| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiu-Lan Ma, Fusheng Yang, Frédéric Calon, Oliver J Ubeda, James E Hansen, Richard H Weisbart, Walter Beech, Sally A Frautschy, Greg M Col. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. The Journal of biological chemistry. vol 283. issue 20. 2008-07-09. PMID:18347024. |
in addition, anti-oligomer curcumin comparatively suppressed pak translocation in aged tg2576 transgenic mice with alzheimer amyloid pathology and in abeta42 oligomer-treated cultured hippocampal neurons. |
2008-07-09 |
2023-08-12 |
mouse |
| Florian V Ermini, Stefan Grathwohl, Rebecca Radde, Masohiro Yamaguchi, Matthias Staufenbiel, Theo D Palmer, Mathias Jucke. Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis. The American journal of pathology. vol 172. issue 6. 2008-07-08. PMID:18467698. |
the hippocampus in alzheimer's disease is burdened with amyloid plaques and is one of the few locations where neurogenesis continues throughout adult life. |
2008-07-08 |
2023-08-12 |
mouse |
| V Jefremov, A Rakitin, R Mahlapuu, K Zilmer, N Bogdanovic, M Zilmer, E Karelso. 17beta-Oestradiol stimulation of G-proteins in aged and Alzheimer's human brain: comparison with phytoestrogens. Journal of neuroendocrinology. vol 20. issue 5. 2008-07-03. PMID:18363809. |
although in the hippocampus and frontal cortex of the alzheimer's disease (ad) women's brain, 10 microm 17beta-oestradiol produced significantly (p < 0.05) lower stimulation of g-proteins than in the control regions, stimulation by phytoestrogens revealed no remarkable decline. |
2008-07-03 |
2023-08-12 |
human |
| Robert Bartha, Matthew Smith, Raul Rupsingh, Jane Rylett, Jennie L Wells, Michael J Borri. High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 3. 2008-07-02. PMID:18252268. |
high field (1)h mrs of the hippocampus after donepezil treatment in alzheimer disease. |
2008-07-02 |
2023-08-12 |
human |
| A-M Bao, G Meynen, D F Swaa. The stress system in depression and neurodegeneration: focus on the human hypothalamus. Brain research reviews. vol 57. issue 2. 2008-07-01. PMID:17524488. |
this 'glucocorticoid cascade hypothesis' of stress and hippocampal damage was proposed to be causally involved in age-related accumulation of hippocampal damage in disorders like alzheimer's disease and depression. |
2008-07-01 |
2023-08-12 |
human |
| Laura A Craig, Nancy S Hong, Joelle Kopp, Robert J McDonal. Emergence of spatial impairment in rats following specific cholinergic depletion of the medial septum combined with chronic stress. The European journal of neuroscience. vol 27. issue 9. 2008-07-01. PMID:18445217. |
a consistent finding in patients suffering from alzheimer's disease is a loss of the cholinergic neurons of the basal forebrain that project to the hippocampus. |
2008-07-01 |
2023-08-12 |
rat |
| Alim Muhammad, Ingrid Flores, Hong Zhang, Rui Yu, Agnieszka Staniszewski, Emmanuel Planel, Mathieu Herman, Lingling Ho, Robert Kreber, Lawrence S Honig, Barry Ganetzky, Karen Duff, Ottavio Arancio, Scott A Smal. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 20. 2008-06-24. PMID:18480253. |
retromer deficiency observed in alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and abeta accumulation. |
2008-06-24 |
2023-08-12 |
mouse |
| J Barnes, J Foster, R G Boyes, T Pepple, E K Moore, J M Schott, C Frost, R I Scahill, N C Fo. A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus. NeuroImage. vol 40. issue 4. 2008-06-23. PMID:18353687. |
hippocampal atrophy rates have been used in a number of studies in alzheimer's disease (ad) to assess disease progression and are being increasingly utilized as an outcome measure in clinical trials of new pharmaceutical agents. |
2008-06-23 |
2023-08-12 |
human |
| Yuan Xu, Daniel J Valentino, Ann I Scher, Ivo Dinov, Lon R White, Paul M Thompson, Lenore J Launer, Arthur W Tog. Age effects on hippocampal structural changes in old men: the HAAS. NeuroImage. vol 40. issue 3. 2008-06-17. PMID:18280181. |
this study further investigates the age effects on hippocampal morphology in three groups (104 normal controls, 24 alzheimer's disease (ad) and 14 vascular dementia (vad) patients). |
2008-06-17 |
2023-08-12 |
human |
| L Truchot, N Costes, L Zimmer, B Laurent, D Le Bars, C Thomas-Antérion, B Mercier, M Hermier, A Vighetto, P Krolak-Salmo. A distinct [18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease. NeuroImage. vol 40. issue 3. 2008-06-17. PMID:18313943. |
to date, two positron emission tomography (pet) studies have explored 5-ht(1a) receptor density in the hippocampus of alzheimer's disease (ad) patients. |
2008-06-17 |
2023-08-12 |
Not clear |
