| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jurre den Haan, Sarah F Janssen, Jacoba A van de Kreeke, Philip Scheltens, Frank D Verbraak, Femke H Bouwma. Retinal thickness correlates with parietal cortical atrophy in early-onset Alzheimer's disease and controls. Alzheimer's & dementia (Amsterdam, Netherlands). vol 10. 2020-10-01. PMID:29201990. |
the retina may reflect alzheimer's disease (ad) neuropathological changes and is easily visualized with optical coherence tomography (oct). |
2020-10-01 |
2023-08-13 |
Not clear |
| David Tes, Karl Kratkiewicz, Ahmed Aber, Luke Horton, Mohsin Zafar, Nour Arafat, Afreen Fatima, Mohammad Rn Avanak. Development and Optimization of a Fluorescent Imaging System to Detect Amyloid-β Proteins: Phantom Study. Biomedical engineering and computational biology. vol 9. 2020-10-01. PMID:29977121. |
during the progression of alzheimer disease, a particular protein begins to accumulate in the brain and also in extensions of the brain, ie, the retina. |
2020-10-01 |
2023-08-13 |
Not clear |
| Benjamin J Kim, Murray Grossman, Delu Song, Samantha Saludades, Wei Pan, Sophia Dominguez-Perez, Joshua L Dunaief, Tomas S Aleman, Gui-Shuang Ying, David J Irwi. Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31019447. |
while alzheimer's disease is associated with inner retina thinning measured by spectral-domain optical coherence tomography (sd-oct), our previous cross-sectional study suggested outer retina thinning in frontotemporal degeneration (ftd) patients compared to controls without neurodegenerative disease; we sought to evaluate longitudinal changes of this potential biomarker. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jennifer Ngolab, Patrick Honma, Robert A Rissma. Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. Neurology and therapy. vol 8. issue Suppl 2. 2020-10-01. PMID:31833024. |
reflections on the utility of the retina as a biomarker for alzheimer's disease: a literature review. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jennifer Ngolab, Patrick Honma, Robert A Rissma. Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. Neurology and therapy. vol 8. issue Suppl 2. 2020-10-01. PMID:31833024. |
indeed, a concerted effort has been put forth to understand how alzheimer's disease (ad) pathology may manifest in the retina as a means to assess the state of the ad brain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Peter J Snyder, Lenworth N Johnson, Yen Ying Lim, Cláudia Y Santos, Jessica Alber, Paul Maruff, Brian Fernánde. Nonvascular retinal imaging markers of preclinical Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 4. 2020-09-30. PMID:27830174. |
in patients with alzheimer's disease (ad) and mild cognitive impairment, structural changes in the retina (i.e., reduced thicknesses of the ganglion cell and retinal nerve fiber layers and inclusion bodies that appear to contain beta-amyloid protein [ab]) have been previously reported. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jiangling Jiang, Hongyan Wang, Wei Li, Xinyi Cao, Chunbo L. Amyloid Plaques in Retina for Diagnosis in Alzheimer's Patients: a Meta-Analysis. Frontiers in aging neuroscience. vol 8. 2020-09-30. PMID:27891091. |
amyloid plaques in retina for diagnosis in alzheimer's patients: a meta-analysis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jonah Doustar, Tania Torbati, Keith L Black, Yosef Koronyo, Maya Koronyo-Hamaou. Optical Coherence Tomography in Alzheimer's Disease and Other Neurodegenerative Diseases. Frontiers in neurology. vol 8. 2020-09-30. PMID:29312125. |
over the past decade, a surge of evidence has documented various pathological processes in the retina of patients suffering from mild cognitive impairment, alzheimer's disease (ad), parkinson's disease (pd), and other neurodegenerative diseases. |
2020-09-30 |
2023-08-13 |
Not clear |
| Alfonso Grimaldi, Natalia Pediconi, Francesca Oieni, Rocco Pizzarelli, Maria Rosito, Maria Giubettini, Tiziana Santini, Cristina Limatola, Giancarlo Ruocco, Davide Ragozzino, Silvia Di Angelantoni. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31551688. |
neuroinflammatory processes, a1 astrocyte activation and protein aggregation in the retina of alzheimer's disease patients, possible biomarkers for early diagnosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rameshwar Patil, Yosef Koronyo, Alexander V Ljubimov, Brenda Salumbides, Adam Mamelak, Pallavi R Gangalum, Hui Ding, Jose Portilla-Arias, Eggehard Holler, Pramod Butte, Maya Koronyo-Hamaoui, Julia Y Ljubimova, Keith L Blac. Advances in Imaging: Brain Tumors to Alzheimer's Disease. The Bangkok medical journal. vol 10. 2020-09-29. PMID:29142857. |
in the detection of alzheimer disease, amyloid plaque is deposited in retina tissue (including the rgc, rnfl and inner plexiform layer) which can produce a fluorescence effect by using curcumin as a contrast. |
2020-09-29 |
2023-08-13 |
mouse |
