| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia A Lawlor, Ross J Bland, Pritam Das, Robert W Price, Vallie Holloway, Lisa Smithson, Bridget L Dicker, Matthew J During, Deborah Young, Todd E Gold. Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels. Molecular neurodegeneration. vol 2. 2007-08-01. PMID:17559680. |
novel rat alzheimer's disease models based on aav-mediated gene transfer to selectively increase hippocampal abeta levels. |
2007-08-01 |
2023-08-12 |
human |
| Carmen Quintana, Ting-Di Wu, Benoit Delatour, Marc Dhenain, Jean Luc Guerquin-Kern, Alain Crois. Morphological and chemical studies of pathological human and mice brain at the subcellular level: correlation between light, electron, and nanosims microscopies. Microscopy research and technique. vol 70. issue 4. 2007-07-25. PMID:17465396. |
in the human brain our results put forward the subcellular distribution of iron-ferritin-hemosiderin in the hippocampus of alzheimer disease patients. |
2007-07-25 |
2023-08-12 |
mouse |
| T M Shepherd, E Ozarslan, A T Yachnis, M A King, S J Blackban. Diffusion tensor microscopy indicates the cytoarchitectural basis for diffusion anisotropy in the human hippocampus. AJNR. American journal of neuroradiology. vol 28. issue 5. 2007-07-25. PMID:17494678. |
observing changes to water diffusivity and fractional anisotropy (fa) for particular hippocampal regions may improve the sensitivity and specificity of diffusion tensor mr imaging for hippocampal pathologies like alzheimer disease and mesial temporal sclerosis. |
2007-07-25 |
2023-08-12 |
human |
| Kouhei Fujimi, Kazuhito Noda, Kensuke Sasaki, Yoshinobu Wakisaka, Yumihiro Tanizaki, Mitsuo Iida, Yutaka Kiyohara, Shigenobu Kanba, Toru Iwak. Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study. Dementia and geriatric cognitive disorders. vol 23. issue 6. 2007-07-24. PMID:17457030. |
altered expression of cox-2 in subdivisions of the hippocampus during aging and in alzheimer's disease: the hisayama study. |
2007-07-24 |
2023-08-12 |
Not clear |
| Matthew R Holahan, Kyle S Honegger, Nino Tabatadze, Aryeh Routtenber. GAP-43 gene expression regulates information storage. Learning & memory (Cold Spring Harbor, N.Y.). vol 14. issue 6. 2007-07-24. PMID:17554085. |
(neuroscience 126: 579-584) who described elevated levels of gap-43 protein in the hippocampus of alzheimer's patients. |
2007-07-24 |
2023-08-12 |
mouse |
| Vikas Dhikav, Kuljeet Anan. Hippocampal atrophy may be a predictor of seizures in Alzheimer's disease. Medical hypotheses. vol 69. issue 1. 2007-07-18. PMID:17276608. |
hippocampal atrophy may be a predictor of seizures in alzheimer's disease. |
2007-07-18 |
2023-08-12 |
Not clear |
| Jia-Min Zhuo, Sonya L Prescott, Melissa E Murray, Hai-Yan Zhang, Mark G Baxter, Michelle M Nicoll. Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice. Neurobiology of aging. vol 28. issue 8. 2007-07-10. PMID:16828204. |
to understand the relationship between amyloid-beta and cognitive decline in alzheimer's disease, we evaluated cortical and hippocampal function in a transgenic mouse model of amyloid over-expression in alzheimer's disease, the tg2576 mouse. |
2007-07-10 |
2023-08-12 |
mouse |
| Honghui Chen, Yunn-Chyn Tung, Bin Li, Khalid Iqbal, Inge Grundke-Iqba. Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiology of aging. vol 28. issue 8. 2007-07-10. PMID:16859812. |
in alzheimer disease (ad) brain, especially the hippocampus, the level of basic fibroblast growth factor (fgf-2) is markedly elevated. |
2007-07-10 |
2023-08-12 |
rat |
| Philip W Landfield, Eric M Blalock, Kuey-Chu Chen, Nada M Porte. A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease. Current Alzheimer research. vol 4. issue 2. 2007-07-10. PMID:17430248. |
the original glucocorticoid (gc) hypothesis of brain aging and alzheimer's disease proposed that chronic exposure to gcs promotes hippocampal aging and ad. |
2007-07-10 |
2023-08-12 |
rat |
| Catalina Amador-Ortiz, Wen-Lang Lin, Zeshan Ahmed, David Personett, Peter Davies, Ranjan Duara, Neill R Graff-Radford, Michael L Hutton, Dennis W Dickso. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Annals of neurology. vol 61. issue 5. 2007-07-10. PMID:17469117. |
tdp-43 immunoreactivity in hippocampal sclerosis and alzheimer's disease. |
2007-07-10 |
2023-08-12 |
Not clear |
| Catalina Amador-Ortiz, Wen-Lang Lin, Zeshan Ahmed, David Personett, Peter Davies, Ranjan Duara, Neill R Graff-Radford, Michael L Hutton, Dennis W Dickso. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Annals of neurology. vol 61. issue 5. 2007-07-10. PMID:17469117. |
this study aimed to determine the frequency of frontotemporal lobar degeneration with ubiquitinated inclusions (ftld-u) in the setting of hippocampal sclerosis (hpscl) and alzheimer's disease (ad) using immunohistochemistry for tar dna binding protein 43 (tdp-43), a putative marker for ftld-u. |
