| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charlotte Keatin. Theoretical perspective on anorexia nervosa: the conflict of reward. Neuroscience and biobehavioral reviews. vol 34. issue 1. 2010-01-21. PMID:19619579. |
anhedonia is the reduced ability to experience reward and is considered a feature of an. |
2010-01-21 |
2023-08-12 |
Not clear |
| Michael T Treadway, Joshua W Buckholtz, Ashley N Schwartzman, Warren E Lambert, David H Zal. Worth the 'EEfRT'? The effort expenditure for rewards task as an objective measure of motivation and anhedonia. PloS one. vol 4. issue 8. 2010-01-19. PMID:19672310. |
anhedonia is generally assumed to reflect aberrant motivation and reward responsivity. |
2010-01-19 |
2023-08-12 |
Not clear |
| Bettina H Bewernick, René Hurlemann, Andreas Matusch, Sarah Kayser, Christiane Grubert, Barbara Hadrysiewicz, Nikolai Axmacher, Matthias Lemke, Deirdre Cooper-Mahkorn, Michael X Cohen, Holger Brockmann, Doris Lenartz, Volker Sturm, Thomas E Schlaepfe. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biological psychiatry. vol 67. issue 2. 2010-01-07. PMID:19914605. |
since anhedonia is a feature of depression and there is evidence of dysfunction of the reward system, dbs to the nucleus accumbens (nacc) might be promising. |
2010-01-07 |
2023-08-12 |
Not clear |
| Jan Wacker, Daniel G Dillon, Diego A Pizzagall. The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: integration of resting EEG, fMRI, and volumetric techniques. NeuroImage. vol 46. issue 1. 2009-08-19. PMID:19457367. |
in the present study, we used resting electroencephalography, functional magnetic resonance imaging, and volumetric analyses to probe putative associations between anhedonia and individual differences in key nodes of the brain's reward system in a non-clinical sample. |
2009-08-19 |
2023-08-12 |
Not clear |
| S H Wang, Zhi-jun Zhang, Y J Guo, H Zhou, G J Teng, B A Che. Anhedonia and activity deficits in rats: impact of post-stroke depression. Journal of psychopharmacology (Oxford, England). vol 23. issue 3. 2009-07-09. PMID:18562439. |
decreased locomotor and rearing represents activity deficits, whereas reduced sucrose preference may indicate desensitisation of the brain reward mechanism (anhedonia). |
2009-07-09 |
2023-08-12 |
human |
| Tomas Palomo, Richard J Beninger, Richard M Kostrzewa, Trevor Arche. Affective status in relation to impulsive, motor and motivational symptoms: personality, development and physical exercise. Neurotoxicity research. vol 14. issue 2-3. 2009-03-31. PMID:19073423. |
affective disorder states may be studied through analyses of personal characteristics that unfold predispositions for symptoms-profiles and biomarkers derived from properties of dysfunction, such as impulsiveness, temperament dimensions, anhedonia and 'over-sensitivity', whether interpersonal or to reward. |
2009-03-31 |
2023-08-12 |
Not clear |
| Roy A Wis. Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotoxicity research. vol 14. issue 2-3. 2009-03-31. PMID:19073424. |
dopamine and reward: the anhedonia hypothesis 30 years on. |
2009-03-31 |
2023-08-12 |
Not clear |
| Roy A Wis. Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotoxicity research. vol 14. issue 2-3. 2009-03-31. PMID:19073424. |
the anhedonia hypothesis--that brain dopamine plays a critical role in the subjective pleasure associated with positive rewards--was intended to draw the attention of psychiatrists to the growing evidence that dopamine plays a critical role in the objective reinforcement and incentive motivation associated with food and water, brain stimulation reward, and psychomotor stimulant and opiate reward. |
2009-03-31 |
2023-08-12 |
Not clear |
| Jennifer A Dinieri, Christina L Nemeth, Aram Parsegian, Tiffany Carle, Vsevolod V Gurevich, Eugenia Gurevich, Rachael L Neve, Eric J Nestler, William A Carlezo. Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 6. 2009-03-06. PMID:19211892. |
together with previous findings, these studies raise the possibility that disruption of creb in the nac influences motivation by simultaneously facilitating reward and reducing depressive-like states such as anhedonia and dysphoria. |
2009-03-06 |
2023-08-12 |
mouse |
| Chantal Martin-Soelc. Is depression associated with dysfunction of the central reward system? Biochemical Society transactions. vol 37. issue Pt 1. 2009-02-11. PMID:19143654. |
