| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anqi Qiu, Laurent Younes, Michael I Miller, John G Csernansk. Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type. NeuroImage. vol 40. issue 1. 2008-04-23. PMID:18249009. |
hippocampal surface structure was assessed at twice 2 years apart in 26 nondemented subjects (cdr 0), in 18 subjects with early dementia of alzheimer type (dat, cdr 0.5), and in 9 subjects who converted from the nondemented (cdr 0) to the demented (cdr 0.5) state using magnetic resonance (mr) imaging. |
2008-04-23 |
2023-08-12 |
human |
| C Nocjar, M D Hammonds, S S Shi. Chronic lithium treatment magnifies learning in rats. Neuroscience. vol 150. issue 4. 2008-04-08. PMID:17996377. |
thus chronic lithium treatment may improve learning and memory in alzheimer's disease, and do so not only by blocking the formation of beta-amyloid and neurofibrillary tangles as suggested by previous research, but also by enhancing mechanisms involved in basal learning and memory formation, such as hippocampal synaptic plasticity. |
2008-04-08 |
2023-08-12 |
rat |
| M Cachard-Chastel, S Devers, S Sicsic, M Langlois, F Lezoualc'h, A M Gardier, C Belzun. Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice. Behavioural brain research. vol 187. issue 2. 2008-04-07. PMID:18061284. |
it is known that 5-ht(4) receptor agonists increase sappalpha levels in the cortex and hippocampus of mice as well as in a model of alzheimer's disease (ad). |
2008-04-07 |
2023-08-12 |
mouse |
| Jae K Ryu, James G McLarno. Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-alpha in an animal model of inflamed Alzheimer's disease brain. Neurobiology of disease. vol 29. issue 2. 2008-04-04. PMID:17964176. |
injection of abeta(1-42) peptide into rat hippocampus has been found to induce microglial reactivity and perturbed vasculature in an animal model of inflamed alzheimer's disease (ad) brain. |
2008-04-04 |
2023-08-12 |
human |
| Kate M Webber, Gemma Casadesus, Richard L Bowen, George Perry, Mark A Smit. Evidence for the role of luteinizing hormone in Alzheimer disease. Endocrine, metabolic & immune disorders drug targets. vol 7. issue 4. 2008-04-03. PMID:18220951. |
importantly, luteinizing hormone, which is capable of modulating cognitive behavior, is not only present in the brain, but also has the highest receptor levels in the hippocampus, a key processor of cognition that is severely deteriorated in alzheimer disease. |
2008-04-03 |
2023-08-12 |
mouse |
| Matthew Schrag, Sunita Sharma, Holly Brown-Borg, Othman Ghrib. Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus. vol 18. issue 3. 2008-03-27. PMID:18000817. |
because the hippocampus is a brain area that is severely affected in alzheimer's disease, our study proposes that organotypic slices from hippocampi of adult ames dwarf mice may constitute a model system for understanding endogenous factors that may confer protection against abeta. |
2008-03-27 |
2023-08-12 |
mouse |
| Jerome J Maller, Kaarin J Anstey, Chantal Réglade-Meslin, Helen Christensen, Wei Wen, Perminder Sachde. Hippocampus and amygdala volumes in a random community-based sample of 60-64 year olds and their relationship to cognition. Psychiatry research. vol 156. issue 3. 2008-03-25. PMID:17988837. |
reduced volumes of the hippocampus (hc) and amygdala (ag) are potential biomarkers for alzheimer's disease (ad) and other neuropsychiatric disorders. |
2008-03-25 |
2023-08-12 |
human |
| Ji-Ping Qi, He Wu, Yi Yang, Dan-Dan Wang, Yan-Xi Chen, Yun-He Gu, Tao Li. Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampus. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198420. |
cerebral ischemia and alzheimer's disease: the expression of amyloid-beta and apolipoprotein e in human hippocampus. |
2008-03-25 |
2023-08-12 |
human |
| Ji-Ping Qi, He Wu, Yi Yang, Dan-Dan Wang, Yan-Xi Chen, Yun-He Gu, Tao Li. Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampus. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198420. |
we investigated the expression and distribution of abeta1-40, beta1-42 and apoe in human hippocampus after cerebral ischemia in this study to determine the role of cerebral ischemia in alzheimer's disease. |
2008-03-25 |
2023-08-12 |
human |
| HyeSook Youn, Inhae Ji, Hanlee P Ji, William R Markesbery, Tae H J. Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. Journal of Alzheimer's disease : JAD. vol 12. issue 3. 2008-03-19. PMID:18057561. |
under-expression of kalirin-7 increases inos activity in cultured cells and correlates to elevated inos activity in alzheimer's disease hippocampus. |
2008-03-19 |
2023-08-12 |
