| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-hong Jiang, Yi-na Zhang, Xiao-wei Wu, Fang-fang Song, Da-yun Gu. Effect of insulin on the cognizing function and expression of hippocampal Abeta1-40 of rat with Alzheimer disease. Chinese medical journal. vol 121. issue 9. 2008-09-09. PMID:18701049. |
a model of simulated alzheimer's disease (ad) induced by aggregated amyloid protein (abeta(1-40)) was built in wistar rats to observe the behavioral and pathological changes of abeta(1-40) and the effect of hypodermic insulin injected on the function of study and memory and the expression of abeta(1-40) from the ca1 area of the hippocampus. |
2008-09-09 |
2023-08-12 |
rat |
| Mark E Bardgett, Megan Points, Christian Ramsey-Faulkner, Jeff Topmiller, John Roflow, Travis McDaniel, Timberly Lamontagne, Molly S Griffit. The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 8. 2008-09-02. PMID:17882233. |
spatial memory impairments observed in alzheimer's disease and schizophrenia have been attributed to many factors, including glutamate hypofunction and reduced hippocampal volume. |
2008-09-02 |
2023-08-12 |
rat |
| Yongxia Zhou, John H Dougherty, Karl F Hubner, Bing Bai, Rex L Cannon, R Kent Hutso. Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 4. issue 4. 2008-08-26. PMID:18631977. |
abnormal connectivity in the posterior cingulate and hippocampus in early alzheimer's disease and mild cognitive impairment. |
2008-08-26 |
2023-08-12 |
Not clear |
| Juan Chen, Yuan Long, Min Han, Ting Wang, Qiang Chen, Rui Wan. Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18485465. |
these results indicated that wsdp may mitigate amnesia in vivo through inhibition of ache activity in the hippocampus, which suggested propolis may have potential as a pharmaceutical of brain protection with elderly population for preventing alzheimer's disease (ad) and other neurodegenerative diseases. |
2008-08-25 |
2023-08-12 |
mouse |
| Mikio Aoki, Inga Volkmann, Lars O Tjernberg, Bengt Winblad, Nenad Bogdanovi. Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain. Neuroreport. vol 19. issue 11. 2008-08-25. PMID:18596605. |
we investigated whether abeta levels are increased in cornu ammonis 1 pyramidal neurons of alzheimer's disease hippocampus, using laser capture microdissection to isolate the neurons and enzyme-linked immunosorbent assay for quantification. |
2008-08-25 |
2023-08-12 |
Not clear |
| Dabing Li, Jun Tang, Haiwei Xu, Xiaotang Fan, Yun Bai, Li Yan. Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1DeltaE9 mouse model of Alzheimer's disease. Hippocampus. vol 18. issue 7. 2008-08-20. PMID:18398851. |
decreased hippocampal cell proliferation correlates with increased expression of bmp4 in the appswe/ps1deltae9 mouse model of alzheimer's disease. |
2008-08-20 |
2023-08-12 |
mouse |
| Dabing Li, Jun Tang, Haiwei Xu, Xiaotang Fan, Yun Bai, Li Yan. Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1DeltaE9 mouse model of Alzheimer's disease. Hippocampus. vol 18. issue 7. 2008-08-20. PMID:18398851. |
alterations in hippocampal cell proliferation have been identified in transgenic (tg) mouse models of alzheimer's disease (ad); however, relatively little is known about the underlying mechanisms. |
2008-08-20 |
2023-08-12 |
mouse |
| Marcelo A Chacón, Lorena Varela-Nallar, Nibaldo C Inestros. Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. Journal of cellular physiology. vol 217. issue 1. 2008-08-19. PMID:18521822. |
the activation of the canonical wnt signaling pathway protects hippocampal neurons against the toxicity of alzheimer's amyloid-beta-peptide (abeta), however, the role played by the wnt receptors frizzleds, has not been studied. |
2008-08-19 |
2023-08-12 |
Not clear |
| Lionel M Igaz, Linda K Kwong, Yan Xu, Adam C Truax, Kunihiro Uryu, Manuela Neumann, Christopher M Clark, Lauren B Elman, Bruce L Miller, Murray Grossman, Leo F McCluskey, John Q Trojanowski, Virginia M-Y Le. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. The American journal of pathology. vol 173. issue 1. 2008-07-29. PMID:18535185. |
tdp-43 inclusions in alzheimer's disease brains also were examined, and similar enrichment in c-t tdp-43 fragments was observed in cortex and hippocampus. |
2008-07-29 |
2023-08-12 |
Not clear |
| Yasuhiro Kosuge, Toru Imai, Mitsuru Kawaguchi, Tetsuroh Kihara, Kumiko Ishige, Yoshihisa It. Subregion-specific vulnerability to endoplasmic reticulum stress-induced neurotoxicity in rat hippocampal neurons. Neurochemistry international. vol 52. issue 6. 2008-07-28. PMID:18280615. |
it is well known that in certain disease states, including ischemia and alzheimer's disease, neurodegeneration occurs in the hippocampus and that vulnerability to neuronal death is area dependent. |
2008-07-28 |
2023-08-12 |
rat |
| Masahiro Mishina, Masashi Ohyama, Kenji Ishii, Shin Kitamura, Yuichi Kimura, Kei-ichi Oda, Kazunori Kawamura, Toru Sasaki, Shiro Kobayashi, Yasuo Katayama, Kiichi Ishiwat. Low density of sigma1 receptors in early Alzheimer's disease. Annals of nuclear medicine. vol 22. issue 3. 2008-07-23. PMID:18498028. |
