| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keren Wood, Idit Maharshak, Yosef Koronyo, Maya Koronyo-Hamaou. [THE RETINA AS A TOOL FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASE]. Harefuah. vol 161. issue 8. 2022-08-18. PMID:35979573. |
[the retina as a tool for early diagnosis of alzheimer disease]. |
2022-08-18 |
2023-08-14 |
Not clear |
| Keren Wood, Idit Maharshak, Yosef Koronyo, Maya Koronyo-Hamaou. [THE RETINA AS A TOOL FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASE]. Harefuah. vol 161. issue 8. 2022-08-18. PMID:35979573. |
changes in the retina can reflect the cerebral pathological process in alzheimer's disease. |
2022-08-18 |
2023-08-14 |
Not clear |
| Keren Wood, Idit Maharshak, Yosef Koronyo, Maya Koronyo-Hamaou. [THE RETINA AS A TOOL FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASE]. Harefuah. vol 161. issue 8. 2022-08-18. PMID:35979573. |
indeed, evidence of aβ plaques and abnormal tau proteins in the retina of alzheimer's patients has been reported. |
2022-08-18 |
2023-08-14 |
Not clear |
| Nathanael Matei, Sophie Leahy, Norman P Blair, James Burford, Mansour Rahimi, Mahnaz Shahid. Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer's Disease. Cells. vol 11. issue 15. 2022-08-12. PMID:35954257. |
alzheimer's disease (ad) is a neurodegenerative disorder that affects the brain and retina and lacks reliable biomarkers for early diagnosis. |
2022-08-12 |
2023-08-14 |
mouse |
| Hugo Ferreira, Pedro Serranho, Pedro Guimarães, Rita Trindade, João Martins, Paula I Moreira, António Francisco Ambrósio, Miguel Castelo-Branco, Rui Bernarde. Stage-independent biomarkers for Alzheimer's disease from the living retina: an animal study. Scientific reports. vol 12. issue 1. 2022-08-11. PMID:35953633. |
stage-independent biomarkers for alzheimer's disease from the living retina: an animal study. |
2022-08-11 |
2023-08-14 |
mouse |
| Mohd Aizuddin Mohd Lazaldin, Igor Iezhitsa, Renu Agarwal, Puneet Agarwal, Nafeeza Mohd Ismai. Neuroprotective effects of exogenous brain-derived neurotrophic factor on amyloid-beta 1-40-induced retinal degeneration. Neural regeneration research. vol 18. issue 2. 2022-07-28. PMID:35900434. |
amyloid-beta (aβ)-related alterations, similar to those found in the brains of patients with alzheimer's disease, have been observed in the retina of patients with glaucoma. |
2022-07-28 |
2023-08-14 |
Not clear |
| Inés López-Cuenca, Alberto Marcos-Dolado, Miguel Yus-Fuertes, Elena Salobrar-García, Lorena Elvira-Hurtado, José A Fernández-Albarral, Juan J Salazar, Ana I Ramírez, Lidia Sánchez-Puebla, Manuel Enrique Fuentes-Ferrer, Ana Barabash, Federico Ramírez-Toraño, Lidia Gil-Martínez, Juan Arrazola-García, Pedro Gil, Rosa de Hoz, José M Ramíre. The relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer's disease: an exploratory analysis. Alzheimer's research & therapy. vol 14. issue 1. 2022-06-06. PMID:35659054. |
two main genetic risks for sporadic alzheimer's disease (ad) are a family history and ɛ4 allele of apolipoprotein e. the brain and retina are part of the central nervous system and share pathophysiological mechanisms in ad. |
2022-06-06 |
2023-08-14 |
Not clear |
| Virginie Dinet, Louiza Arouche-Delaperche, Julie Dégardin, Marie-Christine Naud, Serge Picaud, Slavica Kranti. Concomitant Retinal Alterations in Neuronal Activity and TNFα Pathway Are Detectable during the Pre-Symptomatic Stage in a Mouse Model of Alzheimer's Disease. Cells. vol 11. issue 10. 2022-05-28. PMID:35626688. |
the pre-symptomatic stage of alzheimer's disease (ad) is associated with increased amyloid-β (aβ) precursor protein (app) processing and aβ accumulation in the retina and hippocampus. |
2022-05-28 |
2023-08-13 |
mouse |
| Gabrielle Frame, Adam Schuller, Matthew A Smith, Samuel D Crish, Christine M Dengler-Cris. Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer's Disease Mice. Journal of Alzheimer's disease : JAD. 2022-05-23. PMID:35599482. |
visual disturbances often precede cognitive dysfunction in patients with alzheimer's disease (ad) and may coincide with early accumulation of amyloid-β (aβ) protein in the retina. |
2022-05-23 |
2023-08-13 |
mouse |
| Than Sein, David Abram, Vladimir Bondarenk. Biomarkers Indicative of Late Stage Alzheimer's Disease Found in the Brain and Retina. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554041. |
biomarkers indicative of late stage alzheimer's disease found in the brain and retina. |
2022-05-13 |
2023-08-13 |
Not clear |
| Ciriaco Corral-Domenge, Pedro de la Villa, Alicia Mansilla, Francisco Germai. Tools and Biomarkers for the Study of Retinal Ganglion Cell Degeneration. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457104. |
