| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuliya Voskobiynyk, Zhiyong Li, J Nicholas Cochran, M Natalie Davis, Nancy V N Carullo, Rose B Creed, Susan C Buckingham, Alicia M Hall, Scott M Wilson, Erik D Roberso. Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthood. bioRxiv : the preprint server for biology. 2024-05-27. PMID:38798487. |
tau reduction is a promising therapeutic strategy for alzheimer's disease. |
2024-05-27 |
2024-05-31 |
Not clear |
| David Eisenberg, Ke Hou, Peng Ge, Michael Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigo. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. Research square. 2024-05-26. PMID:38766197. |
how short peptides can disassemble ultra-stable tau fibrils extracted from alzheimer's disease brain by a strain-relief mechanism. |
2024-05-26 |
2024-05-27 |
Not clear |
| David Eisenberg, Ke Hou, Peng Ge, Michael Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigo. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. Research square. 2024-05-26. PMID:38766197. |
reducing fibrous aggregates of protein tau is a possible strategy for halting progression of alzheimer's dis-ease (ad). |
2024-05-26 |
2024-05-27 |
Not clear |
| Reyhaneh Arfaei, Narges Mikaeili, Fatemeh Daj, Armin Boroumand, Abbas Kheyri, Pegah Yaraghi Zahra Shirzad, Mohammad Keshavarz, Gholamhossein Hassanshahi, Abdollah Jafarzadeh, Vahid Mohammadi Shahrokhi, Hossein Khorramdelaza. Decoding the role of the CCL2/CCR2 axis in Alzheimer's disease and innovating therapeutic approaches: Keeping All options open. International immunopharmacology. vol 135. 2024-05-26. PMID:38796962. |
alzheimer's disease (ad), as a neurodegenerative disorder, distresses the elderly in large numbers and is characterized by β-amyloid (aβ) accumulation, elevated tau protein levels, and chronic inflammation. |
2024-05-26 |
2024-05-31 |
Not clear |
| Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Sideromenos Spyridon, Stefanie Flunkert, Joerg Neddens, Ake Lignell, Manuela Prokesch, Ute Pazenboeck, Herbert Strobl, Jelena Tadic, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Gerald Hoefle. Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice. Molecular metabolism. vol 85. 2024-05-25. PMID:38763496. |
aggregation and misfolding of amyloid beta (aβ) and tau proteins, suggested to arise from post-translational modification processes, are thought to be the main cause of alzheimer's disease (ad). |
2024-05-25 |
2024-05-27 |
mouse |
| Fahad M Alshabrmi, Faris F Aba Alkhayl, Abdur Rehma. Novel Drug Discovery: Advancing Alzheimer's Therapy through Machine Learning and Network Pharmacology. European journal of pharmacology. 2024-05-25. PMID:38795753. |
alzheimer's disease (ad), marked by tau tangles and amyloid-beta plaques, leads to cognitive decline. |
2024-05-25 |
2024-06-03 |
Not clear |
| Chao Qi, Sofia Lövestam, Alexey G Murzin, Sew Peak-Chew, Catarina Franco, Marika Bogdani, Caitlin Latimer, Jill R Murrell, Patrick W Cullinane, Zane Jaunmuktane, Thomas D Bird, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments with the Alzheimer fold in cases with bioRxiv : the preprint server for biology. 2024-05-24. PMID:38746388. |
tau filaments with the alzheimer fold in cases with frontotemporal dementia (ftd) and alzheimer's disease are the most common forms of early-onset dementia. |
2024-05-24 |
2024-05-27 |
Not clear |
| Zidi Yan, Yiwen Zhang, Jialong Jiang, Zhenwu Liu, He Wang, Ying Zhang, Jinsheng He, Tao Hon. [Human tau N-terminal domain-specific monoclonal antibodies: screening and application in blood detection]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 40. issue 5. 2024-05-24. PMID:38783817. |
the antibodies to the microtubule-associated protein tau play a role in basic and clinical studies of alzheimer's disease (ad) and other tauopathies. |
2024-05-24 |
2024-05-27 |
mouse |
| Leonardo Iaccarino, Jorge J Llibre-Guerra, Eric McDade, Lauren Edwards, Brian Gordon, Tammie Benzinger, Jason Hassenstab, Joel H Kramer, Yan Li, Bruce L Miller, Zachary Miller, John C Morris, Nidhi Mundada, Richard J Perrin, Howard J Rosen, David Soleimani-Meigooni, Amelia Strom, Elena Tsoy, Guoqiao Wang, Chengjie Xiong, Ricardo Allegri, Patricio Chrem, Silvia Vazquez, Sarah B Berman, Jasmeer Chhatwal, Colin L Masters, Martin R Farlow, Mathias Jucker, Johannes Levin, Stephen Salloway, Nick C Fox, Gregory S Day, Maria Luisa Gorno-Tempini, Adam L Boxer, Renaud La Joie, Randall Bateman, Gil D Rabinovic. Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease. Brain communications. vol 6. issue 3. 2024-05-24. PMID:38784820. |
both sporadic early-onset alzheimer's disease and dominantly inherited alzheimer's disease are characterized by brain amyloid-β accumulation, tau tangles, hypometabolism and neurodegeneration, but differences in topography and magnitude of these pathological changes are not fully elucidated. |
2024-05-24 |
2024-05-27 |
Not clear |
| Léa El Hajjar, Adeline Page, Clarisse Bridot, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. Regulation of Glycogen Synthase Kinase-3β by Phosphorylation and O-β-Linked N-Acetylglucosaminylation: Implications on Tau Protein Phosphorylation. Biochemistry. 2024-05-24. PMID:38788673. |
