| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philip S Crooke, John T Tossberg, Rachel M Heinrich, Krislyn P Porter, Thomas M Aun. Reduced RNA adenosine-to-inosine editing in hippocampus vasculature associated with Alzheimer's disease. Brain communications. vol 4. issue 5. 2022-10-05. PMID:36196083. |
here, we investigated if changes in adenosine-to-inosine editing were associated with presence of alzheimer's disease in total prefrontal cortex, total hippocampus, cortex vasculature and hippocampus vasculature using available rna sequencing files. |
2022-10-05 |
2023-08-14 |
Not clear |
| Philip S Crooke, John T Tossberg, Rachel M Heinrich, Krislyn P Porter, Thomas M Aun. Reduced RNA adenosine-to-inosine editing in hippocampus vasculature associated with Alzheimer's disease. Brain communications. vol 4. issue 5. 2022-10-05. PMID:36196083. |
we found similar levels of alu rna adenosine-to-inosine editing in cortex and cortex vasculature from individuals with alzheimer's disease or normal cognition at the time of death and brain donation. |
2022-10-05 |
2023-08-14 |
Not clear |
| Khoren K Epremyan, Tatyana N Goleva, Renata A Zvyagilskay. Effect of Tau Protein on Mitochondrial Functions. Biochemistry. Biokhimiia. vol 87. issue 8. 2022-09-29. PMID:36171651. |
alzheimer's disease is the most common age-related progressive neurodegenerative disorder of brain cortex and hippocampus leading to cognitive impairment. |
2022-09-29 |
2023-08-14 |
Not clear |
| Jaroslav Bendl, Mads E Hauberg, Kiran Girdhar, Eunju Im, James M Vicari, Samir Rahman, Michael B Fernando, Kayla G Townsley, Pengfei Dong, Ruth Misir, Steven P Kleopoulos, Sarah M Reach, Pasha Apontes, Biao Zeng, Wen Zhang, Georgios Voloudakis, Kristen J Brennand, Ralph A Nixon, Vahram Haroutunian, Gabriel E Hoffman, John F Fullard, Panos Rousso. The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease. Nature neuroscience. 2022-09-28. PMID:36171428. |
to characterize the dysregulation of chromatin accessibility in alzheimer's disease (ad), we generated 636 atac-seq libraries from neuronal and nonneuronal nuclei isolated from the superior temporal gyrus and entorhinal cortex of 153 ad cases and 56 controls. |
2022-09-28 |
2023-08-14 |
human |
| Ming-Li Li, Shi-Hao Wu, Bo Song, Jing Yang, Li-Yuan Fan, Yang Yang, Yun-Chao Wang, Jing-Hua Yang, Yuming X. Single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with Alzheimer's disease. Aging cell. 2022-09-27. PMID:36165462. |
single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with alzheimer's disease. |
2022-09-27 |
2023-08-14 |
Not clear |
| Ming-Li Li, Shi-Hao Wu, Bo Song, Jing Yang, Li-Yuan Fan, Yang Yang, Yun-Chao Wang, Jing-Hua Yang, Yuming X. Single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with Alzheimer's disease. Aging cell. 2022-09-27. PMID:36165462. |
the entorhinal cortex is of great importance in cognition and memory, its dysfunction causes a variety of neurological diseases, particularly alzheimer's disease (ad). |
2022-09-27 |
2023-08-14 |
Not clear |
| Gemma Shireby, Emma L Dempster, Stefania Policicchio, Rebecca G Smith, Ehsan Pishva, Barry Chioza, Jonathan P Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mil. DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature communications. vol 13. issue 1. 2022-09-24. PMID:36153390. |
dna methylation signatures of alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. |
2022-09-24 |
2023-08-14 |
Not clear |
| Tsukasa Funane, Heechul Jun, Stephanie Sutoko, Takaomi C Saido, Akihiko Kandori, Kei M Igarash. Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer's disease. Frontiers in systems neuroscience. vol 16. 2022-09-12. PMID:36090186. |
impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal ca1 of knock-in model of alzheimer's disease. |
2022-09-12 |
2023-08-14 |
mouse |
| Tsukasa Funane, Heechul Jun, Stephanie Sutoko, Takaomi C Saido, Akihiko Kandori, Kei M Igarash. Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer's disease. Frontiers in systems neuroscience. vol 16. 2022-09-12. PMID:36090186. |
clinical evidence suggests that the entorhinal cortex is a primary brain area triggering memory impairments in alzheimer's disease (ad), but the underlying brain circuit mechanisms remain largely unclear. |
2022-09-12 |
2023-08-14 |
mouse |
| Yuzhou Chang, Fei He, Juexin Wang, Shuo Chen, Jingyi Li, Jixin Liu, Yang Yu, Li Su, Anjun Ma, Carter Allen, Yu Lin, Shaoli Sun, Bingqiang Liu, José Javier Otero, Dongjun Chung, Hongjun Fu, Zihai Li, Dong Xu, Qin M. Define and visualize pathological architectures of human tissues from spatially resolved transcriptomics using deep learning. Computational and structural biotechnology journal. vol 20. 2022-09-12. PMID:36090815. |
