| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N G Kolosova, N A Stefanova, E E Korbolina, A Zh Fursova, O S Kozhevnikov. [The senescence-accelerated oxys rats--a genetic model of premature aging and age-dependent degenerative diseases]. Advances in gerontology = Uspekhi gerontologii. vol 27. issue 2. 2014-11-21. PMID:25306668. |
this review discusses possible mechanisms of the accelerated senescence: the results of comparison of retinal transcriptomes between oxys and wistar(control) rats at different ages, studies of the markers of alzheimer's disease in the retina and in certain brain regions, and the outcome of the efforts to develop congenic strains of animals via a transfer of several quantitative trait loci (qtls) of chromosome 1 from oxys to wag rats that are associated with the signs of accelerated senescence. |
2014-11-21 |
2023-08-13 |
rat |
| Carol Yim-Lui Cheung, Yi Ting Ong, M Kamran Ikram, Shin Yeu Ong, Xiang Li, Saima Hilal, Joseree-Ann S Catindig, Narayanaswamy Venketasubramanian, Philip Yap, Dennis Seow, Christopher P Chen, Tien Yin Won. Microvascular network alterations in the retina of patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 2. 2014-11-17. PMID:24439169. |
microvascular network alterations in the retina of patients with alzheimer's disease. |
2014-11-17 |
2023-08-12 |
Not clear |
| Lisa M Renzi, Melissa J Dengler, Antonio Puente, L Stephen Miller, Billy R Hammon. Relationships between macular pigment optical density and cognitive function in unimpaired and mildly cognitively impaired older adults. Neurobiology of aging. vol 35. issue 7. 2014-11-17. PMID:24508218. |
low carotenoid status (especially of the xanthophylls, lutein [l], and zeaxanthin [z]) is common in older adults and has been associated with a number of degenerative diseases of the central nervous system ranging from retina (e.g., macular degeneration) to brain (e.g., alzheimer's disease). |
2014-11-17 |
2023-08-12 |
human |
| Yue Yang, Christine Shiao, Jake Frederick Hemingway, Nikolas L Jorstad, Bryan Richard Shalloway, Rubens Chang, C Dirk Keen. Suppressed retinal degeneration in aged wild type and APPswe/PS1ΔE9 mice by bone marrow transplantation. PloS one. vol 8. issue 6. 2014-09-29. PMID:23750207. |
alzheimer's disease (ad) is an age-related condition characterized by accumulation of neurotoxic amyloid β peptides (aβ) in brain and retina. |
2014-09-29 |
2023-08-12 |
mouse |
| Isabelle Audo, Kinga Bujakowska, Elise Orhan, Said El Shamieh, Florian Sennlaub, Xavier Guillonneau, Aline Antonio, Christelle Michiels, Marie-Elise Lancelot, Melanie Letexier, Jean-Paul Saraiva, Hoan Nguyen, Tien D Luu, Thierry Léveillard, Olivier Poch, Hélène Dollfus, Michel Paques, Olivier Goureau, Saddek Mohand-Saïd, Shomi S Bhattacharya, José-Alain Sahel, Christina Zeit. The familial dementia gene revisited: a missense mutation revealed by whole-exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family. Human molecular genetics. vol 23. issue 2. 2014-08-05. PMID:24026677. |
furthermore, itm2b in the retina co-localizes with its known interacting partner in cerebral tissue, the amyloid β precursor protein, critical in alzheimer disease physiopathology. |
2014-08-05 |
2023-08-12 |
human |
| Chia-Wen Chen, Wei-Yong Lin, Kuen-Bao Chen, Yih-Shyuan Wu, Yu-Cheng Kuo, Hsin-Ping Liu, Chi-Yuan L. Inhalational anesthetic sevoflurane rescues retina function in Alzheimer's disease transgenic Drosophila. Current Alzheimer research. vol 10. issue 9. 2014-06-15. PMID:24117114. |
inhalational anesthetic sevoflurane rescues retina function in alzheimer's disease transgenic drosophila. |
2014-06-15 |
2023-08-12 |
drosophila_melanogaster |
| Haikang Zhao, Rui Chang, Haijiang Che, Jianbang Wang, Lei Yang, Wei Fang, Yi Xia, Nan Li, Quanrui Ma, Xuelian Wan. Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer's disease transgenic mouse. Neuroscience letters. vol 551. 2014-03-21. PMID:23810804. |
hyperphosphorylation of tau protein by calpain regulation in retina of alzheimer's disease transgenic mouse. |
2014-03-21 |
2023-08-12 |
mouse |
| Laura Campello, Julián Esteve-Rudd, Nicolás Cuenca, José Martín-Niet. The ubiquitin-proteasome system in retinal health and disease. Molecular neurobiology. vol 47. issue 2. 2014-02-13. PMID:23339020. |
additionally, the relationship between ups dysfunction and human neurodegenerative disorders affecting the retina, including alzheimer's, parkinson's, and huntington's diseases, are dealt with, together with numerous instances of retina-specific illnesses with ups involvement, such as retinitis pigmentosa, macular degenerations, glaucoma, diabetic retinopathy (dr), and aging-related impairments. |
2014-02-13 |
2023-08-12 |
human |
| Ran Antes, Raaya Ezra-Elia, Dov Weinberger, Arie Solomon, Ron Ofri, Daniel M Michaelso. ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice. PloS one. vol 8. issue 5. 2014-01-10. PMID:23741431. |
the present study investigated the extent to which the retina can be used as a model for studying the pathological effects of apolipoprotein e4 (apoe4), the most prevalent genetic risk factor for alzheimer's disease (ad). |
2014-01-10 |
2023-08-12 |
mouse |
