| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xulan Zhang, Lu Ni, Shanshan Hu, Bowen Yue, Xiaochun Chen, Ding Yuan, Ting Wang, Zhiyong Zho. Polygonatum sibiricum ameliorated cognitive impairment of naturally aging rats through BDNF-TrkB signaling pathway. Journal of food biochemistry. 2022-11-14. PMID:36373352. |
in conclusion, ps improves cognitive dysfunction and enhances synaptic plasticity in naturally aged rats by regulating the bdnf-trkb signaling pathway. |
2022-11-14 |
2023-08-14 |
rat |
| Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stéphanie Clerget-Froidevaux, Valérie Enderli. A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233235. |
adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in synaptic plasticity. |
2022-10-14 |
2023-08-14 |
mouse |
| Xiaona Liu, Jing Wan. NMDA receptors mediate synaptic plasticity impairment of hippocampal neurons due to arsenic exposure. Neuroscience. 2022-07-29. PMID:35905926. |
as the cellular basis of cognition, synaptic plasticity is pivotal in arsenic-induced cognitive dysfunction. |
2022-07-29 |
2023-08-14 |
Not clear |
| Gaoshang Chai, Jiajun Wu, Rongfei Fang, Yanlin Liu, Xuechun Wang, Xi Wang, Jinming Zhang, Jiali Zhou, Zhiqian Jiang, Haiyan Yi, Yunjuan Nie, Peng Zhao, Dengxin Zhan. Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice. Behavioural brain research. 2022-06-06. PMID:35659510. |
we recently found that the anaesthetization of aging c57bl/6j mice (14-16 months) with sevoflurane (3%, two hours each day for three consecutive days) can induce cognitive dysfunction and synaptic plasticity deficits. |
2022-06-06 |
2023-08-14 |
mouse |
| Eva Cristina de Oliveira Figueiredo, Bianca Maria Bondiolotti, Anthony Laugeray, Paola Bezz. Synaptic Plasticity Dysfunctions in the Pathophysiology of 22q11 Deletion Syndrome: Is There a Role for Astrocytes? International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457231. |
often, synaptic changes are related to structural and functional changes observed in patients with cognitive dysfunctions, therefore suggesting that synaptic plasticity has a crucial role in the pathophysiology of the syndrome. |
2022-04-23 |
2023-08-13 |
mouse |
| Ziyi Xue, Min Shui, Xiaowan Lin, Yi Sun, Jianhui Liu, Changwei Wei, Anshi Wu, Tianzuo L. Role of BDNF/ProBDNF Imbalance in Postoperative Cognitive Dysfunction by Modulating Synaptic Plasticity in Aged Mice. Frontiers in aging neuroscience. vol 14. 2022-04-04. PMID:35370607. |
role of bdnf/probdnf imbalance in postoperative cognitive dysfunction by modulating synaptic plasticity in aged mice. |
2022-04-04 |
2023-08-13 |
mouse |
| Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing W. Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol. Molecular neurobiology. 2022-01-16. PMID:35034265. |
hippocampal sirt1-mediated synaptic plasticity and glutamatergic neuronal excitability are involved in prolonged cognitive dysfunction of neonatal rats exposed to propofol. |
2022-01-16 |
2023-08-13 |
rat |
| Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing W. Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol. Molecular neurobiology. 2022-01-16. PMID:35034265. |
overexpression of sirt1 attenuated propofol-induced cognitive dysfunction, excitation-inhibition imbalance, and synaptic plasticity damage. |
2022-01-16 |
2023-08-13 |
rat |
| Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing W. Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol. Molecular neurobiology. 2022-01-16. PMID:35034265. |
our findings demonstrate that sirt1 plays an important role in cognitive dysfunction induced by repeated neonatal propofol exposure by suppressing synaptic plasticity and neuronal excitability. |
2022-01-16 |
2023-08-13 |
rat |
| Vishaal Rajani, Aida Maziar, Kwun Nok Mimi Man, Johannes W Hell, Qi Yua. Age-Dependent Contributions of NMDA Receptors and L-Type Calcium Channels to Long-Term Depression in the Piriform Cortex. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948347. |
in the hippocampus, the contributions of n-methyl-d-aspartate receptors (nmdars) and l-type calcium channels (ltccs) to neuronal transmission and synaptic plasticity change with aging, underlying calcium dysregulation and cognitive dysfunction. |
2021-12-24 |
2023-08-13 |
rat |
| Nicole P Kasica, Xueyan Zhou, Qian Yang, Xin Wang, Wenzhong Yang, Helena R Zimmermann, Caroline E Holland, Elizabeth Koscielniak, Hanzhi Wu, Anderson O Cox, Jingyun Lee, Alexey G Ryazanov, Cristina M Furdui, Tao M. Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice. Journal of neurochemistry. 2021-12-21. PMID:34932218. |
