| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allwin Ebenezer Sahayaraj, Arshad Abdul Vahid, Asmita Dhara, Ann Teres Babu, Vinesh Vijaya. Role of G326 in Determining the Aggregation Propensity of R3 Tau Repeat: Insights from Studies on R1R3 Tau Construct. The journal of physical chemistry. B. 2024-04-27. PMID:38676652. |
the microtubule-binding repeat region (mtbr) of tau has been studied extensively due to its pathological implications in neurodegenerative diseases like alzheimer's disease. |
2024-04-27 |
2024-04-30 |
Not clear |
| Sachin P Patil, Bella R Kueh. Discovery of Small Molecule Glycolytic Stimulants for Enhanced ApoE Lipidation in Alzheimer's Disease Cell Model. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675451. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by pathophysiological deposits of extracellular amyloid beta (aβ) peptides and intracellular neurofibrillary tangles of tau. |
2024-04-27 |
2024-04-29 |
human |
| Rosaleena Mohanty, Daniel Ferreira, Eric Westma. Multi-pathological contributions toward atrophy patterns in the Alzheimer's disease continuum. Frontiers in neuroscience. vol 18. 2024-04-26. PMID:38655107. |
heterogeneity in downstream atrophy in alzheimer's disease (ad) is predominantly investigated in relation to pathological hallmarks (aβ, tau) and co-pathologies (cerebrovascular burden) independently. |
2024-04-26 |
2024-04-28 |
Not clear |
| Karly A Cody, Rebecca E Langhough, Matthew D Zammit, Lindsay Clark, Nathaniel Chin, Bradley T Christian, Tobey J Betthauser, Sterling C Johnso. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease. Brain : a journal of neurology. 2024-04-26. PMID:38667631. |
characterizing brain tau and cognitive decline along the amyloid timeline in alzheimer's disease. |
2024-04-26 |
2024-04-28 |
human |
| Karly A Cody, Rebecca E Langhough, Matthew D Zammit, Lindsay Clark, Nathaniel Chin, Bradley T Christian, Tobey J Betthauser, Sterling C Johnso. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease. Brain : a journal of neurology. 2024-04-26. PMID:38667631. |
here we recontextualized amyloid levels into the temporal domain to better understand the downstream alzheimer's disease processes of tau neurofibrillary tangle (nft) accumulation and cognitive decline. |
2024-04-26 |
2024-04-28 |
human |
| Karly A Cody, Rebecca E Langhough, Matthew D Zammit, Lindsay Clark, Nathaniel Chin, Bradley T Christian, Tobey J Betthauser, Sterling C Johnso. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease. Brain : a journal of neurology. 2024-04-26. PMID:38667631. |
this cohort study included a total of 601 individuals from the wisconsin registry for alzheimer's prevention and wisconsin alzheimer's disease research center that underwent amyloid and tau pet, longitudinal neuropsychological assessments, and met clinical criteria for three clinical diagnosis groups: cognitively unimpaired (cu; n=537); mild cognitive impairment (mci; n=48); or dementia (n=16)). |
2024-04-26 |
2024-04-28 |
human |
| Karly A Cody, Rebecca E Langhough, Matthew D Zammit, Lindsay Clark, Nathaniel Chin, Bradley T Christian, Tobey J Betthauser, Sterling C Johnso. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease. Brain : a journal of neurology. 2024-04-26. PMID:38667631. |
whole-brain and region-specific approaches were used to examine tau pet binding along the amyloid timeline and across the alzheimer's disease clinical continuum. |
2024-04-26 |
2024-04-28 |
human |
| Karly A Cody, Rebecca E Langhough, Matthew D Zammit, Lindsay Clark, Nathaniel Chin, Bradley T Christian, Tobey J Betthauser, Sterling C Johnso. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease. Brain : a journal of neurology. 2024-04-26. PMID:38667631. |
overall, the amyloid time framework enabled a spatiotemporal characterization of tau deposition patterns across the alzheimer's disease continuum. |
2024-04-26 |
2024-04-28 |
human |
| Lara Blömeke, Fabian Rehn, Victoria Kraemer-Schulien, Janine Kutzsche, Marlene Pils, Tuyen Bujnicki, Piotr Lewczuk, Johannes Kornhuber, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike J Spruth, Slawek Altenstein, Andrea Lohse, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Carolin Sanzenbacher, Annika Spottke, Nina Roy-Kluth, Michael T Heneka, Frederic Brosseron, Michael Wagner, Steffen Wolfsgruber, Luca Kleineidam, Melina Stark, Matthias Schmid, Frank Jessen, Oliver Bannach, Dieter Willbold, Oliver Peter. Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 2. 2024-04-26. PMID:38666085. |
aβ oligomers peak in early stages of alzheimer's disease preceding tau pathology. |
2024-04-26 |
2024-04-28 |
Not clear |
| Johannes Levin, Simone Baiardi, Corinne Quadalti, Marcello Rossi, Angela Mammana, Jonathan Vöglein, Alexander Bernhardt, Richard J Perrin, Mathias Jucker, Oliver Preische, Anna Hofmann, Günter U Höglinger, Nigel J Cairns, Erin E Franklin, Patricio Chrem, Carlos Cruchaga, Sarah B Berman, Jasmeer P Chhatwal, Alisha Daniels, Gregory S Day, Natalie S Ryan, Alison M Goate, Brian A Gordon, Edward D Huey, Laura Ibanez, Celeste M Karch, Jae-Hong Lee, Jorge Llibre-Guerra, Francisco Lopera, Colin L Masters, John C Morris, James M Noble, Alan E Renton, Jee Hoon Roh, Matthew P Frosch, C Dirk Keene, Catriona McLean, Raquel Sanchez-Valle, Peter R Schofield, Charlene Supnet-Bell, Chengjie Xiong, Armin Giese, Oskar Hansson, Randall J Bateman, Eric McDade, Piero Parch. α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-26. PMID:38666355. |
