| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Biederman, Raun D Melmed, Anil Patel, Keith McBurnett, Jessica Donahue, Andrew Lyn. Long-term, open-label extension study of guanfacine extended release in children and adolescents with ADHD. CNS spectrums. vol 13. issue 12. 2009-03-19. PMID:19179940. |
guanfacine is a noradrenergic agonist that is believed to improve symptoms of attention-deficit/hyperactivity disorder (adhd) through selective actions at alpha2a-adrenoceptors in the prefrontal cortex. |
2009-03-19 |
2023-08-12 |
Not clear |
| Michael C Monuteaux, Larry J Seidman, Stephen V Faraone, Nikos Makris, Thomas Spencer, Eve Valera, Ariel Brown, George Bush, Alysa E Doyle, Samantha Hughes, Meghan Helliesen, Eric Mick, Joseph Biederma. A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 8. 2009-01-06. PMID:18951431. |
our findings suggest that volumetric abnormalities in the dorsolateral prefrontal cortex and cerebellum may represent an intermediate neuroanatomical phenotype between drd4 genotype and the clinical expression of adhd in adults, but only in adhd subjects without comorbid bpd. |
2009-01-06 |
2023-08-12 |
human |
| Jeffrey A Stanley, Heidi Kipp, Erika Greisenegger, Frank P MacMaster, K Panchalingam, Matcheri S Keshavan, Oscar G Bukstein, Jay W Pettegre. Evidence of developmental alterations in cortical and subcortical regions of children with attention-deficit/hyperactivity disorder: a multivoxel in vivo phosphorus 31 spectroscopy study. Archives of general psychiatry. vol 65. issue 12. 2008-12-24. PMID:19047529. |
there is mounting evidence of neurodevelopmental alterations implicating the prefrontal cortex (pfc) and basal ganglia in children with attention-deficit/hyperactivity disorder (adhd). |
2008-12-24 |
2023-08-12 |
Not clear |
| Ann-Christine Ehlis, Christina G Bähne, Christian P Jacob, Martin J Herrmann, Andreas J Fallgatte. Reduced lateral prefrontal activation in adult patients with attention-deficit/hyperactivity disorder (ADHD) during a working memory task: a functional near-infrared spectroscopy (fNIRS) study. Journal of psychiatric research. vol 42. issue 13. 2008-12-18. PMID:18226818. |
compared to the healthy control group, adhd patients showed reduced task-related increases in the concentration of o2hb in nirs channels located over the ventro-lateral prefrontal cortex, indicating reduced activation during performance of the n-back task in this part of the brain. |
2008-12-18 |
2023-08-12 |
Not clear |
| Ann-Christine Ehlis, Christina G Bähne, Christian P Jacob, Martin J Herrmann, Andreas J Fallgatte. Reduced lateral prefrontal activation in adult patients with attention-deficit/hyperactivity disorder (ADHD) during a working memory task: a functional near-infrared spectroscopy (fNIRS) study. Journal of psychiatric research. vol 42. issue 13. 2008-12-18. PMID:18226818. |
the data confirm previous findings of working memory deficits and prefrontal cortex dysfunction in patients suffering from adhd, and are discussed in the light of imaging findings and theoretical models of working memory function. |
2008-12-18 |
2023-08-12 |
Not clear |
| Keun-Ah Cheon, Jin-Yong Jun, Dae-Yeon Ch. Association of the catechol-O-methyltransferase polymorphism with methylphenidate response in a classroom setting in children with attention-deficit hyperactivity disorder. International clinical psychopharmacology. vol 23. issue 5. 2008-10-23. PMID:18703939. |
it has been postulated that the prefrontal cortex plays a key role in attention-deficit hyperactivity disorder (adhd). |
2008-10-23 |
2023-08-12 |
Not clear |
| D J Heal, S L Smith, R S Kulkarni, H L Rowle. New perspectives from microdialysis studies in freely-moving, spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD. Pharmacology, biochemistry, and behavior. vol 90. issue 2. 2008-08-12. PMID:18456311. |
in this review, these three topics are brought together to explore the contribution of in vivo microdialysis studies in spontaneously hypertensive (sh) rats to our understanding of the neurochemical deficits in this rat strain and the actions of adhd drugs on catecholaminergic function in the prefrontocortex (pfc), striatum and nucleus accumbens. |
2008-08-12 |
2023-08-12 |
rat |
| Avis R Brennan, Amy F T Arnste. Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function. Annals of the New York Academy of Sciences. vol 1129. 2008-07-18. PMID:18591484. |
neuropsychological and imaging studies indicate that attention deficit hyperactivity disorder (adhd) is associated with alterations in prefrontal cortex (pfc) and its connections to striatum and cerebellum. |
2008-07-18 |
2023-08-12 |
monkey |
| Avis R Brennan, Amy F T Arnste. Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function. Annals of the New York Academy of Sciences. vol 1129. 2008-07-18. PMID:18591484. |
alpha2a-adrenoceptor stimulation strengthens the functional connectivity of pfc networks, while blockade of alpha2 receptors in the monkey pfc recreates the symptoms of adhd, resulting in impaired working memory, increased impulsivity, and locomotor hyperactivity. |
2008-07-18 |
2023-08-12 |
monkey |
| Li-Li Liu, Jie Yang, Ge-Fei Lei, Gui-Ju Wang, Yu-Wei Wang, Ruo-Peng Su. Atomoxetine increases histamine release and improves learning deficits in an animal model of attention-deficit hyperactivity disorder: the spontaneously hypertensive rat. Basic & clinical pharmacology & toxicology. vol 102. issue 6. 2008-06-12. PMID:18346050. |