2007-07-10 |
2023-08-12 |
Not clear |
| Cynthia A Lemer. A beneficial role for IL-1 beta in Alzheimer disease? The Journal of clinical investigation. vol 117. issue 6. 2007-07-10. PMID:17549252. |
in a report in this issue of the jci, shaftel and coworkers have generated an elegant mouse model in which local hippocampal overexpression of il-1 beta in an alzheimer disease (ad) transgenic mouse model resulted not in the expected exacerbation of the amyloid beta plaque deposition common to ad, but instead in plaque amelioration (see the related article beginning on page 1595). |
2007-07-10 |
2023-08-12 |
mouse |
| Solomon S Shaftel, Stephanos Kyrkanides, John A Olschowka, Jen-nie H Miller, Renee E Johnson, M Kerry O'Banio. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. The Journal of clinical investigation. vol 117. issue 6. 2007-07-10. PMID:17549256. |
sustained hippocampal il-1 beta overexpression mediates chronic neuroinflammation and ameliorates alzheimer plaque pathology. |
2007-07-10 |
2023-08-12 |
mouse |
| W Danysz, C G Parsons, H J Mobius, A Stoffler, G Quac. Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease--a unified glutamatergic hypothesis on the mechanism of action. Neurotoxicity research. vol 2. issue 2-3. 2007-07-09. PMID:16787834. |
in vivo, doses leading to similar brain/serum levels produce neuroprotection in animal models relevant for neurodegeneration in alzheimer's disease such as neurotoxicity produced by inflammation in the nbm or beta-amyloid injection to the hippocampus. |
2007-07-09 |
2023-08-12 |
Not clear |
| David R Riddell, Hua Zhou, Thomas A Comery, Evguenia Kouranova, C Frederick Lo, Helen K Warwick, Robert H Ring, Yolanda Kirksey, Suzan Aschmies, Jane Xu, Katie Kubek, Warren D Hirst, Catherine Gonzales, Yi Chen, Erin Murphy, Sarah Leonard, Dmytro Vasylyev, Aram Oganesian, Robert L Martone, Menelas N Pangalos, Peter H Reinhart, J Steve Jacobse. The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Molecular and cellular neurosciences. vol 34. issue 4. 2007-06-22. PMID:17336088. |
the lxr agonist to901317 selectively lowers hippocampal abeta42 and improves memory in the tg2576 mouse model of alzheimer's disease. |
2007-06-22 |
2023-08-12 |
mouse |
| W H Xu, R Huber, M W Riep. Gender- and region-specific expression of insulin receptor protein in mouse brain: effect of mild inhibition of oxidative phosphorylation. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 3. 2007-06-21. PMID:17086487. |
the latter effect, however, warrants further scrutiny concerning participation in pathophysiological cascades affecting the hippocampus such as in alzheimer's disease. |
2007-06-21 |
2023-08-12 |
mouse |
| R Resende, C Pereira, P Agostinho, A P Vieira, J O Malva, C R Oliveir. Susceptibility of hippocampal neurons to Abeta peptide toxicity is associated with perturbation of Ca2+ homeostasis. Brain research. vol 1143. 2007-06-13. PMID:17336275. |
neuritic dystrophy, loss of synapses and neuronal death in the cerebral cortex and hippocampus are hallmarks of alzheimer's disease. |
2007-06-13 |
2023-08-12 |
rat |
| David Butler, Jennifer Bendiske, Mary L Michaelis, David A Karanian, Ben A Bah. Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers. European journal of pharmacology. vol 562. issue 1-2. 2007-06-13. PMID:17336290. |
reported reductions in a microtubule stability marker, acetylated alpha-tubulin, suggest that disrupted transport occurs in alzheimer's disease neurons, and such a reduction is known to be associated with transport failure and synaptic compromise in a hippocampal slice model of protein accumulation. |
2007-06-13 |
2023-08-12 |
Not clear |
| Alan B MacDonal. Alzheimer's disease Braak Stage progressions: reexamined and redefined as Borrelia infection transmission through neural circuits. Medical hypotheses. vol 68. issue 5. 2007-06-06. PMID:17113237. |
amalgamation of zoster with rabies models produces a hybrid model to explain all of the braak stages of alzheimer's disease under a new paradigm, namely "alzheimer's neuroborreliosis" in which latent borrelia infections ascend neural circuits through the hippocampus to the higher brain centers, creating a trail of neurofibrillary tangle injured neurons in neural circuits of cholinergic neurons by transsynaptic transmission of infection from nerve to nerve. |
2007-06-06 |
2023-08-12 |
Not clear |
| S G Mueller, L Stables, A T Du, N Schuff, D Truran, N Cashdollar, M W Weine. Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Neurobiology of aging. vol 28. issue 5. 2007-05-31. PMID:16713659. |
histological studies suggest that hippocampal subfields are differently affected by aging and alzheimer's disease (ad). |
2007-05-31 |
2023-08-12 |
human |