| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Giraldo-Berrio, Marlene Jimenez-Del-Rio, Carlos Velez-Pard. Sildenafil Reverses the Neuropathological Alzheimer's Disease Phenotype in Cholinergic-Like Neurons Carrying the Presenilin 1 E280A Mutation. Journal of Alzheimer's disease : JAD. vol 99. issue 2. 2024-05-17. PMID:38728184. |
familial alzheimer's disease (fad) presenilin 1 e280a (psen 1 e280a) is characterized by functional impairment and the death of cholinergic neurons as a consequence of amyloid-β (aβ) accumulation and abnormal phosphorylation of the tau protein. |
2024-05-17 |
2024-05-27 |
Not clear |
| Linhui Xie, Yash Raj, Pradeep Varathan, Bing He, Meichen Yu, Kwangsik Nho, Paul Salama, Andrew J Saykin, Jingwen Ya. Deep Trans-Omic Network Fusion for Molecular Mechanism of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 99. issue 2. 2024-05-17. PMID:38728189. |
there are various molecular hypotheses regarding alzheimer's disease (ad) like amyloid deposition, tau propagation, neuroinflammation, and synaptic dysfunction. |
2024-05-17 |
2024-05-27 |
Not clear |
| Duy L B Nguyen, Rachel K Okolicsanyi, Larisa M Haup. Heparan sulfate proteoglycans: Mediators of cellular and molecular Alzheimer's disease pathogenic factors via tunnelling nanotubes? Molecular and cellular neurosciences. vol 129. 2024-05-17. PMID:38750678. |
heparan sulfate proteoglycans (hspgs) are complex extracellular molecules implicated in promoting tau fibril formation resulting in tau tangles, a hallmark of alzheimer's disease (ad). |
2024-05-17 |
2024-05-27 |
Not clear |
| Ling Xiao Yi, Li Zeng, Qing Wang, Eng King Tan, Zhi Dong Zho. Reelin links Apolipoprotein E4, Tau, and Amyloid-β in Alzheimer's disease. Ageing research reviews. vol 98. 2024-05-17. PMID:38754634. |
reelin links apolipoprotein e4, tau, and amyloid-β in alzheimer's disease. |
2024-05-17 |
2024-05-27 |
mouse |
| Nargis Ahmadi, Melanie A Dratva, Nadine Heyworth, Xin Wang, Kaj Blennow, Sarah J Banks, Erin E Suderman. Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease. International journal of aging & human development. 2024-05-16. PMID:38751054. |
moving beyond depression: mood symptoms across the spectrum relate to tau pathology in older women at risk for alzheimer's disease. |
2024-05-16 |
2024-05-27 |
human |
| C Y Chen, Y H Tseng, J P War. A mathematical model on the propagation of tau pathology in neurodegenerative diseases. Journal of mathematical biology. vol 89. issue 1. 2024-05-15. PMID:38750128. |
a system of partial differential equations is developed to study the spreading of tau pathology in the brain for alzheimer's and other neurodegenerative diseases. |
2024-05-15 |
2024-05-27 |
Not clear |
| Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L De Jager, Julie A Schneider, David A Bennet. G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults. Communications biology. vol 7. issue 1. 2024-05-15. PMID:38750228. |
accumulation of amyloid-β (aβ) and tau tangles are hallmarks of alzheimer's disease. |
2024-05-15 |
2024-05-27 |
Not clear |
| Kyan Younes, Viktorija Smith, Emily Johns, Mackenzie L Carlson, Joseph Winer, Zihuai He, Victor W Henderson, Michael D Greicius, Christina B Young, Elizabeth C Mormin. Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease. Brain, behavior, and immunity. vol 119. 2024-05-15. PMID:38710339. |
temporal tau asymmetry spectrum influences divergent behavior and language patterns in alzheimer's disease. |
2024-05-15 |
2024-05-27 |
human |
| Kyan Younes, Viktorija Smith, Emily Johns, Mackenzie L Carlson, Joseph Winer, Zihuai He, Victor W Henderson, Michael D Greicius, Christina B Young, Elizabeth C Mormin. Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease. Brain, behavior, and immunity. vol 119. 2024-05-15. PMID:38710339. |
this cross-sectional study investigated the correlation between temporal tau pet asymmetry and behavior assessed using the neuropsychiatric inventory and composite scores for memory, executive function, and language, using data from the alzheimer's disease neuroimaging initiative (adni) dataset. |
2024-05-15 |
2024-05-27 |
human |
| Hasi Huhe, Sarah M Shapley, Duc Duong, Fang Wu, Seung-Kwon Ha, Sang-Ho Choi, Julia Kofler, Yongshan Mou, Thais Rafael Guimaraes, Amantha Thathiah, Lauren K H Schaeffer, Gregory W Carter, Nicholas T Seyfried, Afonso C Silva, Stacey J Sukoff Rizz. Marmosets as model systems for the study of Alzheimer's disease and related dementias: substantiation of physiological Tau 3R and 4R isoform expression and phosphorylation. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746277. |
