| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tom den Heijer, Fedde van der Lijn, Arfan Ikram, Peter J Koudstaal, Aad van der Lugt, Gabriel P Krestin, Henri A Vrooman, Albert Hofman, Wiro J Niessen, Monique M B Bretele. Vascular risk factors, apolipoprotein E, and hippocampal decline on magnetic resonance imaging over a 10-year follow-up. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 5. 2013-02-06. PMID:22244650. |
decline of hippocampal volume on magnetic resonance imaging (mri) may be considered as a surrogate biomarker of accumulating alzheimer disease (ad) pathology. |
2013-02-06 |
2023-08-12 |
Not clear |
| Qian Shen, Weizhao Zhao, David A Loewenstein, Elizabeth Potter, Maria T Greig, Ashok Raj, Warren Barker, Huntington Potter, Ranjan Duar. Comparing new templates and atlas-based segmentations in the volumetric analysis of brain magnetic resonance images for diagnosing Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 5. 2013-02-06. PMID:22959698. |
this study aims to improve the accuracy of volumetric analysis of hippocampus (hp) and amygdala (amg) in the assessment of early alzheimer's disease (ad) by developing template sets that correspond more closely to the brains of elderly individuals. |
2013-02-06 |
2023-08-12 |
Not clear |
| Gurdeep Marwarha, Othman Ghrib. Leptin signaling and Alzheimer's disease. American journal of neurodegenerative disease. vol 1. issue 3. 2013-02-06. PMID:23383396. |
leptin receptors are highly expressed in the hippocampus, a brain area involved in learning and memory and severely affected during the course of alzheimer's disease. |
2013-02-06 |
2023-08-12 |
Not clear |
| Geoffrey A Kerchner, Gayle K Deutsch, Michael Zeineh, Robert F Dougherty, Manojkumar Saranathan, Brian K Rut. Hippocampal CA1 apical neuropil atrophy and memory performance in Alzheimer's disease. NeuroImage. vol 63. issue 1. 2013-01-29. PMID:22766164. |
memory loss is often the first and most prominent symptom of alzheimer's disease (ad), coinciding with the spread of neurofibrillary pathology from the entorhinal cortex (erc) to the hippocampus. |
2013-01-29 |
2023-08-12 |
Not clear |
| Sara E Rubio, Germán Vega-Flores, Albert Martínez, Carles Bosch, Alberto Pérez-Mediavilla, Joaquín del Río, Agnès Gruart, José María Delgado-García, Eduardo Soriano, Marta Pascua. Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 11. 2013-01-29. PMID:22835830. |
accelerated aging of the gabaergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of alzheimer's disease. |
2013-01-29 |
2023-08-12 |
mouse |
| Juan Eugenio Iglesias, Mert Rory Sabuncu, Koen Van Leempu. Incorporating parameter uncertainty in Bayesian segmentation models: application to hippocampal subfield volumetry. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 15. issue Pt 3. 2013-01-29. PMID:23286113. |
we demonstrate our technique by sampling atlas warps in a recent method for hippocampal subfield segmentation, and show a significant improvement in an alzheimer's disease classification task. |
2013-01-29 |
2023-08-12 |
Not clear |
| Asa Gardner, Peter Jukkola, Chen G. Myelination of rodent hippocampal neurons in culture. Nature protocols. vol 7. issue 10. 2013-01-28. PMID:22955693. |
demyelination in the hippocampus has been observed in patients with multiple sclerosis, alzheimer's disease or temporal lobe epilepsy. |
2013-01-28 |
2023-08-12 |
rat |
| János Kállmán, Magdolna Pákáski, Szabina Szucs, Sára Kálmán, Orsike Fazekas, Petra Santha, Gyula Szabó, Zoltán Janka, János Kálmá. [The role of immobilization stress and sertindole on the expression of APP, MAPK-1 and beta-actin genes in rat brain]. Ideggyogyaszati szemle. vol 65. issue 11-12. 2013-01-25. PMID:23289174. |
as one of its multiple effects, elevated blood cortisol levels decrease the synthesis of the neuroprotective bdnf, thus leading to hippocampal atrophy and synapse loss, and rendering it a possible cause for the alzheimer's disease (ad) related neuropathological and cognitive changes. |
2013-01-25 |
2023-08-12 |
rat |
| Owen Carmichael, Jing Xie, Evan Fletcher, Baljeet Singh, Charles DeCarl. Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22169204. |
localized hippocampus measures are associated with alzheimer pathology and cognition independent of total hippocampal volume. |
2013-01-24 |
2023-08-12 |
human |
| Owen Carmichael, Jing Xie, Evan Fletcher, Baljeet Singh, Charles DeCarl. Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22169204. |
hippocampal injury in the alzheimer's disease (ad) pathological process is region-specific and magnetic resonance imaging (mri)-based measures of localized hippocampus (hp) atrophy are known to detect region-specific changes associated with clinical ad, but it is unclear whether these measures provide information that is independent of that already provided by measures of total hp volume. |
2013-01-24 |
2023-08-12 |
human |
| Vincent Villette, Frédérique Poindessous-Jazat, Brice Bellessort, Elodie Roullot, Yvan Peterschmitt, Jacques Epelbaum, Aline Stéphan, Patrick Duta. A new neuronal target for β-amyloid peptide in the rat hippocampus. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22206845. |
in alzheimer's disease, amyloid beta peptide (aβ) accumulation is associated with hippocampal network dysfunction. |
