| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohit Kumar, Sharma Anita Ashok, Ashok Kumar Datusalia, Gopal L Khati. PPARs (Peroxisome Proliferator-activated Receptors) and Their Agonists in Alzheimer's Disease. Medicinal chemistry (Shariqah (United Arab Emirates)). 2024-05-10. PMID:38726789. |
alzheimer's disease (ad) is a neurodegenerative disease leading to dementia because of complex phathomechanisms like amyloid β (aβ) aggregation, tau aggregates, and neurofibrillary tangles. |
2024-05-10 |
2024-05-27 |
human |
| Jason Langley, Ilana J Bennett, Xiaoping P H. Examining iron-related off-target binding effects of The European journal of neuroscience. 2024-05-09. PMID:38722153. |
examining iron-related off-target binding effects of the presence of neurofibrillary tangles containing hyper-phosphorylated tau is a characteristic of alzheimer's disease (ad) pathology. |
2024-05-09 |
2024-05-27 |
Not clear |
| Stephanie J B Vos, Aurore Delvenne, Clifford R Jack, Dietmar R Thal, Pieter Jelle Visse. The clinical importance of suspected non-Alzheimer disease pathophysiology. Nature reviews. Neurology. 2024-05-09. PMID:38724589. |
the development of biomarkers for alzheimer disease (ad) has led to the origin of suspected non-ad pathophysiology (snap) - a heterogeneous biomarker-based concept that describes individuals with normal amyloid and abnormal tau and/or neurodegeneration biomarker status. |
2024-05-09 |
2024-05-27 |
Not clear |
| Ling Xiao Yi, Eng King Tan, Zhi Dong Zho. Passive immunotherapy for Alzheimer's disease: challenges & future directions. Journal of translational medicine. vol 22. issue 1. 2024-05-08. PMID:38715084. |
passive immunotherapy with specific antibodies targeting amyloid β (aβ) peptide or tubulin-associated unit (tau) protein has emerged as a promising therapeutic approach in alzheimer's disease (ad). |
2024-05-08 |
2024-05-27 |
human |
| Caroline Wasén, Leah C Beauchamp, Julia Vincentini, Shuqi Li, Danielle S LeServe, Christian Gauthier, Juliana R Lopes, Thais G Moreira, Millicent N Ekwudo, Zhuoran Yin, Patrick da Silva, Rajesh K Krishnan, Oleg Butovsky, Laura M Cox, Howard L Weine. Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer's disease mouse models. Nature communications. vol 15. issue 1. 2024-05-08. PMID:38719797. |
the gut microbiota and microglia play critical roles in alzheimer's disease (ad), and elevated bacteroides is correlated with cerebrospinal fluid amyloid-β (aβ) and tau levels in ad. |
2024-05-08 |
2024-05-27 |
mouse |
| Grigorii Sultanakhmetov, Sophia Jobien M Limlingan, Aoi Fukuchi, Keisuke Tsuda, Hirokazu Suzuki, Iori Kato, Taro Saito, Adam Z Weitemier, Kanae And. Brain communications. vol 6. issue 3. 2024-05-08. PMID:38712317. |
accumulation of abnormally phosphorylated tau proteins is linked to various neurodegenerative diseases, including alzheimer's disease and frontotemporal dementia. |
2024-05-08 |
2024-05-27 |
Not clear |
| Grigorii Sultanakhmetov, Sophia Jobien M Limlingan, Aoi Fukuchi, Keisuke Tsuda, Hirokazu Suzuki, Iori Kato, Taro Saito, Adam Z Weitemier, Kanae And. Brain communications. vol 6. issue 3. 2024-05-08. PMID:38712317. |
microtubule affinity-regulating kinase 4 (mark4) has been genetically and pathologically associated with alzheimer's disease and reported to enhance tau phosphorylation and toxicity in |
2024-05-08 |
2024-05-27 |
Not clear |
| Ayesha Tahir, Bushra Mobeen, Fahad Hussain, Abdul Sadiq, Umer Rashi. Pregnenolone derivatives for the treatment of Alzheimer's disease: synthesis, and RSC advances. vol 14. issue 21. 2024-05-08. PMID:38716099. |
one of the major hallmarks of alzheimer's disease includes primarily the extracellular build-up of a peptide known as amyloid-β, which has a sequence consisting of 39 to 42 amino acid residues, and the formation of intracellular neurofibrillary tangles mostly consisting of hyperphosphorylated tau protein. |
2024-05-08 |
2024-05-27 |
Not clear |
| Siddhant Tripathi, Yashika Sharma, Rajesh Rane, Dileep Kuma. CRISPR/Cas9 Gene Editing: A Novel Approach Towards Alzheimer's Disease Treatment. CNS & neurological disorders drug targets. 2024-05-08. PMID:38716549. |
a neurological ailment that progresses and cannot be reversed is alzheimer's disease, which shows neurofibrillary tangles, beta-amyloid plaque, and a lack of cognitive processes that is created by tau protein clumps with hyperphosphorylation that finally advances to neuronal damage without a recognized treatment, which has stimulated research into new therapeutic strategies. |
2024-05-08 |
2024-05-27 |
Not clear |
| Mattia Cort. Exploring tau protein and amyloid-beta propagation: a sensitivity analysis of mathematical models based on biological data. ArXiv. 2024-05-07. PMID:38711430. |
