| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Callum Walsh, Thomas Ridler, Gabriella Margetts-Smith, Maria Garcia Garrido, Jonathan Witton, Andrew D Randall, Jonathan T Brow. Beta bursting in the retrosplenial cortex is a neurophysiological correlate of environmental novelty which is disrupted in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-04. PMID:35927034. |
beta bursting in the retrosplenial cortex is a neurophysiological correlate of environmental novelty which is disrupted in a mouse model of alzheimer's disease. |
2022-08-04 |
2023-08-14 |
mouse |
| Callum Walsh, Thomas Ridler, Gabriella Margetts-Smith, Maria Garcia Garrido, Jonathan Witton, Andrew D Randall, Jonathan T Brow. Beta bursting in the retrosplenial cortex is a neurophysiological correlate of environmental novelty which is disrupted in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-04. PMID:35927034. |
the retrosplenial cortex (rsc) plays a significant role in spatial learning and memory and is functionally disrupted in the early stages of alzheimer's disease. |
2022-08-04 |
2023-08-14 |
mouse |
| Chiara Orciani, Helene Hall, Rowan Pentz, Morgan K Foret, Sonia Do Carmo, A Claudio Cuell. Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. Journal of neurochemistry. 2022-08-03. PMID:35921478. |
basal forebrain cholinergic neurons (bfcns) represent the main source of cholinergic innervation to the cortex and hippocampus and degenerate early in alzheimer's disease (ad) progression. |
2022-08-03 |
2023-08-14 |
rat |
| Desiree Antequera, Laura Carrero, Victoria Cunha Alves, Isidro Ferrer, Jesús Hernández-Gallego, Cristina Municio, Eva Carr. Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer's Disease. Biomedicines. vol 10. issue 7. 2022-07-27. PMID:35884950. |
differentially aquaporin 5 expression in submandibular glands and cerebral cortex in alzheimer's disease. |
2022-07-27 |
2023-08-14 |
mouse |
| Victor Montal, Ibai Diez, Chan-Mi Kim, William Orwig, Elisenda Bueichekú, Raquel Gutiérrez-Zúñiga, Alexandre Bejanin, Jordi Pegueroles, Oriol Dols-Icardo, Patrizia Vannini, Georges El-Fakhri, Keith A Johnson, Reisa A Sperling, Juan Fortea, Jorge Sepulcr. Network Tau spreading is vulnerable to the expression gradients of Science translational medicine. vol 14. issue 655. 2022-07-27. PMID:35895837. |
network tau spreading is vulnerable to the expression gradients of a key hallmark of alzheimer's disease (ad) pathology is the intracellular accumulation of tau protein in the form of neurofibrillary tangles across large-scale networks of the human brain cortex. |
2022-07-27 |
2023-08-14 |
human |
| Fumi Katsuki, Dmitry Gerashchenko, Ritchie E Brow. Alterations of sleep oscillations in Alzheimer's Disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus. Brain research bulletin. 2022-07-19. PMID:35850189. |
alterations of sleep oscillations in alzheimer's disease: a potential role for gabaergic neurons in the cortex, hippocampus, and thalamus. |
2022-07-19 |
2023-08-14 |
mouse |
| Liu Yang, Huimin Zhou, Lei Huang, Yong Su, Liangliang Kong, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li, Weizu L. Stress level of glucocorticoid exacerbates neuronal damage and Aβ production through activating NLRP1 inflammasome in primary cultured hippocampal neurons of APP-PS1 mice. International immunopharmacology. vol 110. 2022-07-01. PMID:35777263. |
glucocorticoid (gc), secreted by adrenal cortex, plays important roles in regulating many physiological functions, while chronic stress level of gc exposure has many adverse effects on the structure and function of hippocampal neurons, and is closely implicated to the deterioration of alzheimer's disease (ad). |
