| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Höflich, Paul Michenthaler, Siegfried Kasper, Rupert Lanzenberge. Circuit Mechanisms of Reward, Anhedonia, and Depression. The international journal of neuropsychopharmacology. vol 22. issue 2. 2020-01-27. PMID:30239748. |
based on this information, the impact of different therapeutic approaches on reward processing is described with a particular focus on deep brain stimulation (dbs) as a possibility for a direct modulation of human brain structures in vivo.overall, results of current studies emphasize the importance of anhedonia in psychiatric disorders and the relevance of targeting this phenotype for a successful psychiatric treatment. |
2020-01-27 |
2023-08-13 |
human |
| Manpreet K Singh, Sara M Leslie, Mary Melissa Packer, Yevgeniya V Zaiko, Owen R Phillips, Elizabeth F Weisman, Danielle M Wall, Booil Jo, Natalie Rasgo. Brain and behavioral correlates of insulin resistance in youth with depression and obesity. Hormones and behavior. vol 108. 2020-01-22. PMID:29596854. |
we found that youth with greater insulin resistance had higher levels of anhedonia and more food seeking behaviors, reduced hippocampal and acc volumes, and greater levels of acc and hippocampal dysconnectivity to fronto-limbic reward networks at rest. |
2020-01-22 |
2023-08-13 |
Not clear |
| Isobel W Green, Diego A Pizzagalli, Roee Admon, Poornima Kuma. Anhedonia modulates the effects of positive mood induction on reward-related brain activation. NeuroImage. vol 193. 2019-12-20. PMID:30831312. |
blunted activation in the reward circuitry has been associated with anhedonia, the inability to experience pleasure in previously rewarding activities. |
2019-12-20 |
2023-08-13 |
human |
| Isobel W Green, Diego A Pizzagalli, Roee Admon, Poornima Kuma. Anhedonia modulates the effects of positive mood induction on reward-related brain activation. NeuroImage. vol 193. 2019-12-20. PMID:30831312. |
accordingly, blunted reward response in anhedonia might involve a failure to appropriately modulate reward-related activation as a function of context. |
2019-12-20 |
2023-08-13 |
human |
| J.-L. Moreau, R. Scherschlicht, F. Jenck, J.R. Marti. Chronic mild stress-induced anhedonia model of depression; sleep abnormalities and curative effects of electroshock treatment. Behavioural pharmacology. vol 6. issue 7. 2019-11-20. PMID:11224370. |
anhedonia, measured as subsensitivity to reward, can be induced in rats by a regimen of repeated, mild, unpredictable stressors. |
2019-11-20 |
2023-08-12 |
human |
| Anka A Vujanovic, Margaret C Wardle, Lia J Smith, Erin C Beren. Reward functioning in posttraumatic stress and substance use disorders. Current opinion in psychology. vol 14. 2019-11-20. PMID:28813319. |
anhedonia, defined as a lack of pleasure from or interest in rewards, stems from deficits in reward functioning and is associated with specific neurocircuitries. |
2019-11-20 |
2023-08-13 |
Not clear |
| Fang Shen, Keke Qi, Ying Duan, Yonghui Li, Jing Liang, Xiaolu Meng, Ming Li, Nan Su. Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews. Journal of psychopharmacology (Oxford, England). vol 32. issue 10. 2019-10-30. PMID:30182783. |
anhedonia is a hallmark symptom in major depression that reflects deficits in hedonic capacity and it is also linked to motivation for reward. |
2019-10-30 |
2023-08-13 |
Not clear |
| Bao-Juan Li, Karl Friston, Maria Mody, Hua-Ning Wang, Hong-Bing Lu, De-Wen H. A brain network model for depression: From symptom understanding to disease intervention. CNS neuroscience & therapeutics. vol 24. issue 11. 2019-10-11. PMID:29931740. |
elevated connectivity of a ventral limbic affective network appears to be associated with excessive negative mood (dysphoria) in the patients; decreased connectivity of a frontal-striatal reward network has been suggested to account for loss of interest, motivation, and pleasure (anhedonia); enhanced default mode network connectivity seems to be associated with depressive rumination; and diminished connectivity of a dorsal cognitive control network is thought to underlie cognitive deficits especially ineffective top-down control of negative thoughts and emotions in depressed patients. |
2019-10-11 |
2023-08-13 |
Not clear |
| Andre Der-Avakian, Diego A Pizzagall. Translational Assessments of Reward and Anhedonia: A Tribute to Athina Markou. Biological psychiatry. vol 83. issue 11. 2019-09-09. PMID:29615189. |
translational assessments of reward and anhedonia: a tribute to athina markou. |
2019-09-09 |
2023-08-13 |
Not clear |
| Andre Der-Avakian, Diego A Pizzagall. Translational Assessments of Reward and Anhedonia: A Tribute to Athina Markou. Biological psychiatry. vol 83. issue 11. 2019-09-09. PMID:29615189. |
loss of pleasure (clinically referred to as anhedonia), impairments in other reward-related processes such as reward learning, motivation, and reward valuation, and blunted affect characterize several mood and other psychiatric disorders. |
