All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Gerard J Nuovo, Madison Rice, Nicola Zanesi, Dwitiya Sawant, Candice Crilly, Esmerina Til. The Prevention of Fatal Tauopathy in a Mouse Model of Alzheimer Disease by Blocking BCL2. Applied immunohistochemistry & molecular morphology : AIMM. 2025-02-11. PMID:39931956. a major goal in alzheimer disease (ad) research is the reduction of the abnormal tau burden. 2025-02-11 2025-02-13 mouse
Nicholas Karagas, Jessica E Young, Elizabeth E Blue, Suman Jayade. The Spectrum of Genetic Risk in Alzheimer Disease. Neurology. Genetics. vol 11. issue 1. 2025-01-31. PMID:39885961. alzheimer disease (ad), the most common dementing syndrome in the united states, is currently established by the presence of amyloid-β and tau protein biomarkers in the setting of clinical cognitive impairment. 2025-01-31 2025-02-02 Not clear
Heather E Dark, Andrea T Shafer, Jenifer Cordon, Yang An, Alexandria Lewis, Abhay Moghekar, Bennett Landman, Susan M Resnick, Keenan A Walke. Association of Plasma Biomarkers of Alzheimer Disease and Neurodegeneration With Longitudinal Intra-Network Functional Brain Connectivity. Neurology. vol 104. issue 4. 2025-01-31. PMID:39889254. alzheimer disease (ad) is defined by cortical β-amyloid (aβ), tau, and neurodegeneration, which contribute to cognitive decline, in part, by altering large-scale functional brain networks. 2025-01-31 2025-02-03 Not clear
Ping Wang, Yeunjoo E Song, Audrey Lynn, Kristy Miskimen, Alex Gulyayev, Michael B Prough, Daniel A Dorfsman, Renee A Laux, Sarada L Fuzzell, Sherri D Hochstetler, Andrew F Zaman, Larry D Adams, Laura J Caywood, Jason E Clouse, Sharlene D Herington, Patrice Whitehead, Yining Liu, Noel Moore, Paula Ogrocki, Alan J Lerner, Anthony J Griswold, Jeffery M Vance, Michael L Cuccaro, William K Scott, Margaret A Pericak-Vance, Jonathan L Haine. Alzheimer Disease Plasma Biomarkers in the Mid-Western Amish. medRxiv : the preprint server for health sciences. 2025-01-13. PMID:39802805. alzheimer disease (ad) plasma biomarkers are noninvasive measures of the key amyloid beta (aβ) and tau pathologies. 2025-01-13 2025-01-16 Not clear
Abid Ali, Mikhail Matveyenka, Davis N Pickett, Axell Rodriguez, Dmitry Kurousk. Tubulin-Binding Region Modulates Cholesterol-Triggered Aggregation of Tau Proteins. Journal of neurochemistry. vol 169. issue 1. 2025-01-08. PMID:39777699. a hallmark of alzheimer disease (ad) and tauopathies, severe neurodegenerative diseases, is the progressive aggregation of tau, also known as microtubule-associated tau protein. 2025-01-08 2025-01-13 Not clear
Isabel MacKenzie Sarty, Cynthia Picard, Anne Labonte, John C S Breitner, Judes Poirie. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751422. inflammation is central to alzheimer disease (ad), as astrocyte reactivity accompanies the appearance of aβ and phosphorylated tau (bellaver et al., 2023). 2025-01-03 2025-01-05 Not clear
Emily Olafson, Matteo Tonietto, Gregory Klein, Edmond Teng, Andrew W Stephens, David S Russell, Karen Pickthorn, Sandra Sanabria Bohorque. In Vivo Head-to-Head Comparison of [ Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2025-01-02. PMID:39746756. in vivo head-to-head comparison of [ alzheimer disease (ad) is characterized by the accumulation of tau neurofibrillary tangles that can be labeled with pet tracers. 2025-01-02 2025-01-05 Not clear
Anja Soldan, Corinne Pettigrew, Jiangxia Wang, Marilyn S Albert, Kaj Blennow, Tobias Bittner, Abhay Mogheka. Blood-Based Biomarkers and Risk of Onset of Mild Cognitive Impairment Over the Short and Long Term. Neurology. vol 104. issue 2. 2024-12-26. PMID:39724536. blood-based biomarkers of amyloid and tau have been shown to predict alzheimer disease (ad) dementia. 2024-12-26 2024-12-29 Not clear
Joshua D Grill, Steven Tam, Gaby Thai, Beatriz Vides, Aimee L Pierce, Kim Green, Daniel L Gillen, Edmond Teng, Sarah Kremen, Maryam Beigi, Robert A Rissman, Gabriel C Léger, Archana Balasubramanian, Carolyn Revta, Rosemary Morrison, Robin Jennings, Judy Pa, Jing Zhang, Shelia Jin, Karen Messer, Howard H Feldma. Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease. Neurology. vol 104. issue 1. 2024-12-13. PMID:39671543. we tested the hypothesis that nicotinamide treatment could reduce tau phosphorylation in early alzheimer disease (ad). 2024-12-13 2024-12-21 Not clear
Dhamidhu Eratne, Qiao-Xin Li, Courtney Lewis, Christa Dang, Matthew J Y Kang, Jasleen Grewal, Samantha Loi, Mark Walterfang, Andrew H Evans, Charles B Malpas, Steve Pedrini, Ralph Martins, Pratishtha Chatterjee, Henrik Zetterberg, Kaj Blennow, Samuel F Berkovic, Alexander F Santillo, Steven Collins, Colin L Masters, Dennis Velakouli. Strong diagnostic performance of plasma ptau217 for CSF biomarker-defined young-onset Alzheimer disease in a diagnostically heterogeneous clinical cohort. Journal of neurology. vol 272. issue 1. 2024-12-12. PMID:39666133. we investigated diagnostic utility of phosphorylated tau 217 and 181 (ptau217, ptau181), glial fibrillary acidic protein (gfap), amyloid beta 42 and 40 (aβ42, aβ40), and neurofilament light (nfl) to distinguish biomarker-defined alzheimer disease (ad) from non-ad conditions, in a heterogenous clinical cohort of younger people. 2024-12-12 2024-12-14 Not clear
