| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosemary J Jackson, Bradley T Hyman, Alberto Serrano-Poz. Multifaceted roles of APOE in Alzheimer disease. Nature reviews. Neurology. 2024-06-21. PMID:38906999. |
multifaceted roles of apoe in alzheimer disease. |
2024-06-21 |
2024-06-24 |
mouse |
| Rosemary J Jackson, Bradley T Hyman, Alberto Serrano-Poz. Multifaceted roles of APOE in Alzheimer disease. Nature reviews. Neurology. 2024-06-21. PMID:38906999. |
for the past three decades, apolipoprotein e (apoe) has been known as the single greatest genetic modulator of sporadic alzheimer disease (ad) risk, influencing both the average age of onset and the lifetime risk of developing ad. |
2024-06-21 |
2024-06-24 |
mouse |
| Ian Fyf. APOE α4 homozygosity - a genetic form of Alzheimer disease? Nature reviews. Neurology. 2024-06-03. PMID:38831096. |
apoe α4 homozygosity - a genetic form of alzheimer disease? |
2024-06-03 |
2024-06-06 |
Not clear |
| Renhao Luo, Dena Zeraatkar, Maria Glymour, Randall J Ellis, Hossein Estiri, Chirag J Pate. Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank. BMC medicine. vol 22. issue 1. 2024-05-29. PMID:38807092. |
in 2020, the lancet commission identified 12 risk factors as priorities for prevention of dementia, and other studies identified apoe e4/e4 genotype and family history of alzheimer's disease strongly associated with dementia outcomes; however, it is unclear how robust these relationships are across dementia subtypes and analytic scenarios. |
2024-05-29 |
2024-06-02 |
Not clear |
| b' Kinga Igloi, Blanca Marin Bosch, No\xe9mie Kuenzi, Aur\xe9lien Thomas, Estelle Lauer, Aur\xe9lien Bringard, Sophie Schwart. Interactions between physical exercise, associative memory, and genetic risk for Alzheimer\'s disease. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 5. 2024-05-27. PMID:38802684.' |
the ε4 allele of the apoe gene heightens the risk of late onset alzheimer's disease. |
2024-05-27 |
2024-06-03 |
human |
| Rohan Nadkarni, Zay Yar Han, Robert J Anderson, Alex J Allphin, Darin P Clark, Alexandra Badea, Cristian T Bade. High-resolution hybrid micro-CT imaging pipeline for mouse brain region segmentation and volumetric morphometry. PloS one. vol 19. issue 5. 2024-05-23. PMID:38781243. |
brain region segmentation and morphometry in humanized apolipoprotein e (apoe) mouse models with a human nos2 background (hn) contribute to alzheimer's disease (ad) research by demonstrating how various risk factors affect the brain. |
2024-05-23 |
2024-05-27 |
mouse |
| Katherine Y Peng, Braison Liemisa, Jonathan Pasato, Pasquale D'Acunzo, Monika Pawlik, Adriana Heguy, Sai C Penikalapati, Amanda Labuza, Harshitha Pidikiti, Melissa J Alldred, Stephen D Ginsberg, Efrat Levy, Paul M Mathew. Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging. Traffic (Copenhagen, Denmark). vol 25. issue 5. 2024-05-22. PMID:38777335. |
the polymorphic apoe gene is the greatest genetic determinant of sporadic alzheimer's disease risk: the apoe4 allele increases risk, while the apoe2 allele is neuroprotective compared with the risk-neutral apoe3 allele. |
2024-05-22 |
2024-05-27 |
mouse |
| Bonnie H Lee, Melike Cevizci, Stephanie E Lieblich, Muna Ibrahim, Yanhua Wen, Rand S Eid, Yvonne Lamers, Paula Duarte-Guterman, Liisa A M Gale. Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age. Brain, behavior, and immunity. 2024-05-21. PMID:38772427. |
female sex and apolipoprotein e (apoe) ε4 genotype are top non-modifiable risk factors for alzheimer's disease (ad). |
2024-05-21 |
2024-05-27 |
rat |
| Madison Bailey, Zlatomira Georgieva Ilchovska, Akram A Hosseini, JeYoung Jun. The impact of APOE ε4 in Alzheimer's disease: a meta-analysis of voxel-based morphometry studies. medRxiv : the preprint server for health sciences. 2024-05-20. PMID:38766196. |
the impact of apoe ε4 in alzheimer's disease: a meta-analysis of voxel-based morphometry studies. |
2024-05-20 |
2024-05-27 |
Not clear |
| Kate E Foley, Donna M Wilcoc. Three major effects of APOE Frontiers in aging neuroscience. vol 16. 2024-05-18. PMID:38756535. |
three major effects of apoe the targeting of amyloid-beta (aβ) plaques therapeutically as one of the primary causes of alzheimer's disease (ad) dementia has been an ongoing effort spanning decades. |
2024-05-18 |
2024-05-27 |
Not clear |
