| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| André Nieoullo. Dopamine and the regulation of cognition and attention. Progress in neurobiology. vol 67. issue 1. 2002-09-27. PMID:12126656. |
some other diseases, which can also involve da dysfunction, such as schizophrenia or attention deficit hyperactivity disorder (adhd) in children, as shown from the ameliorative action of dopaminergic antagonists and agonists, respectively, also show alteration of cognitive functions. |
2002-09-27 |
2023-08-12 |
rat |
| Karen Wigg, Gwyneth Zai, Russell Schachar, Rosemary Tannock, Wendy Roberts, Molly Malone, James L Kennedy, Cathy L Bar. Attention deficit hyperactivity disorder and the gene for dopamine Beta-hydroxylase. The American journal of psychiatry. vol 159. issue 6. 2002-06-21. PMID:12042196. |
attention deficit hyperactivity disorder (adhd) has been shown to be highly heritable, and recent molecular genetics studies have focused on candidate genes in the dopaminergic and noradrenergic systems. |
2002-06-21 |
2023-08-12 |
Not clear |
| Simon E Fisher, Clyde Francks, James T McCracken, James J McGough, Angela J Marlow, I Laurence MacPhie, Dianne F Newbury, Lori R Crawford, Christina G S Palmer, J Arthur Woodward, Melissa Del'Homme, Dennis P Cantwell, Stanley F Nelson, Anthony P Monaco, Susan L Smalle. A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. American journal of human genetics. vol 70. issue 5. 2002-05-23. PMID:11923911. |
molecular genetic studies of adhd have previously focused on examining the roles of specific candidate genes, primarily those involved in dopaminergic pathways. |
2002-05-23 |
2023-08-12 |
Not clear |
| Espen Borgå Johansen, Heidi Aase, Anneke Meyer, Terje Sagvolde. Attention-deficit/hyperactivity disorder (ADHD) behaviour explained by dysfunctioning reinforcement and extinction processes. Behavioural brain research. vol 130. issue 1-2. 2002-05-16. PMID:11864716. |
the various dopaminergic branches may not be equally dysfunctional in all individuals with adhd. |
2002-05-16 |
2023-08-12 |
Not clear |
| Vivienne Ann Russel. Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat. Behavioural brain research. vol 130. issue 1-2. 2002-05-16. PMID:11864734. |
evidence supports dysfunction of dopaminergic and noradrenergic systems in patients with attention-deficit hyperactivity disorder (adhd). |
2002-05-16 |
2023-08-12 |
rat |
| Vivienne Ann Russel. Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat. Behavioural brain research. vol 130. issue 1-2. 2002-05-16. PMID:11864734. |
these findings are consistent with the hypothesis that the behavioral disturbances of adhd are the result of an imbalance between noradrenergic and dopaminergic systems in the prefrontal cortex, with inhibitory dopaminergic activity being decreased and noradrenergic activity increased relative to controls. |
2002-05-16 |
2023-08-12 |
rat |
| S Jiang, R Xin, S Lin, Y Qian, G Tang, D Wang, X W. Linkage studies between attention-deficit hyperactivity disorder and the monoamine oxidase genes. American journal of medical genetics. vol 105. issue 8. 2002-03-05. PMID:11803531. |
molecular genetic and pharmacological studies suggest the involvement of dopaminergic and noradrenergic neurotransmitter systems in adhd, e.g., several reports have found association between adhd and the dopamine receptor gene drd-4, the dopamine transporter gene dat1, and the catecholamine clearance enzyme catechol-o-methyltransferase. |
2002-03-05 |
2023-08-12 |
Not clear |
| Z Hawi, D Foley, A Kirley, M McCarron, M Fitzgerald, M Gil. Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population. Molecular psychiatry. vol 6. issue 4. 2001-09-06. PMID:11443526. |
it has been suggested that genes involved in the dopaminergic system play a primary role in predisposing to attention deficit hyperactivity disorder (adhd). |
2001-09-06 |
2023-08-12 |
Not clear |
| P H Wender, L E Wolf, J Wasserstei. Adults with ADHD. An overview. Annals of the New York Academy of Sciences. vol 931. 2001-09-06. PMID:11462736. |
attention-deficit hyperactivity disorder (adhd) is a common, genetically transmitted neurological disorder, with onset in childhood, probably mediated by decreased brain dopaminergic functioning. |
2001-09-06 |
2023-08-12 |
Not clear |
| A Payton, J Holmes, J H Barrett, T Hever, H Fitzpatrick, A L Trumper, R Harrington, P McGuffin, M O'Donovan, M Owen, W Ollier, J Worthington, A Thapa. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. American journal of medical genetics. vol 105. issue 5. 2001-08-16. PMID:11449400. |
to test the dopaminergic hypothesis further, we have looked for association between adhd and alleles of seven dopamine-related candidate genes using a family-based association approach in a sample of 150 children diagnosed with adhd. |
2001-08-16 |
2023-08-12 |
