| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Moosavi, N Naghdi, N Maghsoudi, S Zahedi As. Insulin protects against stress-induced impairments in water maze performance. Behavioural brain research. vol 176. issue 2. 2007-03-02. PMID:17116337. |
a direct role of hippocampal insulin receptor signaling in improving cognitive functions, including learning and memory, and the association of insulin receptor deterioration with brain degenerative dementia (e.g., alzheimer's disease) have attracted increasing interest. |
2007-03-02 |
2023-08-12 |
Not clear |
| Stéphanie Reix, Naguib Mechawar, Santos A Susin, Rémi Quirion, Slavica Kranti. Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease. Neurobiology of aging. vol 28. issue 3. 2007-03-01. PMID:16504343. |
expression of cortical and hippocampal apoptosis-inducing factor (aif) in aging and alzheimer's disease. |
2007-03-01 |
2023-08-12 |
human |
| Jennifer Bizon, Sonya Prescott, Michelle M Nicoll. Intact spatial learning in adult Tg2576 mice. Neurobiology of aging. vol 28. issue 3. 2007-03-01. PMID:16504344. |
tg2576 mice, a transgenic model of amyloid pathology associated with alzheimer's disease (ad), develop measurable levels of soluble amyloid beta1-40 and 1-42 by 6 months of age and amyloid plaque deposition in cortex, hippocampus and amygdala by 10 months of age. |
2007-03-01 |
2023-08-12 |
mouse |
| Matthew Townsend, James P Cleary, Tapan Mehta, Jacki Hofmeister, Sylvain Lesne, Eugene O'Hare, Dominic M Walsh, Dennis J Selko. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Annals of neurology. vol 60. issue 6. 2007-02-26. PMID:17192927. |
despite progress in defining a pathogenic role for amyloid beta protein (abeta) in alzheimer's disease, orally bioavailable compounds that prevent its effects on hippocampal synaptic plasticity and cognitive function have not yet emerged. |
2007-02-26 |
2023-08-12 |
Not clear |
| Helena C Chui, Chris Zarow, Wendy J Mack, William G Ellis, Ling Zheng, William J Jagust, Dan Mungas, Bruce R Reed, Joel H Kramer, Charles C Decarli, Michael W Weiner, Harry V Vinter. Cognitive impact of subcortical vascular and Alzheimer's disease pathology. Annals of neurology. vol 60. issue 6. 2007-02-26. PMID:17192928. |
to assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [hs], and alzheimer's disease [ad]), cognitive status, and apolipoprotein e genotype. |
2007-02-26 |
2023-08-12 |
Not clear |
| Rodica V Popa, Edna F R Pereira, Cristiane Lopes, Alfred Maelicke, Edson X Albuquerqu. The N-butylcarbamate derivative of galantamine acts as an allosteric potentiating ligand on alpha7 nicotinic receptors in hippocampal neurons: clinical implications for treatment of Alzheimer's disease. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192682. |
the n-butylcarbamate derivative of galantamine acts as an allosteric potentiating ligand on alpha7 nicotinic receptors in hippocampal neurons: clinical implications for treatment of alzheimer's disease. |
2007-02-23 |
2023-08-12 |
Not clear |
| John G Csernansky, Hongxin Dong, Anne M Fagan, Lei Wang, Chengjie Xiong, David M Holtzman, John C Morri. Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. The American journal of psychiatry. vol 163. issue 12. 2007-02-16. PMID:17151169. |
studies of subjects with dementia of the alzheimer type have reported correlations between increases in activity of the hypothalamic-pituitary-adrenal (hpa) axis and hippocampal degeneration. |
2007-02-16 |
2023-08-12 |
human |
| Toshiya Fukui, Soutaro Hieda, Christian Boct. Do lesions involving the cortical cholinergic pathways help or hinder efficacy of donepezil in patients with Alzheimer's disease? Dementia and geriatric cognitive disorders. vol 22. issue 5-6. 2007-02-15. PMID:16974095. |
to investigate the influences of vascular lesions detected by mri, lesions involving the cortical cholinergic pathways and hippocampal thickness on therapeutic responsiveness to donepezil in patients with alzheimer's disease (ad). |
2007-02-15 |
2023-08-12 |
Not clear |
| Letten F Saugsta. Are neurodegenerative disorder and psychotic manifestations avoidable brain dysfunctions with adequate dietary omega-3? Nutrition and health. vol 18. issue 3. 2007-02-08. PMID:17180865. |
this review describes signs of n-3 deficit in alzheimer and parkinson disease, where maximum change involves the primary sites: olfactory cortex and the hippocampus. |
2007-02-08 |
2023-08-12 |
Not clear |
| Elena L Paley, Larisa Smelyanski, Vladimir Malinovskii, Pochi R Subbarayan, Yevgeny Berdichevsky, Natalia Posternak, Jonathan M Gershoni, Olga Sokolova, Galina Denisov. Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease. Molecular immunology. vol 44. issue 4. 2007-02-07. PMID:16616781. |