2022-07-01 |
2023-08-14 |
mouse |
| Petrice M Cogswell, Heather J Wiste, Michelle M Mielke, Christopher G Schwarz, Stephen D Weigand, Val J Lowe, Terry M Therneau, David S Knopman, Jonathan Graff-Radford, Prashanthi Vemuri, Matthew L Senjem, Jeffrey L Gunter, Alicia Algeciras-Schimnich, Ronald C Petersen, Clifford R Jac. CSF phosphorylated tau as an indicator of subsequent tau accumulation. Neurobiology of aging. vol 117. 2022-06-28. PMID:35764037. |
we evaluated the relationship between baseline csf p-tau181 and the rate of tau pet change in the temporal meta-roi and entorhinal cortex (erc) and how it varied by amyloid level (csf aβ42 or amyloid pet) among 143 individuals from the mayo clinic study of aging and mayo alzheimer disease research center. |
2022-06-28 |
2023-08-14 |
human |
| Yun-Long Xu, Lin Zhu, Zi-Jun Chen, Xiao-Fei Deng, Pei-Dong Liu, Shan Li, Bing-Chun Lin, Chuan-Zhong Yang, Wei Xu, Kui-Kui Zhou, Ying-Jie Zh. Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer's Disease. Neuroscience bulletin. 2022-06-28. PMID:35764752. |
release of endogenous brain-derived neurotrophic factor into the lateral entorhinal cortex from the paraventricular thalamus ameliorates social memory deficits in a mouse model of alzheimer's disease. |
2022-06-28 |
2023-08-14 |
mouse |
| Itsuki Hasegawa, Yoko Hirayoshi, Shinobu Minatani, Toshikazu Mino, Akitoshi Takeda, Yoshiaki Ito. In Vivo Dynamic Movement of Polymerized Amyloid β in the Perivascular Space of the Cerebral Cortex in Mice. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742862. |
disposition of amyloid β (aβ) into the perivascular space of the cerebral cortex has been recently suggested as a major source of its clearance, and its disturbance may be involved in the pathogenesis of cerebral amyloid angiopathy and alzheimer's disease. |
2022-06-24 |
2023-08-14 |
mouse |
| Akanksha Malaiya, Mansha Singhai, Manisha Singh, Shiv Kumar Prajapati, Hira Choudhury, Mahak Fatima, Amit Alexander, Sunil Kumar Dubey, Khaled Greish, Prashant Kesharwan. Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches. Current drug targets. 2022-06-03. PMID:35657283. |
however, alois alzheimer initially mentioned that the reduction in brain volume in ad might be associated with the "deposition of a special substance in the cortex". |
2022-06-03 |
2023-08-14 |
Not clear |
| Raquel Martínez-Serra, Lidia Alonso-Nanclares, Kwangwook Cho, K Peter Gies. Emerging insights into synapse dysregulation in Alzheimer's disease. Brain communications. vol 4. issue 2. 2022-06-02. PMID:35652120. |
further, multi-synapses also appear to be altered in alzheimer's disease by doubling the abundance of multi-innervated spines in the transentorhinal cortex of alzheimer's disease brain. |
2022-06-02 |
2023-08-14 |
human |
| Rahul Dhandapani, Marilisa Neri, Mario Bernhard, Irena Brzak, Tatjana Schweizer, Stefan Rudin, Stefanie Joller, Ramon Berth, Jasmin Kernen, Anna Neuhaus, Annick Waldt, Rachel Cuttat, Ulrike Naumann, Caroline Gubser Keller, Guglielmo Roma, Dominik Feuerbach, Derya R Shimshek, Ulf Neumann, Fabrizio Gasparini, Ivan Galimbert. Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease. Cell reports. vol 39. issue 9. 2022-06-01. PMID:35649351. |
using single-cell transcriptomic profiling of mouse cortex, we show that sustained trem2 stabilization induces a shift of fate in microglial maturation and accelerates microglial responses to aβ pathology in a mouse model of alzheimer's disease. |
