| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John S Markowitz, Arthur B Straughn, Kennerly S Patric. Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: focus on methylphenidate formulations. Pharmacotherapy. vol 23. issue 10. 2004-03-04. PMID:14594346. |
evidence of a dopaminergic basis both for the actions of mph and for the underlying neuropathology in adhd continues to mount. |
2004-03-04 |
2023-08-12 |
Not clear |
| Karen Müller Smith, Mark Daly, Mariellen Fischer, Constantin T Yiannoutsos, Lorri Bauer, Russell Barkley, Bradford A Navi. Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 119B. issue 1. 2004-02-06. PMID:12707943. |
attention deficit hyperactivity disorder (adhd) is a highly heritable and common disorder that partly reflects disturbed dopaminergic function in the brain. |
2004-02-06 |
2023-08-12 |
human |
| Klaus Henning Krause, Stefan H Dresel, Johanna Krause, Christian la Fougere, Manfred Ackenhei. The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624805. |
for instance, dopaminergic psychostimulants, the drugs of first choice in adhd, interact directly with the dopamine transporter (dat). |
2004-01-15 |
2023-08-12 |
Not clear |
| Damiana Leo, Eleonora Sorrentino, Floriana Volpicelli, Maria Eyman, Dario Greco, Davide Viggiano, Umberto di Porzio, Carla Perrone-Capan. Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624810. |
altered midbrain dopaminergic neurotransmission during development in an animal model of adhd. |
2004-01-15 |
2023-08-12 |
rat |
| Damiana Leo, Eleonora Sorrentino, Floriana Volpicelli, Maria Eyman, Dario Greco, Davide Viggiano, Umberto di Porzio, Carla Perrone-Capan. Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624810. |
to understand the onset and the molecular mechanisms triggering dopaminergic (da) dysregulation in attention-deficit hyperactivity disorder (adhd), we have used the spontaneously hypertensive rats (shr), the most widely studied animal model for this disease. |
2004-01-15 |
2023-08-12 |
rat |
| Michelle D Jones, Ellen J Hes. Norepinephrine regulates locomotor hyperactivity in the mouse mutant coloboma. Pharmacology, biochemistry, and behavior. vol 75. issue 1. 2004-01-07. PMID:12759129. |
an imbalance between dopaminergic and noradrenergic systems is implicated in hyperactivity disorders such as attention deficit hyperactivity disorder (adhd) and tourette syndrome. |
2004-01-07 |
2023-08-12 |
mouse |
| C C E Overtoom, M N Verbaten, C Kemner, J L Kenemans, H van Engeland, J K Buitelaar, M W van der Molen, J van der Gugten, H Westenberg, R A A Maes, H S Koeleg. Effects of methylphenidate, desipramine, and L-dopa on attention and inhibition in children with Attention Deficit Hyperactivity Disorder. Behavioural brain research. vol 145. issue 1-2. 2003-12-10. PMID:14529800. |
the objective of this study was to investigate the effects of methylphenidate (mph) on attention and inhibition in children with attention deficit hyperactivity disorder (adhd) and to establish what the relative contributions of the noradrenergic and dopaminergic systems to this effect were. |
2003-12-10 |
2023-08-12 |
Not clear |
| Hilla Ben-Pazi, Varda Gross-Tsur, Hagai Bergman, Ruth S Shale. Abnormal rhythmic motor response in children with attention-deficit-hyperactivity disorder. Developmental medicine and child neurology. vol 45. issue 11. 2003-12-01. PMID:14580129. |
this specific error pattern, also seen in parkinson's disease, has been attributed to an abnormal oscillatory mechanism mediated by dopaminergic fronto-striatal circuitry, which might also be pathophysiologically relevant for adhd. |
2003-12-01 |
2023-08-12 |
human |
| Z Hawi, N Lowe, A Kirley, F Gruenhage, M Nöthen, T Greenwood, J Kelsoe, M Fitzgerald, M Gil. Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci. Molecular psychiatry. vol 8. issue 3. 2003-11-04. PMID:12660802. |
abnormalities in dopaminergic neurotransmission are now accepted as factors in predisposing to adhd. |
2003-11-04 |
2023-08-12 |
Not clear |
| Keun-Ah Cheon, Young Hoon Ryu, Young-Kee Kim, Kee Namkoong, Chan-Hyung Kim, Jong Doo Le. Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder. European journal of nuclear medicine and molecular imaging. vol 30. issue 2. 2003-09-26. PMID:12552351. |
in this study, we investigated dopamine transporter (dat) density in children with adhd using iodine-123 labelled n-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ([(123)i]ipt) single-photon emission tomography (spet) and postulated that an alteration in dat density in the basal ganglia is responsible for dopaminergic dysfunction in children with adhd. |