2019-09-09 |
2023-08-13 |
Not clear |
| Liang Gong, Cancan He, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Chunming Xi. Disrupted reward and cognitive control networks contribute to anhedonia in depression. Journal of psychiatric research. vol 103. 2019-09-03. PMID:29783076. |
disrupted reward and cognitive control networks contribute to anhedonia in depression. |
2019-09-03 |
2023-08-13 |
human |
| Liang Gong, Cancan He, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Chunming Xi. Disrupted reward and cognitive control networks contribute to anhedonia in depression. Journal of psychiatric research. vol 103. 2019-09-03. PMID:29783076. |
neuroimaging studies have identified that anhedonia, a core feature of major depressive disorder (mdd), is associated with dysfunction in reward and cognitive control processing. |
2019-09-03 |
2023-08-13 |
human |
| Liang Gong, Cancan He, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Chunming Xi. Disrupted reward and cognitive control networks contribute to anhedonia in depression. Journal of psychiatric research. vol 103. 2019-09-03. PMID:29783076. |
however, it is still not clear how the reward network (β-network) and the cognitive control network (δ-network) are linked to biased anhedonia in mdd patients. |
2019-09-03 |
2023-08-13 |
human |
| Simona Scheggi, Maria Graziella De Montis, Carla Gambaran. Making Sense of Rodent Models of Anhedonia. The international journal of neuropsychopharmacology. vol 21. issue 11. 2019-08-29. PMID:30239762. |
this condition can be labeled as "anhedonia," although in its most rigorous connotation the term refers to the lost capacity to feel pleasure that is one aspect of the complex phenomenon of processing and responding to reward. |
2019-08-29 |
2023-08-13 |
Not clear |
| Marina Šagud, Ivona Šimunović Filipčić, Nenad Jakšić, Lucija Šimunić, Dejana Jezernik, Lucija Tudor, Zoran Madžarac, Ivana Stefanović, Biljana Kosanović Rajačić, Alma Mihaljević-Peleš, Bjanka Vuksan-Ćusa, Suzan Kudlek Mikulić, Nela Piva. Anhedonia in Schizophrenia: Mini-Review. Psychiatria Danubina. vol 31. issue Suppl 2. 2019-08-26. PMID:31158114. |
while gene-environment interactions affect reward circuity, anhedonia modulates clinical features, such as suicidality and nicotine consumption. |
2019-08-26 |
2023-08-13 |
human |
| Joan L Luby, Arpana Agrawal, Andy Belden, Diana Whalen, Rebecca Tillman, Deanna M Barc. Developmental Trajectories of the Orbitofrontal Cortex and Anhedonia in Middle Childhood and Risk for Substance Use in Adolescence in a Longitudinal Sample of Depressed and Healthy Preschoolers. The American journal of psychiatry. vol 175. issue 10. 2019-08-19. PMID:29558817. |
volume reductions of the orbitofrontal cortex and the striatum, regions that subserve neural response to reward, have been shown to be related to anhedonia in depressive and substance use disorders. |
2019-08-19 |
2023-08-13 |
Not clear |
| Laith Alexander, Philip L R Gaskin, Stephen J Sawiak, Tim D Fryer, Young T Hong, Gemma J Cockcroft, Hannah F Clarke, Angela C Robert. Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex. Neuron. vol 101. issue 2. 2019-08-12. PMID:30528065. |
fractionating blunted reward processing characteristic of anhedonia by over-activating primate subgenual anterior cingulate cortex. |
2019-08-12 |
2023-08-13 |
monkey |
| Eeske van Roekel, Vera E Heininga, Charlotte Vrijen, Evelien Snippe, Albertine J Oldehinke. Reciprocal associations between positive emotions and motivation in daily life: Network analyses in anhedonic individuals and healthy controls. Emotion (Washington, D.C.). vol 19. issue 2. 2019-06-18. PMID:29672074. |
anhedonia reflects a dysfunction in the reward system, which can be manifested in an inability to enjoy pleasurable situations (i.e., lack of positive emotions), but also by a lack of motivation to engage in pleasurable activities (i.e., lack of motivation). |
2019-06-18 |
2023-08-13 |
human |
| Rose-Marie Karlsson, Alice S Wang, Anup N Sonti, Heather A Camero. Adult neurogenesis affects motivation to obtain weak, but not strong, reward in operant tasks. Hippocampus. vol 28. issue 7. 2019-06-17. PMID:29663595. |
this anhedonia, or apathy, likely reflects impairment in reward circuitry, but the specific neuronal populations controlling motivation are unclear. |
2019-06-17 |
2023-08-13 |
mouse |
| Paige Ethridge, Aislinn Sandre, Melanie A Dirks, Anna Weinber. Past-year relational victimization is associated with a blunted neural response to rewards in emerging adults. Social cognitive and affective neuroscience. vol 13. issue 12. 2019-06-17. PMID:30307568. |
emerging evidence suggests that anhedonia is the result of interactions between life stress and the brain's reward systems, and that social stress, in particular, may drive these processes. |
2019-06-17 |
2023-08-13 |
Not clear |