| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung Hoon Jung, Kyongman An, Oh Bin Kwon, Hye-sun Kim, Joung-Hun Ki. Pathway-specific alteration of synaptic plasticity in Tg2576 mice. Molecules and cells. vol 32. issue 2. 2011-12-30. PMID:21638202. |
various animal models of alzheimer disease (ad) are characterized by deficits in spatial memory that are causally related to altered synaptic function and impairment of long-term potentiation (ltp) in the hippocampus. |
2011-12-30 |
2023-08-12 |
mouse |
| L L Beason-Hel. Dementia and the default mode. Current Alzheimer research. vol 8. issue 4. 2011-12-23. PMID:21222595. |
individuals with age-related disease such as mild cognitive impairment (mci) and alzheimer's disease (ad) demonstrate additional default-related changes particularly in posterior cingulate/precuneus and hippocampal regions. |
2011-12-23 |
2023-08-12 |
Not clear |
| Justin Longenberger, Zahoor A Sha. Simvastatin and other HMG-CoA reductase inhibitors on brain cholesterol levels in Alzheimer's disease. Current Alzheimer research. vol 8. issue 4. 2011-12-23. PMID:21244355. |
one of the most widely accepted theories of alzheimer's pathology is the aggregation of amyloid-beta (aβ) into extracellular cortical and hippocampal plaques. |
2011-12-23 |
2023-08-12 |
Not clear |
| Lindsay C Reese, Fernanda Laezza, Randall Woltjer, Giulio Taglialatel. Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease. Journal of neurochemistry. vol 119. issue 4. 2011-12-23. PMID:21883216. |
dysregulated phosphorylation of ca(2+) /calmodulin-dependent protein kinase ii-α in the hippocampus of subjects with mild cognitive impairment and alzheimer's disease. |
2011-12-23 |
2023-08-12 |
mouse |
| Igor Yakushev, Alex Gerhard, Matthias J Müller, Markus Lorscheider, Hans-Georg Buchholz, Ingrid Schermuly, Carsten Weibrich, Alexander Hammers, Peter Stoeter, Matthias Schreckenberger, Andreas Fellgiebe. Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer's disease. Brain structure & function. vol 216. issue 3. 2011-12-12. PMID:21318476. |
relationships between hippocampal microstructure, metabolism, and function in early alzheimer's disease. |
2011-12-12 |
2023-08-12 |
human |
| Igor Yakushev, Alex Gerhard, Matthias J Müller, Markus Lorscheider, Hans-Georg Buchholz, Ingrid Schermuly, Carsten Weibrich, Alexander Hammers, Peter Stoeter, Matthias Schreckenberger, Andreas Fellgiebe. Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer's disease. Brain structure & function. vol 216. issue 3. 2011-12-12. PMID:21318476. |
abnormal microstructural integrity and glucose metabolism of the hippocampus are common in subjects with alzheimer's disease (ad) that typically manifest as episodic memory impairment. |
2011-12-12 |
2023-08-12 |
human |
| Athanasios Zovoilis, Hope Y Agbemenyah, Roberto C Agis-Balboa, Roman M Stilling, Dieter Edbauer, Pooja Rao, Laurent Farinelli, Ivana Delalle, Andrea Schmitt, Peter Falkai, Sanaz Bahari-Javan, Susanne Burkhardt, Farahnaz Sananbenesi, Andre Fische. microRNA-34c is a novel target to treat dementias. The EMBO journal. vol 30. issue 20. 2011-12-12. PMID:21946562. |
here, we employed massive parallel sequencing and provide, at an unprecedented depth, the complete and quantitative mirnaome of the mouse hippocampus, the prime target of neurodegenerative diseases such as alzheimer's disease (ad). |
2011-12-12 |
2023-08-12 |
mouse |
| Janita Bralten, Alejandro Arias-Vásquez, Remco Makkinje, Joris A Veltman, Han G Brunner, Guillén Fernández, Mark Rijpkema, Barbara Frank. Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adults. The American journal of psychiatry. vol 168. issue 10. 2011-12-08. PMID:21730226. |
association of the alzheimer's gene sorl1 with hippocampal volume in young, healthy adults. |
2011-12-08 |
2023-08-12 |
Not clear |
| Janita Bralten, Alejandro Arias-Vásquez, Remco Makkinje, Joris A Veltman, Han G Brunner, Guillén Fernández, Mark Rijpkema, Barbara Frank. Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adults. The American journal of psychiatry. vol 168. issue 10. 2011-12-08. PMID:21730226. |
the authors used a gene-wide approach to test whether sorl1 is associated with volume of the hippocampus, one of the first structures to be affected by alzheimer's disease in young, healthy individuals, in an attempt to map potential pathways from gene to disease. |
2011-12-08 |
2023-08-12 |
Not clear |
| Andreas Goette, Ruediger C Braun-Dullaeu. Atrial fibrillation is associated with impaired cognitive function and hippocampal atrophy: silent cerebral ischaemia vs. Alzheimer's disease? European heart journal. vol 29. issue 17. 2011-12-07. PMID:18676399. |
atrial fibrillation is associated with impaired cognitive function and hippocampal atrophy: silent cerebral ischaemia vs. alzheimer's disease? |
2011-12-07 |
2023-08-12 |
Not clear |
