| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Smolen, Douglas A Baxter, John H Byrn. Simulations suggest pharmacological methods for rescuing long-term potentiation. Journal of theoretical biology. vol 360. 2015-05-20. PMID:25034337. |
congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie the induction or maintenance of synaptic plasticity. |
2015-05-20 |
2023-08-13 |
Not clear |
| Shelly A Buffington, Wei Huang, Mauro Costa-Mattiol. Translational control in synaptic plasticity and cognitive dysfunction. Annual review of neuroscience. vol 37. 2015-03-30. PMID:25032491. |
translational control in synaptic plasticity and cognitive dysfunction. |
2015-03-30 |
2023-08-13 |
human |
| Yuki Kuwabara, Masato Ishizeki, Naoto Watamura, Junya Toba, Aya Yoshii, Takafumi Inoue, Toshio Ohshim. Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice. Journal of neurochemistry. vol 130. issue 3. 2014-09-16. PMID:24684630. |
amyloid beta (aβ) peptides in extracellular aβ plaques, produced from the amyloid precursor protein (app) via sequential processing by β- and γ-secretases, impair hippocampal synaptic plasticity, and cause cognitive dysfunction in ad patients. |
2014-09-16 |
2023-08-12 |
mouse |
| Aline Winkelmann, Nicola Maggio, Joanna Eller, Gürsel Caliskan, Marcus Semtner, Ute Häussler, René Jüttner, Tamar Dugladze, Birthe Smolinsky, Sarah Kowalczyk, Ewa Chronowska, Günter Schwarz, Fritz G Rathjen, Gideon Rechavi, Carola A Haas, Akos Kulik, Tengis Gloveli, Uwe Heinemann, Jochen C Meie. Changes in neural network homeostasis trigger neuropsychiatric symptoms. The Journal of clinical investigation. vol 124. issue 2. 2014-04-07. PMID:24430185. |
the increased network excitability associated with gain-of-function glyr expression in glutamatergic neurons resulted in recurrent epileptiform discharge, which provoked cognitive dysfunction and memory deficits without affecting bidirectional synaptic plasticity. |
2014-04-07 |
2023-08-12 |
mouse |
| Jaclyn M Schwarz, Staci D Bilb. Sex, glia, and development: interactions in health and disease. Hormones and behavior. vol 62. issue 3. 2013-03-14. PMID:22387107. |
microglia influence processes including neural development, synaptic plasticity and cognition; while their activation and production of immune molecules can induce stereotyped sickness behaviors or pathologies including cognitive dysfunction. |
2013-03-14 |
2023-08-12 |
Not clear |
| Szabina Szücs, Magdolna Pákáski, Agnes Domokos, János Kálmán, Sára Kálmán, Dénes Garab, Botond Penke, Gyula Szabó, Zoltán Janka, János Kálmá. [The effects of duloxetine on beta-actin stress response in rat brain]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 12. issue 1. 2010-08-20. PMID:20305306. |
our findings indicate that antidepressant treatment with duloxetine could play a protective role against the chronic stress-induced changes in the nervous system, such as disorders of synaptic plasticity, and the consequent cognitive dysfunctions in case of both affective disorders and ad. |
2010-08-20 |
2023-08-12 |
rat |
| Poonam Mathur, Carolyn Graybeal, Michael Feyder, Margaret I Davis, Andrew Holme. Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing. Pharmacology, biochemistry, and behavior. vol 91. issue 3. 2009-04-02. PMID:18809426. |
n-methyl-d-aspartate receptors (nmdars) are mediators of synaptic plasticity and learning and are implicated in the pathophysiology of neuropsychiatric disease and age-related cognitive dysfunction. |
2009-04-02 |
2023-08-12 |
mouse |
| Julie Vallortigara, Serge Alfos, Jacques Micheau, Paul Higueret, Valérie Enderli. T3 administration in adult hypothyroid mice modulates expression of proteins involved in striatal synaptic plasticity and improves motor behavior. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18585460. |
adult-onset hypothyroidism is associated with neurological changes such as cognitive dysfunction and impaired learning, which may be related to alterations of synaptic plasticity. |
2008-12-15 |
2023-08-12 |
mouse |
| Xiangyou Hu, Qi Shi, Xiangdong Zhou, Wanxia He, Hong Yi, Xinghua Yin, Marla Gearing, Allan Levey, Riqiang Ya. Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities. The EMBO journal. vol 26. issue 11. 2008-03-06. PMID:17476306. |
importantly, we show that the presence of dystrophic neurites in tg-rtn3 mice causes impairments in spatial learning and memory, as well as synaptic plasticity, implying that ridns potentially contribute to ad cognitive dysfunction. |
