticity deficits and cognitive dysfunction in multiple sclerosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Edwin E Reza-Zaldivar, Mercedes A Hernández-Sapiéns, Benito Minjarez, Yanet K Gutiérrez-Mercado, Ana L Márquez-Aguirre, Alejandro A Canales-Aguirr. Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer's Disease. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30319358. |
ad is characterized by progressive cognitive dysfunction, memory loss and behavioral disturbances of synaptic plasticity and energy metabolism. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xu-Sheng Yan, Zhan-Jun Yang, Jian-Xin Jia, Wei Song, Xin Fang, Zhi-Ping Cai, Dong-Sheng Huo, He Wan. Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease. Neural regeneration research. vol 14. issue 4. 2020-10-01. PMID:30632505. |
cognitive dysfunction in alzheimer's disease is strongly associated with a reduction in synaptic plasticity, which may be induced by oxidative stress. |
2020-10-01 |
2023-08-13 |
rat |
| Xu-Sheng Yan, Zhan-Jun Yang, Jian-Xin Jia, Wei Song, Xin Fang, Zhi-Ping Cai, Dong-Sheng Huo, He Wan. Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease. Neural regeneration research. vol 14. issue 4. 2020-10-01. PMID:30632505. |
our data showed that the protective effect of testosterone on cognitive dysfunction in alzheimer's disease is mediated via androgen receptors to scavenge free radicals, thereby enhancing synaptic plasticity. |
2020-10-01 |
2023-08-13 |
rat |
| Alessandra Musella, Antonietta Gentile, Francesca Romana Rizzo, Francesca De Vito, Diego Fresegna, Silvia Bullitta, Valentina Vanni, Livia Guadalupi, Mario Stampanoni Bassi, Fabio Buttari, Diego Centonze, Georgia Mandoles. Interplay Between Age and Neuroinflammation in Multiple Sclerosis: Effects on Motor and Cognitive Functions. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30135651. |
the persistence of the inflammatory status in the brain in turn may cause synaptopathy and synaptic plasticity impairments that underlie both motor and cognitive dysfunctions. |
2020-09-30 |
2023-08-13 |
Not clear |
| Man-Man Zong, Zhi-Qiang Zhou, Mu-Huo Ji, Min Jia, Hui Tang, Jian-Jun Yan. Activation of β2-Adrenoceptor Attenuates Sepsis-Induced Hippocampus-Dependent Cognitive Impairments by Reversing Neuroinflammation and Synaptic Abnormalities. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31354429. |
sepsis-associated encephalopathy induces cognitive dysfunction via mechanisms that commonly involve neuroinflammation and synaptic plasticity impairment of the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Wenxiang Qing, Fan Li, Xueqin Wang, Chengxuan Quan, Wen Ouyang, Qin Lia. Inhibiting RIP1 Improves Chronic Stress-Induced Cognitive Impairments in D-Galactose-Induced Aging Mice. Frontiers in behavioral neuroscience. vol 12. 2020-09-29. PMID:30356849. |
mounting evidence shows that chronic stress can affect both the structure and function of the brain resulting in decreased synaptic plasticity and cognitive dysfunction. |
2020-09-29 |
2023-08-13 |
mouse |
| Lu Yu, Yanhong Duan, Zheng Zhao, Wendi He, Ming Xia, Qiujuan Zhang, Xiaohua Ca. Hydroxysafflor Yellow A (HSYA) Improves Learning and Memory in Cerebral Ischemia Reperfusion-Injured Rats via Recovering Synaptic Plasticity in the Hippocampus. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30405354. |
taken together, these results for the first time demonstrate that hsya has the capacity to protect cognitive function and synaptic plasticity against cerebral ischemia-reperfusion injury, and provide a new insight that hsya may be a promising alternative for recovery of cognitive dysfunction after brain ischemic injury. |
2020-09-29 |
2023-08-13 |
rat |
| Ziyi Wang, Yuying Lin, Weitang Liu, Ping Kuang, Wenwen Lao, Yonghua Ji, Hongyan Zh. Voltage-Gated Sodium Channels Are Involved in Cognitive Impairments in Parkinson's Disease- like Rats. Neuroscience. vol 418. 2020-09-24. PMID:31473280. |
the abnormal synaptic plasticity in the hippocampus is suggested to be associated with cognitive dysfunction in pd. |
2020-09-24 |
2023-08-13 |
rat |
| Zhi-Hao Wang, Jie Xiang, Xia Liu, Shan Ping Yu, Fredric P Manfredsson, Ivette M Sandoval, Shengxi Wu, Jian-Zhi Wang, Keqiang Y. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell reports. vol 28. issue 3. 2020-08-27. PMID:31315045. |
inhibition of this pathological cascade can also rescue impaired synaptic plasticity and cognitive dysfunctions. |
2020-08-27 |
2023-08-13 |
human |
| Al Anoud D Baddour, Lauren A Apodaca, Leila Alikhani, Celine Lu, Harutyun Minasyan, Raja S Batra, Munjal M Acharya, Janet E Baulc. Sex-Specific Effects of a Wartime-Like Radiation Exposure on Cognitive Function. Radiation research. vol 193. issue 1. 2020-04-27. PMID:31671010. |
molecular analyses showed alterations in post-synaptic protein levels that might affect synaptic plasticity and increased levels of global dna methylation, suggesting a potential epigenetic mechanism that might contribute to radiation-induced cognitive dysfunction. |
2020-04-27 |
2023-08-13 |
mouse |
| Corinne G Jolivalt, Alexandra Marquez, David Quach, Michelle C Navarro Diaz, Carlos Anaya, Betelhem Kifle, Nabeel Muttalib, Gabriela Sanchez, Lucy Guernsey, Mike Hefferan, Darrel R Smith, Paul Fernyhough, Karl Johe, Nigel A Calcut. Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189. Diabetes. vol 68. issue 11. 2020-03-17. PMID:31492662. |
nsi-189 is a new chemical entity that when orally administered promotes neurogenesis in the adult hippocampus, increases hippocampal volume, enhances synaptic plasticity, and reduces cognitive dysfunction. |
2020-03-17 |
2023-08-13 |
mouse |