| Nikolai V Malykhin, Thomas P Bouchard, Richard Camicioli, Nicholas J Couplan. Aging hippocampus and amygdala. Neuroreport. vol 19. issue 5. 2008-06-12. PMID:18388735. |
although limited by the cross-sectional design, these data suggest that hippocampal subregions show a gradient of volume reduction in healthy aging that contrasts with the preferential reduction of anterior hippocampal volumes in alzheimer's and parkinson's diseases. |
2008-06-12 |
2023-08-12 |
Not clear |
| Michael A Rapp, Michal Schnaider-Beeri, Dushyant P Purohit, Daniel P Perl, Vahram Haroutunian, Mary San. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 16. issue 2. 2008-05-14. PMID:18239198. |
recent evidence suggests that a history of major depression may lead to increases in hippocampal neuropathology in alzheimer disease (ad). |
2008-05-14 |
2023-08-12 |
Not clear |
| Areechun Sotthibundhu, Alex M Sykes, Briony Fox, Clare K Underwood, Wipawan Thangnipon, Elizabeth J Coulso. Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 15. 2008-05-08. PMID:18400893. |
alzheimer's disease is characterized by the accumulation of neurotoxic amyloidogenic peptide abeta, degeneration of the cholinergic innervation to the hippocampus (the septohippocampal pathway), and progressive impairment of cognitive function, particularly memory. |
2008-05-08 |
2023-08-12 |
mouse |
| Philip Thomas, Michael Fenec. Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease. Mutagenesis. vol 23. issue 1. 2008-05-07. PMID:18048581. |
however, aneuploidy rate for chromosomes 17 and 21 in the nuclei of hippocampus cells of brains from alzheimer's patients and controls were not significantly different. |
2008-05-07 |
2023-08-12 |
Not clear |
| B Coles, L A K Wilton, M Good, P F Chapman, K T Wan. Potassium channels in hippocampal neurones are absent in a transgenic but not in a chemical model of Alzheimer's disease. Brain research. vol 1190. 2008-05-06. PMID:18093574. |
potassium channels in hippocampal neurones are absent in a transgenic but not in a chemical model of alzheimer's disease. |
2008-05-06 |
2023-08-12 |
mouse |
| Li-Yan Li, Jin-Tao Li, Qing-Ying Wu, Jin Li, Zhong-Tang Feng, Su Liu, Ting-Hua Wan. Transplantation of NGF-gene-modified bone marrow stromal cells into a rat model of Alzheimer' disease. Journal of molecular neuroscience : MN. vol 34. issue 2. 2008-05-05. PMID:18074108. |
it is well known that bone marrow stromal cells (bmsc) grafted into the hippocampus of the rat model of alzheimer's disease (ad) could survive and differentiate into cholinergic neurons as well as contribute towards functional restoration. |
2008-05-05 |
2023-08-12 |
mouse |
| Clifford R Jack, Val J Lowe, Matthew L Senjem, Stephen D Weigand, Bradley J Kemp, Maria M Shiung, David S Knopman, Bradley F Boeve, William E Klunk, Chester A Mathis, Ronald C Peterse. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain : a journal of neurology. vol 131. issue Pt 3. 2008-05-01. PMID:18263627. |
our objectives were to compare cognitive performance and diagnostic group-wise discrimination between cognitively normal, amnestic mild cognitive impairment (mci) and alzheimer's disease subjects with mri-based measures of hippocampal volume and pib retention, and secondly to evaluate the topographic distribution of pib retention and grey matter loss using 3d voxel-wise methods. |
2008-05-01 |
2023-08-12 |
human |
| Clifford R Jack, Val J Lowe, Matthew L Senjem, Stephen D Weigand, Bradley J Kemp, Maria M Shiung, David S Knopman, Bradley F Boeve, William E Klunk, Chester A Mathis, Ronald C Peterse. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain : a journal of neurology. vol 131. issue Pt 3. 2008-05-01. PMID:18263627. |
alzheimer's disease subjects had high global cortical pib retention and low hippocampal volume; most cognitively normal subjects had low pib retention and high hippocampal volume; and on average amnestic mci subjects were intermediate on both pib and hippocampal volume. |
2008-05-01 |
2023-08-12 |
human |
| Keun W Park, Byung K Ji. Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: role of neuronal NADPH oxidase. Journal of neuroscience research. vol 86. issue 5. 2008-04-23. PMID:18183616. |
this strongly suggests that thrombin can act as an endogenous neurotoxin, and inhibitors of thrombin and/or antioxidants can be useful agents for treating oxidative stress-mediated hippocampal neurodegenerative diseases, such as alzheimer's disease. |
2008-04-23 |
2023-08-12 |
Not clear |
| Anqi Qiu, Laurent Younes, Michael I Miller, John G Csernansk. Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type. NeuroImage. vol 40. issue 1. 2008-04-23. PMID:18249009. |
parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the alzheimer's type. |
2008-04-23 |
2023-08-12 |
human |