| Natalia A Muraleva, Oyuna S Kozhevnikova, Anzhela Z Fursova, Nataliya G Kolosov. Suppression of AMD-Like Pathology by Mitochondria-Targeted Antioxidant SkQ1 Is Associated with a Decrease in the Accumulation of Amyloid β and in mTOR Activity. Antioxidants (Basel, Switzerland). vol 8. issue 6. 2020-09-29. PMID:31208023. |
recent studies strongly indicate that amyloid β (aβ) accumulation -found in the brain and a defining feature of alzheimer's disease-also forms in the retina in both alzheimer's disease and amd. |
2020-09-29 |
2023-08-13 |
rat |
| Savannah A Lynn, Eloise Keeling, Rosie Munday, Gagandeep Gabha, Helen Griffiths, Andrew J Lotery, J Arjuna Ratnayak. The complexities underlying age-related macular degeneration: could amyloid beta play an important role? Neural regeneration research. vol 12. issue 4. 2020-09-28. PMID:28553324. |
the discovery of this key driver of alzheimer's disease in the senescent retina was unexpected and surprising, enabling an altogether different perspective of amd. |
2020-09-28 |
2023-08-13 |
mouse |
| Jurre den Haan, Jacoba A van de Kreeke, Bart N van Berckel, Frederik Barkhof, Charlotte E Teunissen, Philip Scheltens, Frank D Verbraak, Femke H Bouwma. Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease? Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2020-09-28. PMID:31193094. |
the retina is a potential source of noninvasive vascular biomarkers for alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Samuel Chiquita, Elisa J Campos, João Castelhano, Mário Ribeiro, José Sereno, Paula I Moreira, Miguel Castelo-Branco, António Francisco Ambrósi. Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31722748. |
however, concerning alzheimer's disease (ad), it still remains controversial whether changes occurring in the brain and retina are associated. |
2020-08-06 |
2023-08-13 |
mouse |
| R N Guliyev. [Assessment of changes in the retina of patients with Alzheimer's disease]. Vestnik oftalmologii. vol 136. issue 3. 2020-08-03. PMID:32504480. |
[assessment of changes in the retina of patients with alzheimer's disease]. |
2020-08-03 |
2023-08-13 |
Not clear |
| Javed Iqbal, Kaoyuan Zhang, Na Jin, Yuxi Zhao, Xukun Liu, Qiong Liu, Jiazuan Ni, Liming She. Alzheimer's Disease Is Responsible for Progressive Age-Dependent Differential Expression of Various Protein Cascades in Retina of Mice. ACS chemical neuroscience. vol 10. issue 5. 2020-05-29. PMID:30695639. |
alzheimer's disease is responsible for progressive age-dependent differential expression of various protein cascades in retina of mice. |
2020-05-29 |
2023-08-13 |
mouse |
| Gema Esquiva, Jens Hanniba. Melanopsin-expressing retinal ganglion cells in aging and disease. Histology and histopathology. vol 34. issue 12. 2020-05-18. PMID:31219170. |
in this review, we briefly summarise the melanopsin system in the normal retina and discuss its role in connection to human aging (sleep/wake problems) and retinal pathology in alzheimer and parkinson diseases, diabetic retinopathy, mitochondrial optic neuropathies, glaucoma, retinitis pigmentosa, and in photophobia during migraine and in seasonal affective disorder (sad). |
2020-05-18 |
2023-08-13 |
human |
| Elena Salobrar-García, Rosa de Hoz, Ana I Ramírez, Inés López-Cuenca, Pilar Rojas, Ravi Vazirani, Carla Amarante, Raquel Yubero, Pedro Gil, María D Pinazo-Durán, Juan J Salazar, José M Ramíre. Changes in visual function and retinal structure in the progression of Alzheimer's disease. PloS one. vol 14. issue 8. 2020-03-05. PMID:31415594. |
alzheimer's disease (ad) can cause degeneration in the retina and optic nerve either directly, as a result of amyloid beta deposits, or secondarily, as a result of the degradation of the visual cortex. |
2020-03-05 |
2023-08-13 |
Not clear |
| Ana Nunes, Gilberto Silva, Cristina Duque, Cristina Januário, Isabel Santana, António Francisco Ambrósio, Miguel Castelo-Branco, Rui Bernarde. Retinal texture biomarkers may help to discriminate between Alzheimer's, Parkinson's, and healthy controls. PloS one. vol 14. issue 6. 2020-03-02. PMID:31226150. |
a top priority in biomarker development for alzheimer's disease (ad) and parkinson's disease (pd) is the focus on early diagnosis, where the use of the retina is a promising avenue of research. |
2020-03-02 |
2023-08-13 |
human |
| Einar Stefánsson, Olof Birna Olafsdottir, Thorunn S Eliasdottir, Wouter Vehmeijer, Anna Bryndis Einarsdottir, Toke Bek, Thomas Lee Torp, Jakob Grauslund, Thor Eysteinsson, Robert Arnar Karlsson, Karel Van Keer, Ingeborg Stalmans, Evelien Vandewalle, Margarita G Todorova, Martin Hammer, Gerhard Garhöfer, Leopold Schmetterer, Martin Šín, Sveinn Hakon Hardarso. Retinal oximetry: Metabolic imaging for diseases of the retina and brain. Progress in retinal and eye research. vol 70. 2020-02-07. PMID:30999027. |
oximetry biomarkers have been discovered in alzheimer's disease and multiple sclerosis and oxygen levels in the retina correspond well with brain. |
2020-02-07 |
2023-08-13 |
Not clear |