amyloid beta and tau pathology are the hallmarks of sporadic alzheimer's disease (ad) and autosomal dominant ad (adad). |
2024-04-26 |
2024-04-28 |
Not clear |
| Carlos Antonio García-Carlos, Gustavo Basurto-Islas, George Perry, Siddhartha Mondragón-Rodrígue. Meta-Analysis in Transgenic Alzheimer's Disease Mouse Models Reveals Opposite Brain Network Effects of Amyloid-β and Phosphorylated Tau Proteins. Journal of Alzheimer's disease : JAD. 2024-04-26. PMID:38669540. |
meta-analysis in transgenic alzheimer's disease mouse models reveals opposite brain network effects of amyloid-β and phosphorylated tau proteins. |
2024-04-26 |
2024-04-29 |
mouse |
| Min Kyoung Kam, Jee-Yun Park, Gwang Ho Yun, Hee-Young Sohn, Jung Hyun Park, Jiyoung Choi, Young Ho Koh, Chulman J. Rottlerin Enhances the Autophagic Degradation of Phosphorylated Tau in Neuronal Cells. Molecular neurobiology. 2024-04-26. PMID:38671330. |
intra-neuronal accumulation of hyper-phosphorylated tau as neurofibrillary tangles (nft) is a hallmark of alzheimer's disease (ad). |
2024-04-26 |
2024-04-29 |
Not clear |
| Brian J Burkett, Derek R Johnson, Val J Low. Evaluation of Neurodegenerative Disorders with Amyloid-β, Tau, and Dopaminergic PET Imaging: Interpretation Pitfalls. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024-04-25. PMID:38664015. |
amyloid and tau pet are valuable tools that can provide objective evidence of alzheimer pathophysiology in living patients and will increasingly be used to complement |
2024-04-25 |
2024-04-28 |
Not clear |
| Florian Ermini, Victoria F Low, Jennifer J Song, Adelie Y S Tan, Richard L M Faull, Michael Dragunow, Maurice A Curtis, Stephen S Domin. Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-25. PMID:38664405. |
gingipains were recently identified in the middle temporal gyrus of postmortem alzheimer's disease (ad) brains, where gingipain load correlated with ad diagnosis and tau and ubiquitin pathology. |
2024-04-25 |
2024-04-28 |
Not clear |
| Elisenda Bueichekú, Ibai Diez, Chan-Mi Kim, John Alex Becker, Elouise A Koops, Kenneth Kwong, Kathryn V Papp, David H Salat, David A Bennett, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Jorge Sepulcre, Heidi I L Jacob. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature aging. 2024-04-25. PMID:38664576. |
autopsy studies indicated that the locus coeruleus (lc) accumulates hyperphosphorylated tau before allocortical regions in alzheimer's disease. |
2024-04-25 |
2024-04-28 |
Not clear |
| Elisenda Bueichekú, Ibai Diez, Chan-Mi Kim, John Alex Becker, Elouise A Koops, Kenneth Kwong, Kathryn V Papp, David H Salat, David A Bennett, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Jorge Sepulcre, Heidi I L Jacob. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature aging. 2024-04-25. PMID:38664576. |
these findings advance our understanding of the spatiotemporal patterns of initial tau spreading from the lc and lc's selective vulnerability to alzheimer's disease pathology. |
2024-04-25 |
2024-04-28 |
Not clear |
| Bing-Yi Wang, Si-Yu Liu, Kai-Min Hao, Wen-Xiu Q. [Age-dependent expression of HSP90 in the hippocampus of APP/PS1 mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 2. 2024-04-25. PMID:38658375. |
the present study aims to observe the change in expression of heat shock protein 90 (hsp90) along with amyloid-β (aβ) and phosphorylated tau (p-tau) protein levels in the hippocampus tissue of alzheimer's disease (ad) transgenic animal model with age. |
2024-04-25 |
2024-04-28 |
mouse |
| . Erratum: Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease. Frontiers in aging neuroscience. vol 16. 2024-04-25. PMID:38659705. |
erratum: effect of the rock inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of alzheimer's disease. |
2024-04-25 |
2024-04-28 |
mouse |
| Jayvik Joshi, Minmin Yao, Aaron Kakazu, Yuxiao Ouyang, Wenzhen Duan, Manisha Aggarwa. Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659855. |
tauopathies, including alzheimer's disease (ad), are neurodegenerative disorders characterized by hyperphosphorylated tau protein aggregates in the brain. |
2024-04-25 |
2024-04-28 |
mouse |
| Ethan D Smith, Robert McKenna, Mario Mietzsch, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Hyperacetylation mimetics within the tau filament core inhibits prion-like propagation of misfolded tau. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659970. |
acetylation of key lysine residues characterizes aggregates of the microtubule-associated protein tau constituting the neuropathological hallmark of many neurodegenerative diseases, such as alzheimer's disease (ad) and progressive supranuclear palsy (psp). |
2024-04-25 |
2024-04-28 |
Not clear |