| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takafumi Noshita, Norihito Murayama, Tetsushi Oka, Ryoko Ogino, Shizuo Nakamura, Teruyoshi Inou. Effect of bFGF on neuronal damage induced by sequential treatment of amyloid β and excitatory amino acid in vitro and in vivo. European journal of pharmacology. vol 695. issue 1-3. 2013-03-19. PMID:23026373. |
in a rat model of alzheimer's disease, in which aggregated aβ(1-40) (4μg/1μl) was injected into the hippocampus, followed by an injection of ibotenate (an nmda receptor agonist, 0.3μg/0.5μl) into the same sites at 48h later, significant neuronal damage and learning deficit was induced. |
2013-03-19 |
2023-08-12 |
rat |
| Marzia Martina, Tanya Comas, Geoffrey A R Mealin. Selective Pharmacological Modulation of Pyramidal Neurons and Interneurons in the CA1 Region of the Rat Hippocampus. Frontiers in pharmacology. vol 4. 2013-03-18. PMID:23493925. |
interestingly, the uncompetitive n-methyl-d-aspartate receptor (nmdar) antagonist memantine, currently in clinical use for the treatment of alzheimer's disease, may alter the excitation-inhibition balance in the hippocampus. |
2013-03-18 |
2023-08-12 |
rat |
| T den Heijer, F van der Lijn, M W Vernooij, M de Groot, P J Koudstaal, A van der Lugt, G P Krestin, A Hofman, W J Niessen, M M B Bretele. Structural and diffusion MRI measures of the hippocampus and memory performance. NeuroImage. vol 63. issue 4. 2013-03-14. PMID:22960084. |
hippocampal atrophy on mri and changes in diffusion tensor imaging (dti) measures of the hippocampus have been reported in patients with alzheimer's disease. |
2013-03-14 |
2023-08-12 |
Not clear |
| T den Heijer, F van der Lijn, M W Vernooij, M de Groot, P J Koudstaal, A van der Lugt, G P Krestin, A Hofman, W J Niessen, M M B Bretele. Structural and diffusion MRI measures of the hippocampus and memory performance. NeuroImage. vol 63. issue 4. 2013-03-14. PMID:22960084. |
follow-up studies will be needed to determine whether higher md of hippocampus at younger ages could be an earlier marker of incident alzheimer's disease than hippocampal volume. |
2013-03-14 |
2023-08-12 |
Not clear |
| Dong-Mei Wang, Ya-Jun Yang, Li Zhang, Xu Zhang, Fei-Fei Guan, Lian-Feng Zhan. Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 14. issue 3. 2013-03-14. PMID:23478434. |
the amyloid-β (aβ)-induced impairment of hippocampal synaptic plasticity is an underlying mechanism of memory loss in the early stages of alzheimer's disease (ad) in human and mouse models. |
2013-03-14 |
2023-08-12 |
mouse |
| A Mogha, S R Guariglia, P R Debata, G Y Wen, P Banerje. Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus. Translational psychiatry. vol 2. 2013-03-04. PMID:22832728. |
finally, compared with the wild type, the 5-ht(1a)-r(-/-) mice harbor significantly less synapses in the hippocampus, but infusion of the pkc-stimulator and alzheimer drug bryostatin into the 5-ht(1a)-r(-/-) mice to bypass the non-existent 5-ht(1a)-r boosted psd95 expression and synaptogenesis. |
2013-03-04 |
2023-08-12 |
mouse |
| Takao Tak. An approach to glycobiology from glycolipidomics: ganglioside molecular scanning in the brains of patients with Alzheimer's disease by TLC-blot/matrix assisted laser desorption/ionization-time of flight MS. Biological & pharmaceutical bulletin. vol 35. issue 10. 2013-03-01. PMID:23037154. |
the levels of gangliosides gd1b and gt1b were lower in the hippocampal gray matter of patients with alzheimer's disease than in the hippocampal gray matter of patients with parkinson's disease or the control patients. |
2013-03-01 |
2023-08-12 |
human |
| Takao Tak. An approach to glycobiology from glycolipidomics: ganglioside molecular scanning in the brains of patients with Alzheimer's disease by TLC-blot/matrix assisted laser desorption/ionization-time of flight MS. Biological & pharmaceutical bulletin. vol 35. issue 10. 2013-03-01. PMID:23037154. |
these findings suggest that alzheimer's disease is a kind of ganglioside metabolic disease affecting the hippocampal area. |
2013-03-01 |
2023-08-12 |
human |
| Juan Beauquis, Patricio Pavía, Carlos Pomilio, Angeles Vinuesa, Natalia Podlutskaya, Verónica Galvan, Flavia Saravi. Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease. Experimental neurology. vol 239. 2013-02-28. PMID:23022919. |
environmental enrichment prevents astroglial pathological changes in the hippocampus of app transgenic mice, model of alzheimer's disease. |
2013-02-28 |
2023-08-12 |
mouse |
| Enrica Boda, Eriola Hoxha, Alessandro Pini, Francesca Montarolo, Filippo Tempi. Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21912965. |
in addition, we measured the levels of kv3.1 and kv3.4 messenger rnas (mrnas) and proteins in neocortex and hippocampus of appps1 mice, a transgenic model of alzheimer's disease. |
2013-02-25 |
2023-08-12 |