| Marilita M Moschos, Ioannis Markopoulos, Irini Chatziralli, Alexandros Rouvas, Sokratis G Papageorgiou, Ioannis Ladas, Dimitrios Vassilopoulo. Structural and functional impairment of the retina and optic nerve in Alzheimer's disease. Current Alzheimer research. vol 9. issue 7. 2013-08-16. PMID:22698074. |
structural and functional impairment of the retina and optic nerve in alzheimer's disease. |
2013-08-16 |
2023-08-12 |
Not clear |
| Christian Schön, Nadine A Hoffmann, Simon M Ochs, Steffen Burgold, Severin Filser, Sonja Steinbach, Mathias W Seeliger, Thomas Arzberger, Michel Goedert, Hans A Kretzschmar, Boris Schmidt, Jochen Herm. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PloS one. vol 7. issue 12. 2013-06-24. PMID:23300938. |
especially in alzheimer's disease, pathological alterations in the retina are discussed as potential biomarkers to improve early diagnosis of the disease. |
2013-06-24 |
2023-08-12 |
mouse |
| Christian Schön, Nadine A Hoffmann, Simon M Ochs, Steffen Burgold, Severin Filser, Sonja Steinbach, Mathias W Seeliger, Thomas Arzberger, Michel Goedert, Hans A Kretzschmar, Boris Schmidt, Jochen Herm. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PloS one. vol 7. issue 12. 2013-06-24. PMID:23300938. |
in contradiction to previous studies, our observations do not support the notion that aβ or tau in the retina are of diagnostic value in alzheimer's disease. |
2013-06-24 |
2023-08-12 |
mouse |
| Joanna Kur, Eric A Newman, Tailoi Chan-Lin. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Progress in retinal and eye research. vol 31. issue 5. 2012-10-04. PMID:22580107. |
we review the cellular and molecular components of the neurovascular unit in the retina and choroid, techniques for monitoring retinal and choroidal blood flow, responses of the retinal and choroidal circulation to light stimulation, the role of capillaries, astrocytes and pericytes in regulating blood flow, putative signaling mechanisms mediating neurovascular coupling in the retina, and changes that occur in the retinal and choroidal circulation during diabetic retinopathy, age-related macular degeneration, glaucoma, and alzheimer's disease. |
2012-10-04 |
2023-08-12 |
Not clear |
| Walter J Lukiw, Bhattacharjee Surjyadipta, Prerna Dua, Peter N Alexandro. Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD). International journal of biochemistry and molecular biology. vol 3. issue 1. 2012-10-02. PMID:22509485. |
alzheimer's disease (ad) and age-related macular degeneration (amd) are complex and progressive inflammatory degenerations of the human neocortex and retina. |
2012-10-02 |
2023-08-12 |
human |
| Kin Chiu, Tin-Fung Chan, Andrew Wu, Irene Yan-Pui Leung, Kwok-Fai So, Raymond Chuen-Chung Chan. Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina? Age (Dordrecht, Netherlands). vol 34. issue 3. 2012-09-25. PMID:21559868. |
neurodegeneration of the retina in mouse models of alzheimer's disease: what can we learn from the retina? |
2012-09-25 |
2023-08-12 |
mouse |
| Yosef Koronyo, Brenda C Salumbides, Keith L Black, Maya Koronyo-Hamaou. Alzheimer's disease in the retina: imaging retinal aβ plaques for early diagnosis and therapy assessment. Neuro-degenerative diseases. vol 10. issue 1-4. 2012-08-29. PMID:22343730. |
alzheimer's disease in the retina: imaging retinal aβ plaques for early diagnosis and therapy assessment. |
2012-08-29 |
2023-08-12 |
Not clear |
| Zhizhang Dong, Juan Li, Yunxia Leng, Xuerong Sun, Huiling Hu, Yuan He, Zhiqun Tan, Jian G. Cyclic intensive light exposure induces retinal lesions similar to age-related macular degeneration in APPswe/PS1 bigenic mice. BMC neuroscience. vol 13. 2012-08-10. PMID:22443196. |
several studies including the one from us already showed accumulation of aβ deposits in the retina in alzheimer's transgenic mice. |
2012-08-10 |
2023-08-12 |
mouse |
| Peter N Alexandrov, Aileen Pogue, Surjyadipta Bhattacharjee, Walter J Luki. Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease. Neuroreport. vol 22. issue 12. 2011-11-10. PMID:21734608. |
the superior colliculus and retina obtained from late-stage alzheimer's disease revealed upregulated amyloidogenic and inflammatory signaling along the anteroposterior axis of the retinal-primary visual cortex pathway. |
2011-11-10 |
2023-08-12 |
mouse |
| Ian L Jones, Paolo Livi, Marta K Lewandowska, Michele Fiscella, Branka Roscic, Andreas Hierleman. The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics. Analytical and bioanalytical chemistry. vol 399. issue 7. 2011-08-22. PMID:20676620. |
models of disease or the response of cellular networks to pharmacological compounds can be studied in vitro, allowing one to investigate pathologies, such as cardiac arrhythmias, memory impairment due to alzheimer's disease, or vision impairment caused by ganglion cell degeneration in the retina. |
2011-08-22 |
2023-08-12 |
Not clear |
| Meng Liu, James Duggan, Thomas E Salt, M Francesca Cordeir. Dendritic changes in visual pathways in glaucoma and other neurodegenerative conditions. Experimental eye research. vol 92. issue 4. 2011-05-13. PMID:21310146. |
there is increasing evidence that neuronal changes occur both in retina and central visual targets in glaucoma and other neurodegenerative diseases such as alzheimer's disease (ad) and amyotrophic lateral sclerosis (als). |
2011-05-13 |
2023-08-12 |
Not clear |