| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuliya Nikolova, Ryan Bogdan, Diego A Pizzagall. Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness. Neuropsychobiology. vol 65. issue 1. 2012-04-10. PMID:22094432. |
given these findings, we hypothesized that exposure to a naturalistic stressor (school final examinations) would disrupt reward responsiveness (a key behavioral component of anhedonia), and that this effect would be strongest in s' participants. |
2012-04-10 |
2023-08-12 |
human |
| Birgit Abler, Georg Grön, Antonie Hartmann, Coraline Metzger, Martin Walte. Modulation of frontostriatal interaction aligns with reduced primary reward processing under serotonergic drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 4. 2012-03-12. PMID:22279217. |
downregulation of the reward system by serotonin has also been suggested as the mode of action accounting for unsatisfactory effects of serotonin reuptake inhibitors (ssris) such as insufficient alleviation or even increase of anhedonia, and loss of interest. |
2012-03-12 |
2023-08-12 |
human |
| Jamie Horder, Catherine J Harmer, Philip J Cowen, Ciara McCab. Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers. The international journal of neuropsychopharmacology. vol 13. issue 8. 2011-12-19. PMID:20426883. |
reduced subjective experience of reward (anhedonia) is a key symptom of major depression. |
2011-12-19 |
2023-08-12 |
human |
| Aaron N A Verty, Megan J Evetts, Geraldine J Crouch, Iain S McGregor, Aneta Stefanidis, Brian J Oldfiel. The cannabinoid receptor agonist THC attenuates weight loss in a rodent model of activity-based anorexia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 7. 2011-08-10. PMID:21412227. |
anorexia nervosa (an) is characterized by anhedonia whereby patients experience little pleasure or reward in many aspects of their lives. |
2011-08-10 |
2023-08-12 |
Not clear |
| Wei Wang, Dalong Sun, Bin Pan, Christopher J Roberts, Xinglai Sun, Cecilia J Hillard, Qing-song Li. Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 11. 2011-08-08. PMID:20664582. |
the nucleus accumbens (nac) is a critical component of the reward circuitry, and dysfunction of the nac may account for anhedonia and other symptoms of depression. |
2011-08-08 |
2023-08-12 |
mouse |
| Elsa Isingrini, Vincent Camus, Anne-Marie Le Guisquet, Maryse Pingaud, Séverine Devers, Catherine Belzun. Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice. PloS one. vol 5. issue 4. 2011-06-16. PMID:20436931. |
the results demonstrate that during the second procedure, ucms induced behavioural changes, including coat state degradation, disturbances in self-care behaviour (splash test) and anhedonia (reward maze test) and these were reversed by fluoxetine in the regular diet condition. |
2011-06-16 |
2023-08-12 |
mouse |
| Michael T Treadway, David H Zal. Reconsidering anhedonia in depression: lessons from translational neuroscience. Neuroscience and biobehavioral reviews. vol 35. issue 3. 2011-06-01. PMID:20603146. |
in the present review, we argue that this has resulted from an underspecified definition of anhedonia, which has failed to dissociate between consummatory and motivational aspects of reward behavior. |
2011-06-01 |
2023-08-12 |
Not clear |
| Michael T Treadway, David H Zal. Reconsidering anhedonia in depression: lessons from translational neuroscience. Neuroscience and biobehavioral reviews. vol 35. issue 3. 2011-06-01. PMID:20603146. |
given substantial preclinical evidence that da is involved primarily in motivational aspects of reward, we suggest that a refined definition of anhedonia that distinguishes between deficits in pleasure and motivation is essential for the purposes of identifying its neurobiological substrates. |
2011-06-01 |
2023-08-12 |
Not clear |
| Michael T Treadway, David H Zal. Reconsidering anhedonia in depression: lessons from translational neuroscience. Neuroscience and biobehavioral reviews. vol 35. issue 3. 2011-06-01. PMID:20603146. |
consequently, we introduce the term "decisional anhedonia" to address the influence of anhedonia on reward decision-making. |
2011-06-01 |
2023-08-12 |
Not clear |
| Naomi I Eisenberger, Elliot T Berkman, Tristen K Inagaki, Lian T Rameson, Nehjla M Mashal, Michael R Irwi. Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biological psychiatry. vol 68. issue 8. 2011-02-09. PMID:20719303. |
inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. |
2011-02-09 |
2023-08-12 |
Not clear |
