| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexa Pichet Binette, Chris Gaiteri, Malin Wennström, Atul Kumar, Ines Hristovska, Nicola Spotorno, Gemma Salvadó, Olof Strandberg, Hansruedi Mathys, Li-Huei Tsai, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Shorena Janelidze, Erik Stomrud, Jacob W Vogel, Oskar Hansso. Proteomic changes in Alzheimer disease associated with progressive Aβ plaque and tau tangle pathologies. Nature neuroscience. 2024-08-26. PMID:39187705. |
proteomic changes in alzheimer disease associated with progressive aβ plaque and tau tangle pathologies. |
2024-08-26 |
2024-08-30 |
Not clear |
| Nuo Jia, Dhasarathan Ganesan, Hongyuan Guan, Yu Young Jeong, Sinsuk Han, Gavesh Rajapaksha, Marialaina Nissenbaum, Alexander W Kusnecov, Qian Ca. Mitochondrial bioenergetics stimulates autophagy for pathological MAPT/Tau clearance in tauopathy neurons. Autophagy. 2024-08-22. PMID:39171695. |
hyperphosphorylation and aggregation of mapt (microtubule-associated protein tau) is a pathogenic hallmark of tauopathies and a defining feature of alzheimer disease (ad). |
2024-08-22 |
2024-08-24 |
mouse |
| Md Rejaul Hoq, Anllely Fernandez, Frank S Vago, Grace I Hallinan, Sakshibeedu R Bharath, Daoyi Li, Kadir A Ozcan, Holly J Garringer, Wen Jiang, Ruben Vidal, Bernardino Ghett. Cryo-EM structures of cotton wool plaques' amyloid β and of tau filaments in dominantly inherited Alzheimer disease. Acta neuropathologica. vol 148. issue 1. 2024-08-15. PMID:39147931. |
cryo-em structures of cotton wool plaques' amyloid β and of tau filaments in dominantly inherited alzheimer disease. |
2024-08-15 |
2024-08-18 |
Not clear |
| Audrey A Keleman, Rebecca M Bollinger, Julie K Wisch, Suzanne E Schindler, John C Morris, Beau Ances, Susan L Star. Clinical Manifestations. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 19 Suppl 18. 2024-08-07. PMID:39112074. |
the preclinical stage of alzheimer disease (ad) is a clinically silent period that is detectable through neuroimaging and biofluid biomarkers of amyloid, tau, and neurodegeneration. |
2024-08-07 |
2024-08-10 |
Not clear |
| Robel K Gebre, Alexis Moscoso Rial, Sheelakumari Raghavan, Heather J Wiste, Fiona Heeman, Alejandro Costoya-Sánchez, Christopher G Schwarz, Anthony J Spychalla, Val J Lowe, Jonathan Graff-Radford, David S Knopman, Ronald C Petersen, Michael Schöll, Melissa E Murray, Clifford R Jack, Prashanthi Vemur. Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024-07-25. PMID:39054278. |
advancing tau pet quantification in alzheimer disease with machine learning: introducing theta, a novel tau summary measure. |
2024-07-25 |
2024-07-28 |
human |
| Robel K Gebre, Alexis Moscoso Rial, Sheelakumari Raghavan, Heather J Wiste, Fiona Heeman, Alejandro Costoya-Sánchez, Christopher G Schwarz, Anthony J Spychalla, Val J Lowe, Jonathan Graff-Radford, David S Knopman, Ronald C Petersen, Michael Schöll, Melissa E Murray, Clifford R Jack, Prashanthi Vemur. Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024-07-25. PMID:39054278. |
alzheimer disease (ad) exhibits spatially heterogeneous 3- or 4-repeat tau deposition across participants. |
2024-07-25 |
2024-07-28 |
human |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as seen, for example, in conditions such as frontotemporal dementia and alzheimer disease. |
2024-07-16 |
2024-07-19 |
human |