the retina is part of the central nervous system, its analysis may provide an idea of the health and functionality, not only of the retina, but also of the entire central nervous system, as has been shown in alzheimer's or parkinson's diseases. |
2022-04-23 |
2023-08-13 |
Not clear |
| Justin P Ma, Cason B Robbins, Jia Min Lee, Srinath Soundararajan, Sandra S Stinnett, Rupesh Agrawal, Brenda L Plassman, Eleonora M Lad, Heather Whitson, Dilraj S Grewal, Sharon Fekra. Longitudinal analysis of the retina and choroid in cognitively normal individuals at higher genetic risk for Alzheimer disease. Ophthalmology. Retina. 2022-03-14. PMID:35283324. |
longitudinal analysis of the retina and choroid in cognitively normal individuals at higher genetic risk for alzheimer disease. |
2022-03-14 |
2023-08-13 |
Not clear |
| Elise Léger-Charnay, Ségolène Gambert, Lucy Martine, Elisabeth Dubus, Marie-Annick Maire, Bénédicte Buteau, Tristan Morala, Vincent Gigot, Alain M Bron, Lionel Bretillon, Elodie A Y Masso. Retinal cholesterol metabolism is perturbated in response to experimental glaucoma in the rat. PloS one. vol 17. issue 3. 2022-03-11. PMID:35275950. |
alterations of cholesterol metabolism have been described for many neurodegenerative pathologies, such as alzheimer's disease in the brain and age-related macular degeneration in the retina. |
2022-03-11 |
2023-08-13 |
rat |
| Jie Zhang, Lei Shi, Yong She. The retina: A window in which to view the pathogenesis of Alzheimer's disease. Ageing research reviews. 2022-02-22. PMID:35192959. |
the retina: a window in which to view the pathogenesis of alzheimer's disease. |
2022-02-22 |
2023-08-13 |
mouse |
| Jonah Doustar, Altan Rentsendorj, Tania Torbati, Giovanna C Regis, Dieu-Trang Fuchs, Julia Sheyn, Nazanin Mirzaei, Stuart Graham, Prediman K Shah, Mitra Mastali, Jennifer E Eyk, Keith L Black, Vivek K Gupta, Mehdi Mirzaei, Yosef Koronyo, Maya Koronyo-Hamaou. Retina mirrors brain pathology and response to GA immunotherapy in advanced stage AD-model mice. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109176. |
characteristic signs of alzheimer's disease (ad) are increasingly reported in the neurosensory retina of human patients and animal models, however examination of the retino-cerebral relationship, especially at late disease stages and in response to therapy, is scarce. |
2022-02-03 |
2023-08-13 |
mouse |
| Jinfeng Liu, Larry Baum, Shasha Yu, Youhong Lin, Guoying Xiong, Raymond Chuen-Chung Chang, Kwok Fai So, Kin Chi. Preservation of Retinal Function Through Synaptic Stabilization in Alzheimer's Disease Model Mouse Retina by Lycium Barbarum Extracts. Frontiers in aging neuroscience. vol 13. 2022-01-31. PMID:35095474. |
preservation of retinal function through synaptic stabilization in alzheimer's disease model mouse retina by lycium barbarum extracts. |
2022-01-31 |
2023-08-13 |
mouse |
| Lieve Moons, Lies De Groe. Multimodal retinal imaging to detect and understand Alzheimer's and Parkinson's disease. Current opinion in neurobiology. vol 72. 2021-11-30. PMID:34399146. |
retinal neurodegeneration and visual dysfunctions have been reported in a majority of alzheimer's and parkinson's patients, and, in light of the quest for novel biomarkers for these neurodegenerative proteinopathies, the retina has been receiving increasing attention as an organ for diagnosing, monitoring, and understanding disease. |
2021-11-30 |
2023-08-13 |
Not clear |
| Lieve Moons, Lies De Groe. Multimodal retinal imaging to detect and understand Alzheimer's and Parkinson's disease. Current opinion in neurobiology. vol 72. 2021-11-30. PMID:34399146. |
it makes the retina not only a promising target for biomarker development, but it also suggests that novel fundamental insights into the pathophysiology of alzheimer's and parkinson's disease can be obtained by studying the retina-brain axis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Benjamin J Kim, Vivian Lee, Edward B Lee, Adrienne Saludades, John Q Trojanowski, Joshua L Dunaief, Murray Grossman, David J Irwi. Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau. Acta neuropathologica communications. vol 9. issue 1. 2021-11-29. PMID:34794500. |
alzheimer's disease (ad) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. |
2021-11-29 |
2023-08-13 |
Not clear |
| Ioannis-Nikolaos Chalkias, Thomas Tegos, Fotis Topouzis, Magda Tsolak. Ocular biomarkers and their role in the early diagnosis of neurocognitive disorders. European journal of ophthalmology. vol 31. issue 6. 2021-11-23. PMID:34000876. |
since the introduction of the non-invasive optical coherence tomography (oct) and the newly developed modality oct-angiography (oct-a) that can demonstrate the structure and the microvasculature of the retina and choroid, respectively, there have been promising results regarding the value of the ophthalmologic examination in the early diagnosis of alzheimer's disease. |
2021-11-23 |
2023-08-13 |
Not clear |