immunohistochemically both mabs revealed extracellular plaque-like aggregates in hippocampus of alzheimer's disease brain. |
2007-02-07 |
2023-08-12 |
mouse |
| Gregory A Elder, Rita De Gasperi, Miguel A Gama Sos. Research update: neurogenesis in adult brain and neuropsychiatric disorders. The Mount Sinai journal of medicine, New York. vol 73. issue 7. 2007-02-01. PMID:17195878. |
altered hippocampal neurogenesis may also play a pathophysiological role in neurodegenerative disorders such as alzheimer's disease. |
2007-02-01 |
2023-08-12 |
mouse |
| Matthew Mei, Bo Su, Kristen Harrison, Mark Chao, Sandra L Siedlak, Laura A Previll, LaMia Jackson, Dan X Cai, Xiongwei Zh. Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. Journal of neurochemistry. vol 99. issue 5. 2007-01-23. PMID:17064357. |
both phospho-raf-1 (ser259) and phospho-raf-1 (ser338) were localized to intracytoplasmic granular structures, whereas phospho-raf-1 (tyr340/341) was localized to neurofibrillary tangles and granules in pyramidal neurons in alzheimer's disease hippocampus. |
2007-01-23 |
2023-08-12 |
Not clear |
| Hyoung-gon Lee, Masumi Ueda, Yoichi Miyamoto, Yoshihiro Yoneda, George Perry, Mark A Smith, Xiongwei Zh. Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease. Brain research. vol 1124. issue 1. 2007-01-23. PMID:17070506. |
aberrant localization of importin alpha1 in hippocampal neurons in alzheimer disease. |
2007-01-23 |
2023-08-12 |
Not clear |
| Frank Jessen, Ludger Feyen, Katrin Freymann, Ralf Tepest, Wolfgang Maier, Reinhard Heun, Hans-H Schild, Lukas Schee. Volume reduction of the entorhinal cortex in subjective memory impairment. Neurobiology of aging. vol 27. issue 12. 2007-01-03. PMID:16309795. |
to examine the biological basis of subjective memory impairment (smi), defined as the feeling of memory worsening with normal memory performance, we measured the volume of the entorhinal cortex (ec) and the hippocampus in smi subjects, patients with mild cognitive impairment (mci), patients with alzheimer's disease (ad) and healthy controls (co). |
2007-01-03 |
2023-08-12 |
human |
| Rui-Sheng Duan, Zhiguo Chen, Ying-Chun Dou, Hernan Concha Quezada, Inger Nennesmo, Abdu Adem, Bengt Winblad, Jie Zh. Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16919271. |
taken together, these findings imply that apoe modulates hippocampal damage induced by ka and found early in the sequence of human alzheimer's brain changes, by modulating microglial activation. |
2007-01-03 |
2023-08-12 |
mouse |
| Yi-Ju Li, Puting Xu, Xuejun Qin, Donald E Schmechel, Christine M Hulette, Jonathan L Haines, Margaret A Pericak-Vance, John R Gilber. A comparative analysis of the information content in long and short SAGE libraries. BMC bioinformatics. vol 7. 2007-01-03. PMID:17109755. |
to dissect the differences between these two types of libraries, we utilized four libraries (two longsage and two shortsage libraries) generated from the hippocampus of alzheimer and control samples. |
2007-01-03 |
2023-08-12 |
Not clear |
| Josephine Barnes, Alison K Godbolt, Chris Frost, Richard G Boyes, Bethany F Jones, Rachael I Scahill, Martin N Rossor, Nick C Fo. Atrophy rates of the cingulate gyrus and hippocampus in AD and FTLD. Neurobiology of aging. vol 28. issue 1. 2006-12-28. PMID:16406154. |
this study explores the diagnostic utility of atrophy rates of the cingulate gyrus, its subdivisions and the hippocampus in alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld). |
2006-12-28 |
2023-08-12 |
Not clear |
| James G McLarnon, Jae K Ryu, Douglas G Walker, Hyun B Cho. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086106. |
upregulated expression of purinergic p2x(7) receptor in alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. |
2006-12-27 |
2023-08-12 |
human |
| James G McLarnon, Jae K Ryu, Douglas G Walker, Hyun B Cho. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086106. |
the expression of the purinergic receptor subtype p2x(7)r, a nonselective cationic channel activated by high levels of adenosine triphosphate (atp), has been studied in adult microglia obtained from alzheimer disease (ad) and nondemented (nd) brains, in fetal human microglia exposed to abeta(1-42) peptide and in vivo in abeta(1-42)-injected rat hippocampus. |
2006-12-27 |
2023-08-12 |
human |
| Falk Fahrenholz, Rolf Postin. Alpha-secretase activation--an approach to Alzheimer's disease therapy. Neuro-degenerative diseases. vol 3. issue 4-5. 2006-12-12. PMID:17047365. |
the identification of a member of the disintegrin and metalloproteinase family, adam10, as an alpha-secretase that prevents plaque formation and hippocampal deficits in vivo gave us the possibility to examine the alpha-secretase as a potential target for the therapy of alzheimer's disease. |
2006-12-12 |
2023-08-12 |
human |