2008-03-06 |
2023-08-12 |
mouse |
| Yossi Dagon, Yosefa Avraham, Gabriela Link, Olga Zolotarev, Raphael Mechoulam, Elliot M Berr. The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells. Neurobiology of disease. vol 27. issue 2. 2007-11-07. PMID:17604177. |
diabetic neuropathy (dn) is a common complication of diabetes mellitus resulting in cognitive dysfunction and synaptic plasticity impairment. |
2007-11-07 |
2023-08-12 |
mouse |
| Paolo Calabresi, Barbara Picconi, Lucilla Parnetti, Massimiliano Di Filipp. A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance. The Lancet. Neurology. vol 5. issue 11. 2006-11-28. PMID:17052664. |
we also discuss a convergent versus parallel model to explain cognitive dysfunctions in parkinson's disease according to dopamine-acetylcholine dependent alterations in synaptic plasticity. |
2006-11-28 |
2023-08-12 |
Not clear |
| Alasdair M Barr, Candace E Hofmann, Anthony G Phillips, Joanne Weinberg, William G Hone. Prenatal ethanol exposure in rats decreases levels of complexin proteins in the frontal cortex. Alcoholism, clinical and experimental research. vol 29. issue 11. 2006-10-18. PMID:16340446. |
to determine a potential molecular substrate for cognitive dysfunction in adulthood, we measured regional levels of the presynaptic proteins complexin i and ii in a rat model of prenatal ethanol exposure, as levels of these proteins are altered in cognitive-related synaptic plasticity. |
2006-10-18 |
2023-08-12 |
rat |
| Kenneth T Kishida, Charles A Hoeffer, Daoying Hu, Maryland Pao, Steven M Holland, Eric Klan. Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease. Molecular and cellular biology. vol 26. issue 15. 2006-09-19. PMID:16847341. |
taken together, our results are consistent with nadph oxidase being required for hippocampal synaptic plasticity and memory and are consistent with reports of cognitive dysfunction in patients with cgd. |
2006-09-19 |
2023-08-12 |
mouse |
| Dean-Chuan Wang, Shun-Sheng Chen, Yi-Ching Lee, Tsan-Ju Che. Amyloid-beta at sublethal level impairs BDNF-induced arc expression in cortical neurons. Neuroscience letters. vol 398. issue 1-2. 2006-05-10. PMID:16412575. |
alzheimer's disease (ad) is characterized by progressive memory loss and cognitive dysfunction that probably due to a deficit in synaptic plasticity. |
2006-05-10 |
2023-08-12 |
rat |
| Thomas J Van de Ven, Hendrika M A VanDongen, Antonius M J VanDonge. The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221859. |
abnormalities in dendritic spines have long been associated with cognitive dysfunction and neurodevelopmental delay, whereas rapid changes in spine shape underlie synaptic plasticity. |
2006-03-13 |
2023-08-12 |
Not clear |
| André Fischer, Farahnaz Sananbenesi, Joachim Spiess, Jelena Radulovi. Cdk5 in the adult non-demented brain. Current drug targets. CNS and neurological disorders. vol 2. issue 6. 2004-01-30. PMID:14683465. |
on the basis of the newly identified role of cdk5 in synaptic plasticity, learning and memory the view that cdk5 represents a good drug target in ad accompanied by cognitive dysfunctions may have to be revisited. |
2004-01-30 |
2023-08-12 |
Not clear |
| Paul E Schulz, Adeka D McIntosh, Michael R Kasten, Berend Wieringa, Henry F Epstei. A role for myotonic dystrophy protein kinase in synaptic plasticity. Journal of neurophysiology. vol 89. issue 3. 2003-05-09. PMID:12612014. |
these results suggest a role for dmpk in synaptic plasticity that could be relevant to the cognitive dysfunction associated with dm. |
2003-05-09 |
2023-08-12 |
mouse |
| M E Gilbert, C M Mack, S M Lasle. Chronic developmental lead exposure and hippocampal long-term potentiation: biphasic dose-response relationship. Neurotoxicology. vol 20. issue 1. 1999-05-19. PMID:10091860. |
we have used long-term potentiation (ltp) in the dentate gyrus of the pb-exposed rats to determine the potential of a reduced capacity for synaptic plasticity to contribute to pb-induced cognitive dysfunction. |
1999-05-19 |
2023-08-12 |
rat |
| M R Quinn, C L Harri. Lead inhibits Ca(2+)-stimulated nitric oxide synthase activity from rat cerebellum. Neuroscience letters. vol 196. issue 1-2. 1996-01-18. PMID:7501259. |
pb2+ is reported to cause cognitive dysfunctions in children and to inhibit long-term potentiation (ltp), a model form of synaptic plasticity that involves nitric oxide (no). |
1996-01-18 |
2023-08-12 |
rat |