| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meghan Vinograd, Michelle G Crask. Using Neuroscience to Augment Behavioral Interventions for Depression. Harvard review of psychiatry. vol 28. issue 1. 2021-06-07. PMID:31913979. |
neuroscience research has increased our understanding of the neural bases of reward processing and regulation of positive affect, and anhedonia among depressed samples can be related to deficits in each of these domains. |
2021-06-07 |
2023-08-13 |
Not clear |
| Meghan Vinograd, Michelle G Crask. Using Neuroscience to Augment Behavioral Interventions for Depression. Harvard review of psychiatry. vol 28. issue 1. 2021-06-07. PMID:31913979. |
treatments that specifically target reward processing and regulation of positive affect in order to reduce anhedonia represent a recent advance in the field. |
2021-06-07 |
2023-08-13 |
Not clear |
| Ann F Haynos, Lisa M Anderson, Autumn J Askew, Michelle G Craske, Carol B Peterso. Adapting a neuroscience-informed intervention to alter reward mechanisms of anorexia nervosa: a novel direction for future research. Journal of eating disorders. vol 9. issue 1. 2021-05-30. PMID:34039415. |
this pattern of reward processing likely perpetuates eating-disorder symptoms, as the rewards derived from eating-disorder behaviors provide temporary relief from the anhedonia associated with limited responsivity to other rewards. |
2021-05-30 |
2023-08-13 |
Not clear |
| Ann F Haynos, Lisa M Anderson, Autumn J Askew, Michelle G Craske, Carol B Peterso. Adapting a neuroscience-informed intervention to alter reward mechanisms of anorexia nervosa: a novel direction for future research. Journal of eating disorders. vol 9. issue 1. 2021-05-30. PMID:34039415. |
positive affect treatment (pat) is a cognitive-behavioral intervention designed to target reward deficits that contribute to anhedonia in mood and anxiety disorders, including problems with reward anticipation, experiencing, and learning. |
2021-05-30 |
2023-08-13 |
Not clear |
| Jonathan D Hakim, Jason Chami, Kevin A Kea. μ-Opioid and dopamine-D2 receptor expression in the nucleus accumbens of male Sprague-Dawley rats whose sucrose consumption, but not preference, decreases after nerve injury. Behavioural brain research. vol 381. 2021-05-26. PMID:31836522. |
functional-anatomical changes in reward related brain circuits are described in chronic pain patients who report anhedonia or depressed mood. |
2021-05-26 |
2023-08-13 |
rat |
| Laura Crucianelli, Benedetta Demartini, Diana Goeta, Veronica Nisticò, Alkistis Saramandi, Sara Bertelli, Patrizia Todisco, Orsola Gambini, Aikaterini Fotopoulo. The Anticipation and Perception of Affective Touch in Women with and Recovered from Anorexia Nervosa. Neuroscience. vol 464. 2021-05-24. PMID:32937191. |
disruptions in reward processing and anhedonia have long been observed in anorexia nervosa (an). |
2021-05-24 |
2023-08-13 |
Not clear |
| Andrew S Huhn, Robert K Brooner, Mary M Sweeney, Denis Antoine, Alexis S Hammond, Hasan Ayaz, Kelly E Dun. The association of prefrontal cortex response during a natural reward cue-reactivity paradigm, anhedonia, and demoralization in persons maintained on methadone. Addictive behaviors. vol 113. 2021-05-14. PMID:33022538. |
the association of prefrontal cortex response during a natural reward cue-reactivity paradigm, anhedonia, and demoralization in persons maintained on methadone. |
2021-05-14 |
2023-08-13 |
human |
| Andrew S Huhn, Robert K Brooner, Mary M Sweeney, Denis Antoine, Alexis S Hammond, Hasan Ayaz, Kelly E Dun. The association of prefrontal cortex response during a natural reward cue-reactivity paradigm, anhedonia, and demoralization in persons maintained on methadone. Addictive behaviors. vol 113. 2021-05-14. PMID:33022538. |
participants who reported clinically-significant anhedonia on the shps displayed decreased neural activity in the right prefrontal cortex (pfc) in response to natural reward cues (f(1,25) = 3.612, p = 0.027, η |
2021-05-14 |
2023-08-13 |
human |
| Laith Alexander, Rana Banai-Tizkar, Christian M Wood, Angela C Robert. Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning. STAR protocols. vol 2. issue 2. 2021-05-14. PMID:33982011. |
blunted reward responsivity is associated with anhedonia in humans and is a core feature of depression. |
2021-05-14 |
2023-08-13 |
marmoset |
| Mandakh Bekhbat, Michael T Treadway, David R Goldsmith, Bobbi J Woolwine, Ebrahim Haroon, Andrew H Miller, Jennifer C Felge. Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32198016. |
we have previously shown that high inflammation as measured by c-reactive protein (crp) in mdd patients is associated with symptoms of anhedonia, a core symptom of mdd, along with deficits in dopaminergic reward circuitry. |
2021-04-27 |
2023-08-13 |
Not clear |
