| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanpan Gao, Jiaqi Liu, Jiayu Wang, Yifan Liu, Ling-Hui Zeng, Wei Ge, Chao M. Proteomic analysis of human hippocampal subfields provides new insights into the pathogenesis of Alzheimer's disease and the role of glial cells. Brain pathology (Zurich, Switzerland). 2022-01-11. PMID:35016256. |
the hippocampus and entorhinal cortex (ec), the earliest affected areas, are considered relative to early memory loss in alzheimer's disease (ad). |
2022-01-11 |
2023-08-13 |
human |
| Wafaa S Ramadan, Saleh Alkari. Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer's Model. Cells. vol 10. issue 12. 2021-12-24. PMID:34944019. |
ellagic acid modulates the amyloid precursor protein gene via superoxide dismutase regulation in the entorhinal cortex in an experimental alzheimer's model. |
2021-12-24 |
2023-08-13 |
rat |
| G M Godbersen, M Murgaš, G Gryglewski, M Klöbl, J Unterholzner, L Rischka, M Spies, P Baldinger-Melich, D Winkler, R Lanzenberge. Coexpression of Gene Transcripts with Monoamine Oxidase A Quantified by Human In Vivo Positron Emission Tomography. Cerebral cortex (New York, N.Y. : 1991). 2021-12-24. PMID:34952543. |
the analysis revealed 35 genes in cortex (including b-cell translocation gene family, member 3, implicated in neuroinflammation) and 247 genes in subcortex (including kallikrein-related peptidase 10, implicated in alzheimer's disease). |
2021-12-24 |
2023-08-13 |
human |
| Andrew M Shafik, Huiqing Zhou, Junghwa Lim, Bryan Dickinson, Peng Ji. Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease. Human molecular genetics. 2021-12-13. PMID:34897434. |
here, we applied the newly developed m1a-quant-seq approach to map the brain abundant m1a rna modification in the cortex of an alzheimer's disease mouse model, 5xfad. |
2021-12-13 |
2023-08-13 |
mouse |
| Jason H Y Yeung, Joshua L Walby, Thulani H Palpagama, Clinton Turner, Henry J Waldvogel, Richard L M Faull, Andrea Kwakowsk. Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex. Brain pathology (Zurich, Switzerland). vol 31. issue 6. 2021-12-11. PMID:34269494. |
glutamatergic receptor expression changes in the alzheimer's disease hippocampus and entorhinal cortex. |
2021-12-11 |
2023-08-13 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
in alzheimer's disease, post-mortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with brodmann area 35, and the entorhinal cortex. |
2021-12-09 |
2023-08-13 |
human |
| Paul A Yushkevich, Mónica Muñoz López, María Mercedes Iñiguez de Onzoño Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R Das, Emilio Artacho-Pérula, Marı'a Del Mar Arroyo Jiménez, Marı'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa-Prieto, Marta Córcoles Parada, Edward B Lee, John Q Trojanowski, Daniel T Ohm, Laura E M Wisse, David A Wolk, David J Irwin, Ricardo Insaust. Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:34259858. |
overall, the three-dimensional maps of neurofibrillary tangle burden presented here provide more complete information about the distribution of this neurodegenerative pathology in the region of the cortex where it first emerges in alzheimer's disease, and may help inform the field about the patterns of pathology spread, as well as support development and validation of neuroimaging biomarkers. |
2021-12-09 |
2023-08-13 |
human |
| Elena Puris, Seppo Auriola, Paula Korhonen, Sanna Loppi, Katja M Kanninen, Tarja Malm, Jari Koistinaho, Mikko Gynthe. Systemic Inflammation Induced Changes in Protein Expression of ABC Transporters and Ionotropic Glutamate Receptor Subunit 1 in the Cerebral Cortex of Familial Alzheimer`s Disease Mouse Model. Journal of pharmaceutical sciences. vol 110. issue 12. 2021-12-06. PMID:34403652. |
systemic inflammation induced changes in protein expression of abc transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial alzheimer`s disease mouse model. |
2021-12-06 |
2023-08-13 |
mouse |
| Kun-Yu Li, Pi-Fang Gong, Jia-Tong Li, Nan-Jie Xu, Song Qi. Morphological and molecular alterations of reactive astrocytes without proliferation in cerebral cortex of an APP/PS1 transgenic mouse model and Alzheimer's patients. Glia. vol 68. issue 11. 2021-11-30. PMID:32469469. |
morphological and molecular alterations of reactive astrocytes without proliferation in cerebral cortex of an app/ps1 transgenic mouse model and alzheimer's patients. |
2021-11-30 |
2023-08-13 |
mouse |
| Shayan Aliakbari, Mohammad Sayyah, Hadi Mirzapourdelavar, Niloufar Amini, Naser Naghdi, Hamid Gholami Pourbadi. Overexpression of protein kinase Mζ in the hippocampal dentate gyrus rescues amyloid-β-induced synaptic dysfunction within entorhinal-hippocampal circuit. Neurobiology of aging. vol 101. 2021-11-30. PMID:33618267. |
entorhinal cortex (ec) is one of the first cerebral regions affected in the early phase of alzheimer's disease (ad). |
2021-11-30 |