| Laura van de Pol, Hermann-Josef Gertz, Philip Scheltens, Henrike Wol. Hippocampal atrophy in subcortical vascular dementia. Neuro-degenerative diseases. vol 8. issue 6. 2011-12-07. PMID:21613775. |
hippocampal (hc) atrophy is a hallmark of alzheimer's disease (ad), but it also occurs in other dementia disorders including vascular dementias. |
2011-12-07 |
2023-08-12 |
Not clear |
| Maheen M Adamson, J Benjamin Hutchinson, Amy L Shelton, Anthony D Wagner, Joy L Taylo. Reduced hippocampal activity during encoding in cognitively normal adults carrying the APOE ɛ4 allele. Neuropsychologia. vol 49. issue 9. 2011-12-06. PMID:21549723. |
the hippocampus and the surrounding medial temporal lobe (mtl) structures are the first site affected by alzheimer's disease (ad) and the mtl is the seat of episodic memory, including visuo-spatial memory. |
2011-12-06 |
2023-08-12 |
human |
| Shigeru Maeda, Yukiko Arai, Hitoshi Higuchi, Yumiko Tomoyasu, Ryuichiro Mizuno, Toru Takahashi, Takuya Miyawak. Induction of apoptotic change in the rat hippocampus caused by ferric nitrilotriacetate. Redox report : communications in free radical research. vol 16. issue 3. 2011-11-28. PMID:21801493. |
in alzheimer's disease, the hippocampus is vulnerable to oxidative stress, leading to impairment in memory formation. |
2011-11-28 |
2023-08-12 |
rat |
| H N Noristani, R S Meadows, M Olabarria, A Verkhratsky, J J Rodrígue. Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study. Cell death & disease. vol 2. 2011-11-28. PMID:21918544. |
alzheimer's disease (ad) is a neurodegenerative pathology that deteriorates mnesic functions and associated brain regions including the hippocampus. |
2011-11-28 |
2023-08-12 |
mouse |
| Raymond Y Lo, Alan E Hubbard, Leslie M Shaw, John Q Trojanowski, Ronald C Petersen, Paul S Aisen, Michael W Weiner, William J Jagus. Longitudinal change of biomarkers in cognitive decline. Archives of neurology. vol 68. issue 10. 2011-11-23. PMID:21670386. |
to delineate the trajectories of aβ42 level in cerebrospinal fluid (csf), fludeoxyglucose f18 (fdg) uptake using positron emission tomography, and hippocampal volume using magnetic resonance imaging and their relative associations with cognitive change at different stages in aging and alzheimer disease (ad). |
2011-11-23 |
2023-08-12 |
Not clear |
| Clifford R Jack, Frederik Barkhof, Matt A Bernstein, Marc Cantillon, Patricia E Cole, Charles Decarli, Bruno Dubois, Simon Duchesne, Nick C Fox, Giovanni B Frisoni, Harald Hampel, Derek L G Hill, Keith Johnson, Jean-François Mangin, Philip Scheltens, Adam J Schwarz, Reisa Sperling, Joyce Suhy, Paul M Thompson, Michael Weiner, Norman L Foste. Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 7. issue 4. 2011-11-23. PMID:21784356. |
steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for alzheimer's disease. |
2011-11-23 |
2023-08-12 |
Not clear |
| Clifford R Jack, Frederik Barkhof, Matt A Bernstein, Marc Cantillon, Patricia E Cole, Charles Decarli, Bruno Dubois, Simon Duchesne, Nick C Fox, Giovanni B Frisoni, Harald Hampel, Derek L G Hill, Keith Johnson, Jean-François Mangin, Philip Scheltens, Adam J Schwarz, Reisa Sperling, Joyce Suhy, Paul M Thompson, Michael Weiner, Norman L Foste. Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 7. issue 4. 2011-11-23. PMID:21784356. |
hippocampal volumetry is the most widely studied quantitative magnetic resonance imaging measure in alzheimer's disease and thus represents the most rational target for an initial effort at standardization. |
2011-11-23 |
2023-08-12 |
Not clear |
| M Atienza, K C Atalaia-Silva, G Gonzalez-Escamilla, E Gil-Neciga, A Suarez-Gonzalez, J L Canter. Associative memory deficits in mild cognitive impairment: the role of hippocampal formation. NeuroImage. vol 57. issue 4. 2011-11-21. PMID:21640840. |
neuropathological events featuring early stages of alzheimer's disease (ad) appear in the entorhinal cortex (ec), subiculum (sb) and cornu ammonis 1 (ca1) of hippocampus, which may account for associative memory deficits in non-demented people with mild cognitive impairment (mci). |
2011-11-21 |
2023-08-12 |
human |
| Christy M Kelley, Sylvia E Perez, Cassia R Overk, David Wynick, Elliott J Mufso. Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AβPPswe/PS1ΔE9 mice. Journal of Alzheimer's disease : JAD. vol 25. issue 3. 2011-11-15. PMID:21471639. |
amyloid-β (aβ) plaques occur in close apposition to thickened or swollen cholinergic and galaninergic neurites within the neocortex and hippocampus in alzheimer's disease (ad). |
2011-11-15 |
2023-08-12 |
mouse |
| Cristina Marchetti, Hélène Mari. Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models? Reviews in the neurosciences. vol 22. issue 4. 2011-11-15. PMID:21732714. |
hippocampal synaptic plasticity in alzheimer's disease: what have we learned so far from transgenic models? |
2011-11-15 |
2023-08-12 |
mouse |