Not clear |
| C B Denne. Stimulant effects in attention deficit hyperactivity disorder: theoretical and empirical issues. Journal of clinical child psychology. vol 30. issue 1. 2001-08-09. PMID:11294083. |
similarly, human molecular genetic studies have provided a glimpse into the possible role that genes related to dopaminergic neurotransmission may play in the etiology of adhd. |
2001-08-09 |
2023-08-12 |
human |
| S Dresel, J Krause, K H Krause, C LaFougere, K Brinkbäumer, H F Kung, K Hahn, K Tatsc. Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. European journal of nuclear medicine. vol 27. issue 10. 2001-03-01. PMID:11083541. |
involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (adhd) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (dat). |
2001-03-01 |
2023-08-12 |
human |
| S Dresel, J Krause, K H Krause, C LaFougere, K Brinkbäumer, H F Kung, K Hahn, K Tatsc. Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. European journal of nuclear medicine. vol 27. issue 10. 2001-03-01. PMID:11083541. |
the data of this study help to elucidate the complex dysregulation of the dopaminergic neurotransmitter system in patients suffering from adhd and the effect of treatment with psychoactive drugs. |
2001-03-01 |
2023-08-12 |
human |
| G A Sunohara, W Roberts, M Malone, R J Schachar, R Tannock, V S Basile, T Wigal, S B Wigal, S Schuck, J Moriarty, J M Swanson, J L Kennedy, C L Bar. Linkage of the dopamine D4 receptor gene and attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 39. issue 12. 2001-01-25. PMID:11128331. |
because stimulant medications act primarily on the dopaminergic system, dopamine system genes are prime candidates for genetic susceptibility factors for adhd. |
2001-01-25 |
2023-08-12 |
Not clear |
| P M Kid. Attention deficit/hyperactivity disorder (ADHD) in children: rationale for its integrative management. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 5. 2000-12-22. PMID:11056411. |
abnormalities in the frontostriatal brain circuitry and possible hypofunctioning of dopaminergic pathways are apparent in adhd, and are consistent with the benefits obtained in some instances by the use of methylphenidate (ritalin) and other potent psychostimulants. |
2000-12-22 |
2023-08-12 |
human |
| T S Hale, A R Hariri, J T McCracke. Attention-deficit/hyperactivity disorder: perspectives from neuroimaging. Mental retardation and developmental disabilities research reviews. vol 6. issue 3. 2000-10-16. PMID:10982499. |
current etiologic theories suggest that adhd stems from abnormalities in dopaminergic and possibly noradrenergic brainstem nuclei that act to regulate a cortico-striato-thalamo-cortical network, believed to be critical for executive functions and the regulation of behavioral responses such as arousal, attention, and inhibition. |
2000-10-16 |
2023-08-12 |
Not clear |
| E Tahir, Y Yazgan, B Cirakoglu, F Ozbay, I Waldman, P J Asherso. Association and linkage of DRD4 and DRD5 with attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children. Molecular psychiatry. vol 5. issue 4. 2000-09-14. PMID:10889550. |
the search for genetic factors predisposing to attention deficit hyperactivity disorder (adhd) has focused on genes that regulate dopaminergic pathways such as dopamine receptors and enzymes that regulate levels of dopamine in the synapse. |
2000-09-14 |
2023-08-12 |
Not clear |
| D J Vandenbergh, M D Thompson, E H Cook, E Bendahhou, T Nguyen, M D Krasowski, D Zarrabian, D Comings, E M Sellers, R F Tyndale, S R George, B F O'Dowd, G R Uh. Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Molecular psychiatry. vol 5. issue 3. 2000-09-12. PMID:10889531. |
associations between dat gene polymorphisms and human disorders with possible links to dopaminergic neurotransmission, including attention-deficit/hyperactivity disorder (adhd) and consequences of cocaine and alcohol administration, have been reported. |
2000-09-12 |
2023-08-12 |
human |
| Z Hawi, M McCarron, A Kirley, G Daly, M Fitzgerald, M Gil. No association of the dopamine DRD4 receptor (DRD4) gene polymorphism with attention deficit hyperactivity disorder (ADHD) in the Irish population. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898897. |
although the biological basis of adhd is unknown, a dopaminergic abnormality has long been suggested. |
2000-08-10 |
2023-08-12 |
Not clear |
| Z Hawi, N Millar, G Daly, M Fitzgerald, M Gil. No association between catechol-O-methyltransferase (COMT) gene polymorphism and attention deficit hyperactivity disorder (ADHD) in an Irish sample. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898900. |
pharmacological and biochemical studies have indicated that imbalances in dopaminergic transmission may contribute to the aetiology of attention deficit hyperactivity disorder (adhd). |
2000-08-10 |
2023-08-12 |
Not clear |