| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tony Valente, Alejandro Gella, Montse Solé, Núria Durany, Mercedes Unzet. Immunohistochemical study of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 in the hippocampal vasculature: pathological synergy of Alzheimer's disease and diabetes mellitus. Journal of neuroscience research. vol 90. issue 10. 2013-01-04. PMID:22714978. |
immunohistochemical study of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 in the hippocampal vasculature: pathological synergy of alzheimer's disease and diabetes mellitus. |
2013-01-04 |
2023-08-12 |
human |
| Li-Chun Wei, Yin-Xiu Ding, Yong-Hong Liu, Li Duan, Ya Bai, Mei Shi, Liang-Wei Che. Low-dose radiation stimulates Wnt/β-catenin signaling, neural stem cell proliferation and neurogenesis of the mouse hippocampus in vitro and in vivo. Current Alzheimer research. vol 9. issue 3. 2012-12-21. PMID:22272614. |
neurogenesis in the hippocampus is actively involved in neural circuit plasticity and learning function of mammals, but it may decrease dramatically with aging and aging-related neurodegenerative disorder alzheimer's disease. |
2012-12-21 |
2023-08-12 |
mouse |
| Li-Chun Wei, Yin-Xiu Ding, Yong-Hong Liu, Li Duan, Ya Bai, Mei Shi, Liang-Wei Che. Low-dose radiation stimulates Wnt/β-catenin signaling, neural stem cell proliferation and neurogenesis of the mouse hippocampus in vitro and in vivo. Current Alzheimer research. vol 9. issue 3. 2012-12-21. PMID:22272614. |
taken together, this study has revealed certain beneficial effects of low-dose radiation to stimulate neural stem cell proliferation, the neurogenesis of hippocampus and animal learning most possibly by triggering wnt/β-catenin signaling cascades, suggesting its translational application role in devising new therapy for aging-related neurodegenerative disorders particularly alzheimer's disease. |
2012-12-21 |
2023-08-12 |
mouse |
| Hyun Kook Lim, Seung Chul Hong, Won Sang Jung, Kook Jin Ahn, Wang Youn Won, Changtae Hahn, In Seong Kim, Chang Uk Le. Automated hippocampal subfield segmentation in amnestic mild cognitive impairments. Dementia and geriatric cognitive disorders. vol 33. issue 5. 2012-12-12. PMID:22759884. |
additionally, we explored the correlation pattern between hippocampal subfield volumes and the korean version of the consortium to establish a registry for alzheimer's disease (cerad-k) neuropsychological test scores in amci subjects. |
2012-12-12 |
2023-08-12 |
human |
| Johannes Attems, Dietmar R Thal, Kurt A Jellinge. The relationship between subcortical tau pathology and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817721. |
the stepwise progression of tau pathology [nfts (neurofibrillary tangles) and nts (neuropil threads)] in ad (alzheimer's disease) is generally assumed to begin in the transentorhinal region (entorhinal stage) from which it progresses to the hippocampus (limbic stage) and to neocortical regions (neocortical stage). |
2012-12-07 |
2023-08-12 |
Not clear |
| Beatriz Baño Otalora, Natalija Popovic, Juan Gambini, Miroljub Popovic, José Viña, Vicent Bonet-Costa, Russel J Reiter, Pedro Javier Camello, Maria Ángeles Rol, Juan Antonio Madri. Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswe/PS1dE9 transgenic model of Alzheimer disease: effects of melatonin or ramelteon. Chronobiology international. vol 29. issue 7. 2012-12-06. PMID:22823866. |
circadian system functionality, hippocampal oxidative stress, and spatial memory in the appswe/ps1de9 transgenic model of alzheimer disease: effects of melatonin or ramelteon. |
2012-12-06 |
2023-08-12 |
mouse |
| Masakazu Hashimoto, Nenad Bogdanovic, Hiroyuki Nakagawa, Inga Volkmann, Mikio Aoki, Bengt Winblad, Jun Sakai, Lars O Tjernber. Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease. Journal of cellular and molecular medicine. vol 16. issue 8. 2012-12-03. PMID:21883897. |
