| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco García-Sierra, Jose J Jarero-Basulto, Zdena Kristofikova, Emerich Majer, Lester I Binder, Daniela Ripov. Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 22. issue 2. 2012-11-06. PMID:21919991. |
for this reason, we sought to determine whether ubiquitin-targeting of tau is associated with particular tau modifications that herald specific stages of nfts maturation in the hippocampus of alzheimer's disease cases. |
2012-11-06 |
2023-08-12 |
Not clear |
| Alessandro Martorana, Giulia M Sancesario, Zaira Esposito, Marzia Nuccetelli, Roberto Sorge, Amanda Formosa, Vincenzo Dinallo, Giorgio Bernardi, Sergio Bernardini, Giuseppe Sancesari. Plasmin system of Alzheimer's disease patients: CSF analysis. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 7. 2012-11-06. PMID:22415062. |
alzheimer's disease (ad) is a multifactorial neurodegenerative disorder characterized by the extracellular deposit of amyloid beta (aβ), mainly of the amyloid beta(1-42) (aβ(1-42)) peptide in the hippocampus and neocortex leading to progressive cognitive decline and dementia. |
2012-11-06 |
2023-08-12 |
Not clear |
| C Venkateshappa, G Harish, Anita Mahadevan, M M Srinivas Bharath, S K Shanka. Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease. Neurochemical research. vol 37. issue 8. 2012-11-05. PMID:22461064. |
elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in alzheimer's disease. |
2012-11-05 |
2023-08-12 |
human |
| C Venkateshappa, G Harish, Anita Mahadevan, M M Srinivas Bharath, S K Shanka. Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease. Neurochemical research. vol 37. issue 8. 2012-11-05. PMID:22461064. |
to understand whether aging contributes to the vulnerability of brain regions in alzheimer's disease, we assessed the oxidant and antioxidant markers, glutathione (gsh) metabolic enzymes, glial fibrillary acidic protein (gfap) expression and mitochondrial complex i (ci) activity in hippocampus (hc) and frontal cortex (fc) compared with cerebellum (cb) in human brains with increasing age (0.01-80 years). |
2012-11-05 |
2023-08-12 |
human |
| Martina L Mustroph, Michael A King, Ronald L Klein, Julio J Ramire. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22561128. |
tauopathy in the hippocampus is one of the earliest cardinal features of alzheimer's disease (ad), a condition characterized by progressive memory impairments. |
2012-11-05 |
2023-08-12 |
mouse |
| Masanori Nomoto, Yohei Takeda, Shusaku Uchida, Koji Mitsuda, Hatsune Enomoto, Kaori Saito, Tesu Choi, Ayako M Watabe, Shizuka Kobayashi, Shoichi Masushige, Toshiya Manabe, Satoshi Kid. Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity. Molecular brain. vol 5. 2012-10-31. PMID:22316320. |
furthermore, recent studies have shown that treatment with retinoic acid alleviates age-related deficits in hippocampal long-term potentiation (ltp) and memory performance and, furthermore, memory deficits in a transgenic mouse model of alzheimer's disease. |
2012-10-31 |
2023-08-12 |
mouse |
| Jennifer G Goldman, Glenn T Stebbins, Bryan Bernard, Travis R Stoub, Christopher G Goetz, Leyla deToledo-Morrel. Entorhinal cortex atrophy differentiates Parkinson's disease patients with and without dementia. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 6. 2012-10-25. PMID:22410753. |
both in vivo mri and postmortem tissue studies in alzheimer's disease, however, demonstrate that the entorhinal cortex (erc) is involved earlier in disease-related pathology than the hippocampus. |
2012-10-25 |
2023-08-12 |
human |
| Robert Wykes, Abigail Kalmbach, Marina Eliava, Jack Water. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. Neurobiology of aging. vol 33. issue 8. 2012-10-24. PMID:21676499. |
these changes in intrinsic properties may affect information flow through the hippocampus and contribute to the behavioral deficits observed in mouse models and patients with early-stage alzheimer's disease. |
2012-10-24 |
2023-08-12 |
mouse |
| Barbara Biscaro, Olle Lindvall, Giuseppina Tesco, Christine T Ekdahl, Roger M Nitsc. Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease. Neuro-degenerative diseases. vol 9. issue 4. 2012-10-23. PMID:22584394. |
inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for alzheimer's disease. |
2012-10-23 |
2023-08-12 |
mouse |
| Lisa M Nichols, Joseph C Masdeu, Venkata S Mattay, Philip Kohn, Matthew Emery, Fabio Sambataro, Bhaskar Kolachana, Brita Elvevåg, Shane Kippenhan, Daniel R Weinberger, Karen F Berma. Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults. Archives of general psychiatry. vol 69. issue 8. 2012-10-18. PMID:22868934. |
although the apolipoprotein e (apoe) ϵ4 allele is a major genetic risk factor for late-onset alzheimer disease, its effect on hippocampal function during episodic memory is controversial because studies have yielded mixed results. |
2012-10-18 |
2023-08-12 |
mouse |