2013-01-24 |
2023-08-12 |
rat |
| S Prasad Gabbita, Minu K Srivastava, Pirooz Eslami, Ming F Johnson, Naomi K Kobritz, David Tweedie, Nigel H Greig, Frank P Zemlan, Sherven P Sharma, Marni E Harris-Whit. Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22632257. |
multiple clinical studies implicate tumor necrosis factor-α as an inflammatory mediator of neurodegeneration in patients with alzheimer's because of elevated levels of this cytokine in the cerebrospinal fluid, hippocampus and cortex. |
2013-01-17 |
2023-08-12 |
mouse |
| Tao Ma, Xueliang Du, Joseph E Pick, Guangzhi Sui, Michael Brownlee, Eric Klan. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 40. 2013-01-17. PMID:23035082. |
similarly, hippocampal ltp impairments in amyloid precursor protein/presenilin 1 (app/ps1) mutant mice that model alzheimer's disease (ad) were prevented by glp-1(9-36)(amide). |
2013-01-17 |
2023-08-12 |
mouse |
| Elliott J Mufson, Bin He, Muhammad Nadeem, Sylvia E Perez, Scott E Counts, Sue Leurgans, Jason Fritz, James Lah, Stephen D Ginsberg, Joanne Wuu, Stephen W Schef. Hippocampal proNGF signaling pathways and β-amyloid levels in mild cognitive impairment and Alzheimer disease. Journal of neuropathology and experimental neurology. vol 71. issue 11. 2013-01-17. PMID:23095849. |
hippocampal prongf signaling pathways and β-amyloid levels in mild cognitive impairment and alzheimer disease. |
2013-01-17 |
2023-08-12 |
human |
| Elliott J Mufson, Bin He, Muhammad Nadeem, Sylvia E Perez, Scott E Counts, Sue Leurgans, Jason Fritz, James Lah, Stephen D Ginsberg, Joanne Wuu, Stephen W Schef. Hippocampal proNGF signaling pathways and β-amyloid levels in mild cognitive impairment and Alzheimer disease. Journal of neuropathology and experimental neurology. vol 71. issue 11. 2013-01-17. PMID:23095849. |
hippocampal precursor of nerve growth factor (prongf)/ngf signaling occurs in conjunction with β-amyloid (aβ) accumulations in alzheimer disease (ad). |
2013-01-17 |
2023-08-12 |
human |
| Michael Hornberger, Stephanie Wong, Rachel Tan, Muireann Irish, Olivier Piguet, Jillian Kril, John R Hodges, Glenda Hallida. In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. Brain : a journal of neurology. vol 135. issue Pt 10. 2013-01-15. PMID:23012333. |
the integrity of the papez circuit (hippocampus, fornix, mammillary bodies, anterior thalamus, cingulate cortex) was investigated in vivo and at post-mortem in behavioural variant frontotemporal dementia and alzheimer's disease cohorts using voxel-based morphometry, diffusion tensor imaging and manual volumetric tracing. |
2013-01-15 |
2023-08-12 |
Not clear |
| Michael Hornberger, Stephanie Wong, Rachel Tan, Muireann Irish, Olivier Piguet, Jillian Kril, John R Hodges, Glenda Hallida. In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. Brain : a journal of neurology. vol 135. issue Pt 10. 2013-01-15. PMID:23012333. |
our findings indicate that behavioural variant frontotemporal dementia and alzheimer's disease show similar degrees of hippocampal atrophy in vivo, but patients with behavioural variant frontotemporal dementia show greater hippocampal atrophy at post-mortem, with the frontotemporal lobar degeneration with tdp-43 inclusions subtype being particularly affected. |
2013-01-15 |
2023-08-12 |
Not clear |
| Michael Hornberger, Stephanie Wong, Rachel Tan, Muireann Irish, Olivier Piguet, Jillian Kril, John R Hodges, Glenda Hallida. In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. Brain : a journal of neurology. vol 135. issue Pt 10. 2013-01-15. PMID:23012333. |
hippocampal atrophy does not appear to be an efficient diagnostic marker for underlying behavioural variant frontotemporal dementia or alzheimer's disease pathology, although for behavioural variant frontotemporal dementia, episodic memory deficits in conjunction with marked hippocampal atrophy emerge as potential biomarkers for frontotemporal lobar degeneration with tdp-43 inclusions pathology. |
2013-01-15 |
2023-08-12 |
Not clear |
| D Scarpi, D Cirelli, C Matrone, G Castronovo, P Rosini, E G Occhiato, F Romano, L Bartali, A M Clemente, G Bottegoni, A Cavalli, G De Chiara, P Bonini, P Calissano, A T Palamara, E Garaci, M G Torcia, A Guarna, F Cozzolin. Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity. Cell death & disease. vol 3. 2013-01-14. PMID:22951986. |
consistently, in an ngf-deprived rat hippocampal neuronal model of alzheimer disease, mt2 could correct the biochemical abnormalities and sustain cell survival. |
2013-01-14 |
2023-08-12 |
rat |
| Yaisa Andrews-Zwilling, Anna K Gillespie, Alexxai V Kravitz, Alexandra B Nelson, Nino Devidze, Iris Lo, Seo Yeon Yoon, Nga Bien-Ly, Karen Ring, Daniel Zwilling, Gregory B Potter, John L R Rubenstein, Anatol C Kreitzer, Yadong Huan. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PloS one. vol 7. issue 7. 2013-01-10. PMID:22792368. |
although extensive research has demonstrated the importance of excitatory granule neurons in the dentate gyrus of the hippocampus in normal learning and memory and in the pathogenesis of amnesia in alzheimer's disease (ad), the role of hilar gabaergic inhibitory interneurons, which control the granule neuron activity, remains unclear. |
2013-01-10 |
2023-08-12 |
Not clear |