mouse |
| Pravat K Mandal, Himanshu Akolkar, Manjari Tripath. Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male/female, mild cognitive impairment, and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 31 Suppl 3. 2013-02-22. PMID:22426021. |
mapping of hippocampal ph and neurochemicals from in vivo multi-voxel 31p study in healthy normal young male/female, mild cognitive impairment, and alzheimer's disease. |
2013-02-22 |
2023-08-12 |
human |
| Liam Zaidel, Greg Allen, C Munro Cullum, Richard W Briggs, Linda S Hynan, Myron F Weiner, Roderick McColl, Kaundinya S Gopinath, Elizabeth McDonald, Craig D Rubi. Donepezil effects on hippocampal and prefrontal functional connectivity in Alzheimer's disease: preliminary report. Journal of Alzheimer's disease : JAD. vol 31 Suppl 3. 2013-02-22. PMID:22886013. |
donepezil effects on hippocampal and prefrontal functional connectivity in alzheimer's disease: preliminary report. |
2013-02-22 |
2023-08-12 |
Not clear |
| Kioko Guzmán-Ramos, Perla Moreno-Castilla, Monica Castro-Cruz, James L McGaugh, Hilda Martínez-Coria, Frank M LaFerla, Federico Bermúdez-Ratton. Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease. Learning & memory (Cold Spring Harbor, N.Y.). vol 19. issue 10. 2013-02-22. PMID:22984283. |
the aim of this study was to assess, by in vivo microdialysis, cortical and hippocampal dopamine, norepinephrine, and glutamate release during the acquisition of object recognition memory (orm) in 5- and 10-mo-old triple-transgenic alzheimer's disease mice (3xtg-ad) and to relate the extracellular changes to 24-h memory performance. |
2013-02-22 |
2023-08-12 |
mouse |
| Tao Tan, Bao-Liang Zhang, Xin Tia. [Chronic effects of oligomeric Aβ(1-42) on hippocampal synaptic plasticity in vivo]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 3. 2013-02-21. PMID:21681340. |
this study explored hippocampal synaptic plasticity and spatial memory formation of an alzheimer's disease (ad) rat model established by intrahippocampal injection of oligomeric aβ(1-42). |
2013-02-21 |
2023-08-12 |
rat |
| Deborah M Little, Sean Foxely, Orly Lazaro. A preliminary study targeting neuronal pathways activated following environmental enrichment by resting state functional magnetic resonance imaging. Journal of Alzheimer's disease : JAD. vol 32. issue 1. 2013-02-20. PMID:22766734. |
we have shown that experience of transgenic mice harboring familial alzheimer's disease (fad)-linked aβppswe/ps1Δe9 in an enriched environment enhances hippocampal neurogenesis and synaptic plasticity and attenuates neuropathology. |
2013-02-20 |
2023-08-12 |
mouse |
| Hong-Qi Yang, Xue Li, Wei-Min Yang, Shu-Man Feng, Jian-Jun M. Neuroprotective effects of new protein kinase C activator TPPB against Aβ₂₅₋₃₅ induced neurotoxicity in PC12 cells. Neurochemical research. vol 37. issue 10. 2013-02-19. PMID:22832950. |
alzheimer's disease (ad) is pathologically characterized by presence of senile plaques in the hippocampus, which are composed mainly of extracellular deposition of a polypeptide known as the beta amyloid, the aβ. |
2013-02-19 |
2023-08-12 |
Not clear |
| Adam M Brickman, Frank A Provenzano, Jordan Muraskin, Jennifer J Manly, Sonja Blum, Zoltan Apa, Yaakov Stern, Truman R Brown, José A Luchsinger, Richard Mayeu. Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community. Archives of neurology. vol 69. issue 12. 2013-02-12. PMID:22945686. |
regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident alzheimer disease in the community. |
2013-02-12 |
2023-08-12 |
human |
| Adam M Brickman, Frank A Provenzano, Jordan Muraskin, Jennifer J Manly, Sonja Blum, Zoltan Apa, Yaakov Stern, Truman R Brown, José A Luchsinger, Richard Mayeu. Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community. Archives of neurology. vol 69. issue 12. 2013-02-12. PMID:22945686. |
background new-onset alzheimer disease (ad) is often attributed to degenerative changes in the hippocampus. |
2013-02-12 |
2023-08-12 |
human |
| Claire L Russell, Sophia Semerdjieva, Ruth M Empson, Brian M Austen, Philip W Beesley, Pavlos Alifragi. Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. PloS one. vol 7. issue 8. 2013-02-11. PMID:22905234. |
it is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in alzheimer's disease (ad) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (aβ42). |
2013-02-11 |
2023-08-12 |
Not clear |
| Nicole Chow, Dag Aarsland, Hedieh Honarpisheh, Mona K Beyer, Johanne H Somme, David Elashoff, Arvid Rongve, Ole B Tysnes, Paul M Thompson, Liana G Apostolov. Comparing hippocampal atrophy in Alzheimer's dementia and dementia with lewy bodies. Dementia and geriatric cognitive disorders. vol 34. issue 1. 2013-02-07. PMID:22922563. |
comparing hippocampal atrophy in alzheimer's dementia and dementia with lewy bodies. |
2013-02-07 |
2023-08-12 |
human |