| Jiechao Zhou, Yang 'an Chuang, Javier Redding-Ochoa, Rongzhen Zhang, Alexander J Platero, Alexander H Barrett, Juan C Troncoso, Paul F Worley, Wenchi Zhan. The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation. Nature cell biology. 2024-07-15. PMID:39009640. |
in human alzheimer disease brain, triad3a co-localizes with tau amyloid in multiple histological forms, suggesting a role in tau proteostasis. |
2024-07-15 |
2024-07-18 |
mouse |
| Louise M Wait. New and emerging drug therapies for Alzheimer disease. Australian prescriber. vol 47. issue 3. 2024-07-04. PMID:38962384. |
biomarker measures of amyloid, tau and neurodegeneration have been integral to alzheimer disease clinical trials for biologic drugs, for patient selection and efficacy monitoring. |
2024-07-04 |
2024-07-10 |
Not clear |
| Romain Perbet, Anastasie Mate de Gerando, Calina Glynn, Cameron Donahue, Angelica Gaona, Raquel N Taddei, Teresa Gomez-Isla, Aurelien Lathuiliere, Bradley T Hyma. In situ seeding assay: A novel technique for direct tissue localization of bioactive tau. Journal of neuropathology and experimental neurology. 2024-06-25. PMID:38917443. |
the probe design aimed to replicate the recruitment process seen in prion-like mechanisms based on the cryo-em structure of tau aggregates in alzheimer disease (ad). |
2024-06-25 |
2024-06-29 |
human |
| Aikaterini Theodorou, Ioanna Tsantzali, Maria-Ioanna Stefanou, Simona Sacco, Aristeidis H Katsanos, Ashkan Shoamanesh, Theodoros Karapanayiotides, Ioanna Koutroulou, Polyxeni Stamati, David J Werring, Charlotte Cordonnier, Lina Palaiodimou, Christina Zompola, Efstathios Boviatsis, Lampis Stavrinou, Frantzeska Frantzeskaki, Thorsten Steiner, Andrei V Alexandrov, Georgios P Paraskevas, Georgios Tsivgouli. CSF and plasma biomarkers in cerebral amyloid angiopathy: A single-center study and a systematic review/meta-analysis. European stroke journal. 2024-06-13. PMID:38869035. |
we sought to investigate the levels of four biomarkers [β-amyloids (aβ42 and aβ40), total tau (tau) and phosphorylated tau (p-tau)] in caa patients compared to healthy controls (hc) and patients with alzheimer disease (ad). |
2024-06-13 |
2024-06-15 |
Not clear |
| Hsin-I Chang, Chi-Wei Huang, Shu-Hua Huang, Shih-Wei Hsu, Kun-Ju Lin, Tsung-Ying Ho, Hsiu-Chuan Wu, Chiung-Chih Chan. Distinct biological property of tau in tau-first cognitive proteinopathy: Evidence by longitudinal clinical neuroimaging profiles and compared with late-onset Alzheimer disease. Psychiatry and clinical neurosciences. 2024-06-12. PMID:38864501. |
distinct biological property of tau in tau-first cognitive proteinopathy: evidence by longitudinal clinical neuroimaging profiles and compared with late-onset alzheimer disease. |
2024-06-12 |
2024-06-14 |
Not clear |
| C F de Veij Mestdagh, M E Witte, W Scheper, A B Smit, R H Henning, R E van Kestere. Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau. Acta neuropathologica communications. vol 12. issue 1. 2024-06-05. PMID:38835043. |
whereas wildtype mice primarily showed increased levels of diffusely organized hyperphosphorylated tau during torpor, htau mice contained clear somato-dendritic accumulations of at8 reactivity resembling tau pre-tangles as observed in the alzheimer brain. |
2024-06-05 |
2024-06-07 |
mouse |
| Faruk Hossen, Grace Y Sun, James C Le. Oligomeric Tau-induced oxidative damage and functional alterations in cerebral endothelial cells: Role of RhoA/ROCK signaling pathway. Free radical biology & medicine. vol 221. 2024-05-31. PMID:38815773. |
