| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Zeng, Ya-ping Lu, Hao Xu, Jiang-ning Zho. [Estrogen receptor alpha and colocalization of Bcl-2 in hippocampus of Alzheimer's disease]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 26. issue 2. 2004-07-22. PMID:15171543. |
[estrogen receptor alpha and colocalization of bcl-2 in hippocampus of alzheimer's disease]. |
2004-07-22 |
2023-08-12 |
Not clear |
| T den Heijer, S E Vermeer, E J van Dijk, N D Prins, P J Koudstaal, A Hofman, M M B Bretele. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia. vol 46. issue 12. 2004-07-21. PMID:14595538. |
in vivo, hippocampal and amygdalar atrophy on brain mri are good, early markers of the degree of alzheimer neuropathology. |
2004-07-21 |
2023-08-12 |
Not clear |
| Andreana P Haley, Jack Knight-Scott, Kathleen L Fuchs, Virginia I Simnad, Carol A Mannin. Shortening of hippocampal spin-spin relaxation time in probable Alzheimer's disease: a 1H magnetic resonance spectroscopy study. Neuroscience letters. vol 362. issue 3. 2004-07-19. PMID:15158006. |
shortening of hippocampal spin-spin relaxation time in probable alzheimer's disease: a 1h magnetic resonance spectroscopy study. |
2004-07-19 |
2023-08-12 |
human |
| Andreana P Haley, Jack Knight-Scott, Kathleen L Fuchs, Virginia I Simnad, Carol A Mannin. Shortening of hippocampal spin-spin relaxation time in probable Alzheimer's disease: a 1H magnetic resonance spectroscopy study. Neuroscience letters. vol 362. issue 3. 2004-07-19. PMID:15158006. |
we quantified the differential effects of the spin-spin relaxation times (t2) of tissue water and cerebral spinal fluid in order to examine hippocampal t2 changes as a non-invasive bio-marker of alzheimer's disease (ad). |
2004-07-19 |
2023-08-12 |
human |
| Hyoung-gon Lee, Xiongwei Zhu, Michael J O'Neill, Kate Webber, Gemma Casadesus, Michael Marlatt, Arun K Raina, George Perry, Mark A Smit. The role of metabotropic glutamate receptors in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 64. issue 1. 2004-07-06. PMID:15190683. |
while glutamatergic transmission is severely altered by early degeneration of cortico-cortical connections and hippocampal projections in alzheimer's disease (ad), the role of glutamate receptors in the pathogenesis of ad is not yet defined clearly. |
2004-07-06 |
2023-08-12 |
Not clear |
| Marcin Sadowski, Joanna Pankiewicz, Henrieta Scholtzova, Yong Ji, David Quartermain, Catrin H Jensen, Karen Duff, Ralph A Nixon, Rand J Gruen, Thomas Wisniewsk. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. Journal of neuropathology and experimental neurology. vol 63. issue 5. 2004-07-06. PMID:15198121. |
in alzheimer disease (ad) patients, early memory dysfunction is associated with glucose hypometabolism and neuronal loss in the hippocampus. |
2004-07-06 |
2023-08-12 |
mouse |
| Scott A Small, Monica K Chawla, Michael Buonocore, Peter R Rapp, Carol A Barne. Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 18. 2004-06-22. PMID:15118105. |
this pattern isolates the locus of age-related hippocampal dysfunction and differentiates normal aging from alzheimer's disease. |
2004-06-22 |
2023-08-12 |
rat |
| Rolf Postina, Anja Schroeder, Ilse Dewachter, Juergen Bohl, Ulrich Schmitt, Elzbieta Kojro, Claudia Prinzen, Kristina Endres, Christoph Hiemke, Manfred Blessing, Pascaline Flamez, Antoine Dequenne, Emile Godaux, Fred van Leuven, Falk Fahrenhol. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. The Journal of clinical investigation. vol 113. issue 10. 2004-06-17. PMID:15146243. |
a disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an alzheimer disease mouse model. |
2004-06-17 |
2023-08-12 |
mouse |
| Carlo Bertoni-Freddari, Patrizia Fattoretti, Moreno Solazzi, Belinda Giorgetti, Giuseppina Di Stefano, Tiziana Casoli, William Meier-Rug. Neuronal death versus synaptic pathology in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033803. |
neuron and synapse numeric densities as well as the average size and surface density of the synaptic junctional areas were measured in the hippocampus and cerebellum of adult, old, and demented (alzheimer's disease) patients. |
2004-06-15 |
2023-08-12 |
Not clear |
| Sahar S Abd El-Rahma. Neuropathology of aluminum toxicity in rats (glutamate and GABA impairment). Pharmacological research. vol 47. issue 3. 2004-05-21. PMID:12591013. |
the most pronounced changes in brain tissue included spongioform changes in the neurons specially those of hippocampus, nuclear deformity, and neurofibrillary degeneration, similar to neurofibrillary tangles in alzheimer's disease. |
2004-05-21 |
2023-08-12 |
rat |
