| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G C Siek, L S Katz, E B Fishman, T S Korosi, J K Marqui. Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain. Biological psychiatry. vol 27. issue 6. 1990-05-24. PMID:2322617. |
we have previously reported that the 10s molecular form (g4) of acetylcholinesterase (ache) is selectively lost from several cortical areas of alzheimer's disease (ad) brain. |
1990-05-24 |
2023-08-11 |
Not clear |
| K M Schegg, S Nielsen, R M Zweig, J H Peacoc. Decrease in membrane-bound G4 form of acetylcholinesterase in postmortem Alzheimer brain. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2602428. |
decrease in membrane-bound g4 form of acetylcholinesterase in postmortem alzheimer brain. |
1990-01-31 |
2023-08-11 |
mouse |
| V Kumar, E Giacobini, S Markwel. CSF choline and acetylcholinesterase in early-onset vs. late-onset Alzheimer's disease patients. Acta neurologica Scandinavica. vol 80. issue 5. 1989-12-28. PMID:2589014. |
csf choline and acetylcholinesterase in early-onset vs. late-onset alzheimer's disease patients. |
1989-12-28 |
2023-08-11 |
Not clear |
| V Kumar, E Giacobini, S Markwel. CSF choline and acetylcholinesterase in early-onset vs. late-onset Alzheimer's disease patients. Acta neurologica Scandinavica. vol 80. issue 5. 1989-12-28. PMID:2589014. |
cerebrospinal fluid acetylcholinesterase (ache) activity levels and choline (ch) levels were studied in 52 dementia of alzheimer type (dat) patients and 20 age-matched controls. |
1989-12-28 |
2023-08-11 |
Not clear |
| F J Huff, C T Reiter, J Protetc. Activities and kinetic properties of lumbar cerebrospinal fluid cholinesterases in relation to clinical diagnosis, severity, and progression of Alzheimer's disease. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 16. issue 4. 1989-12-20. PMID:2804802. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities of lumbar cerebrospinal fluid (csf) have been measured in seventeen patients with a clinical diagnosis of probable alzheimer's disease (prob ad), possible alzheimer's disease (poss ad), or dementia of non-alzheimer aetiology (non-ad). |
1989-12-20 |
2023-08-11 |
Not clear |
| K Urakami, Y Adachi, E Awaki, K Takahash. Characterization of the course of senile dementia of the Alzheimer type using cerebrospinal fluid levels of acetylcholinesterase and somatostatin. Acta neurologica Scandinavica. vol 80. issue 3. 1989-11-20. PMID:2572139. |
characterization of the course of senile dementia of the alzheimer type using cerebrospinal fluid levels of acetylcholinesterase and somatostatin. |
1989-11-20 |
2023-08-11 |
human |
| K Urakami, Y Adachi, E Awaki, K Takahash. Characterization of the course of senile dementia of the Alzheimer type using cerebrospinal fluid levels of acetylcholinesterase and somatostatin. Acta neurologica Scandinavica. vol 80. issue 3. 1989-11-20. PMID:2572139. |
the acetylcholinesterase (ache) activity and somatostatin (srif) concentration of the cerebrospinal fluid (csf) were measured in patients with alzheimer's disease (ad) and 3 types of sdat. |
1989-11-20 |
2023-08-11 |
human |
| C Geula, M Mesula. Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease. Brain research. vol 498. issue 1. 1989-11-08. PMID:2790472. |
selective cholinesterase inhibitors such as bw284c51 and iso-ompa showed that the plaques and tangles of alzheimer's disease contain acetylcholinesterase and butyrylcholinesterase activity. |
1989-11-08 |
2023-08-11 |
Not clear |
| G M Shutske, F A Pierrat, K J Kapples, M L Cornfeldt, M R Szewczak, F P Huger, G M Bores, V Haroutunian, K L Davi. 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics. Journal of medicinal chemistry. vol 32. issue 8. 1989-09-07. PMID:2754707. |
they inhibit acetylcholinesterase in vitro and are active in a model that may be predictive of activity in alzheimer's disease--the scopolamine-induced impairment of 24-h memory of a passive dark-avoidance paradigm in mice. |
1989-09-07 |
2023-08-11 |
mouse |
| J Yoshinaga, T Sasaki, H Ideshita, A Hikiji, T Kuwak. [Acetylcholinesterase activity in CSF in senile dementia of Alzheimer type, vascular dementia, and Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 29. issue 3. 1989-08-31. PMID:2752667. |
[acetylcholinesterase activity in csf in senile dementia of alzheimer type, vascular dementia, and parkinson's disease]. |
1989-08-31 |
2023-08-11 |
human |
| J Yoshinaga, T Sasaki, H Ideshita, A Hikiji, T Kuwak. [Acetylcholinesterase activity in CSF in senile dementia of Alzheimer type, vascular dementia, and Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 29. issue 3. 1989-08-31. PMID:2752667. |
acetylcholinesterase (ache) activity was measured in cerebrospinal fluid (csf) from 25 patients with senile dementia of alzheimer type (sdat), 11 patients with vascular dementia (vd), 26 patients with parkinson's disease (pd), and 30 normal controls. |
1989-08-31 |