our data revealed that treatment with eef2k inhibitors improved ad-associated synaptic plasticity impairments and cognitive dysfunction, without altering brain amyloid β (aβ) and tau pathology. |
2021-12-21 |
2023-08-13 |
mouse |
| Judit Català-Solsona, Alfredo J Miñano-Molina, José Rodríguez-Álvare. Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review. Frontiers in molecular neuroscience. vol 14. 2021-12-11. PMID:34880728. |
nr4a2 transcription factor in hippocampal synaptic plasticity, memory and cognitive dysfunction: a perspective review. |
2021-12-11 |
2023-08-13 |
Not clear |
| Judit Català-Solsona, Alfredo J Miñano-Molina, José Rodríguez-Álvare. Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review. Frontiers in molecular neuroscience. vol 14. 2021-12-11. PMID:34880728. |
in this review, we highlight the specific effects of nr4a2 in hippocampal synaptic plasticity and memory formation and we discuss whether the dysregulation of this transcription factor could contribute to hippocampal synaptic dysfunction, altogether suggesting the possibility that nr4a2 may emerge as a novel synaptic therapeutic target in brain pathologies associated to cognitive dysfunctions. |
2021-12-11 |
2023-08-13 |
Not clear |
| Xin Zhang, Xiaohua Shi, Jiaoqi Wang, Zhongxin Xu, Jinting H. Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca Aging. vol 13. issue 16. 2021-11-29. PMID:34462377. |
enriched environment remedies cognitive dysfunctions and synaptic plasticity through nmdar-ca chronic cerebral ischemia (cci) is one of the critical factors in the occurrence and development of vascular cognitive impairment (vci). |
2021-11-29 |
2023-08-13 |
Not clear |
| Wing-Yu Fu, Kwok-Wang Hung, Shun-Fat Lau, Busma Butt, Vincent Wai-Hin Yuen, Guangmiao Fu, Ivy C Chan, Fanny C F Ip, Amy K Y Fu, Nancy Y I. Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model. ACS chemical neuroscience. vol 12. issue 22. 2021-11-23. PMID:34738783. |
we previously reported that rhynchophylline (rhy), a small molecule epha4 inhibitor, rescues impaired hippocampal synaptic plasticity and cognitive dysfunctions in app/ps1 mice, an ad transgenic mouse model. |
2021-11-23 |
2023-08-13 |
mouse |
| Zhao-Hui Yao, Jing Wang, Jing-Ping Yuan, Kai Xiao, Shao-Feng Zhang, Yan-Chun Xie, Jun-Hua Me. EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment. Aging. vol 13. issue 7. 2021-08-16. PMID:33539323. |
egb761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Che. Intermittent Hypoxia Activates N-Methyl-D-Aspartate Receptors to Induce Anxiety Behaviors in a Mouse Model of Sleep-Associated Apnea. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33660202. |
to evaluate how ih alters neuronal function to yield anxiety-like behavior and cognitive dysfunction, we examined synaptic plasticity and neuronal inflammation in related brain areas, including the medial prefrontal cortex (mpfc), striatum, and hippocampus. |
2021-07-06 |
2023-08-13 |
mouse |
| Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubaméa, Stéphanie Chasseigneaux, Véronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnès Dodacki, Salvatore Cisternino, Xavier Declèves, Fanchon Bourasse. Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration. Neuropharmacology. vol 191. 2021-06-23. PMID:33940010. |
the inducible p25 overexpression mouse model recapitulate many hallmark features of alzheimer's disase including progressive neuronal loss, elevated aβ, tau pathology, cognitive dysfunction, and impaired synaptic plasticity. |
2021-06-23 |
2023-08-13 |
mouse |
| Zeinab Momeni, Maricris Bautista, Joseph Neapetung, Rylan Urban, Yasuhiko Yamamoto, Anand Krishnan, Verónica A Campanucc. RAGE signaling is required for AMPA receptor dysfunction in the hippocampus of hyperglycemic mice. Physiology & behavior. vol 229. 2021-06-21. PMID:33221393. |
in rodent animal models, cognitive dysfunction can manifest as impaired hippocampal synaptic plasticity. |
2021-06-21 |
2023-08-13 |
mouse |
| Anna Rita Zuena, Paola Casolini, Aldina Venerosi, Giovanni Sebastiano Alemà, Ferdinando Nicoletti, Gemma Calamandre. Selective reduction in the expression of type-1 metabotropic glutamate receptors in the hippocampus of adult rats born by caesarean section. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 4. 2021-06-17. PMID:33759234. |
perinatal hypoxia causes long-term neurobiological consequences, including alterations in mechanisms of activity-dependent synaptic plasticity and cognitive dysfunction. |
2021-06-17 |
2023-08-13 |
rat |