we calibrate the model parameters using biological measurements in the brain cortex for the tau protein and the amyloid-$eta$ in alzheimer's patients and controls. |
2024-05-07 |
2024-05-27 |
Not clear |
| Kondalarao Bankapalli, Ruth E Thomas, Evelyn S Vincow, Gillian Milstein, Laura V Fisher, Leo J Pallanc. A bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712083. |
previous work indicates that specific protein components of these aggregates are toxic, including tau in alzheimer's disease and related tauopathies. |
2024-05-07 |
2024-05-27 |
Not clear |
| Adriana N Santiago-Ruiz, Siewert Hugelier, Charles R Bond, Edward B Lee, Melike Lakadamyal. Super-Resolution Imaging Uncovers Nanoscale Tau Aggregate Hyperphosphorylation Patterns in Human Alzheimer's Disease Brain Tissue. bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712162. |
super-resolution imaging uncovers nanoscale tau aggregate hyperphosphorylation patterns in human alzheimer's disease brain tissue. |
2024-05-07 |
2024-05-27 |
human |
| Adriana N Santiago-Ruiz, Siewert Hugelier, Charles R Bond, Edward B Lee, Melike Lakadamyal. Super-Resolution Imaging Uncovers Nanoscale Tau Aggregate Hyperphosphorylation Patterns in Human Alzheimer's Disease Brain Tissue. bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712162. |
tau aggregation plays a critical role in alzheimer's disease (ad), where tau neurofibrillary tangles (nfts) are a key pathological hallmark. |
2024-05-07 |
2024-05-27 |
human |
| Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706571. |
proteinopathies include synucleinopathies triggered by misfolded amyloid α-synuclein, tauopathies triggered by misfolded tau, and amyloidopathies triggered by misfolded amyloid of which alzheimer's disease (β-amyloid) is most prevalent. |
2024-05-06 |
2024-05-08 |
mouse |
| Min Wang, Jiaying Lu, Ying Zhang, Qi Zhang, Luyao Wang, Ping Wu, Matthias Brendel, Axel Rominger, Kuangyu Shi, Qianhua Zhao, Jiehui Jiang, Chuantao Zu. Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer's disease. Human brain mapping. vol 45. issue 7. 2024-05-04. PMID:38703095. |
characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in alzheimer's disease. |
2024-05-04 |
2024-05-07 |
human |
| Min Wang, Jiaying Lu, Ying Zhang, Qi Zhang, Luyao Wang, Ping Wu, Matthias Brendel, Axel Rominger, Kuangyu Shi, Qianhua Zhao, Jiehui Jiang, Chuantao Zu. Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer's disease. Human brain mapping. vol 45. issue 7. 2024-05-04. PMID:38703095. |
tau pathology and its spatial propagation in alzheimer's disease (ad) play crucial roles in the neurodegenerative cascade leading to dementia. |
2024-05-04 |
2024-05-07 |
human |
| Nianzhuang Qiu, Chenliang Qian, Tingting Guo, Yaling Wang, Hongwei Jin, Mingli Yao, Mei Li, Tianyang Guo, Yuli Lv, Xinxin Si, Song Wu, Hao Wang, Xuehui Zhang, Jie Xi. Discovery of a novel chemotype as DYRK1A inhibitors against Alzheimer's disease: Computational modeling and biological evaluation. International journal of biological macromolecules. 2024-05-04. PMID:38704072. |
dual-specificity tyrosine phosphorylation-regulated kinase 1 a (dyrk1a) plays an essential role in tau and aβ pathology closely related to alzheimer's disease (ad). |
2024-05-04 |
2024-05-07 |
mouse |
| Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Thomas K Karikari, Nicholas J Ashton, Andréa L Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medin. Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer's disease. Communications biology. vol 7. issue 1. 2024-05-04. PMID:38704445. |
personalized whole-brain neural mass models reveal combined aβ and tau hyperexcitable influences in alzheimer's disease. |
2024-05-04 |
2024-05-07 |
Not clear |
| Yuta Katsumi, Inola A Howe, Ryan Eckbo, Bonnie Wong, Megan Quimby, Daisy Hochberg, Scott M McGinnis, Deepti Putcha, David A Wolk, Alexandra Touroutoglou, Bradford C Dickerso. Default mode network tau predicts future clinical decline in atypical early Alzheimer's disease. medRxiv : the preprint server for health sciences. 2024-05-03. PMID:38699357. |
default mode network tau predicts future clinical decline in atypical early alzheimer's disease. |
2024-05-03 |
2024-05-05 |
Not clear |
| Yuya Xu, Mengrong Xu, Chengyu Zhou, Ling Sun, Wenqiang Cai, Xuling L. Ferroptosis and its implications in treating cognitive impairment caused by aging: A study on the mechanism of repetitive transcranial magnetic stimulation. Experimental gerontology. 2024-05-02. PMID:38697556. |
research has established that alzheimer's disease (ad)-associated proteins, such as amyloid precursor protein (app) and phosphorylated tau, are involved in brain iron metabolism. |
2024-05-02 |
2024-05-05 |
Not clear |