| A Der-Avakian, A Marko. Neonatal maternal separation exacerbates the reward-enhancing effect of acute amphetamine administration and the anhedonic effect of repeated social defeat in adult rats. Neuroscience. vol 170. issue 4. 2011-01-18. PMID:20691770. |
these two disorders are often comorbid and characterized by anhedonia, defined as the reduced ability to experience pleasure or reward. |
2011-01-18 |
2023-08-12 |
rat |
| b' Simon Zhornitsky, St\\xc3\\xa9phane Potvin, Emmanuel Stip, Pierre-Paul Rompr\\xc3\\xa. Acute quetiapine dose-dependently exacerbates anhedonia induced by withdrawal from escalating doses of d-amphetamine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 10. 2010-12-22. PMID:20605419.' |
quetiapine attenuated reward in the vehicle-control animals, and amplified the anhedonia at the moderate, but not the low, dose in the animals under withdrawal. |
2010-12-22 |
2023-08-12 |
rat |
| Svetlana Semenova, Athina Marko. The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 10. 2010-12-22. PMID:20627663. |
based on phenomenological similarities between anhedonia (reward deficits) associated with drug withdrawal and the negative symptoms of schizophrenia, we showed previously that the atypical antipsychotic clozapine attenuated reward deficits associated with psychostimulant withdrawal. |
2010-12-22 |
2023-08-12 |
rat |
| Yulia Chentsova-Dutton, Kaitlin Hanle. The effects of anhedonia and depression on hedonic responses. Psychiatry research. vol 179. issue 2. 2010-10-26. PMID:20478624. |
we conclude that clinical reports of anhedonia and depression in a college student population primarily reflect low levels of anticipation of reward, and tendency to accurately estimate their enjoyment of future rewards. |
2010-10-26 |
2023-08-12 |
human |
| Karolina M Lempert, Diego A Pizzagall. Delay discounting and future-directed thinking in anhedonic individuals. Journal of behavior therapy and experimental psychiatry. vol 41. issue 3. 2010-08-10. PMID:20219184. |
as a first step to evaluate whether difficulties experiencing pleasure might affect delay discounting, 36 undergraduate students with varying levels of anhedonia performed a delay discounting task in which they made choices between a small immediate and larger future monetary reward. |
2010-08-10 |
2023-08-12 |
Not clear |
| Karolina M Lempert, Diego A Pizzagall. Delay discounting and future-directed thinking in anhedonic individuals. Journal of behavior therapy and experimental psychiatry. vol 41. issue 3. 2010-08-10. PMID:20219184. |
increasing levels of anhedonia (snaith-hamilton pleasure scale) were negatively associated with delay discounting rate, indicating that anhedonic individuals tended to choose the larger, albeit delayed reward. |
2010-08-10 |
2023-08-12 |
Not clear |
| Kerstin Brinkmann, Laurent Schüpbach, Isabelle Ancel Joye, Guido H E Gendoll. Anhedonia and effort mobilization in dysphoria: reduced cardiovascular response to reward and punishment. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. vol 74. issue 3. 2010-07-29. PMID:19808061. |
anhedonia and effort mobilization in dysphoria: reduced cardiovascular response to reward and punishment. |
2010-07-29 |
2023-08-12 |
human |
| Joe J Simon, Armin Biller, Stephan Walther, Daniela Roesch-Ely, Christoph Stippich, Matthias Weisbrod, Stefan Kaise. Neural correlates of reward processing in schizophrenia--relationship to apathy and depression. Schizophrenia research. vol 118. issue 1-3. 2010-07-13. PMID:20005675. |
impaired hedonic reward processing might contribute to the development of depressive symptoms in patients with schizophrenia, but it is not directly associated with self-rated anhedonia. |
2010-07-13 |
2023-08-12 |
Not clear |
| Yukihiko Shirayama, Shigeyuki Chak. Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents. Current neuropharmacology. vol 4. issue 4. 2010-06-10. PMID:18654637. |
given that clinical depression is marked by anhedonia (diminished interest or pleasure), dysfunction of the brain reward pathway has been suggested as contributing to the pathophysiology of depression.since the nac is the center of reward and learning, it is hypothesized that anhedonia might be produced by hampering the function of the nac. |
2010-06-10 |
2023-08-12 |
Not clear |
| Aaron S Heller, Tom Johnstone, Alexander J Shackman, Sharee N Light, Michael J Peterson, Gregory G Kolden, Ned H Kalin, Richard J Davidso. Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 52. 2010-02-17. PMID:20080793. |
these findings support the hypothesis that anhedonia in depressed patients reflects the inability to sustain engagement of structures involved in positive affect and reward. |
2010-02-17 |
2023-08-12 |
Not clear |