| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vivienne A Russell, Terje Sagvolden, Espen Borgå Johanse. Animal models of attention-deficit hyperactivity disorder. Behavioral and brain functions : BBF. vol 1. 2005-07-29. PMID:16022733. |
several animal models of adhd suggest that the dopaminergic system is functionally impaired. |
2005-07-29 |
2023-08-12 |
human |
| Vivienne A Russell, Terje Sagvolden, Espen Borgå Johanse. Animal models of attention-deficit hyperactivity disorder. Behavioral and brain functions : BBF. vol 1. 2005-07-29. PMID:16022733. |
aspects of adhd behaviour may result from an imbalance between increased noradrenergic and decreased dopaminergic regulation of neural circuits that involve the prefrontal cortex. |
2005-07-29 |
2023-08-12 |
human |
| L Park, J T Nigg, I D Waldman, K A Nummy, C Huang-Pollock, M Rappley, K H Frideric. Association and linkage of alpha-2A adrenergic receptor gene polymorphisms with childhood ADHD. Molecular psychiatry. vol 10. issue 6. 2005-07-27. PMID:15520832. |
although the noradrenergic (na) system is thought to mediate a portion of the pathophysiology of adhd, genes in this pathway have not been investigated as frequently as those in the dopaminergic system. |
2005-07-27 |
2023-08-12 |
Not clear |
| Bowen Chung, Alejandra R Suzuki, James J McGoug. New drugs for treatment of attention-deficit/hyperactivity disorder. Expert opinion on emerging drugs. vol 7. issue 2. 2005-07-13. PMID:15989550. |
the underlying pathophysiology of adhd has been theorised to be dysregulation of inhibitory noradrenergic frontocortical activity on dopaminergic striatal structures. |
2005-07-13 |
2023-08-12 |
Not clear |
| Robert D Oades, Adolfo G Sadile, Terje Sagvolden, Davide Viggiano, Alessandro Zuddas, Paola Devoto, Heidi Aase, Espen B Johansen, Lucia A Ruocco, Vivienne A Russel. The control of responsiveness in ADHD by catecholamines: evidence for dopaminergic, noradrenergic and interactive roles. Developmental science. vol 8. issue 2. 2005-06-17. PMID:15720370. |
the control of responsiveness in adhd by catecholamines: evidence for dopaminergic, noradrenergic and interactive roles. |
2005-06-17 |
2023-08-12 |
human |
| Monika Johann, Albert Putzhammer, Peter Eichhammer, Norbert Wodar. Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15389757. |
several lines of evidence indicate an involvement of the dopaminergic system in alcoholism, withdrawal, suicidality, and attention-deficit hyperactivity disorder (adhd). |
2005-05-12 |
2023-08-12 |
human |
| Katharina Domschke, Karen Sheehan, Naomi Lowe, Aiveen Kirley, Celine Mullins, Roderick O'sullivan, Christine Freitag, Tim Becker, Judith Conroy, Michael Fitzgerald, Michael Gill, Ziarih Haw. Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 134B. issue 1. 2005-05-09. PMID:15717295. |
pharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of attention deficit hyperactivity disorder (adhd). |
2005-05-09 |
2023-08-12 |
Not clear |
| Kevin C F Fone, David J Nut. Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder. Current opinion in pharmacology. vol 5. issue 1. 2005-05-04. PMID:15661631. |
however, recent advances in molecular genetics and brain imaging implicate dopaminergic hypofunction in the frontal lobes and basal ganglia in adhd. |
2005-05-04 |
2023-08-12 |
Not clear |
| Ryszard Brus, Przemyslaw Nowak, Ryszard Szkilnik, Urszula Mikolajun, Richard M Kostrzew. Serotoninergics attenuate hyperlocomotor activity in rats. Potential new therapeutic strategy for hyperactivity. Neurotoxicity research. vol 6. issue 4. 2005-04-22. PMID:15545015. |
therefore, previously we proposed this as an animal model of attention deficit hyperactivity disorder (adhd) - induced by destruction of dopaminergic neurons with 6-hydroxydopamine (6-ohda) (neonatally) and serotoninergic neurons with 5,7-dihydroxytryptamine (5,7-dht) (in adulthood). |
2005-04-22 |
2023-08-12 |
human |
| R Rodrigues Pereira, B J M van de Weterin. [Caffeine, cannabis and cocaine: from automedication to 'automutilation' in adults with ADHD]. Nederlands tijdschrift voor geneeskunde. vol 148. issue 52. 2005-04-08. PMID:15646857. |
the other two patients, a man aged 25 and a woman aged 35, were initially not diagnosed with adhd; they had noticed that dopaminergic drugs like cocaine and an amphetamine-containing medication taken to lose weight made their behaviour much more 'normal', although the man was addicted. |