our data confirmed that atomoxetine increases extracellular levels of histamine in the prefrontal cortex, a brain region that is implicated in the pathophysiology of adhd. |
2008-06-12 |
2023-08-12 |
rat |
| K M Kantak, T Singh, K A Kerstetter, K A Dembro, M M Mutebi, R C Harvey, C F Deschepper, L P Dwoski. Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder. Behavioral neuroscience. vol 122. issue 2. 2008-06-03. PMID:18410173. |
to advance the spontaneous hypertensive rat (shr) model of attention deficit/hyperactivity disorder (adhd), experiments examined the shr in tasks recognized to assess functioning of the prefrontal cortex or dorsal striatal. |
2008-06-03 |
2023-08-12 |
rat |
| Chao-Zhe Zhu, Yu-Feng Zang, Qing-Jiu Cao, Chao-Gan Yan, Yong He, Tian-Zi Jiang, Man-Qiu Sui, Yu-Feng Wan. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder. NeuroImage. vol 40. issue 1. 2008-04-23. PMID:18191584. |
moreover, some highly discriminative brain regions, like the prefrontal cortex and anterior cingulate cortex, well confirmed the previous findings on adhd. |
2008-04-23 |
2023-08-12 |
Not clear |
| Joel Nigg, Molly Nikolas, Karen Friderici, Leeyoung Park, Robert A Zucke. Genotype and neuropsychological response inhibition as resilience promoters for attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder under conditions of psychosocial adversity. Development and psychopathology. vol 19. issue 3. 2008-01-18. PMID:17705902. |
results illustrate potential neurobiological protective factors related to development of prefrontal cortex that may enable children to avoid developing adhd and cd in the presence of psychosocial adversity. |
2008-01-18 |
2023-08-12 |
Not clear |
| Xiaobo Li, Jiefeng Jiang, Wanlin Zhu, Chunshui Yu, Manqiu Sui, Yufeng Wang, Tianzi Jian. Asymmetry of prefrontal cortical convolution complexity in males with attention-deficit/hyperactivity disorder using fractal information dimension. Brain & development. vol 29. issue 10. 2008-01-09. PMID:17573219. |
prefrontal cortex, known to be a crucial region for the function of attention, is generally thought to be largely associated with the pathogenesis of attention-deficit hyperactivity disorder (adhd). |
2008-01-09 |
2023-08-12 |
Not clear |
| Amy F Arnsten, Lawrence Scahill, Robert L Findlin. alpha2-Adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new data. Journal of child and adolescent psychopharmacology. vol 17. issue 4. 2007-11-13. PMID:17822336. |
the following provides a brief review of this field, explaining how compounds like guanfacine and the traditional stimulant medications can reduce the core symptoms of adhd by optimizing the neurochemical environment in the prefrontal cortex (pfc). |
2007-11-13 |
2023-08-12 |
Not clear |
| Margaret A Sheridan, Stephen Hinshaw, Mark D'Esposit. Efficiency of the prefrontal cortex during working memory in attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 46. issue 10. 2007-11-08. PMID:17885578. |
previous research has demonstrated that during task conditions requiring an increase in inhibitory function or working memory, children and adults with attention-deficit/hyperactivity disorder (adhd) exhibit greater and more varied prefrontal cortical (pfc) activation compared to age-matched control participants. |
2007-11-08 |
2023-08-12 |
human |
| R Rodriguez-Jimenez, C Avila, M A Jimenez-Arriero, G Ponce, R Monasor, M Jimenez, M Aragües, J Hoenicka, G Rubio, T Palom. Impulsivity and sustained attention in pathological gamblers: influence of childhood ADHD history. Journal of gambling studies. vol 22. issue 4. 2007-11-01. PMID:16912931. |
our results suggest a possible selective implication of the prefrontal cortex in pg, which would be especially evident in those with a childhood history of adhd. |
2007-11-01 |
2023-08-12 |
Not clear |
| Augusto Pasini, Claudio Paloscia, Riccardo Alessandrelli, Maria Cristina Porfirio, Paolo Curatol. Attention and executive functions profile in drug naive ADHD subtypes. Brain & development. vol 29. issue 7. 2007-10-10. PMID:17207595. |
since right prefrontal cortex seems to be crucial in controlling response inhibition, while left dorsolateral prefrontal cortex seems important in modulating divided attention, these areas are deputated to be involved in the pathogenesis of neuropsychological deficits in adhd subtypes. |
2007-10-10 |
2023-08-12 |
human |
| Katherine A Johnson, Ian H Robertson, Simon P Kelly, Timothy J Silk, Edwina Barry, Aoife Dáibhis, Amy Watchorn, Michelle Keavey, Michael Fitzgerald, Louise Gallagher, Michael Gill, Mark A Bellgrov. Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention. Neuropsychologia. vol 45. issue 10. 2007-07-24. PMID:17433378. |
these data imply involvement of fronto-parietal attentional networks and sub-cortical arousal systems in the pathology of adhd and prefrontal cortex dysfunction in children with hfa. |
2007-07-24 |
2023-08-12 |
Not clear |
| Benjamin Charles Campbell, Dan Eisenber. Obesity, attention deficit-hyperactivity disorder and the dopaminergic reward system. Collegium antropologicum. vol 31. issue 1. 2007-07-20. PMID:17600916. |
detailed consideration suggests that dopaminergic changes in the prefrontal cortex among individuals with the adhd subtype attention deficit disorder (add) may increase their risk for obesity. |
2007-07-20 |
2023-08-12 |
Not clear |