| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqun Tan, Jian G. Amyloid-beta, the retina, and mouse models of Alzheimer disease. The American journal of pathology. vol 176. issue 4. 2010-12-14. PMID:20167871. |
amyloid-beta, the retina, and mouse models of alzheimer disease. |
2010-12-14 |
2023-08-12 |
mouse |
| Ying Chi, Yin-hua Wang, Liu Yan. [The investigation of retinal nerve fiber loss in Alzheimer's disease]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. vol 46. issue 2. 2010-11-09. PMID:20388347. |
to determine if there are retinal abnormalities in alzheimer's disease and if retinal changes are one of the causes of the visual symptom, and if the changes of retina thickness correlated with the severity of dementia. |
2010-11-09 |
2023-08-12 |
Not clear |
| Panitha Jindahra, Thomas R Hedges, Carlos E Mendoza-Santiesteban, Gordon T Plan. Optical coherence tomography of the retina: applications in neurology. Current opinion in neurology. vol 23. issue 1. 2010-03-10. PMID:20009925. |
the application of optical coherence tomography imaging of the retina in multiple sclerosis, neuromyelitis optica, alzheimer disease, and parkinson disease are reviewed. |
2010-03-10 |
2023-08-12 |
Not clear |
| Bingqian Liu, Suhail Rasool, Zhikuan Yang, Charles G Glabe, Steven S Schreiber, Jian Ge, Zhiqun Ta. Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19834067. |
amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of alzheimer's transgenic mice. |
2010-01-11 |
2023-08-12 |
mouse |
| Bingqian Liu, Suhail Rasool, Zhikuan Yang, Charles G Glabe, Steven S Schreiber, Jian Ge, Zhiqun Ta. Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19834067. |
although numerous studies have demonstrated a relationship between brain pathology and ad progression, the alzheimer's pathological hallmarks have not been found in the ad retina. |
2010-01-11 |
2023-08-12 |
mouse |
| Jean-Yves Le Gall, Raymond Ardaillo. [The biology of aging]. Bulletin de l'Academie nationale de medecine. vol 193. issue 2. 2009-09-29. PMID:19718893. |
the different organs age in different ways: vessel walls become rigid due to protein glycation and develop atheroma; the heart is invaded by fibrosis; the brain suffers from neurofibrillar degeneration and senile plaques (responsible for alzheimer's disease); the retina undergoes macular degeneration; renal function declines in parallel with the fall in the glomerular filtration rate due to a gradual decrease in the nephron pool; and immune defenses become less effective due to the functional degradation of b and t lymphocytes and thymus involution. |
2009-09-29 |
2023-08-12 |
mouse |
| Ram Fridlich, Francois Delalande, Céline Jaillard, Jun Lu, Laetitia Poidevin, Thérèse Cronin, Ludivine Perrocheau, Géraldine Millet-Puel, Marie-Laure Niepon, Olivier Poch, Arne Holmgren, Alain Van Dorsselaer, Jose-Alain Sahel, Thierry Léveillar. The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina. Molecular & cellular proteomics : MCP. vol 8. issue 6. 2009-09-01. PMID:19279044. |
we demonstrate that the level of phosphorylation of tau is increased in the retina of the nxnl1(-/-) mice as it is hyperphosphorylated in the brain of patients suffering from alzheimer disease, presumably in some cases through oxidative stress. |
2009-09-01 |
2023-08-12 |
mouse |
| Sylvia E Perez, Stephen Lumayag, Beatrix Kovacs, Elliott J Mufson, Shunbin X. Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease. Investigative ophthalmology & visual science. vol 50. issue 2. 2009-02-06. PMID:18791173. |
beta-amyloid deposition and functional impairment in the retina of the appswe/ps1deltae9 transgenic mouse model of alzheimer's disease. |
2009-02-06 |
2023-08-12 |
mouse |
| Sylvia E Perez, Stephen Lumayag, Beatrix Kovacs, Elliott J Mufson, Shunbin X. Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease. Investigative ophthalmology & visual science. vol 50. issue 2. 2009-02-06. PMID:18791173. |
to determine whether beta-amyloid (abeta) deposition affects the structure and function of the retina of the appswe/ps1deltae9 transgenic (tg) mouse model of alzheimer's disease. |
2009-02-06 |
2023-08-12 |
mouse |
| Allison Ning, Jing Cui, Eleanor To, Karen Hsiao Ashe, Joanne Matsubar. Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Investigative ophthalmology & visual science. vol 49. issue 11. 2008-11-18. PMID:18566467. |