| Mandakh Bekhbat, Michael T Treadway, David R Goldsmith, Bobbi J Woolwine, Ebrahim Haroon, Andrew H Miller, Jennifer C Felge. Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32198016. |
increased inflammation can shift metabolic demand and reprogram cellular energy sources, which may collectively impact the brain and reward processing to contribute to symptoms of anhedonia. |
2021-04-27 |
2023-08-13 |
Not clear |
| Albert J Fenoy, Joao Quevedo, Jair C Soare. Deep brain stimulation of the "medial forebrain bundle": a strategy to modulate the reward system and manage treatment-resistant depression. Molecular psychiatry. 2021-04-27. PMID:33903731. |
we will focus on the reward system, an evolutionarily conserved pathway whose underperformance leads to anhedonia and lack of motivation, which are key traits in depression. |
2021-04-27 |
2023-08-13 |
human |
| Amita R Somalwar, Amit G Choudhary, Nagalakshmi Balasubramanian, Amul J Sakharkar, Nishikant K Subhedar, Dadasaheb M Kokar. Cocaine- and amphetamine-regulated transcript peptide promotes reward seeking behavior in socially isolated rats. Brain research. vol 1728. 2021-04-23. PMID:31830460. |
reward deficit, expressed as anhedonia, is one of the major symptoms associated with neuropsychiatric disorders, but the underlying maladaptations have not been understood. |
2021-04-23 |
2023-08-13 |
rat |
| Amita R Somalwar, Amit G Choudhary, Nagalakshmi Balasubramanian, Amul J Sakharkar, Nishikant K Subhedar, Dadasaheb M Kokar. Cocaine- and amphetamine-regulated transcript peptide promotes reward seeking behavior in socially isolated rats. Brain research. vol 1728. 2021-04-23. PMID:31830460. |
we suggest that down-regulation of endogenous cartergic system in the lh-pvta-acbsh reward circuitry may be causal to motivational anhedonia like phenotype seen in neuropsychiatric conditions. |
2021-04-23 |
2023-08-13 |
rat |
| Sari Goldstein Ferber, Aron Weller, Gal Yadid, Alexander Friedma. Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico-Striatal Loop That Are Implicated in Major Depression. International journal of molecular sciences. vol 22. issue 4. 2021-04-15. PMID:33668515. |
depression, the most prevalent psychiatric disorder in the western world, is characterized by increased negative affect (i.e., depressed mood, cost value increase) and reduced positive affect (i.e., anhedonia, reward value decrease), fatigue, loss of appetite, and reduced psychomotor activity except for cases of agitative depression. |
2021-04-15 |
2023-08-13 |
Not clear |
| A O Kibitov, G E Maz. [Anhedonia in depression: neurobiological and genetic aspects]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 121. issue 3. 2021-04-12. PMID:33834733. |
neurobiological mechanisms of anhedonia are impaired functioning of the reward system of the brain, which is confirmed by many neuroimaging, genetic and experimental studies. |
2021-04-12 |
2023-08-13 |
Not clear |
| Claudie Gaillard, Matthias Guillod, Monique Ernst, Andrea Federspiel, Dominik Schoebi, Romina Evelyn Recabarren, Xinyi Ouyang, Christoph Mueller-Pfeiffer, Antje Horsch, Philipp Homan, Roland Wiest, Gregor Hasler, Chantal Martin-Soelc. Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study. NeuroImage. Clinical. vol 26. 2021-03-26. PMID:32036303. |
anhedonia, a core symptom of major depressive disorder (mdd), manifests as a lack or loss of motivation as reflected by decreased reward responsiveness, at both behavioral and neural (i.e., striatum) levels. |
2021-03-26 |
2023-08-13 |
Not clear |
| D Chamith Halahakoon, Karel Kieslich, Ciarán O'Driscoll, Akshay Nair, Glyn Lewis, Jonathan P Roise. Reward-Processing Behavior in Depressed Participants Relative to Healthy Volunteers: A Systematic Review and Meta-analysis. JAMA psychiatry. vol 77. issue 12. 2021-03-11. PMID:32725180. |
dysfunctional reward processing is a leading candidate mechanism for the development of certain depressive symptoms, such as anhedonia. |
2021-03-11 |
2023-08-13 |
human |
| Jennifer C Felger, Ebrahim Haroon, Trusharth A Patel, David R Goldsmith, Evanthia C Wommack, Bobbi J Woolwine, Ngoc-Anh Le, Rachel Feinberg, Malu G Tansey, Andrew H Mille. What does plasma CRP tell us about peripheral and central inflammation in depression? Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:29895893. |
furthermore, increased peripheral blood crp in mdd has been associated with altered reward circuitry and increased brain glutamate in relation with symptoms of anhedonia. |
2021-03-09 |
2023-08-13 |
Not clear |
| Chloe C Boyle, Annette L Stanton, Naomi I Eisenberger, Teresa E Seeman, Julienne E Bowe. Effects of stress-induced inflammation on reward processing in healthy young women. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31580931. |
further, although anhedonia may reflect dysregulation in multiple dimensions of reward, the extent to which stress-induced inflammation alters these dimensions is unclear. |
2021-03-08 |
2023-08-13 |
human |