marmosets as model systems for the study of alzheimer's disease and related dementias: substantiation of physiological tau 3r and 4r isoform expression and phosphorylation. |
2024-05-15 |
2024-05-27 |
marmoset |
| Andreas Tapia-Arellano, Pablo Cabrera, Elizabeth Cortés-Adasme, Ana Riveros, Natalia Hassan, Marcelo J Koga. Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases. Journal of nanobiotechnology. vol 22. issue 1. 2024-05-14. PMID:38741193. |
they can be functionalized with specific molecules to selectively target pathological proteins such as tau and α-synuclein for alzheimer's and parkinson's disease, respectively. |
2024-05-14 |
2024-05-27 |
Not clear |
| Tomasz Mazur, Magdalena Malik, Dariusz C Bieńk. The impact of chelating compounds on Cu Journal of inorganic biochemistry. vol 257. 2024-05-14. PMID:38744143. |
the impact of chelating compounds on cu alzheimer's disease (ad) is a neurodegenerative disorder characterized by the accumulation of amyloid - β extracellular plaques and tau interfibrillar tangles, leading to memory loss, cognitive decline, and behavioral changes. |
2024-05-14 |
2024-05-27 |
Not clear |
| Yasmina S M Elmahboub, Amal A Elkord. Polymeric nanoparticles: A promising strategy for treatment of Alzheimer's disease. Journal of Taibah University Medical Sciences. vol 19. issue 3. 2024-05-13. PMID:38736898. |
alzheimer's disease (ad), is characterised by two major hallmarks: the formation of extracellular β-amyloid (aβ) plaques and the hyperphosphorylation of tau protein, thus leading to the formation of neurofibrillary tangles. |
2024-05-13 |
2024-05-27 |
Not clear |
| Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P Hemachandra Redd. Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer's Disease. Aging and disease. 2024-05-13. PMID:38739937. |
amyloid-β and phosphorylated tau are the key biomarkers and predictors of alzheimer's disease. |
2024-05-13 |
2024-05-27 |
Not clear |
| Kevin P Kotredes, Ravi S Pandey, Scott Persohn, Kierra Elderidge, Charles P Burton, Ethan W Miner, Kathryn A Haynes, Diogo Francisco S Santos, Sean-Paul Williams, Nicholas Heaton, Cynthia M Ingraham, Christopher Lloyd, Dylan Garceau, Rita O'Rourke, Sarah Herrick, Claudia Rangel-Barajas, Surendra Maharjan, Nian Wang, Michael Sasner, Bruce T Lamb, Paul R Territo, Stacey J Sukoff Rizzo, Gregory W Carter, Gareth R Howell, Adrian L Obla. Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-05-12. PMID:38735056. |
characterizing molecular and synaptic signatures in mouse models of late-onset alzheimer's disease independent of amyloid and tau pathology. |
2024-05-12 |
2024-05-27 |
mouse |
| Magdalena Pszczołowska, Kamil Walczak, Weronika Miśków, Katarzyna Antosz, Joanna Batko, Donata Kurpas, Jerzy Lesze. Chronic Traumatic Encephalopathy as the Course of Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38731858. |
chronic traumatic encephalopathy (cte) and alzheimer's disease (ad) present a series of similar neuropathological features that were investigated in this work like recombinant tau into filaments or the accumulation and aggregation of aβ protein. |
2024-05-11 |
2024-05-27 |
Not clear |
| Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. |
brain-targeted tet-1 peptide-plga nanoparticles for berberine delivery against stz-induced alzheimer's disease in a rat model: alleviation of hippocampal synaptic dysfunction, tau pathology and amyloidogenesis. |
2024-05-11 |
2024-05-27 |
rat |
| Huiting Zheng, Huimin Sun, Qixu Cai, Hwan-Ching Ta. The Enigma of Tau Protein Aggregation: Mechanistic Insights and Future Challenges. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732197. |
tau protein misfolding and aggregation are pathological hallmarks of alzheimer's disease and over twenty neurodegenerative disorders. |
2024-05-11 |
2024-05-27 |
Not clear |
| Lei Yu, Tianhao Wang, Oskar Hansson, Shorena Janelidze, Melissa Lamar, Konstantinos Arfanakis, David A Bennett, Julie A Schneider, Patricia A Boyl. MRI-Derived AD Signature of Cortical Thinning and Plasma P-Tau217 for Predicting Alzheimer Dementia Among Community-Dwelling Older Adults. Neurology. Clinical practice. vol 14. issue 3. 2024-05-10. PMID:38720951. |
structural brain mri and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive alzheimer's disease (ad) biomarkers to date. |
2024-05-10 |
2024-05-27 |
Not clear |
| Sophia Nazi. Salivary biomarkers: The early diagnosis of Alzheimer's disease. Aging medicine (Milton (N.S.W)). vol 7. issue 2. 2024-05-10. PMID:38725701. |
the findings support the use of salivary amyloid protein, tau species, and novel biomarkers in the diagnosis of alzheimer's disease. |
2024-05-10 |
2024-05-27 |
Not clear |