| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jamie M Walker, William Goette, Kurt Farrell, Megan A Iida, Esma Karlovich, Charles L White, John F Crary, Timothy E Richardso. The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-02-04. PMID:36738450. |
neurofibrillary degeneration in alzheimer's disease (ad) typically involves the entorhinal cortex and ca1 subregion of the hippocampus early in the disease process, whereas in primary age-related tauopathy (part), there is an early selective vulnerability of the ca2 subregion. |
2023-02-04 |
2023-08-14 |
Not clear |
| Anish Kapadia, Krish Billimoria, Prarthna Desai, James T Grist, Chris Heyn, Pejman Maralani, Sean Symons, Fulvio Zaccagn. Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data. Journal of clinical neurology (Seoul, Korea). 2023-01-17. PMID:36647226. |
tau deposition in the entorhinal cortex is the earliest pathological feature of alzheimer's disease (ad). |
2023-01-17 |
2023-08-14 |
Not clear |
| Arunkumar Subramanian, T Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V Chinni, Nur Najihah Izzati Mat Rani, Nagaraja Suryadevara, Shadma Waha. Trilateral association of autophagy, mTOR and Alzheimer's disease: Potential pathway in the development for Alzheimer's disease therapy. Frontiers in pharmacology. vol 13. 2023-01-09. PMID:36618946. |
alzheimer's disease (ad) is the chief cause of progressive dementia, and it is characterized by irreparable loss of cognitive abilities, forming senile plaques having amyloid beta (aβ) aggregates and neurofibrillary tangles with considerable amounts of tau in affected hippocampus and cortex regions of human brains. |
2023-01-09 |
2023-08-14 |
human |
| Pan Wang, Shuman Zhang, Chunli Hu, Lili Ren, Jing B. Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of Aβ Molecular biology reports. 2023-01-05. PMID:36602704. |
regulatory role of melatonin in notch1 signaling pathway in cerebral cortex of aβ soluble amyloid-beta (aβ) oligomers are thought to play a key role in the pathogenesis of alzheimer's disease (ad), which is the most common age-associated neurodegenerative diseases with obvious neuropathological changes and functional decline in both cortical and subcortical regions. |
2023-01-05 |
2023-08-14 |
Not clear |
| J H Y Yeung, T H Palpagama, C Turner, H J Waldvogel, R L M Faull, A Kwakowsk. mGluR1α expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer's disease. IBRO neuroscience reports. vol 13. 2023-01-02. PMID:36590090. |
mglur1α expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in alzheimer's disease. |
2023-01-02 |
2023-08-14 |
human |
| Yuek Ling Chai, Nathan Hao Ping Liang, Joyce R Chong, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Saima Hilal, Christopher P Chen, Mitchell K P La. Serum Cathepsin D Is a Potential Biomarker for Alzheimer's Disease Dementia and Cognitive Decline. Journal of Alzheimer's disease : JAD. 2022-12-24. PMID:36565119. |
the lysosomal protease cathepsin d (catd) has been reported to be upregulated in postmortem alzheimer's disease (ad) cortex, where it colocalized with neurofibrillary tangles and correlated with levels of phosphorylated tau, suggesting pathophysiological links between catd and neurodegeneration. |
2022-12-24 |
2023-08-14 |
Not clear |
| Arnab Kumar Nath, Madhuparna Roy, Chinmay Dey, Abhishek Dey, Somdatta Ghosh De. Spin state dependent peroxidase activity of heme bound amyloid β peptides relevant to Alzheimer's disease. Chemical science. vol 13. issue 48. 2022-12-22. PMID:36545147. |
the colocalization of heme rich deposits in the senile plaque of aβ in the cerebral cortex of the alzheimer's disease (ad) brain along with altered heme homeostasis and heme deficiency symptoms in ad patients has invoked the association of heme in ad pathology. |
2022-12-22 |
2023-08-14 |
Not clear |
| Neha, Suhel Parve. Emerging Therapeutics Agents and Recent Advances in Drug Repurposing for Alzheimer's Disease. Ageing research reviews. 2022-12-18. PMID:36529440. |
alzheimer's disease (ad) is a multivariate and diversified disease and affects the most sensitive areas of the brain, the cerebral cortex, and the hippocampus. |
2022-12-18 |
2023-08-14 |
Not clear |
| Kei M Igarash. Entorhinal cortex dysfunction in Alzheimer's disease. Trends in neurosciences. 2022-12-13. PMID:36513524. |
entorhinal cortex dysfunction in alzheimer's disease. |
2022-12-13 |
2023-08-14 |
Not clear |
| Kei M Igarash. Entorhinal cortex dysfunction in Alzheimer's disease. Trends in neurosciences. 2022-12-13. PMID:36513524. |
the entorhinal cortex (ec) is the brain region that often exhibits the earliest histological alterations in alzheimer's disease (ad), including the formation of neurofibrillary tangles and cell death. |
2022-12-13 |
2023-08-14 |
Not clear |
| Sangjoon Lee, Tae Kyoo Kim, Ji Eun Choi, Hye-Sun Kim, Heh-In I. Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice. International neurourology journal. vol 26. issue Suppl 2. 2022-12-12. PMID:36503213. |