2003-09-26 |
2023-08-12 |
Not clear |
| Keun-Ah Cheon, Young Hoon Ryu, Young-Kee Kim, Kee Namkoong, Chan-Hyung Kim, Jong Doo Le. Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder. European journal of nuclear medicine and molecular imaging. vol 30. issue 2. 2003-09-26. PMID:12552351. |
our findings support the complex dysregulation of the dopaminergic neurotransmitter system in children with adhd. |
2003-09-26 |
2023-08-12 |
Not clear |
| J S Rhodes, T Garlan. Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, but not raclopride in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology. vol 167. issue 3. 2003-09-24. PMID:12669177. |
previous studies of mice ( mus domesticus) selectively bred for high voluntary wheel running have suggested that the hyperactivity is associated with dysfunction in the dopaminergic neuromodulatory system and that high-running mice may represent a useful genetic model for attention deficit hyperactivity disorder (adhd). |
2003-09-24 |
2023-08-12 |
mouse |
| Esti Galili-Weisstub, Ronnen H Segma. Attention deficit and hyperactivity disorder: review of genetic association studies. The Israel journal of psychiatry and related sciences. vol 40. issue 1. 2003-07-30. PMID:12817670. |
based on the mechanism of action of stimulant drugs effective in the alleviation of adhd symptoms, current association studies have focused mainly on dopaminergic genes. |
2003-07-30 |
2023-08-12 |
Not clear |
| J S H Vles, F J M Feron, J G M Hendriksen, J Jolles, M J P G van Kroonenburgh, W E J Webe. Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD). Neuropediatrics. vol 34. issue 2. 2003-07-09. PMID:12776228. |
adults suffering from attention deficit hyperactivity disorder (adhd) are known to have disturbed central dopaminergic transmission. |
2003-07-09 |
2023-08-12 |
Not clear |
| Kerstin Konrad, Siegfried Gauggel, Josef Schure. Catecholamine functioning in children with traumatic brain injuries and children with attention-deficit/hyperactivity disorder. Brain research. Cognitive brain research. vol 16. issue 3. 2003-06-30. PMID:12706222. |
recent studies suggest that children with attention-deficit/hyperactivity disorder (adhd) and children with traumatic brain injuries (tbi) show changes in similar neuronal networks, including the dopaminergic (da) and norepinephrinergic (na) systems. |
2003-06-30 |
2023-08-12 |
Not clear |
| J Biederman, S V Faraon. Current concepts on the neurobiology of Attention-Deficit/Hyperactivity Disorder. Journal of attention disorders. vol 6 Suppl 1. 2003-05-22. PMID:12685515. |
although not entirely sufficient, changes in dopaminergic and noradrenergic function appear necessary for the clinical efficacy of pharmacological treatments for adhd, providing support for the hypothesis that alteration of monoaminergic transmission in critical brain regions may be the basis for therapeutic action in adhd. |
2003-05-22 |
2023-08-12 |
Not clear |
| Deborah C Lawson, Darko Turic, Kate Langley, Helen M Pay, Catherine F Govan, Nadine Norton, Marian L Hamshere, Michael J Owen, Michael C O'Donovan, Anita Thapa. Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 116B. issue 1. 2003-04-30. PMID:12497620. |
although the causes of adhd are unknown, dopaminergic, serotonergic and nor-adrenergic pathways have been strongly implicated. |
2003-04-30 |
2023-08-12 |
human |
| Jean-Philippe Reneric, Manuel-P Bouvar. [Etio-pathogenic hypothesis of attention deficit disorder in children]. La Revue du praticien. vol 52. issue 18. 2003-03-11. PMID:12602163. |
it thus seems that adhd is essentially characterised by its dimension of impulsivity, linked to a defect of inhibitor control, specifically implying certain cerebral structures as well as a dysfunction of the catecholaminergic systems, and in particular, the dopaminergic system. |
2003-03-11 |
2023-08-12 |
Not clear |
| Lenard A Adler, Hong C Chu. Management of ADHD in adults. The Journal of clinical psychiatry. vol 63 Suppl 12. 2003-02-11. PMID:12562059. |
molecular genetics and neuroimaging studies confirm that adhd is a heterogeneous, neurobiological disorder, mainly of dopaminergic and noradrenergic pathways. |
2003-02-11 |
2023-08-12 |
Not clear |
| Aiveen Kirley, Ziarih Hawi, Grainne Daly, Mary McCarron, Celine Mullins, Niamh Millar, Irwin Waldman, Michael Fitzgerald, Michael Gil. Dopaminergic system genes in ADHD: toward a biological hypothesis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 4. 2002-11-19. PMID:12377397. |
dopaminergic system genes in adhd: toward a biological hypothesis. |
2002-11-19 |
2023-08-12 |
Not clear |