it is noteworthy that, for the in-house ad samples, resept can localize cortex layers and cell types based on pre-defined region- or cell-type-enriched genes and furthermore provide critical insights into the identification of amyloid-beta plaques in alzheimer's disease. |
2022-09-12 |
2023-08-14 |
mouse |
| Zhen-Kai Ngian, Yow-Yong Tan, Ching-Thong Choo, Wei-Qi Lin, Chao-Yong Leow, Shan-Jie Mah, Mitchell Kim-Peng Lai, Christopher Li-Hsian Chen, Chin-Tong On. Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 37. 2022-09-06. PMID:36067305. |
truncated tau caused by intron retention is enriched in alzheimer's disease cortex and exhibits altered biochemical properties. |
2022-09-06 |
2023-08-14 |
Not clear |
| Kristina M Gicas, William G Honer, Sue E Leurgans, Robert S Wilson, Patricia A Boyle, Julie A Schneider, David A Bennet. Longitudinal change in serial position scores in older adults with entorhinal and hippocampal neuropathologies. Journal of the International Neuropsychological Society : JINS. 2022-09-05. PMID:36062540. |
serial position scores on verbal memory tests are sensitive to early alzheimer's disease (ad)-related neuropathological changes that occur in the entorhinal cortex and hippocampus. |
2022-09-05 |
2023-08-14 |
Not clear |
| Wei-Bin Shen, James Jiao Yang, Peixin Yan. RNA hypomethylation and unchanged DNA methylation levels in the cortex of ApoE4 carriers and Alzheimer's disease subjects. Current Alzheimer research. 2022-09-01. PMID:36045519. |
rna hypomethylation and unchanged dna methylation levels in the cortex of apoe4 carriers and alzheimer's disease subjects. |
2022-09-01 |
2023-08-14 |
human |
| Qing-Shan Yu, Wan-Qing Feng, Lan-Lan Shi, Rui-Ze Niu, Jia Li. Integrated Analysis of Cortex Single-Cell Transcriptome and Serum Proteome Reveals the Novel Biomarkers in Alzheimer's Disease. Brain sciences. vol 12. issue 8. 2022-08-26. PMID:36009085. |
integrated analysis of cortex single-cell transcriptome and serum proteome reveals the novel biomarkers in alzheimer's disease. |
2022-08-26 |
2023-08-14 |
human |
| Xavier Morató, Vanesa Pytel, Sara Jofresa, Agustín Ruiz, Mercè Boad. Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimer's Disease: Towards a Personalized Polypharmacology Patient-Centered Approach. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012569. |
since 1906, when dr. alois alzheimer first described in a patient "a peculiar severe disease process of the cerebral cortex", people suffering from this pathology have been waiting for a breakthrough therapy. |
2022-08-26 |
2023-08-14 |
Not clear |
| Barbara Kaltschmidt, Laureen P Helweg, Johannes F W Greiner, Christian Kaltschmid. NF-κB in neurodegenerative diseases: Recent evidence from human genetics. Frontiers in molecular neuroscience. vol 15. 2022-08-19. PMID:35983068. |
in particular, we propose that loss of function mutations upstream of nf-κb such as adam17, sharpin, hoil, or otulin affect nf-κb-activity in alzheimer's disease (ad) patients, in turn driving anatomical defects such as shrinkage of entorhinal cortex and the limbic system in early ad. |
2022-08-19 |
2023-08-14 |
human |
| Christian Hölsche. Glucagon-like peptide 1 and glucose-dependent insulinotropic peptide hormones and novel receptor agonists protect synapses in Alzheimer's and Parkinson's diseases. Frontiers in synaptic neuroscience. vol 14. 2022-08-15. PMID:35965783. |
a major pathological feature of both alzheimer's dis-ease (ad) and parkinson's disease (pd) is the loss of synaptic transmission in the cortex in ad and the loss of dopaminergic synapses in the nigra-striatal dopaminergic projection. |
2022-08-15 |
2023-08-14 |
Not clear |
| Fang Wang, Yongzhe Gu, Chenhaoyi Xu, Kangshuai Du, Chence Zhao, Yanxin Zhao, Xueyuan Li. Transplantation of fecal microbiota from APP/PS1 mice and Alzheimer's disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice. Frontiers in aging neuroscience. vol 14. 2022-08-15. PMID:35966768. |
transplantation of fecal microbiota from app/ps1 mice and alzheimer's disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice. |
2022-08-15 |
2023-08-14 |
mouse |
| Philip S Insel, Christina B Young, Paul S Aisen, Keith A Johnson, Reisa A Sperling, Elizabeth C Mormino, Michael C Donohu. Tau positron emission tomography in preclinical Alzheimer's disease. Brain : a journal of neurology. 2022-08-13. PMID:35962782. |
while the entorhinal cortex plays a central role in the early appearance of tau, it may be the inferior temporal cortex that is the critical region for rapid tau accumulation in preclinical alzheimer's disease. |
2022-08-13 |
2023-08-14 |
human |
| Juhyun Son. Comparison of Cerebral Cortex Transcriptome Profiles in Ischemic Stroke and Alzheimer's Disease Models. Clinical nutrition research. vol 11. issue 3. 2022-08-11. PMID:35949563. |
comparison of cerebral cortex transcriptome profiles in ischemic stroke and alzheimer's disease models. |
2022-08-11 |
2023-08-14 |
mouse |