| Emma J Burton, Ian G McKeith, David J Burn, E David Williams, John T O'Brie. Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls. Brain : a journal of neurology. vol 127. issue Pt 4. 2004-05-20. PMID:14749292. |
in addition, significant temporal lobe atrophy, including the hippocampus and parahippocampal gyrus was detected in alzheimer's disease relative to pdd. |
2004-05-20 |
2023-08-12 |
human |
| Nobuyoshi Hagino, Shinjiro Kobayashi, Taiki Tsutsumi, Seikoh Horiuchi, Ryoji Nagai, Gyury Setalo, Erizabet Dettric. Vascular change of hippocampal capillary is associated with vascular change of retinal capillary in aging. Brain research bulletin. vol 62. issue 6. 2004-05-17. PMID:15036569. |
in man in alzheimer's disease (ad), one might speculate that formation and accumulation of cml in the hippocampal microvessels initiate the accumulation of amyloid to produce cerebral amyloid angiopathy and it brings about hypoglycemia and hypoxia in the hippocampal pyramidal neurons. |
2004-05-17 |
2023-08-12 |
human |
| F Q Gao, S E Black, F S Leibovitch, D J Callen, C P Rockel, J P Szala. Linear width of the medial temporal lobe can discriminate Alzheimer's disease from normal aging: the Sunnybrook dementia study. Neurobiology of aging. vol 25. issue 4. 2004-05-11. PMID:15013564. |
to discriminate alzheimer's disease (ad) from healthy controls, the thinnest medial temporal lobe (tmtl) width on 3d-mri was measured according to a newly developed method at the inter-collicular sulcus (ics) level with scans aligned to the long axis of the hippocampus in 22 mild, 27 moderate probable ad patients and 41 healthy controls. |
2004-05-11 |
2023-08-12 |
Not clear |
| Keith Del Villar, Carol A Mille. Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 12. 2004-05-10. PMID:15007167. |
down-regulation of denn/madd, a tnf receptor binding protein, correlates with neuronal cell death in alzheimer's disease brain and hippocampal neurons. |
2004-05-10 |
2023-08-12 |
mouse |
| E M Hol, R F Roelofs, E Moraal, M A F Sonnemans, J A Sluijs, E A Proper, P N E de Graan, D F Fischer, F W van Leeuwe. Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms. Molecular psychiatry. vol 8. issue 9. 2004-05-06. PMID:12931206. |
neuronal gfap is mainly observed in the pyramidal neurons of the hippocampus of alzheimer and down syndrome patients and aged controls, but not in neurons of patients suffering from hippocampal sclerosis. |
2004-05-06 |
2023-08-12 |
human |
| E M Hol, R F Roelofs, E Moraal, M A F Sonnemans, J A Sluijs, E A Proper, P N E de Graan, D F Fischer, F W van Leeuwe. Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms. Molecular psychiatry. vol 8. issue 9. 2004-05-06. PMID:12931206. |
apparently, the hippocampal neurons in patients with alzheimer's disease pathology are capable of expressing glia-specific genes. |
2004-05-06 |
2023-08-12 |
human |
| David M Armstrong, Roxanne Sheffield, Amanda J Mishizen-Eberz, Troy L Carter, Robert A Rissman, Katsuyoshi Mizukami, Milos D Ikonomovi. Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease. Cellular and molecular neurobiology. vol 23. issue 4-5. 2004-04-30. PMID:14514010. |
plasticity of glutamate and gabaa receptors in the hippocampus of patients with alzheimer's disease. |
2004-04-30 |
2023-08-12 |
Not clear |
| Christoph Schmitz, Bart P F Rutten, Andrea Pielen, Stephanie Schäfer, Oliver Wirths, Günter Tremp, Christian Czech, Veronique Blanchard, Gerd Multhaup, Payam Rezaie, Hubert Korr, Harry W M Steinbusch, Laurent Pradier, Thomas A Baye. Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. The American journal of pathology. vol 164. issue 4. 2004-04-29. PMID:15039236. |
hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of alzheimer's disease. |
2004-04-29 |
2023-08-12 |
mouse |
| Christoph Schmitz, Bart P F Rutten, Andrea Pielen, Stephanie Schäfer, Oliver Wirths, Günter Tremp, Christian Czech, Veronique Blanchard, Gerd Multhaup, Payam Rezaie, Hubert Korr, Harry W M Steinbusch, Laurent Pradier, Thomas A Baye. Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. The American journal of pathology. vol 164. issue 4. 2004-04-29. PMID:15039236. |
these findings point to the potential involvement of more than one mechanism in hippocampal neuron loss in this app/ps-1 double-transgenic mouse model of alzheimer's disease. |
2004-04-29 |
2023-08-12 |
mouse |
| Peter Schönknecht, Marcus Henze, Aoife Hunt, Klaus Klinga, Uwe Haberkorn, Johannes Schröde. Hippocampal glucose metabolism is associated with cerebrospinal fluid estrogen levels in postmenopausal women with Alzheimer's disease. Psychiatry research. vol 124. issue 2. 2004-04-21. PMID:14561431. |
hippocampal glucose metabolism is associated with cerebrospinal fluid estrogen levels in postmenopausal women with alzheimer's disease. |
2004-04-21 |
2023-08-12 |
Not clear |