in particular, the gsk3β isoform is implicated in alzheimer's disease (ad) as one of the key kinases involved in the hyperphosphorylation of tau protein, one of the neuropathological hallmarks of ad. |
2024-05-24 |
2024-05-27 |
Not clear |
| Graham Andrew Mackay, Claire Gall, Ravi Jampana, Carolyn Sleith, Gregory Li. Scottish Intercollegiate Guidelines Network (SIGN) Guidance on Dementia. The investigation of suspected dementia (SIGN 168) with focus on biomarkers. Thrombosis and haemostasis. 2024-05-24. PMID:38788775. |
the evidence review supports consideration of the use of structural imaging, nuclear medicine imaging and established alzheimer's cerebrospinal fluid (csf) biomarkers (amyloid and tau) in the diagnosis of dementia. |
2024-05-24 |
2024-05-27 |
Not clear |
| Khairun Nisa Binti Hashim, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Ikuo Tooyama, Takaomi C Saido, Shoko Hashimot. Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice. FEBS letters. 2024-05-24. PMID:38789405. |
neuronal glutathione depletion elevates the aβ42/aβ40 ratio and tau aggregation in alzheimer's disease mice. |
2024-05-24 |
2024-05-27 |
mouse |
| Kevin Rose, Tyler Jepson, Sankalp Shukla, Alex Maya-Romero, Martin Kampmann, Ke Xu, James H Hurle. Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 22. 2024-05-23. PMID:38781206. |
the prion-like spread of protein aggregates is a leading hypothesis for the propagation of neurofibrillary lesions in the brain, including the spread of tau inclusions associated with alzheimer's disease. |
2024-05-23 |
2024-05-27 |
Not clear |
| Correction to "Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology". Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 2. 2024-05-22. PMID:38774606. |
correction to "aβ oligomers peak in early stages of alzheimer's disease preceding tau pathology". |
2024-05-22 |
2024-05-27 |
Not clear |
| Tingting Dan, Mustafa Dere, Won Hwa Kim, Minjeong Kim, Guorong W. TauFlowNet: Revealing latent propagation mechanism of tau aggregates using deep neural transport equations. Medical image analysis. vol 95. 2024-05-22. PMID:38776842. |
mounting evidence shows that alzheimer's disease (ad) is characterized by the propagation of tau aggregates throughout the brain in a prion-like manner. |
2024-05-22 |
2024-05-27 |
Not clear |
| Duygu Tosun, Zachary Hausle, Hirotaka Iwaki, Pamela Thropp, Jennifer Lamoureux, Edward B Lee, Karen MacLeod, Sean McEvoy, Michael Nalls, Richard J Perrin, Andrew J Saykin, Leslie M Shaw, Andrew B Singleton, Russ Lebovitz, Michael W Weiner, Cornelis Blauwendraa. A cross-sectional study of α-synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-05-21. PMID:38770829. |
alzheimer's disease (ad) pathology is defined by β-amyloid (aβ) plaques and neurofibrillary tau, but lewy bodies (lbs; 𝛼-synuclein aggregates) are a common co-pathology for which effective biomarkers are needed. |
2024-05-21 |
2024-05-27 |
Not clear |
| Panpan Sun, Hai-Chao Chen, Wenting Guo, Zefan Zhang, Shihao Sun, Ningshuang Gao, Yu-Hong Jing, Baodui Wan. A ratiometric fluorescent probe revealing the abnormality of acetylated tau by visualizing polarity in Alzheimer's disease. Journal of materials chemistry. B. 2024-05-21. PMID:38770837. |
a ratiometric fluorescent probe revealing the abnormality of acetylated tau by visualizing polarity in alzheimer's disease. |
2024-05-21 |
2024-05-27 |
mouse |
| Yara Yakoub, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Christine Déry, Cherie Strikwerda-Brown, Frédéric St-Onge, Valentin Ourry, Michael Schöll, Maiya R Geddes, Simon Ducharme, Maxime Montembeault, Pedro Rosa-Neto, Jean-Paul Soucy, John C S Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuv. Plasma p-tau217 predicts cognitive impairments up to ten years before onset in normal older adults. medRxiv : the preprint server for health sciences. 2024-05-20. PMID:38766113. |
positron emission tomography (pet) biomarkers are the gold standard for detection of alzheimer amyloid and tau |
2024-05-20 |
2024-05-27 |
Not clear |
| Stephanie Barsoum, Caitlin S Latimer, Amber L Nolan, Alexander Barrett, Koping Chang, Juan Troncoso, C Dirk Keene, Dan Benjamin. Resiliency to Alzheimer's disease neuropathology can be distinguished from dementia using cortical astrogliosis imaging. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766087. |
despite the presence of significant alzheimer's disease (ad) pathology, characterized by amyloid β (aβ) plaques and phosphorylated tau (ptau) tangles, some cognitively normal elderly individuals do not inevitably develop dementia. |
2024-05-20 |
2024-05-27 |
human |
| Alexandre Poirier, Cynthia Picard, Anne Labonté, Isabelle Aubry, Daniel Auld, Henrik Zetterberg, Kaj Blennow, Michel L Tremblay, Judes Poirie. PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766183. |
ptprs is a novel marker for early tau pathology and synaptic integrity in alzheimer's disease. |
2024-05-20 |
2024-05-27 |
Not clear |