because the mesocorticolimbic dopamine system is involved in reward processing, it has been hypothesized that a reduced function of this system could underlie the anhedonia and amotivation associated with depression. |
2009-02-11 |
2023-08-12 |
human |
| Chantal Martin-Soelc. Is depression associated with dysfunction of the central reward system? Biochemical Society transactions. vol 37. issue Pt 1. 2009-02-11. PMID:19143654. |
only a few studies have investigated the neural basis of anhedonia and the responses to rewards in mdd subjects, mostly evidencing a blunted response to reward signals that was associated with reduced brain activation in regions associated with the brain reward system. |
2009-02-11 |
2023-08-12 |
human |
| Tomoyoshi Kond. Dopamine dysregulation syndrome. Hypothetical application of reward system stimulation for the treatment of anhedonia in Parkinson's disease patients. Journal of neurology. vol 255 Suppl 4. 2008-12-31. PMID:18821081. |
hypothetical application of reward system stimulation for the treatment of anhedonia in parkinson's disease patients. |
2008-12-31 |
2023-08-12 |
Not clear |
| Anthony S Rauhut, Isaac J Zentner, Stacey K Mardekian, Jason B Tanenbau. Wistar Kyoto and Wistar rats differ in the affective and locomotor effects of nicotine. Physiology & behavior. vol 93. issue 1-2. 2008-04-22. PMID:17889041. |
anhedonia is a characteristic of clinical depression and has been associated with dysfunction of the mesolimbic dopaminergic system, a system also involved in mediating nicotine reward. |
2008-04-22 |
2023-08-12 |
rat |
| Anthony S Rauhut, Isaac J Zentner, Stacey K Mardekian, Jason B Tanenbau. Wistar Kyoto and Wistar rats differ in the affective and locomotor effects of nicotine. Physiology & behavior. vol 93. issue 1-2. 2008-04-22. PMID:17889041. |
to further examine the relationship between anhedonia, clinical depression and nicotine reward, the present experiment determined if wistar kyoto (wky) rats, an animal model of clinical depression, differed from wistar rats in nicotine conditioned place preference (cpp). |
2008-04-22 |
2023-08-12 |
rat |
| William A Carlezon, Elena H Chartof. Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nature protocols. vol 2. issue 11. 2008-02-19. PMID:18007634. |
tests that reflect reward, reduced ability to experience reward (anhedonia) and aversion (dysphoria) are in high demand because many psychiatric conditions that are currently intractable in humans (e.g., major depression, bipolar disorder, addiction) are characterized by dysregulated motivation. |
2008-02-19 |
2023-08-12 |
mouse |
| Thomas E Schlaepfer, Michael X Cohen, Caroline Frick, Markus Kosel, Daniela Brodesser, Nikolai Axmacher, Alexius Young Joe, Martina Kreft, Doris Lenartz, Volker Stur. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429407. |
deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. |
2008-02-06 |
2023-08-12 |
Not clear |
| Thomas E Schlaepfer, Michael X Cohen, Caroline Frick, Markus Kosel, Daniela Brodesser, Nikolai Axmacher, Alexius Young Joe, Martina Kreft, Doris Lenartz, Volker Stur. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429407. |
because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, dbs to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. |
2008-02-06 |
2023-08-12 |
Not clear |
| Thomas E Schlaepfer, Michael X Cohen, Caroline Frick, Markus Kosel, Daniela Brodesser, Nikolai Axmacher, Alexius Young Joe, Martina Kreft, Doris Lenartz, Volker Stur. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429407. |
dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. |
2008-02-06 |
2023-08-12 |
Not clear |
| Neil E Paterson, Athina Marko. Animal models and treatments for addiction and depression co-morbidity. Neurotoxicity research. vol 11. issue 1. 2007-05-22. PMID:17449445. |
here, we discuss shared neurobiological substrates in drug withdrawal and depression, with an emphasis on changes in brain reward circuitry that may underlie anhedonia, a core symptom of depression and drug withdrawal. |
2007-05-22 |
2023-08-12 |
rat |
| Neil E Paterson, Athina Marko. Animal models and treatments for addiction and depression co-morbidity. Neurotoxicity research. vol 11. issue 1. 2007-05-22. PMID:17449445. |
we explored experimentally whether clinical antidepressant medications or other treatments would reverse the anhedonia observed in rats undergoing spontaneous nicotine or amphetamine withdrawal, defined operationally as elevated brain reward thresholds. |
2007-05-22 |
2023-08-12 |
rat |