it is evident that the symptoms of alzheimer's disease (ad) are derived from severe neuronal damage, and especially pyramidal neurons in the hippocampus are affected pathologically. |
2012-12-03 |
2023-08-12 |
Not clear |
| John Pluta, Paul Yushkevich, Sandhitsu Das, David Wol. In vivo analysis of hippocampal subfield atrophy in mild cognitive impairment via semi-automatic segmentation of T2-weighted MRI. Journal of Alzheimer's disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22504319. |
the measurement of hippocampal volumes using mri is a useful in-vivo biomarker for detection and monitoring of early alzheimer's disease (ad), including during the amnestic mild cognitive impairment (a-mci) stage. |
2012-12-03 |
2023-08-12 |
human |
| Richardson N Leão, Luis V Colom, Lotta Borgius, Ole Kiehn, André Fisah. Medial septal dysfunction by Aβ-induced KCNQ channel-block in glutamatergic neurons. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:21907458. |
our results demonstrate that aβ-induced dysfunction of glutamatergic neurons via i(m) decrease diminishes ms rhythmicity, which may negatively affect hippocampal rhythmogenesis and underlie the memory loss observed in alzheimer's disease. |
2012-11-29 |
2023-08-12 |
mouse |
| Shiri Stempler, Yedael Y Waldman, Lior Wolf, Eytan Ruppi. Hippocampus neuronal metabolic gene expression outperforms whole tissue data in accurately predicting Alzheimer's disease progression. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:22560482. |
hippocampus neuronal metabolic gene expression outperforms whole tissue data in accurately predicting alzheimer's disease progression. |
2012-11-29 |
2023-08-12 |
human |
| Lynn M Bekris, Franziska Lutz, Gail Li, Douglas R Galasko, Martin R Farlow, Joseph F Quinn, Jeffrey A Kaye, James B Leverenz, Debby W Tsuang, Thomas J Montine, Elaine R Peskind, Chang-En Y. ADAM10 expression and promoter haplotype in Alzheimer's disease. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:22572541. |
results from this investigation suggest that the adam10 rs514049-rs653765 c-a promoter haplotype is associated with: (1) higher csf sappα levels in cognitively normal controls compared with alzheimer's disease (ad) patients, (2) higher postmortem brain hippocampus, but not cerebellum, adam10 protein levels in subjects with low plaque scores compared with those with high plaque scores, and (3) higher promoter activity for promoter-only reporter constructs compared with promoter 3' untranslated region (3'utr) constructs in the human neuroblastoma shsy5y cell line, but not in hepg2 or u118 cell lines. |
2012-11-29 |
2023-08-12 |
human |
| Ramakrishna Nirogi, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Ramanatha Saralaya, Nageswararao Muddana, Prashanth Komarnen. Methyllycaconitine: a non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - in vivo target localization and biodistribution in rat brain. Journal of pharmacological and toxicological methods. vol 66. issue 1. 2012-11-29. PMID:22609758. |
reduction of cerebral cortical and hippocampal α7 neuronal nicotinic acetylcholine receptor (nachr) density was observed in the alzheimer's disease (ad) and other neurodegenerative diseases. |
2012-11-29 |
2023-08-12 |
rat |
| Olof Lindberg, Eric Westman, Sari Karlsson, Per Ostberg, Leif A Svensson, Andrew Simmons, Lars-Olof Wahlun. Is the subcallosal medial prefrontal cortex a common site of atrophy in Alzheimer's disease and frontotemporal lobar degeneration? Frontiers in aging neuroscience. vol 4. 2012-11-29. PMID:23189052. |