human |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology. vol 34. issue 1. 2008-03-18. PMID:17961140. |
calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in alzheimer's disease. |
2008-03-18 |
2023-08-12 |
human |
| Leyla deToledo-Morrell, Travis R Stoub, Changsheng Wan. Hippocampal atrophy and disconnection in incipient and mild Alzheimer's disease. Progress in brain research. vol 163. 2008-03-14. PMID:17765748. |
hippocampal atrophy and disconnection in incipient and mild alzheimer's disease. |
2008-03-14 |
2023-08-12 |
Not clear |
| Leyla deToledo-Morrell, Travis R Stoub, Changsheng Wan. Hippocampal atrophy and disconnection in incipient and mild Alzheimer's disease. Progress in brain research. vol 163. 2008-03-14. PMID:17765748. |
in this chapter we review imaging evidence indicating that the entorhinal cortex and hippocampus show atrophy very early in alzheimer's disease (ad) and in individuals who are at risk of developing ad compared to age appropriate controls. |
2008-03-14 |
2023-08-12 |
Not clear |
| Yonghong Li, Andrew Grupe, Charles Rowland, Peter Holmans, Ricardo Segurado, Richard Abraham, Lesley Jones, Joseph Catanese, David Ross, Kevin Mayo, Maribel Martinez, Paul Hollingworth, Alison Goate, Nigel J Cairns, Brad A Racette, Joel S Perlmutter, Michael C O'Donovan, John C Morris, Carol Brayne, David C Rubinsztein, Simon Lovestone, Leon J Thal, Michael J Owen, Julie William. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human molecular genetics. vol 17. issue 5. 2008-03-14. PMID:18063669. |
in exploring a potential mechanism for the association, we observed that expression of nedd9 and apoe show a strong inverse correlation in the hippocampus of alzheimer's cases. |
2008-03-14 |
2023-08-12 |
Not clear |
| Klaus B Fink, Manfred Göther. 5-HT receptor regulation of neurotransmitter release. Pharmacological reviews. vol 59. issue 4. 2008-03-06. PMID:18160701. |
examples for such deficiencies are the impaired release of hippocampal or neocortical acetylcholine, striatal dopamine, and hippocampal or neocortical noradrenaline in disorders such as alzheimer's disease, parkinson's disease, and major depression, respectively. |
2008-03-06 |
2023-08-12 |
Not clear |
| O Schulte-Herbrüggen, U Hamker, V Meske, H Danker-Hopfe, T G Ohm, R Hellwe. Beta/A4-Amyloid increases nerve growth factor production in rat primary hippocampal astrocyte cultures. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 25. issue 6. 2008-02-19. PMID:17646078. |
in processes of chronic degeneration of bfcn like in alzheimer's disease (ad), characterized among others by amyloid containing plaques, ngf has been shown to improve cognitive decline and rescue bfcn but also to reduce survival of hippocampal neurons via p75 neurotrophin receptor (p75). |
2008-02-19 |
2023-08-12 |
rat |
| Scott M MacKenzie, Deborah Dewar, William Stewart, Robert Fraser, John M C Connell, Eleanor Davie. The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. The Journal of endocrinology. vol 196. issue 1. 2008-02-05. PMID:18180323. |
the transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and alzheimer's tissue. |
2008-02-05 |
2023-08-12 |
human |
| Falk Fahrenhol. Alpha-secretase as a therapeutic target. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908044. |
the disintegrin metalloproteinase adam10 has been shown to act as alpha-secretase in vivo, to prevent amyloid plaque formation and hippocampal defects in an alzheimer disease mouse model. |
2008-02-01 |
2023-08-12 |
mouse |
| M P Golan, M Styczyńska, K Jóźwiak, J Walecki, A Maruszak, J Pniewski, R Lugiewicz, S Filipek, C Zekanowski, M Barcikowsk. Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene. Experimental neurology. vol 208. issue 2. 2008-01-31. PMID:17931627. |
neuroimaging conducted 2 years after the first symptoms was typical for the advanced stage of alzheimer's disease (ad), showing cortical brain atrophy, particularly within hippocampus, frontal and temporal cortex. |
2008-01-31 |
2023-08-12 |
Not clear |
| Z-X Yao, Z Han, J Xu, J Greeson, L Lecanu, V Papadopoulo. 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. Neuroscience. vol 148. issue 2. 2008-01-25. PMID:17689017. |
recently, we have shown that 22r-hydroxycholesterol, a steroid intermediate in the pathway of pregnenolone formation from cholesterol, is present at lower levels in alzheimer's disease (ad) hippocampus and frontal cortex tissue specimens than in age-matched controls, and that this substance protects against cell death induced by amyloid beta-peptide in both rat sympathetic nerve pheochromocytoma (pc12) and differentiated human ntera2/d1 teratocarcinoma neurons. |
2008-01-25 |
2023-08-12 |
human |