despite of yet unknown mechanism, microvascular deposition of oligomeric tau (otau) has been implicated in alteration of the blood-brain barrier (bbb) function in alzheimer's disease (ad) brains. |
2024-05-31 |
2024-06-02 |
mouse |
| Amanda Zhao, Laura J Balcer, Jayandra J Himali, Adrienne O'Donnell, Yashar Rahimpour, Charles DeCarli, Mitzi M Gonzales, Hugo J Aparicio, Jaime Ramos-Cejudo, Rachel Kenney, Alexa Beiser, Sudha Seshadri, Joel Salina. Association of Loneliness with Functional Connectivity MRI, Amyloid-β PET, and Tau PET Neuroimaging Markers of Vulnerability for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-05-31. PMID:38820017. |
association of loneliness with functional connectivity mri, amyloid-β pet, and tau pet neuroimaging markers of vulnerability for alzheimer's disease. |
2024-05-31 |
2024-06-02 |
Not clear |
| Andre Altmann, Leon M Aksman, Neil P Oxtoby, Alexandra Young, Daniel C Alexander, Frederik Barkhof, Maryam Shoai, John Hardy, Jonathan M Schot. Towards cascading genetic risk in Alzheimer's disease. Brain : a journal of neurology. 2024-05-31. PMID:38820112. |
alzheimer's disease typically progresses in stages, which have been defined by the presence of disease-specific biomarkers: amyloid (a), tau (t) and neurodegeneration (n). |
2024-05-31 |
2024-06-02 |
human |
| Andre Altmann, Leon M Aksman, Neil P Oxtoby, Alexandra Young, Daniel C Alexander, Frederik Barkhof, Maryam Shoai, John Hardy, Jonathan M Schot. Towards cascading genetic risk in Alzheimer's disease. Brain : a journal of neurology. 2024-05-31. PMID:38820112. |
amyloid (a) and tau (t) status was defined using a combination of available pet and csf biomarkers in the alzheimer's disease neuroimaging initiative cohort. |
2024-05-31 |
2024-06-02 |
human |
| Rong Ye, Anna E Goodheart, Joseph J Locascio, Erin Peterec, Michael Properzi, Emma G Thibault, Erin Chuba, Keith A Johnson, Michael J Brickhouse, Alexandra Touroutoglou, John H Growdon, Bradford C Dickerson, Stephen N Gompert. Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases. Neurology. vol 102. issue 12. 2024-05-30. PMID:38815233. |
alzheimer disease (ad) copathologies of β-amyloid and tau are common in the lewy body diseases (lbd), dementia with lewy bodies (dlb) and parkinson disease (pd), and target distinct hippocampal subfields compared with lewy pathology, including subiculum and ca1. |
2024-05-30 |
2024-07-16 |
Not clear |
| Patrick Lao, Natalie Edwards, Lisi Flores-Aguilar, Mohamad Alshikho, Batool Rizvi, Dana Tudorascu, H Diana Rosas, Michael Yassa, Bradley T Christian, Mark Mapstone, Benjamin Handen, Molly E Zimmerman, Jose Gutierrez, Donna Wilcock, Elizabeth Head, Adam M Brickma. Cerebrovascular disease emerges with age and Alzheimer's disease in adults with Down syndrome. Scientific reports. vol 14. issue 1. 2024-05-29. PMID:38811657. |
in the alzheimer's biomarker consortium-down syndrome study (abc-ds; n = 242; age = 25-72), we estimated the age inflection point at which mri-based white matter hyperintensities (wmh), enlarged perivascular spaces (pvs), microbleeds, and infarcts emerge in relation to demographic data, risk factors, amyloid and tau, and ad diagnosis. |
2024-05-29 |
2024-06-02 |
human |
| Fahad M Alshabrmi, Faris F Aba Alkhayl, Abdur Rehma. Novel Drug Discovery: Advancing Alzheimer's Therapy through Machine Learning and Network Pharmacology. European journal of pharmacology. 2024-05-25. PMID:38795753. |
alzheimer's disease (ad), marked by tau tangles and amyloid-beta plaques, leads to cognitive decline. |
2024-05-28 |
2024-06-03 |
Not clear |