| Ana F Nunes, Joana D Amaral, Adrian C Lo, Maria B Fonseca, Ricardo J S Viana, Zsuzsanna Callaerts-Vegh, Rudi D'Hooge, Cecília M P Rodrigue. TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice. Molecular neurobiology. vol 45. issue 3. 2012-10-17. PMID:22438081. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by accumulation of amyloid-β (aβ) peptide in the hippocampus and frontal cortex of the brain, leading to progressive cognitive decline. |
2012-10-17 |
2023-08-12 |
mouse |
| Jonathan Graff-Radford, Bradley F Boeve, Otto Pedraza, Tanis J Ferman, Scott Przybelski, Timothy G Lesnick, Prashanthi Vemuri, Matthew L Senjem, Glenn E Smith, David S Knopman, Val Lowe, Clifford R Jack, Ronald C Petersen, Kejal Kantarc. Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies. Brain : a journal of neurology. vol 135. issue Pt 8. 2012-10-17. PMID:22810436. |
hippocampal atrophy on magnetic resonance imaging and amyloid-β load on positron emission tomography are associated with the alzheimer's disease-related pathology in patients with dementia with lewy bodies. |
2012-10-17 |
2023-08-12 |
human |
| Jonathan Graff-Radford, Bradley F Boeve, Otto Pedraza, Tanis J Ferman, Scott Przybelski, Timothy G Lesnick, Prashanthi Vemuri, Matthew L Senjem, Glenn E Smith, David S Knopman, Val Lowe, Clifford R Jack, Ronald C Petersen, Kejal Kantarc. Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies. Brain : a journal of neurology. vol 135. issue Pt 8. 2012-10-17. PMID:22810436. |
our objective was to determine whether imaging markers of alzheimer's disease-related pathology such as hippocampal volume, brain amyloid-β load on (11)c pittsburgh compound b positron emission tomography predict treatment response to acetylcholinesterase inhibitors in patients with dementia with lewy bodies. |
2012-10-17 |
2023-08-12 |
human |
| Jonathan Graff-Radford, Bradley F Boeve, Otto Pedraza, Tanis J Ferman, Scott Przybelski, Timothy G Lesnick, Prashanthi Vemuri, Matthew L Senjem, Glenn E Smith, David S Knopman, Val Lowe, Clifford R Jack, Ronald C Petersen, Kejal Kantarc. Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies. Brain : a journal of neurology. vol 135. issue Pt 8. 2012-10-17. PMID:22810436. |
we performed a retrospective analysis on consecutive treatment-naive patients with dementia with lewy bodies (n = 54) from the mayo clinic alzheimer's disease research centre who subsequently received acetylcholinesterase inhibitors and underwent magnetic resonance imaging with hippocampal volumetry. |
2012-10-17 |
2023-08-12 |
human |
| Balu Chakravarthy, Michel Ménard, Shingo Ito, Chantal Gaudet, Ilaria Dal Prà, Ubaldo Armato, James Whitfiel. Hippocampal membrane-associated p75NTR levels are increased in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 30. issue 3. 2012-10-16. PMID:22451321. |
hippocampal membrane-associated p75ntr levels are increased in alzheimer's disease. |
2012-10-16 |
2023-08-12 |
mouse |
| Roger Lefort, Julio Pozueta, Michael Shelansk. Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 31. 2012-10-15. PMID:22855816. |
cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for alzheimer's disease. |
2012-10-15 |
2023-08-12 |
rat |
| Auriel A Willette, Christopher L Coe, Ricki J Colman, Barbara B Bendlin, Erik K Kastman, Aaron S Field, Andrew L Alexander, David B Allison, Richard H Weindruch, Sterling C Johnso. Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys. Psychoneuroendocrinology. vol 37. issue 7. 2012-10-09. PMID:22119476. |
heightened stress reactivity is associated with hippocampal atrophy, age-related cognitive deficits, and increased risk for alzheimer's disease. |
2012-10-09 |
2023-08-12 |
monkey |
| Da-Bing Li, Jun Tang, Xiao-Tang Fan, Min Song, Hai-Wei Xu, Yun Ba. Comparative study of histopathology changes between the PS1/APP double transgenic mouse model and Abeta1-40 -injected rat model of Alzheimer disease. Neuroscience bulletin. vol 22. issue 1. 2012-10-02. PMID:17684540. |
conclusion although abeta1-40-injected rat models could simulate some characteristic pathological features of human alzheimer diseases, abeta deposits and neurons loss in partial hippocampal, it would not simulate the progressive degenenration in the brain of ad. |
2012-10-02 |
2023-08-12 |
mouse |
| G Mecheri, M Marie-Cardine, D Sappey-Marinier, H Bonmartin, G Albrand, G Ferry, N Coppard-Meyer, P Courpro. In vivo hippocampal (31)P NMR metabolites in Alzheimer's disease and ageing. European psychiatry : the journal of the Association of European Psychiatrists. vol 12. issue 3. 2012-10-02. PMID:19698521. |
in vivo hippocampal (31)p nmr metabolites in alzheimer's disease and ageing. |
2012-10-02 |
2023-08-12 |
Not clear |
| Lauren Meredith Willis, Barbara Shukitt-Hale, James A Josep. Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain. Genes & nutrition. vol 4. issue 4. 2012-10-02. PMID:19727886. |
the cholinergic theory of aging states that dysfunction of cholinergic neurons arising from the basal forebrain and terminating in the cortex and hippocampus may be involved in the cognitive decline that occurs during aging and alzheimer's disease. |
2012-10-02 |
2023-08-12 |
Not clear |