| Jillian Belgrad, Qi Tang, Sam Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria, Dan O'Reilly, Eric Luu, Brianna Bramato, Sarah Allen, David Cooper, Julia Alterman, Ken Yamada, Neil Aronin, Marian DiFiglia, Anastasia Khvorov. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic acids research. 2024-05-13. PMID:38726879. |
huntington's disease: msh3 and htt; alzheimer's disease: apoe and jak1) with similar potency to a mixture of single-targeting divalent sirnas against each gene. |
2024-05-13 |
2024-05-27 |
mouse |
| Gulafsha Kausar, Shashi B Chauhan, Ritirupa Roy, Shashi Kumar, Christian Engwerda, Susanne Nylen, Rajiv Kumar, Mary E Wilson, Shyam Sunda. Apolipoprotein E Is Upregulated in Blood and Circulating Monocytes of Indian Patients With Visceral Leishmaniasis. Parasite immunology. vol 46. issue 5. 2024-05-09. PMID:38720445. |
apolipoprotein e (apoe) has been associated with several diseases including parkinson's disease, alzheimer's and multiple sclerosis. |
2024-05-09 |
2024-05-27 |
human |
| Ilenia Libri, Chiara Silvestri, Salvatore Caratozzolo, Antonella Alberici, Andrea Pilotto, Silvana Archetti, Laura Trainini, Barbara Borroni, Alessandro Padovani, Alberto Benuss. Association of APOE genotype with blood-brain barrier permeability in neurodegenerative disorders. Neurobiology of aging. vol 140. 2024-05-08. PMID:38718740. |
this study explores the impact of apoe genotypes on bbb integrity among 230 participants experiencing cognitive impairment, encompassing cases of alzheimer's disease (ad) as well as various non-ad neurodegenerative conditions. |
2024-05-08 |
2024-05-27 |
human |
| Mansour Haidar, Benjamin Schmid, Agustín Ruiz, Andreas Ebneth, Alfredo Cabrera-Socorr. Generation of three isogenic, gene-edited iPSC lines carrying the APOE-Christchurch mutation into the three common APOE variants: APOE2Ch, APOE3Ch and APOE4Ch. Stem cell research. vol 77. 2024-05-04. PMID:38703665. |
late-onset alzheimer's disease (ad) has become the paradigm of a non-mendelian complex neurodegenerative disease, for which a major genetic determinant is known, the apoe locus. |
2024-05-04 |
2024-05-07 |
Not clear |
| Conner Frank, Abigail Albertazzi, Claire Murph. The effect of the apolipoprotein E ε4 allele and olfactory function on odor identification networks. Brain and behavior. vol 14. issue 5. 2024-05-04. PMID:38702902. |
the combination of apolipoprotein e ε4 (apoe ε4) status, odor identification, and odor familiarity predicts conversion to mild cognitive impairment (mci) and alzheimer's disease (ad). |
2024-05-04 |
2024-05-06 |
Not clear |
| Lijuan Xu, Chao Ren, Chenxi Jing, Gang Wang, Hongchun Wei, Min Kong, Maowen B. Predicting amyloid-PET and clinical conversion in apolipoprotein E ε3/ε3 non-demented individuals with multidimensional factors. The European journal of neuroscience. 2024-05-03. PMID:38698692. |
the apolipoprotein e (apoe) ε4 is a well-established risk factor of amyloid-β (aβ) in alzheimer's disease (ad). |
2024-05-03 |
2024-05-05 |
Not clear |
| Zahra Shirzadi, Jasmeer Chhatwa. APOE Genotype and White Matter Hyperintensities in Sporadic Alzheimer Disease-Reply. JAMA neurology. 2024-04-29. PMID:38683603. |
apoe genotype and white matter hyperintensities in sporadic alzheimer disease-reply. |
2024-04-29 |
2024-05-02 |
Not clear |
| Saira Mirza, Tim Wilkinson, Mario Maselli. APOE Genotype and White Matter Hyperintensities in Sporadic Alzheimer Disease. JAMA neurology. 2024-04-29. PMID:38683620. |
apoe genotype and white matter hyperintensities in sporadic alzheimer disease. |
2024-04-29 |
2024-05-02 |
Not clear |
| Sachin P Patil, Bella R Kueh. Discovery of Small Molecule Glycolytic Stimulants for Enhanced ApoE Lipidation in Alzheimer's Disease Cell Model. Pharmaceuticals (Basel, Switzerland). vol 17. issue 4. 2024-04-27. PMID:38675451. |
discovery of small molecule glycolytic stimulants for enhanced apoe lipidation in alzheimer's disease cell model. |
2024-04-27 |
2024-04-29 |
human |
| Matthew W McMaster, Avisha Shah, John Kangarlu, Ryan Cheikhali, William H Frishman, Wilbert S Arono. The Impact of the Apolipoprotein E Genotype on Cardiovascular Disease and Cognitive Disorders. Cardiology in review. 2024-04-25. PMID:38661359. |
the impact of apoe on alzheimer's disease and a discussion of why it is possibly unrelated to ascvd prevention are included. |
2024-04-25 |
2024-04-28 |
Not clear |