2005-04-08 |
2023-08-12 |
Not clear |
| Richard F Kaplan, Michael Steven. A review of adult ADHD: a neuropsychological and neuroimaging perspective. CNS spectrums. vol 7. issue 5. 2005-04-05. PMID:15122107. |
most theories posit that adhd is related to anomalies in frontal lobe function and dopaminergic transmission. |
2005-04-05 |
2023-08-12 |
Not clear |
| Eleni T Tzavara, Frank P Bymaster, Richard J Davis, Mark R Wade, Kenneth W Perry, Jurgen Wess, David L McKinzie, Chris Felder, George G Nomiko. M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 12. 2005-04-05. PMID:15231726. |
dopaminergic dysfunction is an important pathogenetic factor for brain pathologies such as parkinson's disease, adhd, schizophrenia, and addiction as well as for metabolic disorders and anorexia. |
2005-04-05 |
2023-08-12 |
mouse |
| Becky Inkster, Pierandrea Muglia, Umesh Jain, James L Kenned. Linkage disequilibrium analysis of the dopamine beta-hydroxylase gene in persistent attention deficit hyperactivity disorder. Psychiatric genetics. vol 14. issue 2. 2005-03-24. PMID:15167700. |
in view of this evidence, genes that influence dopaminergic transmission have become prime candidates for molecular genetic investigations of adhd. |
2005-03-24 |
2023-08-12 |
Not clear |
| D Turic, H Williams, K Langley, M Owen, A Thapar, M C O'Donova. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD). American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 133B. issue 1. 2005-03-14. PMID:15635644. |
neurobiological studies have suggested that altered dopaminergic function may contribute to the etiology of attention deficit hyperactivity disorder (adhd). |
2005-03-14 |
2023-08-12 |
Not clear |
| Karen Müller Smith, Lorri Bauer, Mariellen Fischer, Russell Barkley, Bradford A Navi. Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 133B. issue 1. 2005-03-14. PMID:15635701. |
dopaminergic cells of the vta provide innervation to the prefrontal cortex, believed to be of major importance in the etiology of adhd, suggesting that nr4a2 is a potential candidate gene for adhd susceptibility. |
2005-03-14 |
2023-08-12 |
human |
| Naomi Lowe, Aiveen Kirley, Celine Mullins, Michael Fitzgerald, Michael Gill, Ziarih Haw. Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: evidence of linkage and association with the SNP -616. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 131B. issue 1. 2005-02-08. PMID:15389764. |
one of the most replicated associations between adhd and the dopaminergic system is the 7-repeat allele of the vntr polymorphism of this gene. |
2005-02-08 |
2023-08-12 |
Not clear |
| M Hus. [Long-term courses in children with attention deficit hyperactivity disorder (ADHD)]. MMW Fortschritte der Medizin. vol 146. issue 12. 2004-12-21. PMID:15357502. |
today, adhd is believed to be a mainly heritable disorder with deviations in the dopaminergic system. |
2004-12-21 |
2023-08-12 |
Not clear |
| Eric Konofal, Michel Lecendreux, Isabelle Arnulf, Marie-Christine Moure. Iron deficiency in children with attention-deficit/hyperactivity disorder. Archives of pediatrics & adolescent medicine. vol 158. issue 12. 2004-12-21. PMID:15583094. |
iron deficiency causes abnormal dopaminergic neurotransmission and may contribute to the physiopathology of attention-deficit/hyperactivity disorder (adhd). |
2004-12-21 |
2023-08-12 |
Not clear |
| Virginia L Misener, Russell Schachar, Abel Ickowicz, Molly Malone, Wendy Roberts, Rosemary Tannock, James L Kennedy, Tejaswee Pathare, Cathy L Bar. Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit/hyperactivity disorder. Neuropsychobiology. vol 50. issue 3. 2004-10-19. PMID:15365221. |
attention-deficit/hyperactivity disorder (adhd) has a strong genetic basis, and aberrant brain dopaminergic and noradrenergic activity is implicated in its etiology. |
2004-10-19 |
2023-08-12 |
Not clear |
| Tatiana Roman, Luis Augusto Rohde, Mara Helena Hut. Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. vol 4. issue 2. 2004-07-26. PMID:15059031. |
although the neurobiology of adhd is not completely understood, imbalances in both dopaminergic and noradrenergic systems have been implicated in the origin and persistence of core symptoms, which include inattention, hyperactivity, and impulsivity. |
2004-07-26 |
2023-08-12 |
Not clear |