| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ciqing Bao, Qiaoyang Zhang, Haowen Zou, Chen He, Rui Yan, Lingling Hua, Qing Lu, Zhijian Ya. The reward positivity mediates the association between adverse childhood experiences and anhedonia in young adults with drug-naïve major depressive disorder. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2024-08-29. PMID:39209021. |
the reward positivity mediates the association between adverse childhood experiences and anhedonia in young adults with drug-naïve major depressive disorder. |
2024-08-29 |
2024-09-04 |
Not clear |
| Bianca T Leonard, Sarah M Kark, Steven J Granger, Joren G Adams, Liv McMillan, Michael A Yass. Anhedonia is associated with higher functional connectivity between the nucleus accumbens and paraventricular nucleus of thalamus. Journal of affective disorders. 2024-08-28. PMID:39197547. |
anhedonia stands as a life-threatening transdiagnostic feature of many mental illnesses, most notably major depression and involves neural circuits for processing reward information. |
2024-08-28 |
2024-09-01 |
Not clear |
| Cara Limpächer, Tordis Kindt, Jürgen Hoye. Counteract Anhedonia! Introducing an Online-Training to Enhance Reward Experiencing - A Pilot Study. Clinical psychology in Europe. vol 6. issue 2. 2024-08-09. PMID:39119054. |
this study presents the training to enhance reward experience (t-rex), a novel self-help approach that uses savoring and mental imagery to target impairments in reward experience associated with anhedonia. |
2024-08-09 |
2024-08-12 |
Not clear |
| María C Gutiérrez, María C Perondi, Gisella L Tortoni, Andrea B Cragnolini, Gabriel R Cuadra, Analía Valdomer. Early protein restriction in rats induces anhedonia in adult offspring: a key role of BDNF-TrkB signaling in the nucleus accumbens shell. Neuropharmacology. 2024-08-04. PMID:39098656. |
furthermore, perinatal protein-restriction-induced anhedonia correlated with increased bdnf and p-trkb protein levels in the nac, a core structure in the reward circuit linked with anhedonia. |
2024-08-04 |
2024-08-07 |
rat |
| Ziqian Cheng, Fangyi Zhao, Jingjing Piao, Wei Yang, Ranji Cui, Bingjin L. Rasd2 regulates depression-like behaviors via DRD2 neurons in the prelimbic cortex afferent to nucleus accumbens core circuit. Molecular psychiatry. 2024-08-03. PMID:39097664. |
depressive symptoms, such as anhedonia, decreased social interaction, and lack of motivation, implicate brain reward systems in the pathophysiology of depression. |
2024-08-03 |
2024-08-06 |
mouse |
| Jie Pu, Yi-Hang Huang, Hui Chen, Simon S Y Lui, Yi Wang, Raymond C K Cha. Differential manifestations of anhedonia in people with social anhedonia and subsyndromal depression. Asian journal of psychiatry. vol 100. 2024-08-01. PMID:39089075. |
we recruited 35 participants with high social anhedonia (sa), 53 participants with subsyndromal depression (sd), 20 participants with co-occurrence of both traits (co), and 47 participants with low levels of both traits (cn) to complete a self-report questionnaire capturing the pleasure experience, and the monetary incentives delay (mid) task and the social incentives delay (sid) task capturing the motivation of reward. |
2024-08-01 |
2024-08-05 |
human |
| Christina F Sandman, Michelle G Crask. Experiential processing increases positive affect and decreases dampening appraisals during autobiographical memory recall in an anhedonic sample. Behaviour research and therapy. vol 181. 2024-07-27. PMID:39067316. |
anhedonia is characterized by diminished reward processing, which may be explained in part by dampening appraisals, or thoughts that blunt positive emotions. |
2024-07-27 |
2024-08-02 |
human |
| Jiayang Xiao, Joshua A Adkinson, John Myers, Anusha B Allawala, Raissa K Mathura, Victoria Pirtle, Ricardo Najera, Nicole R Provenza, Eleonora Bartoli, Andrew J Watrous, Denise Oswalt, Ron Gadot, Adrish Anand, Ben Shofty, Sanjay J Mathew, Wayne K Goodman, Nader Pouratian, Xaq Pitkow, Kelly R Bijanki, Benjamin Hayden, Sameer A Shet. Beta activity in human anterior cingulate cortex mediates reward biases. Nature communications. vol 15. issue 1. 2024-07-15. PMID:39009561. |
our findings suggest that acc beta oscillations may orchestrate the learning of reward information to guide adaptive choice, and, more broadly, suggest a potential biomarker for anhedonia and point to future development of interventions to enhance reward impact for therapeutic benefit. |
2024-07-15 |
2024-07-18 |
human |
| Koen Demyttenaer. Aticaprant, a kappa opioid receptor antagonist, and the recovered 'interest and pleasure' in the concept of major depressive disorder. European archives of psychiatry and clinical neuroscience. 2024-07-05. PMID:38969753. |
anhedonia is a multifaceted concept: the clinical language describes anticipatory/consummatory anhedonia and sensory/social anhedonia while the cognitive neuroscience language describes readiness for reward, energy expenditure to attain reward, updating reward presence and value. |
2024-07-05 |
2024-07-08 |
Not clear |
| E J Hird, A Slanina-Davies, G Lewis, M Hamer, J P Roise. From movement to motivation: a proposed framework to understand the antidepressant effect of exercise. Translational psychiatry. vol 14. issue 1. 2024-07-03. PMID:38961071. |