Association of Seizure Foci and Location of Tau and Amyloid Deposition and Brain Atrophy in Patients With Alzheimer Disease and Seizures. Neurology. vol 104. issue 1. 2024-12-06. PMID:39642343. association of seizure foci and location of tau and amyloid deposition and brain atrophy in patients with alzheimer disease and seizures. 2024-12-06 2024-12-09 Not clear
Bergþóra Þorgeirsdóttir, Theodor Sievert, Anna Lybeck, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Hans Friberg, Attila Frigyes. Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest - a multicentre study. Resuscitation. 2024-12-05. PMID:39637966. we studied the promising alzheimer biomarker plasma tau phosphorylated at threonine 231 (p-tau231) in a cohort of cardiac arrest patients who survived to intensive care to predict long-term neurological outcomes. 2024-12-05 2024-12-08 Not clear
Gérard N Bischof, Elena Jaeger, Kathrin Giehl, Frank Jessen, Oezguer A Onur, Sid O'Bryant, Esra Kara, Peter H Weiss, Alexander Drzezg. Cortical Tau Aggregation Patterns Associated With Apraxia in Patients With Alzheimer Disease. Neurology. vol 103. issue 12. 2024-12-03. PMID:39626130. cortical tau aggregation patterns associated with apraxia in patients with alzheimer disease. 2024-12-03 2024-12-06 Not clear
Ruth Fabian-Fine, Adam L Weaver, Abigail G Roman, Melanie J Winters, John C DeWit. Myelinated Glial Cells: Their Proposed Role in Waste Clearance and Neurodegeneration in Arachnid and Human Brain. The Journal of comparative neurology. vol 532. issue 11. 2024-11-29. PMID:39610046. a prevalent hypothesis relates to impaired waste clearance mechanisms from the brain due to reported waste aggregation in the brains of alzheimer patients, including amyloid-β plaques and neurofibrillary tau tangles. 2024-11-29 2024-12-01 human
Michael Tran Duong, Sandhitsu R Das, Pulkit Khandelwal, Xueying Lyu, Long Xie, Emily McGrew, Nadia Dehghani, Corey T McMillan, Edward B Lee, Leslie M Shaw, Paul A Yushkevich, David A Wolk, Ilya M Nasralla. Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer and Lewy body disease. Brain : a journal of neurology. 2024-11-22. PMID:39573823. hypometabolic mismatch with atrophy and tau pathology in mixed alzheimer and lewy body disease. 2024-11-22 2024-11-24 Not clear
Hiroaki Fukumoto, Tzu-Huei Kao, Chin-Yin Tai, Ming-Kuei Jang, Masaomi Miyamot. High-molecular-weight oligomer tau (HMWoTau) species are dramatically increased in Braak-stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 22. 2024-11-20. PMID:39565643. disease-specific oligomers tau assay system is anticipated in alzheimer disease (ad) to elucidate their etiological roles. 2024-11-20 2024-11-23 mouse
Junhao Wu, Binyin Li, Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Songye Li, Yiyun Henry Huang, Tengfei Guo, Wenlin Dai, Weiwei Xiang, Weihuang Chen, Dake Yang, Jun Zhao, Yihui Guan, Fang Xi. Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at Radiology. vol 313. issue 2. 2024-11-19. PMID:39560478. plasma glial fibrillary acid protein and phosphorated tau 181 association with presynaptic density-dependent tau pathology at background synaptic loss is an important factor in alzheimer disease (ad); however, blood assays that conveniently and rapidly reflect changes in synaptic density are lacking. 2024-11-19 2024-11-22 Not clear
Michelle Safransky, Jenna R Groh, Kaj Blennow, Henrik Zetterberg, Yorghos Tripodis, Brett Martin, Jason Weller, Breton M Asken, Gil D Rabinovici, Wendy Wei Qiao Qiu, Ann C McKee, Thor D Stein, Jesse Mez, Rachel L Henson, Justin Long, John C Morris, Richard J Perrin, Suzanne E Schindler, Michael L Alosc. Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease. Neurology. vol 103. issue 11. 2024-11-04. PMID:39496102. csf biomarkers of aβ42 and phosphorylated tau (p-tau181) are used clinically for the detection of alzheimer disease (ad) pathology during life. 2024-11-04 2024-11-07 Not clear
Hye Yun Kim, YoungSoo Ki. Chemical-Driven Amyloid Clearance for Therapeutics and Diagnostics of Alzheimer's Disease. Accounts of chemical research. 2024-11-04. PMID:39496112. conspectusa century ago, german neurologist alois alzheimer documented the first case of alzheimer's disease (ad), illuminating cognitive impairments associated with the presence of abnormal protein clusters, including amyloid plaques and tau tangles, within the brain. 2024-11-04 2024-11-07 Not clear
Sina Ghandian, Liane Albarghouthi, Kiana Nava, Shivam R Rai Sharma, Lise Minaud, Laurel Beckett, Naomi Saito, Charles DeCarli, Robert A Rissman, Andrew F Teich, Lee-Way Jin, Brittany N Dugger, Michael J Keise. Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386601. accumulation of abnormal tau protein into neurofibrillary tangles (nfts) is a pathologic hallmark of alzheimer disease (ad). 2024-10-10 2024-10-12 human