| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre Poirier, Cynthia Picard, Anne Labonté, Isabelle Aubry, Daniel Auld, Henrik Zetterberg, Kaj Blennow, Michel L Tremblay, Judes Poirie. PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766183. |
we identified that ptprs rs10415488 variant c shows features of neuroprotection against early tau pathology and synaptic degeneration in alzheimer's disease. |
2024-05-20 |
2024-05-27 |
Not clear |
| Zhi Tang, Yaqian Peng, Yi Jiang, Li Wang, Min Guo, Zhuyi Chen, Chao Luo, Ting Zhang, Yan Xiao, Ruiqing Ni, Xiaolan Q. Gastrodin ameliorates synaptic impairment, mitochondrial dysfunction and oxidative stress in N2a/APP cells. Biochemical and biophysical research communications. vol 719. 2024-05-18. PMID:38761634. |
alzheimer's disease is characterized by abnormal β-amyloid and tau accumulation, mitochondrial dysfunction, oxidative stress, and synaptic dysfunction. |
2024-05-18 |
2024-05-27 |
human |
| Afrooz Anbaraki, Zahra Dindar, Zahra Mousavi-Jarrahi, Atiyeh Ghasemi, Zahra Moeini, Mina Evini, Ali Akbar Saboury, Arefeh Seyedarab. The novel anti-fibrillary effects of volatile compounds α-asarone and β-caryophyllene on tau protein: Towards promising therapeutic agents for Alzheimer's disease. International journal of biological macromolecules. 2024-05-18. PMID:38761902. |
the novel anti-fibrillary effects of volatile compounds α-asarone and β-caryophyllene on tau protein: towards promising therapeutic agents for alzheimer's disease. |
2024-05-18 |
2024-05-27 |
Not clear |
| Afrooz Anbaraki, Zahra Dindar, Zahra Mousavi-Jarrahi, Atiyeh Ghasemi, Zahra Moeini, Mina Evini, Ali Akbar Saboury, Arefeh Seyedarab. The novel anti-fibrillary effects of volatile compounds α-asarone and β-caryophyllene on tau protein: Towards promising therapeutic agents for Alzheimer's disease. International journal of biological macromolecules. 2024-05-18. PMID:38761902. |
the abnormal deposition of tau protein is one of the critical causes of tauopathies including alzheimer's disease (ad). |
2024-05-18 |
2024-05-27 |
Not clear |
| Michael J Ellis, Christiana Lekka, Katie L Holden, Hanna Tulmin, Faheem Seedat, Darragh P O'Brien, Shalinee Dhayal, Marie-Louise Zeissler, Jakob G Knudsen, Benedikt M Kessler, Noel G Morgan, John A Todd, Sarah J Richardson, M Irina Stefan. Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry. Acta neuropathologica. vol 147. issue 1. 2024-05-18. PMID:38761203. |
owing to its central role in alzheimer's disease and other dementias, hundreds of distinct antibody clones have been developed against the microtubule-associated protein tau and its multiple proteoforms. |
2024-05-18 |
2024-05-27 |
human |
| Mikko Koivumäki, Laura Ekblad, Juan Lantero-Rodriguez, Nicholas J Ashton, Thomas K Karikari, Semi Helin, Riitta Parkkola, Jyrki Lötjönen, Henrik Zetterberg, Kaj Blennow, Juha O Rinne, Anniina Snellma. Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly. Alzheimer's research & therapy. vol 16. issue 1. 2024-05-18. PMID:38762725. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β (aβ) plaques, neurofibrillary tau tangles, and neurodegeneration in the brain parenchyma. |
2024-05-18 |
2024-05-27 |
Not clear |
| Daniela Giraldo-Berrio, Marlene Jimenez-Del-Rio, Carlos Velez-Pard. Sildenafil Reverses the Neuropathological Alzheimer's Disease Phenotype in Cholinergic-Like Neurons Carrying the Presenilin 1 E280A Mutation. Journal of Alzheimer's disease : JAD. vol 99. issue 2. 2024-05-17. PMID:38728184. |
familial alzheimer's disease (fad) presenilin 1 e280a (psen 1 e280a) is characterized by functional impairment and the death of cholinergic neurons as a consequence of amyloid-β (aβ) accumulation and abnormal phosphorylation of the tau protein. |
2024-05-17 |
2024-05-27 |
Not clear |
| Linhui Xie, Yash Raj, Pradeep Varathan, Bing He, Meichen Yu, Kwangsik Nho, Paul Salama, Andrew J Saykin, Jingwen Ya. Deep Trans-Omic Network Fusion for Molecular Mechanism of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 99. issue 2. 2024-05-17. PMID:38728189. |
there are various molecular hypotheses regarding alzheimer's disease (ad) like amyloid deposition, tau propagation, neuroinflammation, and synaptic dysfunction. |
2024-05-17 |
2024-05-27 |
Not clear |
| Duy L B Nguyen, Rachel K Okolicsanyi, Larisa M Haup. Heparan sulfate proteoglycans: Mediators of cellular and molecular Alzheimer's disease pathogenic factors via tunnelling nanotubes? Molecular and cellular neurosciences. vol 129. 2024-05-17. PMID:38750678. |
heparan sulfate proteoglycans (hspgs) are complex extracellular molecules implicated in promoting tau fibril formation resulting in tau tangles, a hallmark of alzheimer's disease (ad). |
2024-05-17 |
2024-05-27 |
Not clear |
| Ling Xiao Yi, Li Zeng, Qing Wang, Eng King Tan, Zhi Dong Zho. Reelin links Apolipoprotein E4, Tau, and Amyloid-β in Alzheimer's disease. Ageing research reviews. vol 98. 2024-05-17. PMID:38754634. |