drawing on a broad range of research in humans and animals, we propose that by reducing inflammation and boosting dopamine transmission, with consequent effects on effort-based decision making for reward, exercise initially specifically improves 'interest-activity' symptoms of depression-namely anhedonia, fatigue and subjective cognitive impairment - by increasing propensity to exert effort. |
2024-07-03 |
2024-07-08 |
Not clear |
| Minjee Jung, Kyu-Man Ha. Behavioral Activation and Brain Network Changes in Depression. Journal of clinical neurology (Seoul, Korea). vol 20. issue 4. 2024-07-02. PMID:38951971. |
there are clear links between the neural mechanisms underlying reward processing and ba treatment for depressive symptoms, including anhedonia; however, integrated interpretations of these two domains are lacking. |
2024-07-02 |
2024-07-04 |
Not clear |
| Paloma Martinez Gonzalez, Amaya R Jenkins, Kayleigh S LaMalfa, Brian D Kanga. Chronic ecologically relevant stress effects on reverse-translated touchscreen assays of reward responsivity and attentional processes in male rats: Implications for depression. Journal of neurochemistry. 2024-06-26. PMID:38922872. |
these tasks previously have been reverse-translated using touchscreen technology for rodents and nonhuman primates to objectively quantify, respectively, reward responsivity (anhedonia) and attentional processes (impaired cognitive function), each of which are core features of major depressive disorder. |
2024-06-26 |
2024-06-29 |
human |
| Liliana Patarroyo-Rodriguez, Stefanie Cavalcanti, Jennifer L Vande Voort, Balwinder Sing. The Use of Ketamine for the Treatment of Anhedonia in Depression. CNS drugs. 2024-06-23. PMID:38910222. |
anhedonia, a complex symptom rooted in deficits across reward processes, is primarily linked to depression and schizophrenia but transcends diagnostic boundaries across various mental disorders. |
2024-06-23 |
2024-06-26 |
Not clear |
| Shakila Meshkat, Angela T H Kwan, Gia Han Le, Sabrina Wong, Taeho Greg Rhee, Roger Ho, Kayla M Teopiz, Bing Cao, Roger S McIntyr. The role of KCNQ channel activators in management of major depressive disorder. Journal of affective disorders. 2024-05-21. PMID:38772507. |
recent preclinical evidence suggests that kcnq channels, particularly kcnq3, contribute to the regulation of neuronal excitability within the reward circuitry, offering a potential target for alleviating depressive symptoms, notably anhedonia. |
2024-05-21 |
2024-05-27 |
human |
| Hailing Wen, Menglin Wu, Zhao Wang, Bo Gao, Ya Zhen. Aberrant effort-based reward dynamics in anhedonia. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 5. 2024-05-14. PMID:38741268. |
aberrant effort-based reward dynamics in anhedonia. |
2024-05-14 |
2024-05-27 |
Not clear |
| Hailing Wen, Menglin Wu, Zhao Wang, Bo Gao, Ya Zhen. Aberrant effort-based reward dynamics in anhedonia. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 5. 2024-05-14. PMID:38741268. |
anhedonia is a transdiagnostic symptom and associated with a spectrum of reward deficits among which the motivational dysfunction is poorly understood. |
2024-05-14 |
2024-05-27 |
Not clear |
| Hailing Wen, Menglin Wu, Zhao Wang, Bo Gao, Ya Zhen. Aberrant effort-based reward dynamics in anhedonia. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 5. 2024-05-14. PMID:38741268. |
our findings suggest that anhedonia is associated with an inefficient control and motivation allocation along the efforted-based reward dynamics from effort preparation to effort production. |
2024-05-14 |
2024-05-27 |
Not clear |
| Magdalena Ferstl, Anne Kühnel, Johannes Klaus, Wy Ming Lin, Nils B Kroeme. Non-invasive vagus nerve stimulation conditions increased invigoration and wanting in depression. Comprehensive psychiatry. vol 132. 2024-04-24. PMID:38657358. |
major depressive disorder (mdd) is often marked by impaired motivation and reward processing, known as anhedonia. |
2024-04-24 |
2024-04-28 |
human |
| Min Gao, Megan Kirk, Eva Lash, Heather Knight, Moscho Michalopoulou, Nicola Guess, Michael Browning, Scott Weich, Philip Burnet, Susan A Jebb, Richard Stevens, Paul Aveyar. Evaluating the efficacy and mechanisms of a ketogenic diet as adjunctive treatment for people with treatment-resistant depression: A protocol for a randomised controlled trial. Journal of psychiatric research. vol 174. 2024-04-23. PMID:38653031. |
some case reports suggest that ketogenic diets (kds) may improve some mental illnesses, and preclinical data indicate that kds can influence brain reward signalling, anhedonia, cortisol, and gut microbiome which are associated with depression. |
2024-04-23 |
2024-04-26 |
Not clear |
| Filippo Queirazza, Jonathan Cavanagh, Marios G Philiastides, Rajeev Krishnada. Mild exogenous inflammation blunts neural signatures of bounded evidence accumulation and reward prediction error processing in healthy male participants. Brain, behavior, and immunity. 2024-03-31. PMID:38555987. |
so far, it has been reported that blunted mesolimbic dopamine reward signals are associated with inflammation-induced anhedonia and apathy. |
2024-03-31 |
2024-04-03 |
human |