in alzheimer disease (ad), brain regions such as the cortex and the hippocampus show abundant amyloid load which correlates with cognitive function decline. |
2022-12-12 |
2023-08-14 |
mouse |
| Rikki Lissaman, Thomas M Lancaster, Greg D Parker, Kim S Graham, Andrew D Lawrence, Carl J Hodgett. Tract-specific differences in white matter microstructure between young adult Neuroimage. Reports. vol 2. issue 4. 2022-12-12. PMID:36507069. |
tract-specific differences in white matter microstructure between young adult the parahippocampal cingulum bundle (phcb) interconnects regions known to be vulnerable to early alzheimer's disease (ad) pathology, including posteromedial cortex and medial temporal lobe. |
2022-12-12 |
2023-08-14 |
Not clear |
| Nasim Sattari, Fariborz Faeghi, Babak Shekarchi, Mohammad Hossein Heidar. Assessing the Changes of Cortical Thickness in Alzheimer Disease With MRI Using Freesurfer Software. Basic and clinical neuroscience. vol 13. issue 2. 2022-11-25. PMID:36425945. |
in this study, we intend to determine the correlation between the thickness of the cerebral cortex and the severity of the cognitive disorder in alzheimer disease (ad). |
2022-11-25 |
2023-08-14 |
Not clear |
| b' Paulo C\\xc3\\xa9zar Prado, Jos\\xc3\\xa9lia Alencar Lima, Lidilhone Hamerski, Magdalena Nascimento Renn\\xc3\\xb. Natural Products with BACE1 and GSK3\\xce\\xb2 Inhibitory Activity. Mini reviews in medicinal chemistry. 2022-11-22. PMID:36411570.' |
alzheimer's disease (ad) is a neurodegenerative, progressive, and fatal disorder characterized by marked atrophy of the cerebral cortex and loss of basal forebrain cholinergic neurons. |
2022-11-22 |
2023-08-14 |
Not clear |
| Amy E Elias, Thomas A Nuñez, Bianca Kun, Jill A Kreilin. primiReference: a reference for analysis of primary-microRNA expression in single-nucleus sequencing data. Journal of genetics and genomics = Yi chuan xue bao. 2022-11-12. PMID:36371075. |
furthermore, using wild-type and 5xfad mouse model cortex nuclei, to validate the use of primireference, we find cell-type specific expression of pri-mirnas known to be involved in alzheimer's disease. |
2022-11-12 |
2023-08-14 |
mouse |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, we measured plasma amyloid beta (aβ)40, aβ42, total tau, and neurofilament light chain (nfl; n = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (wmh) volumes, and alzheimer's disease (ad)-signature cortical thickness (n = 917). |
2022-11-07 |
2023-08-14 |
human |
| Ankur Kumar, Bhupender Nehra, Dilpreet Singh, Dileep Kuma, Pooja A Chawl. Recent advances in the development of nitrogen-containing heterocyclic Anti-Alzheimer's agents. Current topics in medicinal chemistry. 2022-10-24. PMID:36278462. |
alzheimer's disease is usually triggered by numerous associated factors, including depleted amount of acetylcholine (ach), excessive aggregation of β-amyloid peptide (aβ), tau hyperphosphorylation with neurofibrillary tangle formation as well as deposition of feeble plaques in a specific portion of the brain (hippocampus and cortex). |
2022-10-24 |
2023-08-14 |
Not clear |
| Marie-Ève Martineau-Dussault, Claire André, Véronique Daneault, Andrée-Ann Baril, Katia Gagnon, Hélène Blais, Dominique Petit, Jacques Y Montplaisir, Dominique Lorrain, Célyne Bastien, Carol Hudon, Maxime Descoteaux, Arnaud Boré, Guillaume Theaud, Cynthia Thompson, Julie Legault, Guillermo E Martinez Villar, Alexandre Lafrenière, Chantal Lafond, Danielle Gilbert, Julie Carrier, Nadia Gosseli. Medial temporal lobe and obstructive sleep apnea: Effect of sex, age, cognitive status and free-water. NeuroImage. Clinical. vol 36. 2022-10-22. PMID:36272339. |
medial temporal structures, namely the hippocampus, the entorhinal cortex and the parahippocampal gyrus, are particularly vulnerable to alzheimer's disease and hypoxemia. |
2022-10-22 |
2023-08-14 |
human |
| Hui Zhang, Silu Cao, Yaru Xu, Xiaoru Sun, Miaomiao Fei, Qi Jing, Xiaodong Xu, Jinxuan Tang, Bing Niu, Cheng L. Landscape of immune infiltration in entorhinal cortex of patients with Alzheimer's disease. Frontiers in pharmacology. vol 13. 2022-10-17. PMID:36249779. |
landscape of immune infiltration in entorhinal cortex of patients with alzheimer's disease. |
2022-10-17 |
2023-08-14 |
Not clear |
| Hui Zhang, Silu Cao, Yaru Xu, Xiaoru Sun, Miaomiao Fei, Qi Jing, Xiaodong Xu, Jinxuan Tang, Bing Niu, Cheng L. Landscape of immune infiltration in entorhinal cortex of patients with Alzheimer's disease. Frontiers in pharmacology. vol 13. 2022-10-17. PMID:36249779. |
this study aimed to provide an overview of the immune cell composition in the entorhinal cortex of patients with alzheimer's disease based on the transcriptomes and signature genes of different immune cells and to explore potential therapeutic targets based on the relevance of drug targets. |
2022-10-17 |
2023-08-14 |
Not clear |