2022-06-01 |
2023-08-13 |
mouse |
| Md Ataur Rahman, M D Hasanur Rahman, A N M Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhi. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625764. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2022-05-28 |
2023-08-13 |
Not clear |
| Jan Oltmer, Natalya Slepneva, Josue Llamas Rodriguez, Douglas N Greve, Emily M Williams, Ruopeng Wang, Samantha N Champion, Melanie Lang-Orsini, Kimberly Nestor, Nídia Fernandez-Ros, Bruce Fischl, Matthew P Frosch, Caroline Magnain, Andre J W van der Kouwe, Jean C Augustinac. Quantitative and histologically validated measures of the entorhinal subfields in Brain communications. vol 4. issue 3. 2022-05-27. PMID:35620167. |
the entorhinal cortex is one of the first cortical areas affected by alzheimer's disease; its neurons are especially vulnerable to neurofibrillary tangles. |
2022-05-27 |
2023-08-13 |
human |
| Jan Oltmer, Natalya Slepneva, Josue Llamas Rodriguez, Douglas N Greve, Emily M Williams, Ruopeng Wang, Samantha N Champion, Melanie Lang-Orsini, Kimberly Nestor, Nídia Fernandez-Ros, Bruce Fischl, Matthew P Frosch, Caroline Magnain, Andre J W van der Kouwe, Jean C Augustinac. Quantitative and histologically validated measures of the entorhinal subfields in Brain communications. vol 4. issue 3. 2022-05-27. PMID:35620167. |
we investigated the entorhinal cortex on a subfield-specific level-at a critical time point of alzheimer's disease progression. |
2022-05-27 |
2023-08-13 |
human |
| Lin Wu, Antonietta Canna, Omar Narvaez, Jun Ma, Sheng Sang, Lauri J Lehto, Alejandra Sierra, Heikki Tanila, Yuan Zhang, Olli Gröhn, Walter C Low, Pavel Filip, Silvia Mangia, Shalom Michael. Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition. Scientific reports. vol 12. issue 1. 2022-05-20. PMID:35595790. |
here we utilized os-dbs with a planar 3-channel electrode for stimulating the rat entorhinal cortex (ec) and medial septal nucleus (msn), two promising areas for dbs treatment of alzheimer's disease. |
2022-05-20 |
2023-08-13 |
rat |
| Lilesh Kumar Pradhan, Pradyumna Kumar Sahoo, Santosh Chauhan, Saroj Kumar Da. Recent Advances Towards Diagnosis and Therapeutic Fingerprinting for Alzheimer's Disease. Journal of molecular neuroscience : MN. 2022-05-13. PMID:35553375. |
since the report of "a peculiar severe disease process of the cerebral cortex" by alois alzheimer in 1906, it was considered to be a rare condition characterized by loss of cognition, memory impairment, and pathological markers such as senile plaques or neurofibrillary tangles (nfts). |
2022-05-13 |
2023-08-13 |
Not clear |
| Josué Llamas-Rodríguez, Jan Oltmer, Douglas N Greve, Emily Williams, Natalya Slepneva, Ruopeng Wang, Samantha Champion, Melanie Lang-Orsini, Bruce Fischl, Matthew P Frosch, André J W van der Kouwe, Jean C Augustinac. Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-05-02. PMID:35491780. |
neurofibrillary tangle (nft) accumulation in the entorhinal cortex (ec) precedes the transformation from cognitive controls to mild cognitive impairment and alzheimer's disease (ad). |
2022-05-02 |
2023-08-13 |
Not clear |
| Elena Puris, Seppo Auriola, Sabrina Petralla, Robin Hartman, Mikko Gynther, Elizabeth C M de Lange, Gert Fricke. Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model. Neurobiology of disease. 2022-04-26. PMID:35472634. |
altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat alzheimer's disease model. |
2022-04-26 |
2023-08-13 |
rat |