reelin links apolipoprotein e4, tau, and amyloid-β in alzheimer's disease. |
2024-05-17 |
2024-05-27 |
mouse |
| Nargis Ahmadi, Melanie A Dratva, Nadine Heyworth, Xin Wang, Kaj Blennow, Sarah J Banks, Erin E Suderman. Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease. International journal of aging & human development. 2024-05-16. PMID:38751054. |
moving beyond depression: mood symptoms across the spectrum relate to tau pathology in older women at risk for alzheimer's disease. |
2024-05-16 |
2024-05-27 |
human |
| C Y Chen, Y H Tseng, J P War. A mathematical model on the propagation of tau pathology in neurodegenerative diseases. Journal of mathematical biology. vol 89. issue 1. 2024-05-15. PMID:38750128. |
a system of partial differential equations is developed to study the spreading of tau pathology in the brain for alzheimer's and other neurodegenerative diseases. |
2024-05-15 |
2024-05-27 |
Not clear |
| Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L De Jager, Julie A Schneider, David A Bennet. G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults. Communications biology. vol 7. issue 1. 2024-05-15. PMID:38750228. |
accumulation of amyloid-β (aβ) and tau tangles are hallmarks of alzheimer's disease. |
2024-05-15 |
2024-05-27 |
Not clear |
| Kyan Younes, Viktorija Smith, Emily Johns, Mackenzie L Carlson, Joseph Winer, Zihuai He, Victor W Henderson, Michael D Greicius, Christina B Young, Elizabeth C Mormin. Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease. Brain, behavior, and immunity. vol 119. 2024-05-15. PMID:38710339. |
temporal tau asymmetry spectrum influences divergent behavior and language patterns in alzheimer's disease. |
2024-05-15 |
2024-05-27 |
human |
| Kyan Younes, Viktorija Smith, Emily Johns, Mackenzie L Carlson, Joseph Winer, Zihuai He, Victor W Henderson, Michael D Greicius, Christina B Young, Elizabeth C Mormin. Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease. Brain, behavior, and immunity. vol 119. 2024-05-15. PMID:38710339. |
this cross-sectional study investigated the correlation between temporal tau pet asymmetry and behavior assessed using the neuropsychiatric inventory and composite scores for memory, executive function, and language, using data from the alzheimer's disease neuroimaging initiative (adni) dataset. |
2024-05-15 |
2024-05-27 |
human |
| Hasi Huhe, Sarah M Shapley, Duc Duong, Fang Wu, Seung-Kwon Ha, Sang-Ho Choi, Julia Kofler, Yongshan Mou, Thais Rafael Guimaraes, Amantha Thathiah, Lauren K H Schaeffer, Gregory W Carter, Nicholas T Seyfried, Afonso C Silva, Stacey J Sukoff Rizz. Marmosets as model systems for the study of Alzheimer's disease and related dementias: substantiation of physiological Tau 3R and 4R isoform expression and phosphorylation. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746277. |
marmosets as model systems for the study of alzheimer's disease and related dementias: substantiation of physiological tau 3r and 4r isoform expression and phosphorylation. |
2024-05-15 |
2024-05-27 |
marmoset |
| Andreas Tapia-Arellano, Pablo Cabrera, Elizabeth Cortés-Adasme, Ana Riveros, Natalia Hassan, Marcelo J Koga. Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases. Journal of nanobiotechnology. vol 22. issue 1. 2024-05-14. PMID:38741193. |
they can be functionalized with specific molecules to selectively target pathological proteins such as tau and α-synuclein for alzheimer's and parkinson's disease, respectively. |
2024-05-14 |
2024-05-27 |
Not clear |
| Tomasz Mazur, Magdalena Malik, Dariusz C Bieńk. The impact of chelating compounds on Cu Journal of inorganic biochemistry. vol 257. 2024-05-14. PMID:38744143. |
the impact of chelating compounds on cu alzheimer's disease (ad) is a neurodegenerative disorder characterized by the accumulation of amyloid - β extracellular plaques and tau interfibrillar tangles, leading to memory loss, cognitive decline, and behavioral changes. |
2024-05-14 |
2024-05-27 |
Not clear |
| Yasmina S M Elmahboub, Amal A Elkord. Polymeric nanoparticles: A promising strategy for treatment of Alzheimer's disease. Journal of Taibah University Medical Sciences. vol 19. issue 3. 2024-05-13. PMID:38736898. |
alzheimer's disease (ad), is characterised by two major hallmarks: the formation of extracellular β-amyloid (aβ) plaques and the hyperphosphorylation of tau protein, thus leading to the formation of neurofibrillary tangles. |
2024-05-13 |
2024-05-27 |
Not clear |
| Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P Hemachandra Redd. Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer's Disease. Aging and disease. 2024-05-13. PMID:38739937. |
amyloid-β and phosphorylated tau are the key biomarkers and predictors of alzheimer's disease. |
2024-05-13 |
2024-05-27 |
Not clear |