a postmortem study reported that the sigma(1) receptors were reduced in the hippocampus in alzheimer's disease (ad). |
2008-07-23 |
2023-08-12 |
Not clear |
| Megumi Takahashi, Aiko Sato, Keisuke Nakajima, Aya Inoue, Satoru Oishi, Takayoshi Ishii, Hitoshi Miyaok. Poor performance in Clock-Drawing Test associated with visual memory deficit and reduced bilateral hippocampal and left temporoparietal regional blood flows in Alzheimer's disease patients. Psychiatry and clinical neurosciences. vol 62. issue 2. 2008-07-22. PMID:18412838. |
poor performance in clock-drawing test associated with visual memory deficit and reduced bilateral hippocampal and left temporoparietal regional blood flows in alzheimer's disease patients. |
2008-07-22 |
2023-08-12 |
Not clear |
| Olivier Colliot, Gaël Chételat, Marie Chupin, Béatrice Desgranges, Benoît Magnin, Habib Benali, Bruno Dubois, Line Garnero, Francis Eustache, Stéphane Lehéric. Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus. Radiology. vol 248. issue 1. 2008-07-18. PMID:18458242. |
discrimination between alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus. |
2008-07-18 |
2023-08-12 |
Not clear |
| Olivier Colliot, Gaël Chételat, Marie Chupin, Béatrice Desgranges, Benoît Magnin, Habib Benali, Bruno Dubois, Line Garnero, Francis Eustache, Stéphane Lehéric. Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus. Radiology. vol 248. issue 1. 2008-07-18. PMID:18458242. |
to prospectively evaluate the accuracy of automated hippocampal volumetry to help distinguish between patients with alzheimer disease (ad), patients with mild cognitive impairment (mci), and elderly controls, by using established criteria for patients with ad and mci as the reference standard. |
2008-07-18 |
2023-08-12 |
Not clear |
| D Larry Sparks, Susan K Lemieux, Marc W Haut, Leslie C Baxter, Sterling C Johnson, Lisa M Sparks, Hemalatha Sampath, Jean E Lopez, Marwan H Sabbagh, Donald J Conno. Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial. Cleveland Clinic journal of medicine. vol 75 Suppl 2. 2008-07-18. PMID:18540154. |
hippocampal volume change in the alzheimer disease cholesterol-lowering treatment trial. |
2008-07-18 |
2023-08-12 |
Not clear |
| Haruka Matsumoto, Izuru Matsumot. Alcoholism: protein expression profiles in a human hippocampal model. Expert review of proteomics. vol 5. issue 2. 2008-07-16. PMID:18466060. |
proteomics studies on human hippocampus, an important region for neurocognitive function and psychiatric illnesses (e.g., alzheimer's disease, alcoholism and schizophrenia) are still sparse, and further investigation is warranted to understand the underlying mechanisms. |
2008-07-16 |
2023-08-12 |
human |
| Ute Dreses-Werringloer, Jean-Charles Lambert, Valérie Vingtdeux, Haitian Zhao, Horia Vais, Adam Siebert, Ankit Jain, Jeremy Koppel, Anne Rovelet-Lecrux, Didier Hannequin, Florence Pasquier, Daniela Galimberti, Elio Scarpini, David Mann, Corinne Lendon, Dominique Campion, Philippe Amouyel, Peter Davies, J Kevin Foskett, Fabien Campagne, Philippe Marambau. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell. vol 133. issue 7. 2008-07-16. PMID:18585350. |
alzheimer's disease (ad) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (abeta) peptide deposition. |
2008-07-16 |
2023-08-12 |
human |
| A B Clement, R Hanstein, A Schröder, H Nagel, K Endres, F Fahrenholz, C Beh. Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress. Neuroscience. vol 152. issue 2. 2008-07-10. PMID:18276079. |
neuron-specific adam10 overexpression proved beneficial in the app[v717i] mutant alzheimer mouse model [postina r, schroeder a, dewachter i, bohl j, schmitt u, kojro e, prinzen c, endres k, hiemke c, blessing m, flamez p, dequenne a, godaux e, van leuven f, fahrenholz f (2004) a disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an alzheimer disease mouse model. |
2008-07-10 |
2023-08-12 |
mouse |
| Nicolas Villain, Béatrice Desgranges, Fausto Viader, Vincent de la Sayette, Florence Mézenge, Brigitte Landeau, Jean-Claude Baron, Francis Eustache, Gaël Chétela. Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 24. 2008-07-10. PMID:18550759. |
relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in alzheimer's disease. |
2008-07-10 |
2023-08-12 |
Not clear |
| Nicolas Villain, Béatrice Desgranges, Fausto Viader, Vincent de la Sayette, Florence Mézenge, Brigitte Landeau, Jean-Claude Baron, Francis Eustache, Gaël Chétela. Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 24. 2008-07-10. PMID:18550759. |
in early alzheimer's disease (ad), the hippocampal region is the area most severely affected by cellular and structural alterations, yet glucose hypometabolism predominates in the posterior association cortex and posterior cingulate gyrus. |
2008-07-10 |
2023-08-12 |
Not clear |