to compare the temporal and spatial expression patterns of amyloid precursor protein (app), amyloid-beta deposits, inflammatory chemokines, and apoptosis in the retina of a mouse model of alzheimer disease (ad). |
2008-11-18 |
2023-08-12 |
mouse |
| Kamila Kaczmarczyk, Wojciech Lubiński, Danuta Karczewic. [Ocular changes in Alzheimer's disease]. Klinika oczna. vol 109. issue 10-12. 2008-06-17. PMID:18488402. |
in this study the authors present the ocular diseases and bioelectrical dysfunction of the retina and optic nerve in patients with alzheimer's disease, based on available literature. |
2008-06-17 |
2023-08-12 |
Not clear |
| Anna Richards, David Kavanagh, John P Atkinso. Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degeneration. Advances in immunology. vol 96. 2008-01-22. PMID:17981206. |
we all experience cellular injury and, if we live long enough, will deposit debris in blood vessel walls (atherosclerosis leading to heart attacks and strokes), the brain (amyloid proteins leading to alzheimer's disease), and retina (lipofuscin pigments leading to amd). |
2008-01-22 |
2023-08-12 |
human |
| Fatmire Berisha, Gilbert T Feke, Clement L Trempe, J Wallace McMeel, Charles L Schepen. Retinal abnormalities in early Alzheimer's disease. Investigative ophthalmology & visual science. vol 48. issue 5. 2007-06-13. PMID:17460292. |
there is evidence suggesting that visual disturbances in patients with alzheimer's disease (ad) are due to pathologic changes in the retina and optic nerve, as well as to higher cortical impairment. |
2007-06-13 |
2023-08-12 |
Not clear |
| Egemen Savaskan, Ralf Jockers, Mohammed Ayoub, Debora Angeloni, Franco Fraschini, Josef Flammer, Anne Eckert, Franz Müller-Spahn, Peter Meye. The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease. Current Alzheimer research. vol 4. issue 1. 2007-03-27. PMID:17316165. |
the mt2 melatonin receptor subtype is present in human retina and decreases in alzheimer's disease. |
2007-03-27 |
2023-08-12 |
human |
| Hamdi K Hamdi, Cristina Kenne. Age-related macular degeneration: a new viewpoint. Frontiers in bioscience : a journal and virtual library. vol 8. 2004-02-11. PMID:12700041. |
apoe is not specific to the retina, and has been more intriguingly associated with alzheimer's, another disease of age. |
2004-02-11 |
2023-08-12 |
human |
| A Surguchov, B McMahan, E Masliah, I Surguchev. Synucleins in ocular tissues. Journal of neuroscience research. vol 65. issue 1. 2001-08-16. PMID:11433431. |
we conclude that, in mature eyes, synucleins are present predominantly in the retina and optic nerve, and the immunoreactivity of gamma-synuclein changes specifically in the retina of alzheimer's disease patients. |
2001-08-16 |
2023-08-12 |
mouse |
| S Archer, J Hirano, J K Diss, S P Fraser, M B Djamgo. Expression and localization in the fish retina of a homologue of the Alzheimer's related PS1 gene. Neuroreport. vol 9. issue 13. 1999-06-07. PMID:9804326. |
expression and localization in the fish retina of a homologue of the alzheimer's related ps1 gene. |
1999-06-07 |
2023-08-12 |
human |
| S Archer, J Hirano, J K Diss, S P Fraser, M B Djamgo. Expression and localization in the fish retina of a homologue of the Alzheimer's related PS1 gene. Neuroreport. vol 9. issue 9. 1998-09-25. PMID:9674592. |
expression and localization in the fish retina of a homologue of the alzheimer's related ps1 gene. |
1998-09-25 |
2023-08-12 |
human |
| L S Jen, A J Hart, A Jen, J B Relvas, S M Gentleman, L J Garey, A J Pate. Alzheimer's peptide kills cells of retina in vivo. Nature. vol 392. issue 6672. 1998-03-26. PMID:9515959. |
alzheimer's peptide kills cells of retina in vivo. |
1998-03-26 |
2023-08-12 |
Not clear |
| J C Blanks, Y Torigoe, D R Hinton, R H Blank. Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina. Neurobiology of aging. vol 17. issue 3. 1996-12-03. PMID:8725899. |
morphometric analysis of the numbers of neurons in the ganglion cell layer (gcl) of the central retina (fovea/foveola/parafoveal retina) in eyes from 9 alzheimer's disease (ad) and 11 age-matched control cases revealed an overall decrease of 25% in total numbers of neurons in ad as compared with control eyes. |
1996-12-03 |
2023-08-12 |
Not clear |