2023-08-11 |
human |
| R Elble, E Giacobini, C Higgin. Choline levels are increased in cerebrospinal fluid of Alzheimer patients. Neurobiology of aging. vol 10. issue 1. 1989-08-31. PMID:2755556. |
we measured choline (ch), acetylcholinesterase activity (ache) and total protein in the cerebrospinal fluid (csf) of 66 alzheimer patients (ages 54-89 years) and 22 age-matched controls (ages 52-80 years), looking for markers of the well-established cholinergic deficit and neuronal degeneration in alzheimer disease (ad). |
1989-08-31 |
2023-08-11 |
Not clear |
| J Moossy, G S Zubenko, A J Martinez, G R Rao, U Kopp, I Hani. Lateralization of brain morphologic and cholinergic abnormalities in Alzheimer's disease. Archives of neurology. vol 46. issue 6. 1989-07-07. PMID:2730376. |
the extent of left-right asymmetry in the densities of senile plaques and neurofibrillary tangles and the levels of the cholinergic enzymes choline acetyltransferase and acetylcholinesterase were quantified in the middle frontal and superior temporal cerebral cortex, entorhinal cortex, and prosubiculum of the hippocampus from 21 patients who died with alzheimer's disease. |
1989-07-07 |
2023-08-11 |
Not clear |
| M A Raskind, E R Peskind, R C Veith, S C Risse, T H Lampe, S Borson, G Gumbrecht, D M Dors. Neuroendocrine responses to physostigmine in Alzheimer's disease. Archives of general psychiatry. vol 46. issue 6. 1989-06-30. PMID:2525015. |
to assess central nervous system cholinergic neuroendocrine regulation in alzheimer's disease (ad), we measured plasma arginine vasopressin, beta-endorphin, and epinephrine responses to a cholinergic challenge elicited by intravenous administration of the acetylcholinesterase inhibitor physostigmine (0.0125 mg/kg) in male patients with ad (n = 12) and compared their responses with those of age-matched normal control subjects (n = 12). |
1989-06-30 |
2023-08-11 |
human |
| S Kish, H Karlinsky, L Becker, J Gilbert, M Rebbetoy, L J Chang, L DiStefano, O Hornykiewic. Down's syndrome individuals begin life with normal levels of brain cholinergic markers. Journal of neurochemistry. vol 52. issue 4. 1989-04-21. PMID:2522539. |
we measured the activities of the cholinergic marker enzymes choline acetyltransferase (chat) and acetylcholinesterase (ache) in autopsied brains of seven infants (age range 3 months to 1 year) with down's syndrome (ds), a disorder in which virtually all individuals will develop by middle age the neuropathological changes of alzheimer's disease accompanied by a marked brain cholinergic reduction. |
1989-04-21 |
2023-08-11 |
Not clear |
| F J Huff, C T Reiter, J B Ran. The ratio of acetylcholinesterase to butyrylcholinesterase influences the specificity of assays for each enzyme in human brain. Journal of neural transmission. vol 75. issue 2. 1989-04-04. PMID:2918305. |
data are presented regarding the differential inhibition of acetylcholinesterase and butyrylcholinesterase in several brain areas from a case of alzheimer's disease and a case without neuropsychiatric disease. |
1989-04-04 |
2023-08-11 |
human |
| J Sirviö, R Kutvonen, H Soininen, P Hartikainen, P J Riekkine. Cholinesterases in the cerebrospinal fluid, plasma, and erythrocytes of patients with Alzheimer's disease. Journal of neural transmission. vol 75. issue 2. 1989-04-04. PMID:2918304. |
in patients with probable alzheimer's disease and in controls, acetyl- and butyrylcholinesterase activities were studied in cerebrospinal fluid (csf) and plasma, and acetylcholinesterase activity of erythrocytes was determined. |
1989-04-04 |
2023-08-11 |
Not clear |
| J Sirviö, R Kutvonen, H Soininen, P Hartikainen, P J Riekkine. Cholinesterases in the cerebrospinal fluid, plasma, and erythrocytes of patients with Alzheimer's disease. Journal of neural transmission. vol 75. issue 2. 1989-04-04. PMID:2918304. |
the ratio of the intermediate molecular form of acetylcholinesterase to the light molecular form of the enzyme did not differ significantly between patients with alzheimer's disease and controls. |
1989-04-04 |
2023-08-11 |
Not clear |
| M M Mesulam, C Geul. Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: observations based on the distribution of acetylcholinesterase and choline acetyltransferase. The Journal of comparative neurology. vol 275. issue 2. 1989-03-16. PMID:3220975. |
alzheimer's disease was associated with a marked depletion of cortical acetylcholinesterase. |
1989-03-16 |
2023-08-11 |
human |
| J de Belleroche, I M Gardine. Inhibitory effect of 1,2,3,4-tetrahydro-9-aminoacridine on the depolarization-induced release of GABA from cerebral cortex. British journal of pharmacology. vol 94. issue 4. 1989-02-21. PMID:3207970. |
1,2,3,4-tetrahydro-9-aminoacridine (tha) has an inhibitory effect on the activity of acetylcholinesterase which has led to its use in the treatment of alzheimer's disease. |
1989-02-21 |
2023-08-11 |
rat |