2023-08-13 |
rat |
| Guido Santos, Mario Día. Dimensional Changes in Lipid Rafts from Human Brain Cortex Associated to Development of Alzheimer's Disease. Predictions from an Agent-Based Mathematical Model. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830060. |
dimensional changes in lipid rafts from human brain cortex associated to development of alzheimer's disease. |
2021-11-30 |
2023-08-13 |
human |
| So Tando, Takashi Kasai, Ikuko Mizuta, Hisashi Takahashi, Takeshi Yaoi, Kozo Saito, Tomohito Hojo, Toshiki Mizuno, Masato Hasegawa, Kyoko Ito. An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP-43 proteinopathy, associated with Alzheimer's disease pathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 41. issue 3. 2021-11-25. PMID:33537992. |
an autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with tdp-43 proteinopathy, associated with alzheimer's disease pathology. |
2021-11-25 |
2023-08-13 |
Not clear |
| So Tando, Takashi Kasai, Ikuko Mizuta, Hisashi Takahashi, Takeshi Yaoi, Kozo Saito, Tomohito Hojo, Toshiki Mizuno, Masato Hasegawa, Kyoko Ito. An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP-43 proteinopathy, associated with Alzheimer's disease pathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 41. issue 3. 2021-11-25. PMID:33537992. |
we herein report a case of corticobasal syndrome (cbs) due to asymmetric degeneration of the motor cortex and substantia nigra with transactivation response dna-binding protein of 43 kda (tdp-43) proteinopathy, associated with alzheimer's disease (ad) pathology. |
2021-11-25 |
2023-08-13 |
Not clear |
| Tamar Gefen, Allegra Kawles, Beth Makowski-Woidan, Janessa Engelmeyer, Ivan Ayala, Payam Abbassian, Hui Zhang, Sandra Weintraub, Margaret E Flanagan, Qinwen Mao, Eileen H Bigio, Emily Rogalski, M Marsel Mesulam, Changiz Geul. Paucity of Entorhinal Cortex Pathology of the Alzheimer's Type in SuperAgers with Superior Memory Performance. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 7. 2021-11-23. PMID:33592091. |
paucity of entorhinal cortex pathology of the alzheimer's type in superagers with superior memory performance. |
2021-11-23 |
2023-08-13 |
Not clear |
| Stefan Gaunitz, Lars O Tjernberg, Sophia Schedin-Weis. The N-glycan profile in cortex and hippocampus is altered in Alzheimer disease. Journal of neurochemistry. vol 159. issue 2. 2021-11-19. PMID:32986846. |
the n-glycan profile in cortex and hippocampus is altered in alzheimer disease. |
2021-11-19 |
2023-08-13 |
Not clear |
| Dennis A Turner, Simone Degan, Ulrike Hoffmann, Francesca Galeffi, Carol A Colto. CVN-AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 7. 2021-11-18. PMID:33656270. |
we compared the efficacy of neurovascular coupling and substrate supply in cerebral cortex during severe metabolic challenges in transgenic alzheimer's [cvn-ad] and control [c57bl/6] mice, to evaluate the hypothesis that metabolic insufficiency is a critical component of degeneration leading to dementia. |
2021-11-18 |
2023-08-13 |
mouse |
| Natasha Andressa Nogueira Jorge, Uwe Ueberham, Mara Knobloch, Peter F Stadler, Jörg Fallmann, Thomas Arend. Disturbance of phylogenetic layer-specific adaptation of human brain gene expression in Alzheimer's disease. Scientific reports. vol 11. issue 1. 2021-11-18. PMID:34642398. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder with typical neuropathological hallmarks, such as neuritic plaques and neurofibrillary tangles, preferentially found at layers iii and v. the distribution of both hallmarks provides the basis for the staging of ad, following a hierarchical pattern throughout the cerebral cortex. |
2021-11-18 |
2023-08-13 |
human |
| Christine W Fung, Jia Guo, Hongjun Fu, Helen Y Figueroa, Elisa E Konofagou, Karen E Duf. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science advances. vol 6. issue 42. 2021-11-17. PMID:33067235. |
tau pathology in alzheimer's disease (ad) first develops in the entorhinal cortex (ec), then spreads to the hippocampus, followed by the neocortex. |
2021-11-17 |
2023-08-13 |
mouse |
| Nicholas P Vyleta, Jason S Snyde. Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons. PloS one. vol 16. issue 6. 2021-11-16. PMID:34143843. |
while enhanced critical period plasticity at mpp synapses is relatively well characterized, no studies have examined long-term plasticity at lpp synapses onto adult-born neurons, even though the lateral entorhinal cortex is uniquely vulnerable to aging and alzheimer's pathology. |
2021-11-16 |
2023-08-13 |
Not clear |
| Chao Du, Jiawei Hou, Chunhui Wang, Mengyu Zhang, Yanjie Zheng, Guang Yang, Yanli H. Effects of safflower yellow on cholesterol levels in serum and brain tissue of APP/PS1 mice. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33550459. |
sy improves alzheimer's disease by lowering serum, cortex and cortical cholesterol. |
2021-11-12 |
2023-08-13 |
mouse |