the subcallosal medial prefrontal cortex (smpc) has connections with the dorsolateral prefrontal cortex (dlpfc), orbitofrontal cortex (ofc), and hippocampus (hc), which are regions that may become atrophic in frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad). |
2012-11-29 |
2023-08-12 |
human |
| Joukje M Oosterman, Saskia Oosterveld, Marcel G Olde Rikkert, Jurgen A Claassen, Roy P C Kessel. Medial temporal lobe atrophy relates to executive dysfunction in Alzheimer's disease. International psychogeriatrics. vol 24. issue 9. 2012-11-28. PMID:22717328. |
little is known, however, about the effects of hippocampal atrophy on executive control in alzheimer's disease (ad). |
2012-11-28 |
2023-08-12 |
Not clear |
| Fang-Fang Li, Shi-Jun Song, Ruo-Nan Zhan. [Phosphatidylethanolamine-binding protein (PEBP) in basic and clinical study]. Sheng li ke xue jin zhan [Progress in physiology]. vol 40. issue 3. 2012-11-26. PMID:19803424. |
in clinical researches, it was found that as the precursor of hippocampal cholinergic neurostimulating peptide (hcnp), pebp has an important effect on the development of alzheimer's disease. |
2012-11-26 |
2023-08-12 |
Not clear |
| John P Andrawis, Kristy S Hwang, Amity E Green, Jenny Kotlerman, David Elashoff, Jonathan H Morra, Jeffrey L Cummings, Arthur W Toga, Paul M Thompson, Liana G Apostolov. Effects of ApoE4 and maternal history of dementia on hippocampal atrophy. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:20833446. |
we applied an automated hippocampal segmentation technique based on adaptive boosting (adaboost) to the 1.5 t magnetic resonance imaging (mri) baseline and 1-year follow-up data of 243 subjects with mild cognitive impairment (mci), 96 with alzheimer's disease (ad), and 145 normal controls (nc) scanned as part of the alzheimer's disease neuroimaging initiative (adni). |
2012-11-23 |
2023-08-12 |
human |
| Magdalena Kulijewicz-Nawrot, Alexei Verkhratsky, Alexander Chvátal, Eva Syková, José J Rodrígue. Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease. Journal of anatomy. vol 221. issue 3. 2012-11-21. PMID:22738374. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by the loss of cognitive functions, reflecting pathological damage to the medial prefrontal cortex (mpfc) as well as to the hippocampus and the entorhinal cortex. |
2012-11-21 |
2023-08-12 |
mouse |
| Jenny Wong, Brett Garner, Glenda M Halliday, John B J Kwo. Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease. Journal of neurochemistry. vol 123. issue 1. 2012-11-19. PMID:22788679. |
previously, we reported elevated levels of the neuron-specific tropomyosin receptor kinase b (trkb) transcript, trkb- sarc homology containing (shc) in the hippocampus of alzheimer's disease (ad) brains. |
2012-11-19 |
2023-08-12 |
human |
| N Dolek, S Saylisoy, D Ozbabalik, B Adapina. Comparison of hippocampal volume measured using magnetic resonance imaging in Alzheimer's disease, vascular dementia, mild cognitive impairment and pseudodementia. The Journal of international medical research. vol 40. issue 2. 2012-11-13. PMID:22613435. |
comparison of hippocampal volume measured using magnetic resonance imaging in alzheimer's disease, vascular dementia, mild cognitive impairment and pseudodementia. |
2012-11-13 |
2023-08-12 |
Not clear |
| D Scarpi, D Cirelli, C Matrone, G Castronovo, P Rosini, E G Occhiato, F Romano, L Bartali, A M Clemente, G Bottegoni, A Cavalli, G De Chiara, P Bonini, P Calissano, A T Palamara, E Garaci, M G Torcia, A Guarna, F Cozzolin. Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity. Cell death & disease. vol 3. 2012-11-08. PMID:22764098. |
consistently, in an ngf-deprived rat hippocampal neuronal model of alzheimer disease, mt2 could correct the biochemical abnormalities and sustain cell survival. |
2012-11-08 |
2023-08-12 |
rat |